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Emergency percutaneous thoracic endovascular aortic repair for patients with traumatic thoracic aortic blunt injury: A single center experience

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Chinese Journal of Traumatology 2020年第1期23卷 15-19页

作者： Xin Pu Xiao-Yong huang lian-jun huang Department of Intervention Diagnosis and Therapy Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Purpose:To analyze the efficacy and outcome of percutaneous thoracic endovascular aortic repair(TEVAR)in patients with traumatic blunt aortic injury in our single-center.Methods:From January 2014 to December 2018,a total of 89 patients with traumatic blunt aortic injuries were treated with emergency TEVAR in our center.Their clinical data such as demographics,operative details and postprocedure outcomes were analyzed retrospectively in this study using SPSS 20 software.Continuous variables were expressed as mean and standard deviation or median and interquartile range.Categorical variables are expressed as the numbers and percentages of patients.Results:The median age of the patients was 37 years,and 76(85.4%)were males.All the patients were involved in violent accidents and combined with associated injuries.Two patients died while awaiting the operations and 87 patients underwent emergency percutaneous TEVAR,with a 100%technique success.The mean time interval from admission to operating room was(90.1±18.7)min,and the mean procedure time was(54.6±11.9)min.Eighty(92.0%)patients were operated on under local anesthesia,while other 7(8.0%)patients were under general anesthesia.Two cases underwent open repair of the femoral arteries because of the pseudoaneurysm formation of the access vessels.A total of 98 aortic covered stent grafts were deployed,of which 11 patients used two stent grafts(all in dissection cases).The length of the stent was(177.5±24.6)mm.The horizontal diameter of aorta arch at the proximal left subclavian artery ostium was(24.9±2.4)mm,the proximal diameter of the covered stent was(30.5±2.6)mm,and the oversize rate of proximal site was(22.7±4.0)%.The proximal landing zone length was(14.1±5.5)mm.The left subclavian artery ostium was completely covered in 5 patients and partially covered in 32 patients.No blood flow reconstruction was performed.The overall aortic-related mortality was 2.25%(2/89).Among 87 patients,the median follow-up time was 24 months.Postoperative computed tomography angiography sc

关键词： Nonpenetrating wounds Blunt aortic injury Endovascular aortic repair

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Smoking history increases the risk of long-term mortality after thoracic endovascular aortic repair in patients with an uncomplicated type B dissection

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Chinese Medical Journal 2020年第4期133卷 402-407页

作者： Hui-Qiang Gao Chang-Wei Ren Sheng Yang lian-jun huang Li-Zhong Sun Shang-Dong Xu Department of Cardiac Surgery Beijing Anzhen HospitalBeijing Institute of HeartLung&Vascular DiseasesCapital Medical UniversityBeijing 100029China Department of Intervention Beijing Anzhen HospitalBeijing Institute of HeartLung&Vascular DiseasesCapital Medical UniversityBeijing 100029China

Background:The preferred treatment for uncomplicated type B dissection(thoracic endovascular aortic repair[TEVAR]or medical)is still under debate.Since 2001,our center has performed TEVAR for uncomplicated type B dissection.Based on our data,5-and 10-year survival rates among patients with uncomplicated type B dissection after TEVAR were 96.5%and 83.0%,respectively.We,therefore,believe that TEVAR is preferable for uncomplicated type B dissections.This study analyzed the impact of a pre-operative smoking history on long-term survival after TEVAR in patients with uncomplicated type B dissections.Methods:From May 2001 to December 2013,data from 751 patients with type B dissections were collected and analyzed.Patients were divided into two groups(337 smoking patients and 414 non-smoking patients).The Kaplan-Meier method and log-rank test were used to compare survival curves of the two groups.Multivariable analyses using the Cox proportional hazards model were used to estimate the effects of smoking on survival rates.Results:The 5-and 10-year survival rates of non-smokers were 97.6%(95%confidence interval[CI],96.0%-99.2%)and 87.0%(95%CI,81.6%-92.7%),respectively,and 94.9%(95%CI,92.2%-97.7%)and 73.8%(95%CI,62.3%-87.5%)for smokers,respectively(Log-rank test,P=0.006).Multivariable analyses showed that smoking increased the risk of death during follow-up,2.1-fold when compared to non-smokers(P=0.039).Conclusion:A pre-operative smoking history increases long-term mortality rates after TEVAR in patients with uncomplicated type B dissections.

