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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian wang yun-Feng wang Fan Yang Jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

The role of Dby mRNA in early development of male mouse zygotes

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Asian Journal of Andrology 2010年第4期12卷 567-577页

作者： Chen-Jiang Yao wang-Jie Xu Xiu-Li Gong Ying Zhou Zhi-Qiang Yan Zi-Jue Zhu Zhao-Xia wang Qiao-Li Li Xin-Bin Guo lian-yun wang Duan Ma Zhong-Dong Qiao Department of Biological Science and Technology Key Laboratory of Developmental Genetics ＆ Neuropsychiatric Diseases Ministry of Education School of Life Science ＆ Biotechnology Shanghai Jiao Tong University Shanghai 200240 China Shanghai Institute of Medical Genetics Shanghai Jiao Tong University Shanghai 200240 China School of Medicine Fudan University Shanghai 200030 China

Ejaculated mammalian spermatozoa contain a complex yet specific population of mRNA. However, the possible roles that mRNA has in early zygotic and embryonic development remain unclear. We found that Dby mRNA is selectively retained in capacitated mouse spermatozoa, and is transferred into the oocyte during fertilization by reverse transcription-polymerase chain reaction even though no DBY protein expression is detected. The cellular location ofDby mRNA is seen in the post-acrosome region, and it comprises nearly half of the mouse spermatozoa in in situ hybridization. In contrast, transcripts of the control gene, Smcy, are not detected in capacitated mouse spermatozoa, although the H-Y antigen encoded by Smcy is expressed on the surface of the spermatozoa. In our microinjection experiment, the zygotic development rate of the as-Dby male pronucleus injection group was significantly lower than that of the as-Smcy male pronucleus injection group （35.9% vs. 95%, P = 0.001） and the as-Dby female pronucleus injection group （35.9% vs. 93.8%, P = 0.001）. The rate of male-developed zygotes was also lower than that of the as-Smcy male pronucleus injection group （17.4% vs. 57.9%, P = 0.002） and the as-Dby female pronucleus injection group （17.4% vs. 54.1%, P = 0.002）. Thus, we conclude that Dby mRNA is selectively retained in capaci- tated mouse spermatozoa, and it has an important role in the early zygotic development of male mouse zygotes. This might imply that spermatozoa mRNA is involved in early zygotic and embryonic stages of reproduction.

关键词： Dby early zygotic development function mRNA spermatozoa

Comprehensive understanding of a rare disease:Cardiac metastatic tumor,a double-center 10-year case review

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World Journal of Cardiology 2025年第2期17卷 43-51页

作者： Ling-yun Luo Tian-Shu Yang Zhen He Li Lin Xue-lian Luo Department of Cardiology Division of CardiologyDepartment of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430034Hubei ProvinceChina Department of Cardiac Surgical Intensive Care Unit Guangdong Cardiovascular InstituteGuangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Internal Medicine Huazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina Department of Oncology Chongqing Medical University Affiliated Third HospitalChongqing 400020China

BACKGROUND Cardiac metastatic tumors(CMTs)are rare yet pose significant medical *** studies on CMT are limited,particularly those involving multicenter data *** To systematically analyze the etiology,sources,classification,treatment,and prognosis of *** A total of 226 CMT patients from two centers(2013 to 2023)were reviewed,and 153 tumor patients from China Health and Retirement Longitudinal Study were used as *** survival rates of 96 CMT patients were tracked through medical records and telephone *** regression and survival analyses were conducted to characterize *** CMTs were predominantly male(67.26%vs 39.47%,P<0.001).Intracardiac metastasis patients had worse heart and coagulation function than pericardial metastasis patients(prothrombin time:13.90 vs 13.30,P=0.002),D-dimer levels(2.16 vs 0.85,P=0.001),B-type natriuretic peptide(BNP)levels(324.00 vs 136.50,P=0.004),and troponin levels(5.35 vs 0.03,P<0.001)).Lung and liver cancers were the predominant primary tumor types in *** with lung cancer(76.40%vs 30.77%)and thymoma(7.45%vs 1.54%)exhibited a higher prevalence of pericardial metastasis,while those with liver cancer(35.38%vs 0.62%)showed a higher prevalence of intracardiac *** survival was better for pericardial metastasis than for intracardiac metastasis patients(median survival:419 days vs 129 days,log-rank test P=0.0029).Cox proportional hazards model revealed that advanced age[hazard ratio(HR)=1.034,95%confidence interval(95%CI):1.011-1.057]and higher BNP and troponin levels(HR=1.011,95%CI:1.004-1.018)were associated with worse *** significantly improved the survival rate of *** median survival time was 275 days for patients who did not undergo surgery and 708 days for those who had surgery(log-rank test P=0.0128)CONCLUSION Clinicians should consider CMT in the male lung or liver cancer patients with cardiac *** coagulation,impaired

