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Cadherin 11 Expression Correlates with Pancreatic Carcinogenesis and Clinical Stage in Patients with Pancreatic Cancer

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Journal of Biosciences and Medicines 2023年第7期11卷 18-28页

作者： lian-qiang han Yang Tan Qi Yang Ming-Xian Yan Shandong Provincial Qianfoshan Hospital School of Medicine Nankai University Tianjin China Department of Gastroenterology Affiliated Hospital of Weifang Medical University Weifang China Department of Internal Medicine Shahe Hospital Beijing China Department of Gastroenterology The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China

Objective: The main purpose was to investigate expression of CDH11 in pancreatic tissues and analyze its relations with clinical characteristics of patients with pancreatic cancer (PC). Methods: Expression of CDH11 in cancerous tissues and cancer adjacent tissues were detected by immunohistochemistry staining, and their associations with clinical characteristics were analyzed. The text mining methods were used to assist the study of the effect of CDH11 on prognosis. Results: A total of 79 patients with PC were enrolled in the study, including 51 (64.6%) men and 28 (35.4%) women with a median age of 62 (41 - 84). The CDH11 expression in cancerous tissues was higher than that in adjacent tissues and the expression of CDH11 in both tissues was positively correlated (P 0.999;stage II vs III & IV, P = 0.308). A higher level of CDH11 expression correlated with worse overall survival (OS) time (P = 0.015). Conclusion: CDH11 may be involved in the development of early PC and lead to poor prognosis and could be a new target molecule for early diagnosis and treatment of PC.

关键词： Cadherin 11 Pancreatic Cancer Prognosis

Parity-dependent skin effects and topological properties in the multilayer nonreciprocal Su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： Jia-Rui Li Cui Jiang han Su Di Qi lian-lian Zhang Wei-Jiang Gong College of Sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian Su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

Influence of Micro/Nano-Ti Particles on the Corrosion Behavior of AZ31-Ti Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 484-498页

作者： Jinchao Jiao Jin Zhang Yong lian Shengli han Kaihong Zheng Fusheng Pan Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 10083China Beijing Key Laboratory for Corrosion Erosion and Surface Technology Beijing 100083China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 404100China

Adding Ti particles to magnesium alloy simultaneously enhances its strength and ***,how these particles influence on Mg alloy’s corrosion performance is seldom *** corrosion behavior of AZ31-Ti composites containing titanium nanoparticles(1.5 and 5 wt%)and micron particles(10 wt%)prepared by powder metallurgical in 3.5 wt%NaCl solution was *** results indicate that Ti particles serve as the primary location for the cathodic hydrogen reduction reaction,resulting in intense galvanic corrosion between the Ti and Mg *** nanoparticles distributed at the interface of the original AZ31 powder were in a discontinuous mesh structure,thus failing to act as a barrier against *** corrosion products with the existence of numerous cracks gradually peel off during the corrosion process and cannot protect the *** average corrosion rate P_(w) of AZ31,AZ31-1.5%Ti,AZ31-5%Ti,and AZ31-10%Ti after 7 days of immersion is 27.55,105.65,283.67,and 99.35 mm/y,***,AZ31-Ti composites can be considered as potential candidates for degradable fracturing ***,it is recommended to improve their corrosion resistance through surface treatment.

关键词： AZ31-Ti composite Nano-Ti Micro-Ti Corrosion behavior Scanning Kelvin probe force microscopy(SKPFM)

Residual subsidence time series model in mountain area caused by underground mining based on GNSS online monitoring

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International Journal of Coal Science & Technology 2024年第2期11卷 173-186页

作者： Xugang lian Lifan Shi Weiyu Kong Yu han Haodi Fan School of Mining Engineering Taiyuan University of TechnologyTaiyuanChina

The residual subsidence caused by underground mining in mountain area has a long subsidence duration time and great potential harm,which seriously threatens the safety of people's production and life in the mining ***,it is necessary to use appropriate monitoring methods and mathematical models to effectively monitor and predict the residual subsidence caused by underground *** with traditional level survey and InSAR(Interferometric Synthetic Aperture Radar)technology,GNSS(Global Navigation Satellite System)online monitoring technology has the advantages of long-term monitoring,high precision and more flexible monitoring *** empirical equation method of residual subsidence in mining subsidence is effectively combined with the rock creep equation,which can not only describe the residual subsidence process from the mechanism,but also predict the residual ***,based on GNSS online monitoring technology,combined with the mining subsidence model of mountain area and adding the correlation coefficient of the compaction degree of caving broken rock and the Kelvin model of rock mechanics,this paper constructs the residual subsidence time series model of arbitrary point on the ground in mountain *** the example,the predicted results of the model in the inversion parameter phase and the dynamic prediction phase are compared with the measured data *** results show that the model can carry out effective numerical calculation according to the GNSS monitoring data of any point on the ground,and the model prediction effect is good,which provides a new method for the prediction of residual subsidence in mountain mining.

