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Local and regional flood frequency analysis based on hierarchical Bayesian model in Dongting Lake Basin,China

Water Science and Engineering 2019年第4期12卷 253-262页

作者： Yun-biao Wu lian-qing xue Yuan-hong Liu College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Department of Fundamental Education Wanjiang University of TechnologyMaanshan 243031China College of Water and Architectural Engineering Shihezi UniversityShihezi 832003China

This study developed a hierarchical Bayesian(HB)model for local and regional flood frequency analysis in the Dongting Lake Basin,in *** annual maximum daily flows from 15 streamflow-gauged sites in the study area were analyzed with the HB *** generalized extreme value(GEV)distribution was selected as the extreme flood distribution,and the GEV distribution location and scale parameters were spatially modeled through a regression approach with the drainage area as a *** Markov chain Monte Carlo(MCMC)method with Gibbs sampling was employed to calculate the posterior distribution in the HB *** results showed that the proposed HB model provided satisfactory Bayesian credible intervals for flood quantiles,while the traditional delta method could not provide reliable uncertainty estimations for large flood quantiles,due to the fact that the lower confidence bounds tended to decrease as the return periods ***,the HB model for regional analysis allowed for a reduction in the value of some restrictive assumptions in the traditional index flood method,such as the homogeneity region assumption and the scale invariance *** HB model can also provide an uncertainty band of flood quantile prediction at a poorly gauged or ungauged site,but the index flood method with L-moments does not demonstrate this uncertainty ***,the HB model is an effective method of implementing the flexible local and regional frequency analysis scheme,and of quantifying the associated predictive uncertainty.

关键词： Flood frequency analysis Hierarchical Bayesian model Index flood method Generalized extreme value distribution Dongting Lake Basin

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Mixed D-vine copula-based conditional quantile model for stochastic monthly streamflow simulation

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Water Science and Engineering 2024年第1期17卷 13-20页

作者： Wen-zhuo Wang Zeng-chuan Dong Tian-yan Zhang Li Ren lian-qing xue Teng Wu College of Water Resources and Hydrology Hohai UniversityNanjing 210098China Yellow River Research Center Hohai UniversityNanjing 210098China

Copula functions have been widely used in stochastic simulation and prediction of ***,existing models are usually limited to single two-dimensional or three-dimensional copulas with the same bivariate block for all *** address this limitation,this study developed a mixed D-vine copula-based conditional quantile model that can capture temporal *** model can generate streamflow by selecting different historical streamflow variables as the conditions for different months and by exploiting the conditional quantile functions of streamflows in different months with mixed D-vine *** up-to-down sequential method,which couples the maximum weight approach with the Akaike information criteria and the maximum likelihood approach,was used to determine the structures of multivariate Dvine *** developed model was used in a case study to synthesize the monthly streamflow at the Tangnaihai hydrological station,the inflow control station of the Longyangxia Reservoir in the Yellow River *** results showed that the developed model outperformed the commonly used bivariate copula model in terms of the performance in simulating the seasonality and interannual variability of *** model provides useful information for water-related natural hazard risk assessment and integrated water resources management and utilization.

关键词： Stochastic monthly streamflow simulation Mixed D-vine copula Conditional quantile model Up-to-down sequential method Tangnaihai hydrological station

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论中国人权法学研究的转向——以2015、2016年研究成果为分析基础

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山东大学学报（哲学社会科学版） 2017年第6期 164-176页

作者：齐延平连雪晴山东大学法学院

中国人权法学研究呈现由译介述评向本土叙事、由权利正当性论证向权利释义学、由一般性权利论证向具体权利证成等转向趋势,中国问题意识在这一过程中日益凸显。人权法学研究应当从问题出发,为问题的解决提供开放性的、多元化的智识指引... 详细信息

中国人权法学研究呈现由译介述评向本土叙事、由权利正当性论证向权利释义学、由一般性权利论证向具体权利证成等转向趋势,中国问题意识在这一过程中日益凸显。人权法学研究应当从问题出发,为问题的解决提供开放性的、多元化的智识指引,要有效防方法论上的独断,从中国人权体系抑或基本权利体系的价值信仰出发,促进中国人权抑或基本权利作业范式的形成。

关键词：人权法学研究转向研究范式

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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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Nutrient exchange and release experiment and its simulation study in lake water-sediment interface

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Journal of Environmental Sciences 2006年第3期18卷 591-595页

作者： xue lian-qing HAO Zhen-chun State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering College of Water Resources and Environment Hohai UniversityNanjing 210098 China

The sediment distributed and insolated under lake was collected for experiments. The nutrient layer distribution conditions of sampled sediment and its physical and chemical characteristics were analyzed to simulate and assess the influence degree to lake water quality. Based on the dynamic water exchanging experiments the nutrient release process in sediment and influence mechanism to substance exchanging on water-sediment interface was studied, and the correlation between the changing content of total phosphors and total nitrogen in sediment and covered water were analyzed for setting up a simulation model. At the same time the influence degree is explained in detail. The experimental results indicated that even if clean water without nutrient contents was used for water exchangement so as to decrease pollution or prevent eutrophication, however owing to the vertical nutrient distribution in lake sediment, it will lead to the increasing release amount greatly especially when the organic nutrient contained in sediment turns into inorganic status because of isolation. Besides the release process of total phosphate （TP） and total nitrogen （TN） were modeled and each nutrient＇s exchanging equation at interface caused by covered water nutrient concentration changing was set up. According to the simulating prediction, TP and TN content of cover water will also sustain a steady higher level in a long period. The nutrient release amount of sediment is not only affected by the covered water concentration but also connects with accumulative time. The experiments provide the fundamental theoretical and practical basis for taking ecological restoration project. And research is helpful to prevent or restore lake eutrophication.

