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Exploring non-curative endoscopic submucosal dissection:Current treatment optimization and future indication expansion

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World Journal of Gastroenterology 2024年第9期30卷 1257-1260页

作者： Yi-Nong Zhu Xiang-Lei Yuan Wei Liu Yu-Hang Zhang Yi Mou Bing Hu lian-song ye Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

The increasing popularity of endoscopic submucosal dissection(ESD)as a treatment for early gastric cancer has highlighted the importance of quality assessment in achieving curative *** article emphasizes the significance of evaluating ESD quality,not only for curative cases but also for non-curative *** assessment relies on the endoscopic curability(eCura)classification,but management strategies for eCuraC-1 tumour with a positive horizontal margin are *** research primarily focuses on comparing additional surgical procedures in high-risk patients,while studies specifically targeting eCuraC-1 patients are *** management strategies and follow-up outcomes for such cases could provide valuable ***,the application of molecular imaging using near-infrared fluorescent tracers holds promise for precise tumour diagnosis and navigation,potentially impacting the management of early-stage gastric cancer *** research in these areas is essential for improving the overall efficacy of endoscopic techniques and refining treatment indications.

关键词： Early gastric cancer Endoscopic submucosal dissection Quality control Noncurative endoscopic submucosal dissection Near-infrared fluorescent tracer

Efficacy of spray flushing in the reprocessing of flexible endoscopes:A randomized controlled trial

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World Journal of Gastroenterology 2024年第31期30卷 3680-3688页

作者： Jiang Du Miao Zhang Si-Yuan Tao lian-song ye Hui Gong Bing Hu Qiong-Ying Zhang Fu Qiao Department of Gastroenterology and Hepatology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Nursing Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Infection Control West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Digestive Endoscopy Medical Engineering Research Laboratory West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Commonly used cleaning brushes in the reprocessing of flexible endoscopes often cause damage within the working *** To develop a spray flushing system to achieving effective cleaning of the working channels while minimizing *** This prospective study included 60 used endoscopes and 60 Teflon tubes randomly divided into a control group(n=30)and an experimental group(n=30).The material of Teflon tubes was the same as that of the endoscope working *** in the control group were manually cleaned using traditional cleaning brushes,while those in the experimental group were cleaned using the newly developed spray flushing *** levels,cleanliness,and microbiological testing of the working channels were ***,Teflon tubes in the control group underwent 500 passes with a cleaning brush,while those in the experimental group were subjected to the spray flushing system,and channel damage was *** The ATP levels(RLU)in the two groups were 32.5(13-66)and 26(16-40),respectively(P>0.05).Cleanliness scores were 1.5(1-2)and 1(1-2),respectively(P>0.05).Debris was found in 73.3%of the control group,which was significantly higher than 46.7%in the experimental group(P<0.05).Microbiological tests for both groups yielded negative *** tube damage in the control group was rated at 4(4-5.25),which was significantly higher than in the experimental group 4(3-4)(P<0.01).CONCLUSION The spray flushing system demonstrated superior efficacy in removing debris and resulted in less damage to the endoscope working channels compared with traditional cleaning brushes.

关键词： Endoscope ATP Flexible endoscope Disinfection Reprocessing

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution:Prospective single-centre trial

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World Journal of Gastrointestinal Endoscopy 2024年第5期16卷 259-272页

作者： Yuan Gao lian-song ye Xu Li Bin Yu Ke Liao Jia Xie Jiang Du Qiong-Ying Zhang Bing Hu Department of Gastroenterology and Hepatology Digestive Endoscopy Medical Engineering Research LaboratoryWest China HospitalMed-X Center for MaterialsSichuan UniversityChengdu 610041Sichuan ProvinceChina Design Measurement and Evaluation(CBDME)Department of Clinical Research ManagementWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Institute for Disaster Management and Reconstruction Sichuan University-The Hong Kong Polytechnic UniversityChengdu 610065Sichuan ProvinceChina West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610044Sichuan ProvinceChina Precision Medicine Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Esophageal chromoendoscopy with iodine solution is important for detecting early esophageal *** effect of routine treatment for lesions lightly stained with Lugol’s iodine solution is limited,and the addition of natural substances to a regular diet is becoming increasingly *** has antitumor effects as reported in previous *** To evaluate whether vinegar supplementation could improve the prognosis of patients with lightly stained esophageal *** prospective single-centre trial included consecutive patients with lightly stained lesions between June 2020 and April *** in the experimental group received increased amounts of vinegar for 6 *** primary outcome of the study was the clinical therapeutic *** related to vinegar ingestion and adverse events were also recorded in *** A total of 166 patients were included in the final *** was no significant difference in the baseline data between the two ***-to-treat(ITT)analysis demonstrated that the rates at which endoscopic characteristics improved were 33.72%in the experimental group and 20.00%in the conventional group(P=0.007);and the rates at which biopsy pathology improved were 19.77%and 8.75%,respectively(P=0.011).Additional vinegar consumption had a statistically protective effect on the rate at which endoscopic characteristics improved[hazard ratio(HR)_(ITT)=2.183,95%CI:1.183-4.028;HR_(per-protocol(PP))=2.307,95%CI:1.202-4.426]and biopsy pathology improved(HR_(ITT)=2.931,95%CI:1.212-7.089;HR_(PP)=3.320,95%CI:1.295-8.507).No statistically significant effect of increased vinegar consumption on preventing high-grade intraepithelial neoplasia or early cancer was observed(HR_(ITT)=0.382,95%CI:0.079-1.846;HRPP=0.382,95%CI:0.079-1.846).The subgroup analyses indicated that the overall therapeutic improvement of endoscopic characteristics and biopsy pathology seemed more obvious in older(age>60)male patients w