关键词： Smoking TEVAR Uncomplicated type B dissection Survival rate

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Novel intelligent reasoning system for tool wear prediction and parameter optimization in intelligent milling

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Advances in Manufacturing 2024年第1期12卷 76-93页

作者： Long-Hua Xu Chuan-Zhen huang Zhen Wang Han-lian Liu Shui-Quan huang jun Wang School of Mechanical Engineering Yanshan UniversityQinhuangdao066004HebeiPeople’s Republic of China Center for Advanced Jet Engineering Technologies(CaJET) Key Laboratory of High-efficiency and Clean Mechanical Manufacture(Ministry of Education)National Experimental Teaching Demonstration Center for Mechanical Engineering(Shandong University)School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China Institute of Manufacturing Technology Guangdong University of TechnologyGuangzhou510006People’s Republic of China

Accurate intelligent reasoning systems are vital for intelligent manufacturing.In this study,a new intelligent reasoning system was developed for milling processes to accurately predict tool wear and dynamically optimize machining parameters.The developed system consists of a self-learning algorithm with an improved particle swarm optimization(IPSO)learning algorithm,prediction model determined by an improved case-based reasoning(ICBR)method,and optimization model containing an improved adaptive neural fuzzy inference system(IANFIS)and IPSO.Experimental results showed that the IPSO algorithm exhibited the best global convergence performance.The ICBR method was observed to have a better performance in predicting tool wear than standard CBR methods.The IANFIS model,in combination with IPSO,enabled the optimization of multiple objectives,thus generating optimal milling parameters.This paper offers a practical approach to developing accurate intelligent reasoning systems for sustainable and intelligent manufacturing.

关键词： Improved particle swarm optimization(IPSO)algorithm Improved case-based reasoning(ICBR)method Adaptive neural fuzzy inference system(ANFIS)model Tool wear prediction Intelligent manufacturing

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Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

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World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： lian-Meng huang Ming-Jin Zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further exploration.Pan-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’progression.AIM To investigate the regulatory functions of KIF26B on immune and metastasis of GC.METHODS We analyzed genes’mRNA levels by quantitative real-time polymerase chain reaction.Expression levels of target proteins were detected by immunohistochemistry,ELISA,and Western blotting.We injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of GC.The degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin staining.Transwell and wound healing assays were performed for the evaluation of cell invasion and migration ability.Tube formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow cytometry.RESULTS KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and prognosis.According to in vivo experiments,KIF26B promoted tumor formation and metastasis of GC.KIF26B expression was positively associated with CAFs’degree of infiltration.Moreover,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition process.CONCLUSION KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

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An improved algorithm for retrieving thin sea ice thickness in the Arctic Ocean from SMOS and SMAP L-band radiometer data

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Acta Oceanologica Sinica 2024年第3期43卷 127-138页

作者： lian He Senwen huang Fengming Hui Xiao Cheng School of Geospatial Engineering and Science Sun Yat-Sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-Sen University) Ministry of EducationZhuhai 519082China

The aim of this study was to develop an improved thin sea ice thickness(SIT)retrieval algorithm in the Arctic Ocean from the Soil Moisture Ocean Salinity and Soil Moisture Active Passive L-band radiometer data.This SIT retrieval algorithm was trained using the simulated SIT from the cumulative freezing degree days model during the freeze-up period over five carefully selected regions in the Beaufort,Chukchi,East Siberian,Laptev and Kara seas and utilized the microwave polarization ratio(PR)at incidence angle of 40°.The improvements of the proposed retrieval algorithm include the correction for the sea ice concentration impact,reliable reference SIT data over different representative regions of the Arctic Ocean and the utilization of microwave polarization ratio that is independent of ice temperature.The relationship between the SIT and PR was found to be almost stable across the five selected regions.The SIT retrievals were then compared to other two existing algorithms(i.e.,UH_SIT from the University of Hamburg and UB_SIT from the University of Bremen)and validated against independent SIT data obtained from moored upward looking sonars(ULS)and airborne electromagnetic(EM)induction sensors.The results suggest that the proposed algorithm could achieve comparable accuracies to UH_SIT and UB_SIT with root mean square error(RMSE)being about 0.20 m when validating using ULS SIT data and outperformed the UH_SIT and UB_SIT with RMSE being about 0.21 m when validatng using EM SIT data.The proposed algorithm can be used for thin sea ice thickness(<1.0 m)estimation in the Arctic Ocean and requires less auxiliary data in the SIT retrieval procedure which makes its implementation more practical.

