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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang yuan-yuan Ji Jian-Shuai Zhao Jun-Xiang Gu Xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-lian Li Tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

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Rare Metals 2024年第6期43卷 2349-2370页

作者： Zhi Zeng Dong-Bo Wang Xuan Fang Jia-Mu Cao Bing-Ke Zhang Jing-Wen Pan Dong-Hao Liu Si-Hang Liu Shu-Jie Jiao Tian-yuan Chen Gang Liu lian-Cheng Zhao Jin-Zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

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钢筋混凝土剪力墙抗震滞回性能的多元时序深度神经网络预测

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工程力学 2024年第6期41卷 66-76页

作者：袁程熊青松孔庆钊同济大学土木工程防灾国家重点实验室上海200092

钢筋混凝土剪力墙结构抗震性能优越且造价合理,广泛用于抗震烈度较高的地区。准确地预测剪力墙的滞回性能与骨架曲线,直接决定了结构设计与分析的准确度与可靠性。该文提出了一种基于深度学习的剪力墙结构滞回性能预测方法,可以根据结... 详细信息

钢筋混凝土剪力墙结构抗震性能优越且造价合理,广泛用于抗震烈度较高的地区。准确地预测剪力墙的滞回性能与骨架曲线,直接决定了结构设计与分析的准确度与可靠性。该文提出了一种基于深度学习的剪力墙结构滞回性能预测方法,可以根据结构的基本设计参数(如材料属性、几何尺寸、荷载工况等),直接预测出其承载力。通过3组剪力墙的滞回试验预测1组结构的滞回曲线,结果表明:通过比较时域的特征,深度学习方法具有较高的预测精度。通过与有限元仿真结果对比,深度学习仅需输入不同参数就能够快速预测滞回曲线,其优势还在于具有较高的计算效率,而有限元仿真需要几何建模、本构模型选取、材料属性输入和荷载工况定义,整个过程相较于深度学习耗时耗力。

关键词：钢筋混凝土剪力墙多元时序深度神经网络滞回曲线抗震性能骨架曲线

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Follow-up study of gallbladder stones in 44 children

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World Journal of Clinical Cases 2024年第18期12卷 3403-3409页

作者： Jian-xiong Yu Zhi-Zhong Jiang yuan-Hao Cai Lin Zhou Bin Cai Department of Pediatric The Firs Affiliated Hospital of Naval Medical UniversityShanghai 20000China

BACKGROUND Cholesterol stones affect a certain subpopulation of *** have been raised on the impact of gallbladder surgery on the growth of children and *** To study the population characteristics,clinical features,treatment,and prognosis of gallstones in *** The clinical data of 44 children with gallstones admitted to The First Affiliated Hospital of Naval Medical University from August 2009 to August 2021 were collected,the children were followed up by telephone to monitor their *** follow-up ended in August *** shortest follow-up time was 2 years and 6 months,whereas the longest was 13 years and 11 *** population characteristics,general clinical characteristics,and treatments were retrospectively *** children were divided according to whether they underwent surgical gallbladder removal into an operation group(n=28)and a non-operation group(n=16),The effects of surgical gallbladder resection on the growth and development of children were *** The male–female ratio in the population was 6:5 and 84.09%of the children had onset in ***,29.55%of the children were overweight or *** study identified 26 cases with metabolic abnormalities,9 with hemolytic anemia,and 4 with choledochal *** the population,68.18%had recurrent symptomatic *** treatment accounted for 63.64%,with laparoscopic cholecystectomy accounting for 71.43%of surgical *** significant differences were observed in symptoms and complications between the surgery and non-surgery ***,no significant differences were found between the two groups in the attainment of genetic height target and the rightward shift of height curve during *** The sex characteristics of gallstones in children were not *** gallstones occurred in adolescents and rarely in young children.A considerable proportion of children have inborn causes,which are of

关键词： Gallstones in children Clinical characteristics Growth and development Operation Clinical features

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen yuan xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing Fang Chunyan Li Dexian Chen Qi Wei Xingyu xiong Wenxin Zhao Wen Tan yuan Han Hongxing Zhang He Liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative *** This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major *** In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and *** 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received *** improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,p<0.001)and N2(75.0(36.0-120.8)vs 30.0(1.3-59.3)min,F=12.55,p<0.001);the total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,p<0.001)and N2(488.5(455.5-548.5)vs 346.0(286.5-517.5)min,F=7.36,p=0.007);the deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,p<0.001)and N2(103.5(46.0-154.8)vs 57.5(23.3-106.5)min,F=8.4,p=0.004);and the percentages of light sleep and REM sleep on N1 and N2(p<0.05 for each).The postoperative depression and anxiety scores did not differ significantly between the two *** significant adverse events were *** In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep ***,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