关键词： Underground mining in mountain area Residual subsidence GNSS online monitoring Mathematical model Subsidence prediction

New insights into the pre-lithiation kinetics of single-crystalline Ni-rich cathodes for long-life Li-ion batteries

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Green Energy & Environment 2024年第3期9卷 556-564页

作者： qiang han Lele Cai Zhaofeng Yang Yanjie Hu Hao Jiang Chunzhong Li Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Chemical EngineeringEast China University of Science and TechnologyShanghai200237China Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

Developing single-crystalline Ni-rich cathodes is an effective strategy to improve the safety and cycle life of Li-ion batteries(LIBs).However,the easy-to-loss of Li and O in high-temperature lithiation results in unsatisfactory ordered layered structure and ***,we demonstrate the synthesis of highly-ordered and fully-stoichiometric single-crystalline LiNi_(0.83)Co_(0.12)Mn_(0.05)O_(2)(SC-NCM83)cathodes by the regulation of pre-lithiation *** well-balanced pre-lithiation kinetics have been proved to greatly improve the proportion of layered phase in the intermediate by inhibiting the formation of metastable spinel phase,which promoted the rapid transformation of the intermediate into highly-ordered layered SC-NCM83 in the subsequent lithiation *** coating a layer of Li_(2)O–B_(2)O_(3),the resultant cathodes deliver superior cycling stability with 90.9%capacity retention at 1C after 300 cycles in pouch-type full *** enhancement mechanism has also been *** findings exhibit fundamental insights into the pre-lithiation kinetics process for guiding the synthesis of high-quality singlecrystalline Ni-rich cathodes.

关键词： Single-crystalline cathode Ni-rich oxides Pre-lithiation Li-ion batteries Surface modification

Engineered AAV13 variants with enhanced transduction and confined spread

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Zoological Research 2024年第4期45卷 781-790页

作者： Neng-Song Luo Yu-Xiang Cai Zeng-Peng han Xiao-Kai Sui Wen-Jia Yuan Zi-lian Zhang Hao-Dong Guo Jie Wang Kun-Zhang Lin Fu-qiang Xu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Shenzhen Key Laboratory of Viral Vectors for Biomedicine Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Key Laboratory of Quality Control Technology for Virus-Based Therapeutics Guangdong Provincial Medical Products AdministrationNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Zhongnan Hospital Wuhan UniversityWuhanHubei 430072China Brain Case Biotechnology Co. Ltd.ShenzhenGuangdong 518107China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Precise targeting of specific regions within the central nervous system(CNS)is crucial for both scientific research and gene therapy in the context of brain ***-associated virus 13(AAV13)is known for its restricted diffusion range within the CNS,making it an ideal choice for precise labeling and administration within small brain ***,AAV13 mediates relatively low expression of target ***,we introduced specifically engineered modifications to the AAV13 capsid protein to enhance its transduction *** first constructed AAV13-YF by mutating tyrosine to phenylalanine on the surface of the AAV13 *** then inserted the 7m8 peptide,known to enhance cell transduction,into positions 587/588 and 585/586 of the AAV13 capsid,resulting in two distinct variants named AAV13-587-7m8 and AAV13-585-7m8,*** found that AAV13-YF exhibited superior in vitro infectivity in HEK293T cells compared to AAV13,while AAV13-587-7m8 and AAV13-585-7m8 showed enhanced CNS infection capabilities in C57BL/6 mice,with AAV13-587-7m8 infection retaining a limited spread *** modified AAV13 variants hold promising potential for applications in gene therapy and neuroscience research.

关键词： Adeno-associated virus 13 AAV13-YF AAV13-587-7m8 AAV13-585-7m8 transduction efficiency

Novel intelligent reasoning system for tool wear prediction and parameter optimization in intelligent milling

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Advances in Manufacturing 2024年第1期12卷 76-93页

作者： Long-Hua Xu Chuan-Zhen Huang Zhen Wang han-lian Liu Shui-Quan Huang Jun Wang School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiPeople’s Republic of China Center for Advanced Jet Engineering Technologies(CaJET) Key Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education)National Experimental Teaching Demonstration Center for Mechanical Engineering(Shandong University)School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China Institute of Manufacturing Technology Guangdong University of TechnologyGuangzhou510006People’s Republic of China

Accurate intelligent reasoning systems are vital for intelligent *** this study,a new intelligent reasoning system was developed for milling processes to accurately predict tool wear and dynamically optimize machining *** developed system consists of a self-learning algorithm with an improved particle swarm optimization(IPSO)learning algorithm,prediction model determined by an improved case-based reasoning(ICBR)method,and optimization model containing an improved adaptive neural fuzzy inference system(IANFIS)and *** results showed that the IPSO algorithm exhibited the best global convergence *** ICBR method was observed to have a better performance in predicting tool wear than standard CBR *** IANFIS model,in combination with IPSO,enabled the optimization of multiple objectives,thus generating optimal milling *** paper offers a practical approach to developing accurate intelligent reasoning systems for sustainable and intelligent manufacturing.

