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B7-H4 expression is elevated in human U251 glioma stem-like cells and is inducible in monocytes cultured with U251 stem-like cell conditioned medium

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Chinese Journal of Cancer 2013年第12期32卷 653-660页

作者： lian-jie mo Hong-Xing Ye Ying Mao Yu Yao Jian-Min Zhang Department of Neurosurgery Second Affiliated Hospital School of Medicine Zhejiang University Department of Neurosurgery Huashan Hospital Fudan University

Previous studies indicated that B7-H4,the youngest B7 family,negatively regulates T cell-mediated immunity and is significantly overexpressed in many human *** stem cells are purported to play a role in tumor renewal and resistance to radiation and ***,the link between B7-H4and tumor stem cells is *** this study,we investigated B7-H4 expression in the medium of human glioma U251 cell *** results showed that U251 cells cultured in serum-free medium(supplemented with 2%B27,20 ng/mL epidermal growth factor,20 ng/mL basic fibroblast growth factor)maintained stem-like cell characteristics,including expression of stem cell marker CD133 and the neural progenitor cell markers nestin and *** contrast,U251 cells cultured in serum-containing medium highly expressed differentiation marker glial fibrillary acidic *** cytometry analysis showed serum-free medium-cultured U251 cells expressed higher intracellular B7-H4 than serumcontaining medium-cultured U251 cells(24%-35%vs.8%-11%,Pmonocytes from normal human peripheral blood mononuclear cells revealed moderate expression of B7-H4 after stimulation with conditioned medium from U251 cells cultured in serum-containing ***,conditioned medium from U251 stem-like cells had a significant stimulation effect on B7-H4expression compared with serum-containing conditioned medium(Pmolecule B7-H4 was preferentially expressed in U251 stem-like cells,and conditioned medium from these cells more effectively induced monocytes to express B7-H4 than conditioned medium from U251 cells cultured in the presence of *** results show that U251 stem-like cells may play a more crucial role in tumor immunoloregulation with high expression of B7-H4.

关键词：外周血单核细胞肿瘤干细胞条件培养基脑胶质瘤碱性成纤维细胞生长因子诱导无血清培养基 U251细胞

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Recent progress on stability and applications of flexible perovskite photodetectors

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Journal of Semiconductors 2025年第1期46卷 5-19页

作者： Ying Hu Qianpeng Zhang Junchao Han Xinxin lian Hualiang Lv Yu Pei Siqing Shen Yongli liang Hao Hu Meng Chen Xiaoliang mo Junhao Chu State Key Laboratory of Photovoltaic Science and Technology Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and PerceptionDepartment of Materials ScienceInstitute of OptoelectronicsFudan UniversityShanghai 200433China Advanced Silicon Technology Co. Ltd.Shanghai 201616China

Flexible photodetectors have garnered significant attention by virtue of their potential applications in environmental monitoring,wearable healthcare,imaging sensing,and portable optical *** stand out as particularly promising materials for photodetectors,offering exceptional optoelectronic properties,tunable band gaps,low-temperature solution processing,and notable mechanical *** this review,we explore the latest progress in flexible perovskite photodetectors,emphasizing the strategies developed for photoactive materials and device structures to enhance optoelectronic performance and ***,we discuss typical applications of these devices and offer insights into future directions and potential applications.

关键词： perovskite flexible photodetector stability versatile applications

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Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults

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World Journal of Emergency Medicine 2025年第1期16卷 35-42页

作者： Tianpeng Hu Yan Li Shengtao Yan Lichao Sun Rui lian jieqiong Yu jie Chen Xiaoyu Liu Guoqiang Zhang Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND: Inappropriate antibiotic treatment for patients with viral infections has led to a surge in antimicrobial resistance, increasing mortality and healthcare costs. Viral and bacterial infections are often difficult to distinguish. Myxovirus resistance protein A(MxA), an essential antiviral factor induced by interferon after viral infection, holds promise for distinguishing between viral and bacterial infections. This study aimed to determine the ability of Mx A to distinguish viral from bacterial ***: We quantified MxA in 121 infected patients via dry immunofluorescence chromatography. The Kruskal-Wallis test and receiver operating characteristic(ROC) curve analysis were used to determine the diagnostic value of Mx A, either alone or in combination with C-reactive protein(CRP) or procalcitonin(PCT), in patients with viral, bacterial, or ***: The value of MxA(ng/mL) was significantly higher in patients with viral infections than in those with bacterial and co-infections(82.3 [24.5–182.9] vs. 16.4 [10.8–26.5], Pmoreover, EpsteinBarr virus and human cytomegalovirus infections did not elicit elevated Mx A expression.

