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Chinese Journal of Mechanical Engineering 2023年第4期36卷 167-179页

作者： Dazhu Li Jiang Han xiaoqing Tian lian xia Institute of Artificial Intelligence Anhui Polytechnic UniversityWuhu 241000China CIMS Institute Hefei University of TechnologyHefei 230009China

The current research on noncircular hobbing mainly focuses on the linkage model and motion realization.However,the intermittent cutting characteristics of hobbing would increase uncertainties in the manufacturing process.In this paper,a hobbing machining model with tool-shifting characteristics was proposed to solve the problems of cutting force fluctuation and inconsistency of tooth profile envelope accuracy at different positions of the pitch curve in noncircular gear hobbing.Based on the unit cutting force coefficient method,the undeformed chip volume generated by interrupted cutting was used to characterize the fluctuation trend of the hobbing force.The fluctuation characteristics of the cutting force generated by different hobbing models were compared and analyzed.Using the equivalent gear tooth and hob slotting numbers,an analysis model of the tooth profile envelope error of the noncircular gear was constructed.Subsequently,the tooth profile envelope errors at different positions of the pitch curve were compared and analyzed based on the constructed model.The transmission structure of the electronic gearbox was constructed based on the proposed hobbing model,and the hobbing experiment was conducted based on the selfdeveloped noncircular gear CNC hobbing system.This paper proposes a hobbing method that can effectively suppress the fluctuation of the peak and whole circumference cutting force and reduce the maximum envelope error of the whole circumference gear teeth.

关键词： Noncircular gear Gear hobbing Cutting force Envelope error Machining model

基于电子齿轮箱的内啮合强力珩齿同步误差补偿方法研究

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制造技术与机床 2024年第2期 105-110,121页

作者：孔健韩江夏链合肥工业大学机械工程学院安徽合肥230041 安徽省智能数控技术及装备工程实验室安徽合肥230041

电子齿轮箱作为一种特殊的多轴联动控制技术,是齿轮展成加工机床数控系统中的控制核心,其同步控制精度决定齿轮加工精度。内啮合强力珩齿作为一种重要的齿轮精密加工工艺,其展成加工精度很大程度上由电子齿轮箱的控制精度决定。文章结... 详细信息

电子齿轮箱作为一种特殊的多轴联动控制技术,是齿轮展成加工机床数控系统中的控制核心,其同步控制精度决定齿轮加工精度。内啮合强力珩齿作为一种重要的齿轮精密加工工艺,其展成加工精度很大程度上由电子齿轮箱的控制精度决定。文章结合强力珩齿加工的运动学模型,建立了内啮合强力珩齿的电子齿轮箱模型,将强力珩齿加工各运动轴跟踪误差的相对差值定义为同步误差,并将其映射到齿距偏差、齿廓偏差和螺旋线偏差上;提出一种基于电子齿轮箱的同步误差补偿控制方法,建立了同步补偿控制模型;在dSPACE半实物多轴运动仿真平台上,进行内啮合强力珩齿加工的运动控制实验。实验结果表明:所提出的基于电子齿轮箱的同步误差补偿方法可以有效降低内啮合强力珩齿的同步误差。

关键词：电子齿轮箱内啮合强力珩齿同步误差误差补偿精度

CuO/Cu2O nanowire array photoelectrochemical biosensor for ultrasensitive detection of tyrosinase

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Science China Chemistry 2020年第7期63卷 1012-1018页

作者： xiaoxi Guo Jinghua Wu lian xia Meihao xiang Fengli Qu Jinghong Li College of Chemistry and Chemical Engineering Qufu Normal UniversityQufu 273165China Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China

Photoelectrochemical(PEC) biosensors have shown great promise in bioanalysis and diagnostic applications in recent years. In this work, the CuO/Cu2O nanowire array(CuO/Cu2O Nanowire) supported on copper foam was prepared as a photocathode for detection of tyrosinase though quinone-chitosan conjugation chemistry method. The in-situ generated quinones that were the catalytic product of tyrosinase acted as electron acceptors, which were captured by the chitosan deposited on the surface of the electrode. Direct immobilization of electron acceptor on the electrode surface improved the photocurrent conversion efficiency and thus sensitivity. The as-prepared biosensor can realize a rapid response in a wide linear range of 0.05 U/mL to 10 U/mL with the detection limit as low as 0.016 U/mL of tyrosinase. The current work provides a new perspective to design and develop highly sensitive and selective PEC biosensor.