关键词： Cardiac metastatic tumor Subtype Prognosis Coagulation Primary tumor

微生物法修复陕北油田污染土壤的研究现状与展望

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土壤通报 2011年第4期42卷 1010-1014页

作者：李璐刘梅赵景联王云海西安交通大学环境工程系陕西西安710049

较全面地介绍了油田污染土壤的微生物修复技术,并结合国内外在该领域的研究成果,论述了当今微生物修复陕北油田区污染土壤的研究现状。并针对现有研究中存在的不足,总结了今后研究的趋势与重点。

关键词：石油烃微生物陕北

基于UPLC-QTOF MS/MS技术研究甜叶菊绿原酸类成分的降解机制

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质谱学报 2025年第1期46卷 65-77页

作者：吴娟娟王子璇连运河侯丽娟牛志平王文昌吴迪晨光生物科技集团邯郸有限公司河北邯郸056000 河北省植物资源综合利用重点实验室河北邯郸057250 晨光生物科技集团股份有限公司河北邯郸057250 河北晨光检测技术服务有限公司河北邯郸056000

本文以甜叶菊绿原酸为研究对象,利用高效液相色谱检测样品中3-咖啡酰奎宁酸(3-CQA)、4-咖啡酰奎宁酸(4-CQA)、5-咖啡酰奎宁酸(5-CQA)、咖啡酸、3,4-二咖啡酰奎宁酸(3,4-diCQA)、3,5-二咖啡酰奎宁酸(3,5-diCQA)、4,5-二咖啡酰奎宁酸(4,5-... 详细信息

本文以甜叶菊绿原酸为研究对象,利用高效液相色谱检测样品中3-咖啡酰奎宁酸(3-CQA)、4-咖啡酰奎宁酸(4-CQA)、5-咖啡酰奎宁酸(5-CQA)、咖啡酸、3,4-二咖啡酰奎宁酸(3,4-diCQA)、3,5-二咖啡酰奎宁酸(3,5-diCQA)、4,5-二咖啡酰奎宁酸(4,5-diCQA)等7种绿原酸类成分的含量,并利用超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS/MS)法鉴定绿原酸在不同诱发条件下的降解产物及降解途径。结果表明,样品中绿原酸总量在溶剂、光、热、pH值等诱发条件下均呈下降趋势。通过分析降解产物,甜叶菊绿原酸在溶剂中存放易发生烷基化反应,在光照条件下易发生降解,在高温环境中易发生脱水和烷基化,在酸碱介质中易发生水解和构型转化。综上,脱水、降解、水解和异构化是甜叶菊绿原酸受外界环境干扰时可能发生的4种损失途径。本研究不仅深化了对绿原酸理化性质的理解,也为制定有效的保存策略,确保绿原酸类成分在药品、保健品及化妆品等产品中的质量控制提供了科学依据和实践指导。

关键词：超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF MS/MS) 甜叶菊绿原酸稳定性

叙事医学训练与医学人文教育深度融合的内涵、逻辑与路径

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赣南医科大学学报 2025年第1期45卷 97-101,106页

作者：刘联蓝云赣南医科大学江西环境工程职业学院江西赣州341000

叙事医学与医学人文教育交融,借助叙事医学训练方式可使两者更加深入糅合为一个整体,达到叙事医学应用与医学人文教育共同发展目的。基于叙事医学训练与医学人文教育融合内在逻辑及动力因素探讨,从强化价值塑造、能力培养与知识运用为... 详细信息

叙事医学与医学人文教育交融,借助叙事医学训练方式可使两者更加深入糅合为一个整体,达到叙事医学应用与医学人文教育共同发展目的。基于叙事医学训练与医学人文教育融合内在逻辑及动力因素探讨,从强化价值塑造、能力培养与知识运用为一体的融合、深入推动叙事与医学融合教育教学以及推进医学与叙事的实践融合等方面提出切实可行的建议,为推进医学人文落到实处进行理论探求。