关键词： Arctic sea ice sea ice thickness remote sensing Soil Moisture Active Passive(SMAP) Soil Moisture Ocean Salinity and Soil(SMOS)

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Establishing Modular Cell-Free Expression System for the Biosynthesis of Bicyclomycin from a Chemically Synthesized Cyclodipeptide

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Chinese Journal of Chemistry 2024年第4期42卷 384-390页

作者： Yi-Pei Liu Yu-Heng Zhao Wen-Qi Zhang lian Wu Linjuan huang Gong-Li Tang jun-Bin He Shaanxi Natural Carbohydrate Resource Engineering Research Center College of Food Science and TechnologyNorthwest UniversityXi'anShaanxi710069 China State Key Laboratory of Chemical Biology Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of Sciences(CAS)CASShanghai200032 China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of CAS1 Sub-lane XiangshanHangzhouZhejiang310024 China

Cell-free expression systems have emerged as a versatile and powerful platform for metabolic engineering,biosynthesis and synthetic biology studies.Nevertheless,successful examples of the synthesis of complex natural products using this system are still limited.Bicyclomycin,a structurally unique and complex diketopiperazine alkaloid,is a clinically promising antibiotic that selectively inhibits the transcription termination factor Rho.Here,we established a modular cell-free expression system with cascade catalysis for the biosynthesis of bicyclomycin from a chemically synthesized cyclodipeptide.The six cell-free expressed biosynthetic enzymes,including five iron-andα-ketoglutarate-dependent dioxygenases and one cytochrome P450 monooxygenase,were active in converting their substrates to the corresponding products.The co-expressed enzymes in the cell-free module were able to complete the related partial pathway.In vitro biosynthesis of bicyclomycin was also achieved by reconstituting the entire biosynthetic pathways(i.e.,six enzymes)using the modular cell-free expression system.This study demonstrates that the modular cell-free expression system can be used as a robust and promising platformforthe biosynthesis of complex antibiotics.

关键词： Natural products Bicyclomycin Biosynthesis Iron-andα-ketoglutarate-dependent dioxygenases Cytochrome P450 monooxygenase Cell-freeprotein synthesis Enzyme catalysis

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Structural engineering of BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures towards ultrastable and tunable photoluminescence

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Nano Research 2024年第3期17卷 1636-1645页

作者： Peng Liu Yan Xu Bohan Li Yuchi Zhang Hongzhou lian jun Lin Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China State Key Laboratory of Rare Earth Resource Utilization Chang Chun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Construction of lead halide perovskite nanocrystals(LHP NCs)heterostructures is essential to obtain highly stable photoluminescence and expand their applications.Herein,a novel self-assembly strategy combining with a solvent-free thermal-assisted synthesis and a water-triggered reaction is developed to subsequently grow BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures at low nucleation temperature with high crystallinity.The as-obtained ternary BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(X=Cl,Br,I)heterostructures exhibit remarkably enhanced panchromatic emission and ultrastable luminescence ascribing to the low-defect growth based on lattice matching.Stable white light-emitting diodes(WLEDs)have been constructed with a high correlated color temperature(CCT)of 7225 K and luminous efficiency of 74.4 lm·W-1.Ln^(3+)-doped BaWO_(4)/CsPbX_(3)/CsPb_(2)X_(5)(Ln^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Sm^(3+),Yb^(3+)/Er^(3+))nanocomposites are further designed with excitation-dependent photoluminescence and thermochromic properties,making them excellent candidates for high-level anti-counterfeiting and encryption.This work offers a green and universal approach in assembling CsPbX_(3)(X=Cl,Br,I)on lattice-matched tungstate with adjustable panchromatic emission for versatile optical applications.