关键词： phosphate and nitrogen release water-sediment interface experiments simulation model

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Peak Dynamic Pressure on Semi-and Quarter-Circular Breakwaters Under Wave Troughs

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China Ocean Engineering 2017年第2期31卷 151-159页

作者： JIANG xue-lian ZOU qing-ping SONG Ji-ning State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin Key Laboratory of Soft Soil Characteristics & Engineering Environment School of Civil EngineeringTianjin Chengjian University Department of Civil and Environmental Engineering The University of Maine State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

A series of physical tests are conducted to examine the characteristics of the wave loading exerted on circular-front breakwaters by regular waves. It is found that the wave trough instead of wave crest plays a major role in the failure of submerged circular caissons due to seaward sliding. The difference in the behavior of seaward and shoreward horizontal wave forces is explained based on the variations of dynamic pressure with wave parameters. A wave load model is proposed based on a modified first-order solution for the dynamic pressure on submerged circular-front caissons under a wave trough. This wave loading model is very useful for engineering design. Further studies are needed to include model uncertainties in the reliability assessment of the breakwater.

关键词： semicircular breakwater quarter-circular breakwater wave trough load seaward wave force shoreward wave force

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盐藻GPDH基因的载体构建及在烟草中的表达

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四川大学学报（自然科学版） 2004年第2期41卷 436-439页

作者：张华乔代蓉白林含张庆莲邓雪柯曹毅四川大学生命科学学院成都610064

作者用冻融法,将构建有盐藻3 磷酸甘油脱氢酶基因的植物高效表达载体DsGPDH导入感受态的根癌农杆菌EHA105中.叶盘法转化烟草,在含卡那霉素的MS培养基上进行选择性培养,生根率达到80%.用PCR的方法对再生苗进行了初步筛选,阳性率约为50%.... 详细信息

作者用冻融法,将构建有盐藻3 磷酸甘油脱氢酶基因的植物高效表达载体DsGPDH导入感受态的根癌农杆菌EHA105中.叶盘法转化烟草,在含卡那霉素的MS培养基上进行选择性培养,生根率达到80%.用PCR的方法对再生苗进行了初步筛选,阳性率约为50%.对PCR阳性苗,进行RT PCR分析,证实整合到烟草基因组中的GPDH基因表达产生了mRNA.

关键词：盐藻 GPDH基因叶盘转化法转基因烟草

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Flow Separation and Vortex Dynamics in Waves Propagating over A Submerged Quartercircular Breakwater

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China Ocean Engineering 2018年第5期32卷 514-523页

作者： JIANG xue-lian YANG Tian ZOU qing-ping GU Han-bin Tianjin Key Laboratory of Soft Soil Characteristics & Engineering Environment Tianjin Chengjian University State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University The Lyell Centre for Earth and Marine Science and Technology Institute for Infrastructure and EnvironmentHeriot-Watt University School of Naval Architecture &Mechanical-Electrical Engineering Zhejiang Ocean University

The interactions of cnoidal waves with a submerged quartercircular breakwater are investigated by a ReynoldsAveraged Navier–Stokes(RANS) flow solver with a Volume of Fluid(VOF) surface capturing scheme(RANSVOF) model. The vertical variation of the instantaneous velocity indicates that flow separation occurs at the boundary layer near the breakwater. The temporal evolution of the velocity and vorticity fields demonstrates vortex generation and shedding around the submerged quartercircular breakwater due to the flow separation. An empirical relationship between the vortex intensity and a few hydrodynamic parameters is proposed based on parametric analysis. In addition, the instantaneous and time-averaged vorticity fields reveal a pair of vortices of opposite signs at the breakwater which are expected to have significant effect on sediment entrainment, suspension, and transportation,therefore, scour on the leeside of the breakwater.

关键词： submerged quartercircular breakwater cnoidal wave flow separation vortex dynamics scour

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Hyperbaric Oxygen Treatment for Long COVID:From Molecular Mechanism to Clinical Practice

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Current Medical Science 2023年第6期43卷 1061-1065页

作者： Jian-qing PAN Zhi-min TIAN lian-bi xue Department of Hyperbaric Oxygen Huazhong University of Science and Technology Union Shenzhen HospitalShenzhen518052China BGI-Shenzhen Shenzhen518083China

Long COVID symptoms typically occur within 3 months of an initial COVID-19 infection,last for more than 2 months,and cannot be explained by other *** most common symptoms include fatigue,dyspnea,coughing,and cognitive *** mechanisms of long COVID are not fully understood,but several hypotheses have been put *** include coagulation and fibrosis pathway activation,inflammatory and autoimmune manifestations,persistent virus presence,and Epstein-Barr virus *** oxygen therapy(HBOT)is a therapeutic method in which a person inhales 100%oxygen under pressure greater than that of the *** has some therapeutic effects,including improvement of microcirculation,inhibition of cytokine release leading to a reduction in inflammatory responses,inhibition of autoimmune responses,and promotion of neurological *** clinical trials have been carried out using HBOT to treat long *** results suggest that HBOT helps to improve symptom severity,reduce symptom duration,and enhance patients’quality of *** is believed that HBOT is an effective option for patients with long COVID,which is worth actively promoting.

关键词： long COVID post-COVID-19 condition SARS-CoV-2 hyperbaric oxygen therapy

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