关键词： Chromoendoscopy Esophageal squamous epithelium Vinegar Atypical hyperplasia Prognosis

Synchronous multiple primary malignancies of the esophagus, stomach, and jejunum: A case report

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World Journal of Clinical Cases 2021年第32期9卷 9889-9895页

作者： Yan Li lian-song ye Bing Hu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Treatment of synchronous multiple primary malignancies is quite often very ***,we report on a rare case of synchronous multiple primary malignancies in the esophagus,stomach,and *** SUMMARY A 50-year-old man who was a heavy drinker and smoker with a poor diet,and had a family history of cancer sought treatment due to dysphagia lasting for 4 *** was finally diagnosed with lower esophageal squamous cell carcinoma(pT3N2M0,G2,stage IIIB),gastric angular adenocarcinoma(pT3N2M0,G2-G3,stage IIIA)with greater omental lymph node metastasis,and jejunal stromal tumor(high risk).The high-risk jejunal stromal tumor was found during *** spite of radical resection and adjuvant chemotherapy,lymph node metastasis occurred 21 mo *** patient responded poorly to additional chemotherapy and refused further examination and *** died of widespread metastases 33 mo after *** This case indicates a poor prognosis of synchronous multiple advanced primary malignancies and the importance of comprehensive assessment in the population at high risk for cancer.

关键词： Multiple primary malignancies Gastrointestinal tract Diagnosis Treatment Case report

Noninvasive beam diagnosis based on the TM_(010)mode

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Nuclear Science and Techniques 2024年第7期35卷 115-125页

作者： Chuang-ye song Wen-Hui Huang Department of Engineering Physics Tsinghua University BeijingBeijing100084China of Education Beijing100084China

A resonant cavity based on the TM_(010)mode is an effective tool for noninvasive beam *** technique has the advantages of a high signal-to-noise ratio,compact structure,and is related to multiple parameters compared with other beam *** this study,high-precision measurements of the bunch charge,arrival timne,bunch length,and energy parameters based on the TM_(010)mode are discussed.A cavity beam arrival time monitor(BAM)utilizing a phase cavity has been widely used in many *** bunch-length measurermnents,the influence of the beam energy,beam offset,and longitudinal spectrum on the TM_(010)mode are ca rfully considered to reduce errors,and the theoretical resolution of two cavities with different frequencies is *** to the dependence of the beam velocity of the beam loss factor,this method can also be used for the detection low beam energy using two cavities with the same frequency but different cavity lengths.A set of three cavities with different lengths and frequencies of1902 and 1424 GHz is presented for measuring the four aforementioned parameters.

关键词： TM_(010)mode Noninvasive diagnosis Beam length Low energy

XGCN:a library for large-scale graph neural network recommendations

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Frontiers of Computer Science 2024年第3期18卷 247-249页

作者： Xiran song Hong HUANG Jianxun lian Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Microsoft Research Asia Beijing 100080China

1 Introduction Graph Neural Networks(GNNs)have gained widespread adoption in recommendation systems,and nowadays there is a pressing need to effectively manage large-scale graph data[1].When it comes to large graphs,GNNs may encounter the scalability issue stemming from their multi-layer messagepassing ***,scaling GNNs has emerged as a crucial research area in recent years,with numerous scaling strategies being proposed.