关键词： inorganic lead halide perovskites solvent-free synthesis panchromatic emission anti-counterfeiting and encryption application

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Expanding the horizons of targeted protein degradation:A non-small molecule perspective

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2402-2427页

作者： Xiaowei huang Fengbo Wu Jing Ye lian Wang Xiaoyun Wang Xiang Li Gu He Department of Pharmacy and Department of Dermatology&Venerology West China HospitalSichuan UniversityChengdu 610041China Department of Urology West China HospitalSichuan UniversityChengdu 610041China Laboratory of Dermatology Clinical Institute of Inflammation and ImmunologyFrontiers Science Center for Disease-Related Molecular Network and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but have the potential to unlock functionalities beyond degradation.Non-small-molecule-based approaches play an irreplaceable role in this field.A wide variety of agents spanning a broad chemical spectrum,including peptides,nucleic acids,antibodies,and even vaccines,which not only prove instrumental in overcoming the constraints of conventional small molecule entities but also provided rapidly renewing paradigms.Herein we summarize the burgeoning non-small molecule technological platforms inspired by PROTACs,including three major trajectories,to provide insights for the design strategies based on novel paradigms.

关键词： Targeted protein degradation Proteolysis targeting chimera Endocytosis Autophagy Proximity-inducing modality Post-translational modification

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Energy-information trade-off induces continuous and discontinuous phase transitions in lateral predictive coding

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 79-85页

作者： Zhen-Ye huang Ruyi Zhou Miao huang Hai-jun Zhou Key Laboratory for Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China Minjiang Collaborative Center for Theoretical Physics Minjiang UniversityFuzhou 350108China

Lateral predictive coding is a recurrent neural network that creates energy-efficient internal representations by exploiting statistical regularity in sensory inputs.Here,we analytically investigate the trade-off between information robustness and energy in a linear model of lateral predictive coding and numerically minimize a free energy quantity.We observed several phase transitions in the synaptic weight matrix,particularly a continuous transition that breaks reciprocity and permutation symmetry and builds cyclic dominance and a discontinuous transition with the associated sudden emergence of tight balance between excitatory and inhibitory interactions.The optimal network follows an ideal gas law over an extended temperature range and saturates the efficiency upper bound of energy use.These results provide theoretical insights into the emergence and evolution of complex internal models in predictive processing systems.

关键词： predictive coding recurrent neural network phase transition internal model free energy

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Visible light-driven oxidation of non-native substrate by laccase attached on Ru-based metal-organic frameworks

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Journal of Environmental Sciences 2024年第3期137卷 741-753页

作者： Wenguang huang Wentao Zhang Guantongyi Chen Yun Chen jun Ma Dawei huang Qinzheng Zhaoc Bingdang Wu State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and Environment of PRCGuangzhou 510655China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215002China Key Laboratory of Suzhou Sponge City Technology Suzhou 215002China

Light-induced electron transfer can broaden the substrate range of metalloenzyme.However,the efficiency of photo-enzyme coupling is limited by the poor combination of photosensitizer or photocatalyst with enzyme.Herein,we prepared the nano-photocatalyst MIL-125-NH_(2)@Ru(bpy)by in site embedding ruthenium pyridine-diimine complex[Ru(bpy)_(3)^(2+)into metal organic frameworks MIL-125-NH_(2)and associated it with multicopper oxidase(MCO)laccase.Compared to[Ru(bpy)_(3)]^(2+),the coupling efficiency of MIL-125-NH_(2)@Ru(bpy)_(3)for enzymatic oxygen reduction increased by 35.7%.A series of characterizations confirmed that the amino group of laccase formed chemical bonds with the surface defects or hydrophobic groups of MIL-125-NH_(2)@Ru(bpy)_(3).Consequently,the tight binding accelerated the quenching process and electron transfer between laccase and the immobilized ruthenium pyridine-diimine complex.This work would open an avenue for the synthesis of MOFs photocatalyst towards photo-enzyme coupling.

关键词： Laccase Light-driven biocatalysis Ruthenium photocatalyst Metal-organic frameworks Enzyme immobilization

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