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Prevention of atrial fibrillation with renin-angiotensin system inhibitors on essential hypertensive patients:a meta-analysis of randomized controlled trials

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The Journal of Biomedical Research 2015年第6期29卷 475-485页

作者： Di Zhao Ze-Mu wang lian-sheng wang Department of Cardiology The First Affiliated Hospital of Nanjing Medical University

We aimed to investigate the effectiveness and safety of angiotensin-converting enzyme inhibitors （ACEIs） or angiotensin Ⅱ receptor blockers （ARBs） on preventing atrial fibrillation in essential hypertensive patients. Systematic literature retrieval was carried out to obtain randomized controlled trials on the effects of ACEI/ ARBs on essential hypertensive patients before December, 2013. Data extraction and quality evaluation were performed. Meta-analysis was performed by Review Manager 5.2.3. Ten high quality studies （11 articles） with a total of 42,892 patients （20,491 patients in the ACEI/ARBs group and 22,401 patients in the β-blocker or the calcium antagonist group） met the inclusion criteria and were included in the meta-analysis. The results showed that ACEI/ARBs reduced the incidence of atrial fibrillation （AF） recurrence compared to calcium antagonists （RR=0.48; 95%CI, 0.40-0.58; P〈0.00001） or β-blockers （RR=0.39; 95%CI, 0.20-0.74; P=0.005） in long-term follow-up, respectively. Furthermore, ACEI/ARBs reduced the incidence of conges- tive heart failure （RR=0.86; 95%CI, 0.77-0.96; P=0.007）. However, no significant effects were observed on the incidence of new AF, cardiac death, myocardial infarction, and stroke. Our results suggest that ACEI/ ARBs may reduce the incidence of AF recurrence and congestive heart failure, with fewer serious adverse effects.

关键词： angiotensin-converting enzyme inhibitors angiotensin Ⅱ receptor blockers hypertension atrialfibrillation meta-analysis

Predicting the Relative Retention Time (RRT) of Polybrominated Diphenyl Ethers (PBDEs)

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Chinese Chemical Letters 2005年第11期16卷 1559-1562页

作者： Shu Shen LIU Yan LIU Da Qiang YIN lian sheng wang State Key Laboratory of Pollution Control and Resources Reuse School of Environment Nanjing University Nanjing 210093 Key Laboratory of Nonferrous Materials and New Processing Technology Department of Applied Chemistry Guilin University of Technology Guilin 541004 School of Life Science Southwest China Normal University Chongqing 400715

Using the molecular electronegativity distance vector descriptors derived directly from the molecular topological structures, the relative retention time （RRT） of polybrominated diphenyl ethers （PBDEs） were predicted. A four-variable regression model （M30） with the correlation coefficient of 0.9816 and the root mean square errors of 0.061 was developed using a training set including 30 PBDEs. The correlation coefficient of 0.9841 and the root mean square errors of 0.054 between the values of RRT predicted by M30 and the RRT observed for 16 external PBDEs show a good predictive potential of M30. The descriptors included in the M30 represent four interactions between four pairs of atom types, i.e., atom -C= and -C=, -C= and 〉C=, 〉C= and 〉C=, -C= and -Br.

关键词： Polybrominated diphenyl ethers (PBDEs) relative retention time (RRT) molecular electronegativity distance vector (MEDV).

Determination of ice jam thickness—A new approach

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Journal of Hydrodynamics 2024年第3期36卷 570-581页

作者： Jun wang lian-sheng Sang Fei-hu Song Tie-jie Cheng Jueyi Sui School of Civil and Water Engineering Hefei University of TechnologyHefei230009China School of Engineering University of Northern British ColumbiaPrince GeorgeCanada

In winter,rivers in cold regions often experience flood disasters resulted from ice jams or ice *** of the variation of ice jam thickness and water level during an ice jammed period are not only a practical need for ice prevention to avoid disaster and plan water resource,but also essential for the development of any mathematical model for predicting the evolution of ice *** far,some equations based on the energy equation have been proposed to describe the relationship between ice jam thickness and water ***,in the derivation of these equations,the local head loss coefficient at the ice jam head and the riverbed slope factor were ***,those reported equations cannot be used to preciously describe the flow energy equation with ice jams and accurately calculate the ice jam thickness and water *** the present study,a more comprehensive theoretical model for hydraulic calculation of ice jam thickness has been derived by considering important and essential factors including riverbed slope and local head loss coefficient at the ice jam ***,based on the data collected from laboratory experiments of ice jam accumulation,the local head loss coefficient at the ice jam head has been calculated,and the empirical equation for calculating the local head loss coefficient has been established by considering flow Froude number and the ratio of ice discharge to flow *** results of this study not only provide a new reference for calculating ice jam thickness and water level,but also present a theoretical basis for accurate CFD simulation of ice jams.