关键词： tyrosinase Cu0/Cu20 nanowire photoelectrochemical biosensor chitosan modified electrode quinones

Needle tract seeding of papillary thyroid carcinoma after fine-needle capillary biopsy:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3662-3667页

作者： Liu-Hong Shi liang Zhou Yin-Jiao Lei lian xia Lei Xie Department of Head and Neck Surgery Affiliated Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Pathology Affiliated Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Nursing Affiliated Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Fine-needle biopsy is an accurate and cost-efficient tool for the assessment of thyroid nodules.It includes two primary methods:Fine-needle capillary biopsy(FNCB)and fine-needle aspiration biopsy.Needle tract seeding(NTS)is a rare complication of thyroid fine-needle biopsy mainly caused by fine-needle aspiration biopsy rather than FNCB.Here,we present an extremely rare case of a papillary thyroid carcinoma(PTC)patient with FNCB-derived NTS.CASE SUMMARY We report a 32-year-old woman with PTC who showed subcutaneous NTS 1 year after FNCB and thyroidectomy.NTS was diagnosed based on clinical manifestations,biochemistry indices,and imaging(computed tomography and ultrasound).Pathological identification of PTC metastases consistent with the puncture path is the gold standard for diagnosis.Surgical resection was the main method used to treat the disease.After surgery,thyroid function tests and ultrasound scans were performed every 3-6 mo.To date,no evidence of tumor recurrence has been observed.CONCLUSION FNCB is a safe procedure as NTS is rare,and can be easily removed surgically with no recurrence.Accordingly,NTS should not limit the usefulness of FNCB.

关键词： Needle tract seeding Fine-needle capillary biopsy Papillary thyroid carcinoma Rearranged during transfection gene fusion Thyroglobulin antibody Case report

Metal-organic framework as a multi-component sensor for detection of Fe^(3+),ascorbic acid and acid phosphatase

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Chinese Chemical Letters 2021年第1期32卷 198-202页

作者： Hao Wang Xiuli Wang Rong-Mei Kong lian xia Fengli Qu Key Laboratory of Life-Organic Analysis of Shandong Province Qufu Normal UniversityQufu 273100China

In this research,a hydroxyl group functionalized metal-organic framework(MOF),UiO-66-(OH)_(2),was synthesized as a "on-off-on" fluore scent switching nanoprobe for highly sensitive and selective detection of Fe^(3+),ascorbic acid(AA) and acid phosphatase(ACP).UiO-66-(OH)_(2) emits yellow-green light under ultraviolet light,when Fe^(3+) was added,Fe^(3+) was chelated with hydroxyl group,the electrons in the excited state S_1 of the MOF transferred to the half-filled 3 d orbits of Fe^(3+),resulting in fluorescence quenching because of the nonradiative electron/hole recombination annihilation.AA could reduce Fe^(3+) to Fe^(2+),which can destroy the electron transfer between UiO-66-(OH)_(2) and Fe^(3+) after AA adding,resulted in nonoccurrence of the nonradiative electron transfer,leading to the recovery of UiO-66-(OH)_(2) fluorescence intensity.The probe can also be used to detect ACP based on the enzymolysis of 2-phospho-L-ascorbic acid(AAP) to produce AA.Benefitting from the hydroxyl group and the characteristics of UiO-66,including the high porosity and large surface area,the developed UiO-66-(OH)_(2) showed extensive advantages as a fluorescent probe for detection of multi-component,such as high sensitivity and selectivity,colorimetric detection,fast response kinetics and easy to operate,economical and secure.This is the first time to use active group functionalized MOFs as a multicomponent sensor for these three substances detection.

关键词： Metal-organic frameworks Hydroxyl functionalization UiO-66-(OH)_(2) Multi-component detection

视频脑电图检查在脑卒中后继发癫痫患者中的应用价值

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中国医疗器械信息 2024年第7期30卷 81-83页

作者：李夏连福州市第二总医院电生理诊断科福建福州350000

目的:分析视频脑电图检查在脑卒中后继发癫痫患者中的应用价值。方法:选取2018年6月~2023年6月本院收治的70例脑卒中后继发癫痫患者作为观察对象,入院后全部患者均接受视频脑电图检查与常规脑电图检查,对临床检出情况进行比较分析。结果... 详细信息