关键词： scaling gained operations

Emerging interactively stretchable electronics with optical and electrical dual-signal feedbacks based on structural color materials

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Nano Research 2024年第3期17卷 1837-1855页

作者： Jialin Wang Kai Zhao Changqing ye Yanlin song School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190China

The booming development of wearable devices has aroused increasing interests in flexible and stretchable *** mechanosensory functionality,these devices are highly desirable on account of their wide range of applications in electronic skin,personal healthcare,human–machine interfaces and ***,they are mostly limited by single electrical signal feedback,restricting their diverse applications in visualized mechanical *** by the mechanochromism of structural color materials,interactively stretchable electronics with optical and electrical dual-signal feedbacks are recently emerged as novel sensory platforms,by combining both of their sensing mechanisms and ***,recent studies on interactively stretchable electronics based on structural color materials are *** a brief introduction of their basic components(i.e.,stretchable electronics and mechanochromic structural color materials),two types of interactively stretchable electronics with respect to the nanostructures of mechanochromic materials are outlined,focusing primarily on their design considerations and fabrication ***,the main challenges and future perspectives of these emerging devices are discussed.

关键词： stretchable electronics structural color materials interactive sensing mechanochromism dual-signal feedbacks

Heuristic Expanding Disconnected Graph:A Rapid Path Planning Method for Mobile Robots

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 68-82页

作者： Yong Tao lian Duan He Gao Yufan Zhang Yian song Tianmiao Wang School of Mechanical Engineering&Automation Beihang UniversityBeijing 100191China Aero-Engine Research Institute Beihang UniversityBeijing 102206China School of Large Aircraft Engineering Beihang UniversityBeijing 100191China

Existing mobile robots mostly use graph search algorithms for path planning,which suffer from relatively low planning efficiency owing to high redundancy and large computational *** to the limitations of the neighborhood search strategy,the robots could hardly obtain the most optimal global path.A global path planning algorithm,denoted as EDG*,is proposed by expanding nodes using a well-designed expanding disconnected graph operator(EDG)in this ***,all obstacles are marked and their corners are located through the map ***,the EDG operator is designed to find points in non-obstruction areas to complete the rapid expansion of disconnected ***,the EDG*heuristic iterative algorithm is *** selects the candidate node through a specific valuation function and realizes the node expansion while avoiding collision with a minimum *** planning experiments were conducted in a typical indoor environment and on the public dataset *** result shows that the proposed EDG*reduced the planning time by more than 90%and total length of paths reduced by more than 4.6%.Compared to A*,Dijkstra and JPS,EDG*does not show an exponential explosion effect in map *** EDG*showed better performance in terms of path smoothness,and collision *** shows that the EDG*algorithm proposed in this paper can improve the efficiency of path planning and enhance path quality.

关键词： Global path planning Mobile robot Expanding disconnected graph Edge node Offset

Comparative analysis of DNA-SIP and magnetic-nanoparticle mediated isolation (MMI) on unraveling dimethoate degraders

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 59-69页

作者： Luning lian Yi Xing Dayi Zhang Longfei Jiang Mengke song Bo Jiang School of Energy and Environmental Engineering University of Science&Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science&Technology BeijingBeijing 100083China National Environmental and Energy Science and Technology International Cooperation Base University of Science&Technology BeijingBeijing 100083China College of New Energy and Environment Jilin UniversityChangchun 130021China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China National Engineering Laboratory for Site Remediation Technologies Beijing 100015China

Microorganisms are crucial in the bioremediation of organophosphorus pesticides. However, most functional microorganisms (> 99%) are yet to be cultivated. This study applied two cultivation-independent approaches, DNA-SIP and magnetic-nanoparticle mediated isolation (MMI), to identify the functional microorganisms in degrading dimethoate in agricultural soils. MMI identified five dimethoate degraders: Pseudomonas, Bacillus, Ramlibacter, Arthrobacter, and Rhodococcus, whereas DNA-SIP identified three dimethoate degraders: Ramlibacter, Arthrobacter, and Rhodococcus. Also, MMI showed higher resolution than DNA-SIP in identifying functional microorganisms. Two organic phosphohydrolase (OPH) genes: ophC2 and ophB, were involved in dimethoate metabolism, as revealed by DNA-SIP and MMI. The degradation products of dimethoate include omethoate, O,O,S-trimethyl thiophosphorothioate, N-methyl-2-sulfanylacetamide, O,O-diethyl S-hydrogen phosphorodithioate, O,O,O-trimethyl thiophosphate, O,O,S-trimethyl thiophosphorodithioate, and O,O,O-trimethyl phosphoric. This study emphasizes the feasibility of using SIP and MMI to explore the functional dimethoate degraders, expanding our knowledge of microbial resources with cultivation-independent approaches.

关键词： Stable isotope probing(SIP) Magnetic-nanoparticle mediated isolation(MMI) Dimethoate Biodegradation Cultivation-independent approach