关键词： Improved particle swarm optimization(IPSO)algorithm Improved case-based reasoning(ICBR)method Adaptive neural fuzzy inference system(ANFIS)model Tool wear prediction Intelligent manufacturing

Extreme precipitation detection ability of four high-resolution precipitation product datasets in hilly area:a case study in Nepal

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Advances in Climate Change Research 2024年第3期15卷 390-405页

作者： Sunil Subba Yao-Ming Ma Wei-qiang Ma Cun-Bo han Land-Atmosphere Interaction and its Climatic Effects Group State Key Laboratory of Tibetan Plateau Earth SystemEnvironment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China Kathmandu Center of Research and Education Chinese Academy of SciencesBeijing 100101China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakista

Given Nepal's vulnerability to extreme precipitation(EP),it is imperative to conduct a comprehensive analysis to comprehend the historical trends of such ***,acquiring precise precipitation data for EP remains challenging in mountainous countries like Nepal owing to the scarcity of densely gauged *** limitation impedes the dissemination of knowledge pertaining to EP variability events in *** current research on this topic is deficient for two main reasons:1)there is a lack of studies leveraging recently released high-resolution precipitation products to identify their EP detection capabilities,which further hinders the usability of those products in data-scarce regions like Nepal,and 2)most studies have focused on the characterisation of EP events in Nepal rather than their spatial and temporal *** address these issues,this study evaluated the EP detection capabilities of four high-resolution precipitation product datasets(PPDs)across Nepal from 1985 to *** datasets include the ERA5 Land reanalysis data,satellite-based precipitation data(PERSIANN_CCS_CDR and CHIRPS_V2.0)and a merged dataset(TPHiPr).We used various statistical and categorical indices to assess their ability to capture the spatial and temporal variability of EP *** annual EP events were characterised by 11 indices divided into frequency and intensity *** TPHiPr merged dataset offered a robust depiction of monthly precipitation estimates,achieving the highest critical success index,accuracy,probability of detection and a low false alarm ratio for daily precipitation detection of 0.1 mm in ***,the PERSIANN_CCS_CDR dataset exhibited poor *** PPDs showed increasing trends in EP ***,the TPHiPr dataset showcased those trends with fewer errors and stronger correlations for many frequency(R10mm,R20mm and R25mm)and intensity(RX1day,RX5day,PRCPTOT and R99p)*** results indicate that TPHiPr outperformed ot

关键词： Extreme precipitation Precipitation product Nepal TPHiPr ERA5 land PERSIANN_CCS_CDR CHIRPS_V2.0

Interpreting Larix principis-rupprechtii radial growth in northern China based on the Vaganov-Shashkin model

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Journal of Forestry Research 2024年第3期35卷 99-110页

作者： Jiachuan Wang Shuheng Li qiang Li Yili Guo Yijie han Qi Liu Yiqi Zhao College of Urban and Environmental Sciences Northwest UniversityXi'an 710127People's Republic of China Institute of Global Environmental Change Xi'an Jiaotong UniversityXi'an 710049People's Republic of China Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity Northwest UniversityXi'an 710127People's Republic of China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061People's Republic of China

Changes in annual radial growth is an important indication of climate change. Dendroclimatology studies in northern China have focused on linear statistical analysis,but lacking studies based on the process of ring formation to clarify the radial growth of trees. Tree-ring width standard chronology(STD) was established using samples of Larix principis-rupprechtii collected at 2303 m altitude on Luya Mountain. Using the Vaganov-Shashkin(VS) model to simulate growth and development, the internal physiological mechanism of radial growth is identified. It was concluded that:(1) the growing season of L. principis-rupprechtii was May to September;(2) soil moisture was a significant factor in the early and late growing seasons, and temperature was the dominant factor in its main growth period;and(3) formation of narrow ring widths was closely related to drought stress, the development of wide ring widths will be restricted by increasing future temperatures. The VS model is applicable for radial growth simulation of subalpine coniferous forests and for guiding the cultivation of local tree species in the future.

关键词： Vaganov-Shashkin model Larix principis-rupprechti Tree-ring width Annual growth