目的:分析视频脑电图检查在脑卒中后继发癫痫患者中的应用价值。方法:选取2018年6月~2023年6月本院收治的70例脑卒中后继发癫痫患者作为观察对象,入院后全部患者均接受视频脑电图检查与常规脑电图检查,对临床检出情况进行比较分析。结果:相比于常规脑电图检查,视频脑电图检查的正常占比更低(P<0.05),而异常占比、病理性放电占比则更高(P<0.05)。相比于常规脑电图检查,视频脑电图检查的特异度、敏感度均更高(P<0.05)。结论:在脑卒中后继发癫痫患者中,应用视频脑电图检查具有较高的敏感性和特异性,能准确诊断脑卒中后继发癫痫。

关键词：视频脑电图检查脑卒中癫痫常规脑电图

Colorimetric-assisted photoelectrochemical sensing for dual-model detection of sialic acid via oxidation-power mediator integration

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Chinese Chemical Letters 2023年第3期34卷 269-273页

作者： Yuanyuan Cheng Rong-Mei Kong Wenao Hu xiaoxia Tian Lingdong Zhang lian xia Fengli Qu School of Chemistry and Chemical Engineering Qufu Normal UniversityQufu 273165China

Development of sensitive and accurate methods for sialic acid(SA) determination is of great significance in early cancer diagnosis.Here,a colorimetric-assisted Photoelectrochemical(PEC) sensor was constructed for SA detection based on the two pairs of cis-diol groups in SA molecule.With the specific recognition of SA via the two pairs of cis-diol groups,the prepared gold-modified Bi_(2)S_(3)(AuNPs@Bi_(2)S_(3)) and metal organic framework(Au@PCN-224) were introduced to the electrode and formed a sandwich structure.Based on the properties of inert electroconductivity and nanozyme of the PCN-224,dual-readout of photocurrent and visualization was achieved with the presence of 3',3',5',5'-tetramethylbenzidine(TMB).Moreover,to intensify the visualization signal,Ce^(3+) was employed as the mediator to boost the catalysis capability by transferring energy from PCN-224 surface to the whole system.With the unique SA recognition and the mediation of Ce^(3+),both the photocurrent and the visualization signals sensitively responded with the SA concentration linearly.The present method showed greatly high sensitivity,selectivity and accuracy for SA detection with a limit of detection of 1.44μmol/L and a wide linear range of 5-1000μmol/L.This method provided a new promising platform for SA detection and a potential strategy for design of novel biosensors with dual-model readout.

关键词： Sialic acid Photoelectrochemical sensor Visualization Metal organic frameworks Dual-mode readout

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非圆齿轮滚齿切削力波动特性及抑制研究

合肥工业大学学报（自然科学版） 2024年第2期47卷 169-175,245页

作者：韩江李大柱田晓青夏链合肥工业大学机械工程学院安徽合肥230009

滚齿是非圆齿轮加工实现的重要方法,用于节曲线外凸直或斜齿非圆齿轮的高效高精制造,节曲线非圆特性导致滚切力呈现较大幅度波动,影响制造过程稳定性及加工精度,是非圆齿轮滚齿领域需要研究的重要课题。文章基于单位切削力计算原理及圆... 详细信息

滚齿是非圆齿轮加工实现的重要方法,用于节曲线外凸直或斜齿非圆齿轮的高效高精制造,节曲线非圆特性导致滚切力呈现较大幅度波动,影响制造过程稳定性及加工精度,是非圆齿轮滚齿领域需要研究的重要课题。文章基于单位切削力计算原理及圆柱齿轮滚切力的研究成果,采用单次断续切削产生的未变形切屑体积表征滚切力波动态势,构建非圆齿轮滚切未变形切屑模型的获取方法。选取大偏心率卵形齿轮为研究对象,分析滚刀恒速不窜刀联动加工模型所产生的滚切力波动特性,得出该联动加工模型所对应峰值切削力的波动规律。提出一种滚刀恒速并附加窜刀的联动加工模型,该模型具有恒定弧长增量加工特性,对抑制整周滚切力波动具有重要意义,并开展不同滚切深度所对应滚切力波动规律研究,研究结果为非圆齿轮滚切方案的优化制定提供一定的理论依据。