关键词： Energy equation ice jam thickness local head loss coefficient ice jam head riverbed slope

An Implicit Kinetic Flux Vector Splitting Scheme

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Communications in Nonlinear Science and Numerical Simulation 1997年第3期2卷 56-60页

作者： Yong sheng lian & Ruquan wang (Institute of Computational Mathematics and Scientific/Engineering Computing,Academia Sinica) E mail:wrq@*** Institute of Computational Mathematics and Scientific/Engineering Computing Academia Sinica China

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ＡｎＩｍｐｌｉｃｉｔＫｉｎｅｔｉｃＦｌｕｘＶｅｃｔｏｒＳｐｌｉｔｉｎｇＳｃｈｅｍｅ１，２１ＴｈｅｐａｐｅｒｗａｓｒｅｃｅｉｖｅｄｏｎＪｕｎ．５ｔｈ，１９９７２ＴｈｉｓｗｏｒｋｉｓｓｕｐｐｏｒｔｅｄｂｙｔｈｅＮａｔｉｏｎａｌＮａｔｕｒａｌＳｃｉｅｎｃｅ...

关键词： Boltzmann equation KFVS

Testosterone is negatively associated with the severity of coronary atherosclerosis in men

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Asian Journal of Andrology 2012年第6期14卷 875-878页

作者： Li Li Chang-Yan Guo En-Zhi Jia Tie-Bing Zhu lian-sheng wang Ke-Jiang Cao Wen-Zhu Ma Zhi-Jian Yang Department of Cardiovascular Medicine First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease （CAD） was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores （score ≤ 26 and score 〉26） using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score （r=-0. 188; P=0.000）. A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score （β=-0,110; P=0.002） after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile （highest） of testosterone compared to the first tertile （lowest） of testosterone （odds ratio （0R）=0.465; 95% confidence interval （C1）. 0.327-0.662; P=0.000）. In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.

关键词： coronary artery disease (CAD) Gensini score testosterone

SOLUBILITIES OF POLYCYCLIC AROMATIC HYDROCARBONS AND DI-REGION THEORY

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Science China Chemistry 1989年第1期32卷 44-57页

作者：王连生汪小江 Department of Environmental Science Nanjing University

By using the relationship equation of Partition coefficients with water solubilities for polycyclic aromatic hydrocarbons (PAHs), we have estimated the solubilities of PAHs. In addition the high-performance liquid chromatograph (HPLC) method has been used for the indirect determination of solubilities of PAHs. t3ased on the di-region theory, We have studied the relationship of the solubilities of PAHs with carcinogenicity and introduced the solubility parameter into the di-region theory equation. The calculated carcinogenicity of PAHs from the obtained equation shows little difference from that calculated from Dai Qianhuan’s equation.

关键词： polycyclic aromatic hydrocarbons di-region theory carcinogenicity water solubility.

Research progress on myocardial regeneration: what is new?

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Chinese Medical Journal 2020年第6期133卷 716-723页

作者： Chong Du Yi Fan Ya-Fei Li Tian-Wen Wei lian-sheng wang Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjingJiangsu 210029China

The regeneration capacity of cardiomyocytes(CMs)is retained in neonatal mouse hearts but is limited in adult mouse Myocardial infarction(MI)in adult hearts usually leads to the loss of large amounts of cardiac tissue,and then accelerates the process of cardiac remodeling and heart ***,it is necessary to explore the potential mechanisms of CM regeneration in the neonates and develop potential therapies aimed at promoting CM regeneration and cardiac repair in ***,studies indicate that a number of mechanisms are involved in neonatal endogenous myocardial regeneration,including cell cycle regulators,transcription factors,non-coding RNA,signaling pathways,acute inflammation,hypoxia,protein kinases,and *** the mechanisms of regeneration in neonatal CMs after MI provides theoretical support for the studies related to the promotion of heart repair after MI in adult ***,several difficulties in the study of CM regeneration still need to be *** article reviews the potential mechanisms of endogenous CM regeneration in neonatal mouse hearts and discusses possible therapeutic targets and future research directions.

