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Asian Journal of Andrology 2020年第5期22卷 532-538页

作者： lian-min luo Re-Dian Yang Jia-min Wang Shan-Kun Zhao Yang-Zhou Liu Zhi-Guo Zhu Qian Xiang Zhi-Gang Zhao Department of Urology and Andrology Minimally Invasive Surgery CenterGuangdong Provincial Key Laboratory of UrologyThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China.

5a-reductase inhibitors(5-ARI)are widely employed for the treatment of benign prostatic *** has been noted that 5-ARI exhibit the potential to attenuate the risk of prostate cancer,but consistent agreement has not been ***,the effect of 5-ARI on cancer-specific mortality and progression of prostate cancer remains ***,the goal of the current meta-analysis was to elucidate the impact of 5-ARI on the incidence and progression of prostate *** searched for all studies assessing the effect of 5-ARI on risk of prostate cancer in PubMed,Embase,Medline,and Cochrane Library *** relative risk(RR)and corresponding 95%confidence intervals(CIs)were accepted to evaluate the association between 5-ARI and the risk of prostate *** results implied that subjects who accepted 5-ARI compared with the placebo group experienced a distinctly weakened overall incidence of prostate cancer(RR=0.74;95%C l:0.66-0.82;P7;RR=1.19;95%Cl:0.98-1.43;P=0.069).The results also showed that 5-ARI treatment did not significantly alter prostate cancer-specific mortality(RR=1.0;95%C l:0.95-1.05;P=0.916).In addition,it was worth noting that 5-ARI treatment acted in a protective role that presented a dramatic benefit to delay the progression of low-risk tumors(RR=0.58;95%C l:0.43-0.78;P<0.001).

关键词： 5a-reductase inhibitor meta-analysis prostate cancer

Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured HepG2 cells

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Chinese Medical Journal 2007年第24期120卷 2181-2184页

作者： LEI Jian-hua HE Xing-e YANG Xu ZHANG min lian Jun luo Hong-yu WANG Wen-long Liver Disease Research Center Second Xiangya Hospital CentralSouth University Changsha 410011 China

Background Hepatitis B virus （HBV） X protein （HBx） and p53 could mutually down-regulate at transcriptional level and HBx could bind with p53 protein within its transactivation domain and inhibit the function of p53 protein. In recent years, effects of arsenic trioxide （As2O3） on the expression of p53 protein have been widely studied, while little is known about the activity of p53 protein. This study was undertaken to delineate the effect of HBV X gene and AS203 on p53 protein expression （level and activity） in HepG2 cells by small hairpin RNA （shRNA）-mediated RNA interference （RNAi） technique. Methods Cell line HepG2 and cells with stable expression of HBV X gene （HepG2-X） were treated with 2 pmol/L AS203, with corresponding untreated cells serving as controls. Cell lysates and nuclear extracts were extracted. Total level and the relative activity of p53 protein were detected by modified enzyme-linked immunosorbent assay （ELISA）. HBV X gene sequence-specific shRNA expression vector （pXi-1 and pXi-2） and sequence-unrelated control （pXi-3） were transfected into HepG2-X. Single cell clone with stable expression of shRNA was selected and exposed to propagating culture. The effect of As2O3 on p53 protein expression and activity was re-observed. Results Total p53 protein level was up-regulated and its relative activity ratio was enhanced by As2O3 in HepG2 and HepG2-X cells. The total p53 protein level induced by As2O3 was up-regulated by HBV X gene expression, while its relative activity was significantly suppressed. The suppression was removed after HBV X gene expression was repressed by shRNA. Conclusions As2O3 up-regulates p53 protein expression and enhance its activity. HBV X up-regulates As2O3 induced-p53 protein expression while suppresses its activity.

关键词： hepatitis B virus gene X arsenic trioxide RNA interference tumor suppressor protein p53

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu luo min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei Bi min Li Jiazhi Chen Zhuyong Wang Huantao Wen ming Zhou minjie luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting luo Bin Feng min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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企业金融化对企业创新的影响

江苏商论 2025年第1期 91-96页

作者：罗敏昆明理工大学云南昆明650504

随着经济发展进入高质量发展阶段,引导企业“脱虚向实”,创新升级已然是一个重要的关注点。本文基于2007—2022年中国A股制造业企业数据,实证探究了企业金融化对企业创新的影响效应及高管金融背景、外部环境不确定性在两者间的调节效应... 详细信息

随着经济发展进入高质量发展阶段,引导企业“脱虚向实”,创新升级已然是一个重要的关注点。本文基于2007—2022年中国A股制造业企业数据,实证探究了企业金融化对企业创新的影响效应及高管金融背景、外部环境不确定性在两者间的调节效应。研究认为,适当投资能够促进企业创新,过度的金融化会抑制企业创新。该结论在经过更换模型、倾向得分匹配两个稳健性检验后依旧成立。调节效应显示,高管金融背景能够弱化两者间的倒U关系,而环境不确定性发挥正向调节作用。本文为探究企业金融化与企业创新的关系提供了丰富的经验证据,对为企业创新配置金融资产,提供稳定现金流环境,合理进行金融投资具有重要的实践启示。