关键词：非圆齿轮滚齿切削力切屑体积力波动抑制

腹腔镜结肠癌根治术治疗结肠癌的疗效及对胃肠道功能的影响分析

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中国实用医药 2024年第4期19卷 46-49页

作者：夏连钱孙陆江苏省淮安市涟水县人民医院普外一科 223400 江苏省淮安市金湖县人民医院普外科 211600

目的探讨在结肠癌的治疗中采用腹腔镜手术的临床效果及对患者胃肠道功能的影响。方法选取58例结肠癌患者,采用随机数字表法分成对照组和研究组,每组29例。对照组采用传统开放手术治疗,研究组采用腹腔镜结肠癌根治术治疗。对比两组围手... 详细信息

目的探讨在结肠癌的治疗中采用腹腔镜手术的临床效果及对患者胃肠道功能的影响。方法选取58例结肠癌患者,采用随机数字表法分成对照组和研究组,每组29例。对照组采用传统开放手术治疗,研究组采用腹腔镜结肠癌根治术治疗。对比两组围手术期相关指标、淋巴结清扫数量、血清炎性指标、血清应激指标及并发症发生率。结果研究组术中出血量(87.63±6.24)ml、术后引流量(24.32±2.05)ml较对照组的(122.25±9.52)、(30.23±2.63)ml少,手术时间(136.15±7.16)min、术后排气时间(3.14±0.26)d、肠鸣音恢复时间(2.34±0.43)d、恢复饮食时间(68.74±4.23)h、住院时间(10.42±1.16)d均较对照组的(141.05±8.75)min、(4.25±0.55)d、(3.58±0.75)d、(87.36±5.52)h、(15.27±1.44)d短(P0.05);研究组肿瘤分期Ⅲ期淋巴结清扫数量、阳性淋巴结清扫数量、左半结肠淋巴结清扫数量、右半结肠淋巴结清扫数量分别为(25.11±2.02)、(21.06±2.14)、(18.87±1.42)、(24.23±2.14)个,均多于对照组的(17.58±1.36)、(12.25±1.23)、(16.25±1.26)、(18.54±1.52)个(P<0.05)。术后,对照组白细胞介素-6(IL-6)为(28.85±2.12)pg/ml,C反应蛋白(CRP)为(12.36±1.42)mg/L;研究组IL-6为(17.96±1.63)pg/ml,CRP为(8.64±1.15)mg/L,研究组IL-6、CRP较对照组低(P<0.05)。术后,对照组肾上腺素为(99.87±7.58)pg/ml,去甲肾上腺素为(176.52±9.36)pg/ml,皮质醇为(24.63±2.14)pg/ml;研究组肾上腺素为(64.25±4.31)pg/ml,去甲肾上腺素为(87.56±5.15)pg/ml,皮质醇为(13.54±1.63)pg/ml,两组较术前均有所升高,而研究组肾上腺素、去甲肾上腺素、皮质醇均较对照组低(P<0.05)。研究组并发症发生率(6.90%)较对照组(31.03%)低(P<0.05)。结论在结肠癌治疗中采用腹腔镜结肠癌根治术治疗可提高淋巴结清扫数量,缩短术后胃肠功能的恢复时间,改善血清炎性指标水平,减少应激反应,术后并发症发生率较低,有利于术后机体的康复,建议临床广泛应用。

关键词：结肠癌腹腔镜结肠癌根治术淋巴结清扫数量胃肠道功能血清指标并发症

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液电串联驱动挖掘机回转系统能耗特性研究

液压与气动 2024年第6期48卷 1-6页

作者：王慧杰成杰夏连鹏黄伟男权龙黄家海太原理工大学机械与运载工程学院山西太原030024 安徽理工大学机械工程学院安徽淮南232001

针对液电混驱回转装置制动能量高效回收与利用问题,提出基于电机转速控制模式与转矩控制模式的控制方式。首先,对液电混驱回转系统进行理论与原理分析;之后,在AMESim中对该系统进行了仿真分析,并为后续实验提供参考;最后,通过实验对比... 详细信息

针对液电混驱回转装置制动能量高效回收与利用问题,提出基于电机转速控制模式与转矩控制模式的控制方式。首先,对液电混驱回转系统进行理论与原理分析;之后,在AMESim中对该系统进行了仿真分析,并为后续实验提供参考;最后,通过实验对比分析了转矩模式与转速模式差别。结果表明:转矩模式相对于转速模式运行过程更平稳,功率无波动;转速模式更有效利用蓄能器能量,相对于传统挖掘机节省48.4%,比转矩模式节省42%;转矩模式超调量比转速模式大8%,整体上转速模式优于转矩模式。

关键词：液电混驱回转系统转矩控制转速控制节能