关键词： Myxovirus resistance protein A Viral infections C-reactive protein Procalcitonin Biomarker

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Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota

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Food Science and Human Wellness 2025年第1期14卷 212-225页

作者： Ling mo Huijuan Jing Xiaojing Du Chaochao Zhao Yintao Lin jie Li Hongxin Wang State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Public Health Guilin Medical UniversityGuilin 541199China Sweet Inn(Guangzhou)Technology Development Co. Ltd.Guangzhou 510075China

Insomnia is associated with neurotransmitters and intestinal *** studies have demonstrated the ameliorative effects of milk hydrolysates on insomnia,the underlying mechanisms require further *** this study,we investigated how papain hydrolysates of goat casein(CPH)and whey protein(WPH)affected mice's ***,we show that CPH effectively improved the total sleep time in 12 h and restoring neurotransmitters(5-hydroxytryptamine(5-HT),γ-aminobutyric acid(GABA),dopamine(DA),and norepinephrine(NE))in *** gut microbiota analysis revealed a significant increase in the relative abundance of Helicobacter and Escherichia-Shigella and a decrease in the relative abundance of Lactobacillus in the insomnia model mice(model).Compared to the model group,both CPH and WPH significantly increased the relative abundance of Akkermansia and Lactobacillus while lowering the relative abundance of Helicobacter and ***,while diazepam(DZP)increased mouse sleep duration,it also increased the relative abundance of Colidextribacter,Parasutterella,Muribaculaceae,and ***,the gene expression and protein expression of GABA_A receptor,cAMP-response element binding protein(CREB),and brain-derived neurotrophic factor(BDNF)were upregulated in the *** also discovered a link between intestinal gut microbiota and ***,our results suggest that goat milk hydrolysates,especially CPH,can effectively improve insomnia,providing a theoretical basis for further experimentation and individualized designs.

关键词： Goat casein Hydrolysates Insomnia Gut microbiota

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-Qin Liu jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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High spectral-efficiency, ultra-low MImo SDM transmission over a field-deployed multi-core OAM fiber

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Photonics Research 2025年第01期13卷 18-30页

作者： JUNYI LIU SHUQIN mo ZENGQUAN XU YUMING HUANG YINING HUANG ZHENHUA LI YUYING GUO LEI SHEN SHUO XU RAN GAO CHENG DU QIAN FENG jie LUO jie LIU SIYUAN YU State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen University Yangtze Optical Fibre and Cable Joint Stock Limited Company State Key Laboratory of Optical Fibre and Cable Manufacture Technology School of Information and Electronics Beijing Institute of Technology Fiberhome Telecommunication Technologies Co. Ltd. School of Electronics and Information Technology and Guangdong Provincial Key Laboratory of Optoelectronic Information Processing Chips and Systems Sun Yat-sen University

Space-division multiplexing (SDM) systems based on few-mode multi-core fibers (FM-MCFs) utilize both spatial channels (fiber cores) and modes (optical modes per core) to maximize transmission *** laboratory FM-MCFs or field-deployed single-mode multi-core fibers (SM-MCFs),SDM transmissions over field-deployed FM-MCFs in outdoor settings have not been ***,concerns remain that environmental interference and cabling stress could worsen inter-core and intra-core modal crosstalk and impact the performance of SDM systems over *** this paper,we demonstrate successful bidirectional SDM transmission over a5-km,field-deployed seven ring-core fiber (7-RCF) with a cladding diameter of 178μ*** measurements show no significant differences in attenuation and mode coupling compared to pre-cabling conditions,confirming the fiber’s resilience to environmental disturbances and adaptability to cable *** the field-deployed7-RCF,bi-directional SDM transmission is implemented,achieving spectral efficiency (SE) of 2×201.6 bit/(s Hz)which sets a new record in field-deployed fiber cables that is a tenfold increase over previous ***,these results were achieved using a small-scale 4×4 multiple-input multiple-output (MImo)scheme with a time-domain equalization (TDE) tap number not exceeding *** results demonstrate the substantial potential of using SDM techniques to significantly enhance SE and expand capacity in practical fiber-optic transmission applications.