关键词：企业金融化企业创新倒U型关系

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-min Xu Ke Wang Jia-Zhu Wen Li-Kang luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

PTM： A Topic Model for the Inferring of the Penalty

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Journal of Computer Science & Technology 2018年第4期33卷 756-767页

作者： Tie-Ke He Hao lian Ze-min Qin Zhen-Yu Chen Bin luo Software Institute Nanjing University Nanjing 210093 China National Key Laboratory for Novel Software Technology Nanjing University Nanjing 210093 China

Deciding the penalty of a law case has always been a complex process, which may involve with much coordination. Despite the judicial study based on the rules and conditions, artificial intelligence and machine learning has rarely been used to study the problem of penalty inferring, leaving the large amount of law cases as well as various factors among them untouched. This paper aims to incorporate the state-of-the-art artificial intelligence methods to exploit to what extent this problem can be alleviated. We first analyze 145 000 law cases and observe that there are two sorts of labels, temporal labels and spatial labels, which have unique characteristics. Temporal labels and spatial labels tend to converge towards the final penalty, on condition that the cases are of the same category. In light of this, we propose a latent-class probabilistic generative model, namely Penalty Topic Model （PTM）, to infer the topic of law cases, and the temporal and spatial patterns of topics embedded in the case judgment. Then, the learnt knowledge is utilized to automatically cluster all cases accordingly in a unified way. We conduct extensive experiments to evaluate the performance of the proposed PTM on a real large-scale dataset of law cases. The experimental results show the superiority of our proposed PTM.

关键词： penalty inferring topic model convolutional neural network support vector machine

Electrochemical capacitors based on the composite of graphene and nickel foam

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Science China Chemistry 2016年第4期59卷 405-411页

作者： Songwei Li min Wang Yongfu lian Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education School of Chemistry and Materials Science Heilongjiang University

An improved Hummers method was developed for the simple and efficient production of high-quality graphene oxide （GO）, and the composite of GO and nickel foam （NF）（GO/NF） was fabricated by ultrasonication-vacuum-assisted deposition of an aqueous solution of GO on NF. After chemical or thermal reduction, the composite of reduced GO and nickel foam （rGO/NF） was obtained. The electrochemical capacitance performance of rGO/NF was investigated using cyclic voltammetry and gal- vanostatic charge/discharge measurements. The chemically reduced rGO/NF composite （C-rGO/NF） exhibited high specific capacitance of 379 F/g at 1.0 A/g and 266.5 F/g at 10 A/g. We also prepared thermally reduced graphene oxide at 473 K in or- der to illuminate the difference in effect between the chemical and low-temperature thermal reduction methods on electro- chemical properties. The cycling performance of thermally reduced rGO/NF composite （T-rGO/NF） and C-rGO/NF had ~91% and ~95% capacitance retention after 2000 cycles in a 6 mol/L KOH electrolyte, respectively. Electrochemical experiments in- dicated that the obtained rGO/NF has very good capacitive performance and could be used as a potential application of elec- trochemical capacitors. Our work revealed high electrochemical capacitor performance of rGO/NF composite and provided a facile method of rGO/NF preparation.

关键词： electrochemical capacitor graphene oxide nickel foam reduction

Effects of operating condition on fish behavior and fish injury in an axial pump

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Science China(Technological Sciences) 2022年第1期65卷 157-168页

作者： YANG DanDan ZHAO mingXiang SHEN lian luo XianWu State Key Laboratory of Hydroscience and Engineering Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Saint Anthony Falls Laboratory&Department of Mechanical Engineering University of MinnesotaMinneapolisMN 55414USA

In this study,fish behavior and fish injury at different operating conditions are investigated via numerical simulation to evaluate the fish-friendliness of an axial pump that comprises an inlet pipe,a rotor with six blades,a stator with eight vanes,and an outlet *** precisely obtain the flow field when the fish passes through the axial pump,a hybrid large eddy simulation and immersed boundary method is adopted with the full consideration of the fluid-structure interaction *** results indicate that the collision between the fish and the wall of flow components in the axial pump is concentrated near the inlet of the rotor,which results in the complexity of the fish trajectory,especially under the large flow rate *** is noted that the fish is likely to move in the reverse direction of the main flow after the impact with the rotor blade if the flow rate coefficient is too large,which increases the possibility of collision between the fish and the rotor *** is also indicated that the primary factor affecting the strike injury on the fish when it passes through the axial pump is the strike between the fish and the leading edge of the rotor *** addition,the strike injury becomes more significant as the flow rate coefficient ***,the results demonstrate that the fish may simultaneously suffer from strike,pressure,and shear stress injuries,once the collision between the fish and the wall of flow components occurs in the axial pump,thus aggravating the combined damage on the *** on these results,it is recommended that hydraulic machinery should not be operated at large flow rates during fish migration from the view of fish-friendliness.

关键词： axial pump fish behavior fish injury immersed boundary(IB)method fluid-structure interaction(FSI)