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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-Kui Wang lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

Electrocatalytic Oxidation of NADH Based on Self-assembled Colloidal Gold and Nafion Matrixes and Co Complex Mediator

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Chinese Chemical Letters 2006年第5期17卷 683-686页

作者： Na WANG Ruo YUAN Ya qin chai Dian Ping TANG Qiang ZHU Xue lian LI Chongqing Key Laboratory of Analytical Chemistry College of Chemistry and Chemical Engineering Southwest University Chongqing 400715

A novel approach based on self-assembled colloidal gold and Nation matrixes and Co complex mediator to construct Co（bpy）3^3＋/nano-Au/Co（bpy）3^3＋/nafion/GC electrode, on which formed stable redox-active films. This electrode can decrease the overpotential about 330 mV for the oxidation of NADH with high stability, wide linear range and low detection limit.

关键词： Electrocatalysis NADH gold nanoparticles Co(bpy)3^3+ Nation. coenzymes

New Family of 3-DOF UP-Equivalent Parallel Mechanisms with High Rotational Capability

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 66-77页

作者： Wei Ye qin-Chuan Li Xin-Xue chai Faculty of Mechanical Engineering and Automation Zhejiang Sci-Tech University

Parallel mechanisms(PMs) having the same motion characteristic with a UP kinematic chain(U denotes a universal joint, and P denotes a prismatic joint) are called UP-equivalent PMs. They can be used in many applications, such as machining and milling. However, the existing UP-equivalent PMs suffer from the disadvantages of strict assembly requirements and limited rotational capability. Type synthesis of UP-equivalent PMs with high rotational capability is *** special 2 R1 T motion is briefly discussed and the fact that the parallel module of the Exechon robot is not a UP-equivalent PM is disclosed. Using the Lie group theory, the kinematic bonds of limb chains and their mechanical generators are presented. Structural conditions for constructing such UP-equivalent PMs are proposed,which results in numerous new architectures of UP-equivalent PMs. The high rotational capability of the synthesized mechanisms is illustrated by an example. The advantages of no strict assembly requirements and high rotational capability of the newly developed PMs will facilitate their applications in the manufacturing industry.

关键词： Parallel mechanism Group theory Type synthesis High rotational capability

Fiber Traction Printing:A 3D Printing Method of Continuous Fiber Reinforced Metal Matrix Composite

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Chinese Journal of Mechanical Engineering 2020年第2期33卷 69-79页

作者： Xin Wang Xiaoyong Tian qin lian Dichen Li State Key Laboratory of Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710049China Shaanxi Engineering Research Center for Rapid Manufacturing Technology Xi’an 710049China

A novel metal matrix composite freeform fabrication approach,fiber traction printing(FTP),is demonstrated through controlling the wetting behavior between fibers and the *** process utilizes the fiber bundle to control the cross-sectional shape of the liquid metal,shaping it from circular to rectangular which is more *** FTP process could resolve manufacturing difficulties in the complex structure of continuous fiber reinforced metal matrix *** printing of the first layer monofilament is discussed in detail,and the effects of the fibrous coating thickness on the mechanical properties and microstructures of the composite are also investigated in this *** composite material prepared by the FTP process has a tensile strength of 235.2 MPa,which is close to that of composites fabricated by conventional *** complex structures are printed to demonstrate the advantages and innovations of this ***,the FTP method is suited to other material systems with good wettability,such as modified carbon fiber,surfactants,and aluminum alloys.

关键词： 3D printing Metal matrix composite Capillarity Continuous carbon fiber

Synthesis of N-Aryl-N′- (5-aryloxymethyl-1,3,4-thiadiazol-2-yl) ureas under Microwave Irradiation

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有机化学 2003年第z1期23卷 309-310页

作者： chai Lan-qin College of Chemical Engineering Lanzhou Jiaotong University Lanzhou 730070

　　The rapid heating effect of microwave irradiation has caught the attention of synthetic chemists in the recent times due to the remarkable reduction of reaction time. It is an efficient method because of its virtue of rapid heating capability, high yield and simple procedure. The superiority of these virtues goes beyond of traditional heating reaction.……

关键词： rapid heating microwave irradiation efficient method reaction time

Further results on cloud control systems

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Science China(Information Sciences) 2016年第7期59卷 232-236页

作者： Yuanqing XIA Yongming qin Di-Hua ZHAI Senchun chai School of Automation Key Laboratory of Intelligent Control and Decision of Complex SystemsBeijing Institute of Technology

This paper is devoted to further investigating the cloud control systems(CCSs). The benefits and challenges of CCSs are provided. Both new research results of ours and some typical work made by other researchers are p... 详细信息

关键词： cloud control systems cloud computing cyber-physical systems networked control systems big data

Succinylation modification:a potential therapeutic target in stroke

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Neural Regeneration Research 2024年第4期19卷 781-787页

作者： Jie lian Wenwu Liu qin Hu Xiaohua Zhang Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine Department of Diving and Hyperbaric Medicine Naval Medical CenterNaval Medical University

Stroke is a leading cause of mortality and disability *** cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain *** mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of ***,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ***,the role of succinylation modification in cell metabolism after stroke and its regulation are not well *** aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after *** also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of *** succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by *** evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic ***,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic *** between succinylation and desuccinylation has been implicated in the pathophysiology of *** agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke ***,their therapeutic efficacy in stroke patients should be validated.

关键词： mitochondria metabolism neuroprotection sirtuin 5 stroke succinylation modification

Endurable SSD-Based Read Cache for Improving the Performance of Selective Restore from Deduplication Systems

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Journal of Computer Science & Technology 2018年第1期33卷 58-78页

作者： Jian Liu Yun-Peng chai Xiao qin Yao-Hong Liu Division of Computer Science and Engineering Louisiana State University Baton Rouge LA 70803 U.S.A. Key Laboratory of Data Engineering and Knowledge Engineering Ministry of Education of China Beijing 100872 China School of Information Renmin University of China Beijing 100872 China Shelby Center for Engineering Technology Department of Computer Science and Software Engineering Samuel Ginn College of Engineering Auburn University Auburn AL 368~9-53~7 U.S.A.

Deduplication has been commonly used in both enterprise storage systems and cloud storage. To overcome the performance challenge for the selective restore operations of deduplication systems, solid-state-drive-based （i.e., SSD-based） re^d cache cm, be deployed for speeding up by caching popular restore contents dynamically. Unfortunately, frequent data updates induced by classical cache schemes （e.g., LRU and LFU） significantly shorten SSDs＇ lifetime while slowing down I/O processes in SSDs. To address this problem, we propose a new solution -- LOP-Cache to greatly improve tile write durability of SSDs as well as I/O performance by enlarging the proportion of long-term popular （LOP） data among data written into SSD-based cache. LOP-Cache keeps LOP data in the SSD cache for a long time period to decrease the number of cache replacements. Furthermore, it prevents unpopular or unnecessary data in deduplication containers from being written into the SSD cache. We implemented LOP-Cache in a prototype deduplication system to evaluate its pertbrmance. Our experimental results indicate that LOP-Cache shortens the latency of selective restore by an average of 37.3% at the cost of a small SSD-based cache with only 5.56% capacity of the deduplicated data. Importantly, LOP-Cache improves SSDs＇ lifetime by a factor of 9.77. The evidence shows that LOP-Cache offers a cost-efficient SSD-based read cache solution to boost performance of selective restore for deduplication systems.

关键词： data deduplication solid state drive (SSD) flash cache endurance