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一种用于大视场成像和偏振光谱探测的微型可重构超构光学系统

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Engineering 2024年第4期35卷 67-73页

作者： Fei Zhang Minghao Liao Mingbo Pu Yinghui Guo lianwei Chen xiong Li Qiong He Tongtong Kang Xiaoliang Ma yuan Ke Xiangang Luo State Key Laboratory of Optical Technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China National Key Laboratory of Optical Field Manipulation Science and Technology Chinese Academy of SciencesChengdu 610209China School of Optoelectronics University of Chinese Academy of SciencesBeijing 100049China Research Center on Vector Optical Fields Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China Tianfu Xinglong Lake Laboratory Chengdu 610299China

Wide-angle imaging and spectral detection play vital roles in tasks such as target tracking,object classification,and ***,limited by their intrinsically different architectures,as determined by frequency dispersion requirements,their simultaneous implementation in a shared-aperture system is ***,we propose a novel concept to realize reconfigurable dual-mode detection based on electrical-control tunable *** a proof-of-concept demonstration,the simultaneous implementation of wide-angle imaging and polarization-spectral detection in a miniature sharedaperture meta-optical system is realized for the first time via the electrical control of cascaded catenary-like *** proposed system supports the imaging(spectral)resolution of approximately 27.8 line-pairs per millimeter(lp·mm^(-1);~80 nm)for an imaging(spectral)mode from 8 to 14 μ*** system also bears a large field of view of about 70°,enabling multi-target recognition in both *** work may promote the miniaturization of multifunctional optical systems,including spectrometers and polarization imagers,and illustrates the potential industrial applications of meta-optics in biomedicine,security,space exploration,and more.

关键词： Metasurfaces Reconfigurable Imaging Spectral

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Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer

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中华医学杂志(英文版) 2024年第15期137卷 1844-1856页

作者： Ge Yue Ma Sheng Zhou Qiang xiong Zezhong Wang Yanan Li Le Chao Zheng Zhang Junbiao Li Tengfei Wu Zixi Gao yuan Qu Guanyu Xi Zirui Liu Bo Wu Xi Wang Zhihua Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Urology Qinghai University Affiliated Hospital Qinghai University Medical College Xining Qinghai China Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Urology First Hospital of Laohekou City Xiangyang Hubei China

Background: Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer (PCa), the long tail of cancer genes remains to be defined. Goosecoid (GSC) has been implicated in cancer development. However, the comprehensive biological role ofGSC in pan-cancer, specifically in PCa, remains unexplored. The aim of this study was to investigate the role ofGSC in PCa ***: We performed a systematic bioinformatics exploration ofGSC using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Omnibus, German Cancer Research Center, and our in-house cohorts. First, we evaluated the expression ofGSC and its association with patient prognosis, and identifiedGSC-relevant genetic alterations in cancers. Further, we focused on the clinical characterization and prognostic analysis ofGSC in PCa. To understand the transcriptional regulation ofGSC by E2F transcription factor 1 (E2F1), we performed chromatin immunoprecipitation quantitative polymerase chain reaction (qPCR). Functional experiments were conducted to validate the effect ofGSC on the tumor cellular phenotype and sensitivity to ***: GSC expression was elevated in various tumors and significantly correlated with patient prognosis. The alterations ofGSC contribute to the progression of various tumors especially in PCa. Patients with PCa and highGSC expression exhibited worse progression-free survival and biochemical recurrence outcomes. Further,GSC upregulation in patients with PCa was mostly accompanied with higher Gleason score, advanced tumor stage, lymph node metastasis, and elevated prostate-specific antigen (PSA) levels. Mechanistically, the transcription factor,E2F1, stimulatesGSC by binding to its promoter region. Detailed experiments further demonstrated thatGSC acted as an oncogene and influenced the response of PCa cells to trametinib ***: GSC was highly overexpressed and strongly correlate

关键词： Goosecoid Prostate cancer Prognosis E2F transcription factor 1 Trametinib

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揭示氨对正己酸生产影响的机制——影响途径、关键酶和微生物

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Engineering 2024年第4期35卷 180-190页

作者： Qing-lian Wu Ke-Xin yuan Wei-Tong Ren Lin Deng Hua-Zhe Wang Xiao-Chi Feng He-Shan Zheng Nan-Qi Ren Wan-Qian Guo State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090China College of Architecture and Environment Sichuan UniversityChengdu 610065China State Key Laboratory of Urban Water Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China College of Chemistry and Chemical Engineering Qiqihar UniversityQiqihar 161006China