关键词： Myocardial infarction Cardiomyocyte Endogenous regeneration Mechanism

Arg-gly-asp-mannose-6-phosphate inhibits activation and proliferation of hepatic stellate cells in vitro

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World Journal of Gastroenterology 2006年第8期12卷 1303-1307页

作者： lian-sheng wang Ying-Wei Chen Ding-Guo Li Han-Ming Lu Digestive Disease Laboratory Xinhua Hospital Shanghai Second Medical University Shanghai 200092 China

AIM： To investigate the effect of arg-gly-asp-mannose-6 phosphate （RGD-M6P） on the activation and proliferation of primary hepatic stellate cells in vitro. METHODS： Hepatic steUate cells （HSCs） were isolated from rats by in situ collagenase perfusion of liver and 18% Nycodenz gradient centrifugation and cultured on uncoated plastic plates for 24 h with DMEM containing 10% fetal bovine serum （FBS/DMEM） before the culture medium was substituted with 2% FBS/DMEM for another 24 h. Then, HSCs were cultured in 2% FBS/DMEM with transforming growth factor 131, M6P, RGD, or RGD- M6P, respectively. Cell morphology was observed under inverted microscope, smooth muscle α-actin （α-SMA） was detected by immunocytochemistry, type Ⅲ procollagen （PCⅢ） in supernatant was determined by radioimmunoassay, and the proliferation rate of HSCs was assessed by flow cytometry. RESULTS： RGD-M6P significantly inhibited the morphological transformation and the α-SMA and PC Ⅲ expressions of HSCs in vitro and also dramatically prevented the proliferation of HSCs in vitro. Such effects were remarkably different from those of RGD or M6R CONCLUSION： The new compound, RGD-M6P, which has a dramatic effect on primary cultured HSCs in vitro, can inhibit the transformation of HSCs in culture caused by TGFβ1, suppresses the expression of PCIII and decreases proliferation rate of HSC. RGD-M6P can be applied as a selective drug carrier targeting at HSCs, which may be a new approach to the prevention and treatment of liver fibrosis.

关键词： RGD Mannose-6-phosphate Hepatic stellate cell Liver fibrosis

A correlation between acute kidney injury and myonecrosis after scheduled percutaneous coronary intervention

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 713-720页

作者： Min ZHANG Hao-yu MENG Ying-ming ZHAO Zhi-wen TAO Xiao-xuan GONG Ze-mu wang Bo CHEN Zheng-xian TAO Chun-jian LI Tie-bing ZHU lian-sheng wang Zhi-jian YANG Department of Cardiology the First Affiliated Hospital of Nanjing Medical University

Slight elevations in cardiac troponin I and T are frequently observed after percutaneous coronary inter- vention （PCI）. Contrast-induced acute kidney injury （CI-AKI） is a complex syndrome induced by exposure to in- travascular contrast media （CM）. Currently, the relationships between the CM, pre-existing kidney insufficiency, CI-AKI and myonecrosis after elective PCI are unclear. To investigate the relationship between CI-AKI and post-procedural myonecrosis （PMN） after PCI, we analyzed 327 non-ST-segment elevation acute coronary syndrome subjects un- dertaking elective PCI. The levels of cardiac troponins （cTns）, cTnl and cTnT, at baseline and on at least one occasion 18-24 h after PCI were measured. We also recorded serum levels of creatinine （SCr） and the urine albumin：creatinine ratio （ACR） before coronary angiography, and 24-48 h and 48-72 h after contrast administration. A post-procedure increase in cTns was detected in 16.21% （53/327） of subjects with cTns levels 〉99th to 5x99th percentile upper ref- erence limit （URL）. Twenty-seven patients （8.26%） developed CI-AKI. CI-AKI occurred more often in subjects with PMN than in those without PMN （20.8% versus 5.8%, respectively, /〉=-0.001）. Multiple logistic regression analysis revealed that pre-existing microalbuminuria （MA） was an important independent predictor of PMN （OR： 3.31; 95% CI： 1.26-8.65, P=0.01）. However, there was no correlation between the incidence of CI-AKI and PMN （OR： 2.38; 95% CI： 0.88-6.46, P=-0.09）. We conclude that pre-existing MA was not only an important independent predictor of CI-AKI but also of PMN.

关键词： Percutaneous coronary intervention Myonecrosis Contrast-induced nephropathy Acute kidney injury Contrast media