关键词： Effective refractive index Few mode fibers mode division multiplexing Multicore fibers Signal processing Space division multiplexing

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论魏晋南北朝时期女性文学思想新变——以悼亡文学为例

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兰州文理学院学报(社会科学版) 2025年第1期41卷 58-63页

作者：连捷西北师范大学文学院甘肃兰州730070

魏晋南北朝时期悼亡文学得到了很大的发展,这一时期女性作家对“悼亡”的书写具有独特的价值与意义。通过对该时期女性作家的悼亡诗赋、祭文的分析与解读,可知魏晋南北朝时期女性文学思想的变化主要体现在贞节观的新变、自我意识的觉醒... 详细信息

魏晋南北朝时期悼亡文学得到了很大的发展,这一时期女性作家对“悼亡”的书写具有独特的价值与意义。通过对该时期女性作家的悼亡诗赋、祭文的分析与解读,可知魏晋南北朝时期女性文学思想的变化主要体现在贞节观的新变、自我意识的觉醒及女性地位与话语权的提升三个方面。这对于认识魏晋南北朝时期女性作家在“文学自觉”中的贡献有重要意义。

关键词：魏晋南北朝悼亡文学女性文学思想新变

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Femtosecond laser small incision lenticule extraction on binocularity for myopia with glasses-free 3D technique

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 125-131页

作者： Bing-jie Chen Yu-Chen Fan Yong-Chuan Liao Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Optometry and Visual Science West China School of MedicineSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To evaluate the effect of femtosecond laser small incision lenticule extraction(SMILE)on the binocular visual function in myopic patients with glasses-free threedimensional(3D)***:Totally 50 myopic patients(39 females and 11 males)with SMILE were enrolled in this prospective *** glasses-free 3D technique was used to evaluate the binocular visual function in these subjects including static stereopsis,dynamic stereopsis,foveal suppression,and binocular balance point of signal to noise ratio(s/n ratio).All subjects received measurements in 1d before operation,and 1d,1wk,and 1mo ***:Both static and dynamic stereopsis showed no significant difference after *** foveal suppression improved significantly 1wk and 1mo after SMILE(P=0.005 and P=0.007 respectively).The binocular balance point of signal to noise ratio showed a significant improvement 1d,1wk and 1mo after SMILE for both eyes(P<0.001 for each eye respectively).CONCLUSION:Glasses-free 3D technique can be used to evaluate the effect of SMILE on the binocular visual function in myopic patients perceptively,and SMILE can improve both foveal suppression and binocular imbalance in these patients.

关键词： myopia small incision lenticule extraction foveal suppression binocular imbalance glasses-free threedimensional technique

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焦平面图像制导导弹对地面目标截获概率计算

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兵工学报 2025年第1期46卷 208-219页

作者：赵洁徐子钰莫波石忠佼北京理工大学宇航学院北京100081 北方导航控制技术股份有限公司北京100081

针对图像制导导弹的目标探测和精确制导的需求,研究基于矩形焦平面探测器的图像制导导弹转入末制导时对地面目标的截获概率。根据导弹的高度姿态和探测器参数推导对地面探测的不规则四边形视场(Irregular Quadrilateral Detection Field... 详细信息

针对图像制导导弹的目标探测和精确制导的需求,研究基于矩形焦平面探测器的图像制导导弹转入末制导时对地面目标的截获概率。根据导弹的高度姿态和探测器参数推导对地面探测的不规则四边形视场(Irregular Quadrilateral Detection Field,IQDF)的解析解和简化的矩形探测视场(Simplified Rectangular Detection Field,SRDF)模型,确定影响目标截获概率的主要误差源。利用条件概率思想,将目标截获概率分解为导弹状态概率和当前状态下目标落入地面视场概率,并利用有限元分割算法推导出目标落入地面视场概率,从而建立多源误差下的目标截获概率模型。通过仿真分析在IQDF和SRDF下主要误差源对目标落入地面视场概率的影响,并在多源误差下将推导的目标截获概率与蒙特卡洛方法仿真结果进行对比,验证了目标截获概率计算方法的有效性。

关键词：图像制导导弹焦平面探测器截获概率多源误差探测视场模型

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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu jie Wu Na Yi Lei Shi Yumin Wang Yongzhen mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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