n-Caproate,which is produced via chain elongation(CE)using waste biomass,can supply various fossilderived products,thus advancing the realization of carbon *** released from the degradation of nitrogen-rich waste biomass can act as a nutrient or an inhibitor in anaerobic bioprocesses,including CE,with the distinction being primarily dependent on its ***,the optimal concentration of ammonia and the threshold of toxicity for open-culture n-caproate production using ethanol as an electron donor,along with the underlying mechanisms,remain *** study revealed that the optimal concentration of ammonia for n-caproate production was 2.0 g∙L^(-1),whereas concentrations exceeding this threshold markedly suppressed the CE *** of the mechanism revealed the involvement of two forms of ammonia(i.e.,ammonium ions and free ammonia)in this inhibitory *** ammonia levels(5.0 g∙L^(-1))induced excessive ethanol oxidation and suppressed the reverse β-oxidation(RBO)process,directly leading to the enhanced activities of enzymes(phosphotransacetylase and acetate kinase)responsible for acetate formation and diminished activities of butyryl-coenzyme A(CoA):acetyl-CoA transferase,caproyl-CoA:butyryl-CoA transferase,and caproyl-CoA:acetyl-CoA transferase that are involved in the syntheses of n-butyrate and ***,the composition of the microbial community shifted from Paraclostridium dominance(at 0.1 g∙L^(-1)ammonia)to a co-dominance of Fermentimonas,Clostridium sensu stricto 12,and Clostridium sensu stricto 15 at 2.0 g∙L^(-1)***,these CE-functional bacteria were mostly absent in the presence of excessive ammonia(5.0 g∙L^(-1)ammonia).Metagenomic analysis revealed the upregulation of functions such as RBO,fatty acid synthesis,K^(+)efflux,adenosine triphosphatase(ATPase)metabolism,and metal cation export in the presence of 2.0 g∙L^(-1)ammonia,collectively contributing to enhanced n-caproate produc

关键词： Ammonia inhibition Medium chain fatty acids n-Caproate Enzyme Metagenomics

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Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss

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Signal Transduction and Targeted Therapy 2024年第2期9卷 751-765页

作者： Xudong Xie Peng Cheng liangcong Hu Wu Zhou Detai Zhang Samuel Knoedler Guodong Liu yuan xiong Hang Xue Yiqiang Hu Barbara Kern Doha Obed Adriana CPanayi Lang Chen Chenchen Yan Ze Lin Guandong Dai Bobin Mi Yingze Zhang Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Division of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02152USA Department of Plastic Surgery and Hand Surgery Klinikum Rechts der IsarTechnical University of MunichMunichGermany Medical Center of Trauma and War Injuries Daping HospitalArmy Medical UniversityChonqing 400042China Department of Plastic Surgery Campus CharitéMitte|Campus Virchow-KlinikumCharité-Universitätsmedizin Berlincorporate member of Freie Universität BerlinHumboldt-Universität zu Berlin and Berlin Institute of HealthBerlinGermany Berlin Institute of Health Charité-Universitätsmedizin BerlinBerlinGermany Department of Plastic AestheticHand and Reconstructive SurgeryHannover Medical SchoolHannoverGermany Department of Hand Plastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/RhineGermany Pingshan District People’s Hospital of Shenzhen Pingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical UniversityNO.139 Ziqiang RoadShijiazhuang 050051China

The clinical role and underlying mechanisms of valproic acid(VPA)on bone homeostasis remain ***,we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density(BMD)in both patients and *** effect was attributed to VPA-induced elevation in osteoclast formation and *** RNA-sequencing,we observed a significant rise in precursor miR-6359 expression in VPA-treated osteoclast precursors in vitro,and further,a marked upregulation of mature miR-6359(miR-6359)in vivo was demonstrated using quantitative real-time PCR(qRT-PCR)and miR-6359 fluorescent in situ hybridization(miR-6359-FISH).Specifically,the miR-6359 was predominantly increased in osteoclast precursors and macrophages but not in neutrophils,T lymphocytes,monocytes and bone marrow-derived mesenchymal stem cells(BMSCs)following VPA stimulation,which influenced osteoclast differentiation and bone-resorptive ***,VPA-induced miR-6359 enrichment in osteoclast precursors enhanced reactive oxygen species(ROS)production by silencing the SIRT3 protein expression,followed by activation of the MAPK signaling pathway,which enhanced osteoclast formation and activity,thereby accelerating bone ***,there are no medications that can effectively treat VPA-induced bone ***,we constructed engineered small extracellular vesicles(E-sEVs)targeting osteoclast precursors in bone and naturally carrying anti-miR-6359 by introducing of EXOmotif(CGGGAGC)in the 3’-end of the anti-miR-6359 *** confirmed that the E-sEVs exhibited decent bone/osteoclast precursor targeting and exerted protective therapeutic effects on VPA-induced bone loss,but not on ovariectomy(OVX)and glucocorticoid-induced osteoporotic models,deepening our understanding of the underlying mechanism and treatment strategies for VPA-induced bone loss.

关键词： miR protective stimulation

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