关键词：叙事医学医学人文教育融合

UPLC-CAD法测定疏风再造丸中葛根素、橙皮苷、人参皂苷Rb1及甘草酸铵的含量

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中国新药杂志 2025年第2期34卷 199-204页

作者：郝云芳杜娟史宪海杨艳郑喆连云岚山西省检验检测中心药品检验技术研究所食品药品安全防控山西省重点实验室赛默飞世尔科技有限公司

目的:建立超高效液相色谱-电喷雾检测器法（UPLC-CAD）同时测定疏风再造丸中葛根素、橙皮苷、人参皂苷Rb1及甘草酸铵的含量。方法:采用Waters Atlantis C18柱（150 mm×2.1 mm, 3μm）,乙腈（A）-0.1%甲酸溶液（B）为流动相，梯度洗脱（... 详细信息

目的:建立超高效液相色谱-电喷雾检测器法（UPLC-CAD）同时测定疏风再造丸中葛根素、橙皮苷、人参皂苷Rb1及甘草酸铵的含量。方法:采用Waters Atlantis C18柱（150 mm×2.1 mm, 3μm）,乙腈（A）-0.1%甲酸溶液（B）为流动相，梯度洗脱（0～60 min, 95%～10%B）,流速0.3 mL·min-1,柱温35℃,进样量2μL,电喷雾式检测器雾化温度35℃,数据采集频率5 Hz,过滤常数F为3.6 s。结果:疏风再造丸中葛根素、橙皮苷、人参皂苷Rb1及甘草酸铵均具有良好的线性关系（r>0.999 0）,精密度、重复性、24 h稳定性实验的相对标准偏差均<3.0%,平均加样回收率分别为106.51%,99.81%,105.77%,103.82%。结论:本研究建立的UPLC-CAD法可同时对疏风再造丸中葛根素、橙皮苷、人参皂苷Rb1及甘草酸铵进行含量测定，为疏风再造丸的检测分析和质量控制提供了新方法。

关键词：疏风再造丸超高效液相色谱-电喷雾检测器葛根素橙皮苷人参皂苷Rb1 甘草酸铵含量测定质量控制

Acyclic Choosability of Graphs with Bounded Degree

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Acta Mathematica Sinica,English Series 2022年第3期38卷 560-570页

作者： Juan wang lian Ying MIAO Jin Bo LI yun Long LIU School of Management Qufu Normal UniversityRizhao276826P.R.China School of Mathematics China University of Mining and TechnologyXuzhou221116P.R.China College of Engineering Qufu Normal UniversityRizhao276826P.R.China

An acyclic colouring of a graph G is a proper vertex colouring such that every cycle uses at least three colours. For a list assignment L = {L(v)| v∈V(G)}, if there exists an acyclic colouringρ such that ρ(v)∈L(v) for each v∈V(G), then ρ is called an acyclic L-list colouring of G. If there exists an acyclic L-list colouring of G for any L with |L(v)|≥k for each v∈V(G), then G is called acyclically k-choosable. In this paper, we prove that every graph with maximum degree Δ≤7 is acyclically 13-choosable. This upper bound is first proposed. We also make a more compact proof of the result that every graph with maximum degree Δ≤3(resp., Δ≤4) is acyclically 4-choosable(resp., 5-choosable).

关键词： Acyclic choosability list colouring acyclic colouring maximum degree

Pneumomediastinum and subcutaneous emphysema secondary to dental extraction:Two case reports

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World Journal of Clinical Cases 2022年第27期10卷 9904-9910页

作者： Ling-yun Ye lian-Fei wang Jin-Xing Gao Center for Plastic and Reconstructive Surgery Department of StomatologyZhejiang Provincial People’s Hospital(The Affiliated People's HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina Department of Stomatology The First People's Hospital of Hangzhou Lin An DistrictHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Dental extraction is a common operation in oral surgery and is usually accompanied by pain,swelling,and local *** application of high-speed air turbines increases the comfort of alveolar surgery and makes it more ***,high-speed gas can enter the subcutaneous tissue of the face and neck or even the chest and mediastinum,which is a serious iatrogenic *** SUMMARY We describe two cases of severe subcutaneous and mediastinal emphysema caused by high-speed turbine splitting during dental *** first case involved a 34-year-old man who complained of swelling of the face,mild chest tightness,and chest pain after dental *** tomography(CT)scan showed a large amount of gas in the neck,chest wall,and *** second case involved a 54-year-old woman who complained of swelling and pain of the neck after dental *** showed a large amount of gas collected in the neck and *** of them used high-speed turbine splitting during dental *** High-speed turbine splitting during dental extraction may lead to severe subcutaneous and mediastinal *** should carefully operate to avoid *** emphysema occurs,CT can be used to improve the *** patient should be informed,and the complications dealt with carefully.

关键词： Dental extraction High-speed turbine Mediastinal emphysema Subcutaneous emphysema Complication Case report