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Blossom of CRISPR technologies and applications in disease treatment

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Synthetic and Systems Biotechnology 2018年第4期3卷 217-228页

作者： Huayi Liu lian wang Yunzi Luo Department of Gastroenterology State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu610041PR China

Since 2013,the CRISPR-based bacterial antiviral defense systems have revolutionized the genome editing *** addition to genome editing,CRISPR has been developed as a variety of tools for gene expression regulations,live cell chromatin imaging,base editing,epigenome editing,and nucleic acid ***,in the context of further boosting the usability and feasibility of CRISPR systems,novel CRISPR systems and engineered CRISPR protein mutants have been explored and studied *** the flourish of CRISPR technologies,they have been applied in disease treatment recently,as in gene therapy,cell therapy,immunotherapy,and antimicrobial *** we present the developments of CRISPR technologies and describe the applications of these CRISPR-based technologies in disease treatment.

关键词： CRISPR technologies CRISPR-based tools CRISPR-based therapy

Primary Exploration of Reliability Evaluation of Computer Live Forensics Model on Physical Memory Analysis

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Journal of Harbin Institute of Technology(New Series) 2014年第4期21卷 121-128页

作者： lian-Hai wang Qiu-liang Xu School of Computer Science and Technology Shandong University Shandong Provincial Key Laboratory of Computer Network Shandong Computer Science Center( National Supercomputer Center in Jinan)

The integrity and fidelity of digital evidence are very important in live forensics. Previous studies have focused the uncertainty of live forensics based on different memory snapshots. However,this kind of method is not effective in practice. In fact,memory images are usually acquired by using forensics tools instead of using snapshots. Therefore,the integrity and fidelity of live evidence should be evaluated during the acquisition process. In this paper,we study the problem in a novel viewpoint. Firstly,several definitions about memory acquisition measure error are introduced to describe the trusty. Then,we analyze the experimental error and propose some suggestions on how to reduce it. A novel method is also developed to calculate the system error in detail. The results of a case study on Windows 7 and VMware virtual machine show that the experimental error has good accuracy and precision,which demonstrate the efficacy of the proposed reducing methods. The system error is also evaluated,that is,it accounts for the whole error from 30% to 50%.

关键词： digital investigation live forensics volatile memory acquisition trusted probability

Pretreatment of metallurgical sewage via vacuum distillation driven by low-temperature exhausted gas from steel plants

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Journal of Iron and Steel Research International 2018年第3期25卷 291-297页

作者： lian-yong wang Chao Liu Zhu Ye Wen-qiang Sun Department of Thermal Engineering NortheasternUniversity Shenyang 110819 Liaoning China State Environmental Protection Key Laboratory of Eco-Industry Northeastern University Shenyang 110819Liaoning China Shenyang Branch of China Aluminum International Engineering Co. Ltd. Shenyang Aluminum & Magnesium Engineering & Research Institute Co. Ltd.Shenyang 110001 Liaoning China School of Metallurgy Northeastern UniversityShenyang 110819 Liaoning China

The metallurgical sewage has very complex component and a significant environmental perniciousness and needs high treatment costs. In addition, too much low-temperature waste heat is emitted owing to the lack of suitable users. Considering these concerns, a low-temperature-driven pretreatment method via vacuum distillation was proposed to treat the sewage from the metallurgical production. It uses the sensible heat carried by low-temperature exhausted gases to drive the distillation of sewage. The distilled water can be reused into the process as new water supply, while the enriched wastewater is discharged into the sewage treatment center for subsequent treatment. Converter dust removal sewage was chosen to perform an experimental observation. The variations of chemical oxygen demand, ammonia nitrogen, suspended solids, electrical conductivity, and pH of the condensate under different vacuum degrees and evaporation rates were mainly investigated. It can be found that the quality of the condensate gets better under certain conditions, which validates the feasibility of the proposed approach. Furthermore, by comprehensively analyzing the water quality indices and their influencing factors, the optimal vacuum degree was suggested to be controlled between 0.07 and 0.09 MPa, and the best evaporation rate was between 40 and 60%.

关键词： Metallurgical sewage Vacuum distillation Low-temperature waste heat Steel plant

Effect of Mg/Al atom ratio of support on catalytic performance of Co-Mo/MgO-Al_2O_3 catalyst for water gas shift reaction

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Journal of Natural Gas Chemistry 2009年第2期18卷 161-166页

作者： Yixin lian Huifang wang Quanxing Zheng Weiping Fang Yiquan Yang Department of Chemistry College of Chemistry and Chemical Engineering National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers and Esters Xiamen University Xiamen 361005 Fujian China

Co-Mo-based catalysts supported on mixed oxide supports MgO-Al2O3 with different Mg/Al atom ratios for water gas shift reaction were studied by means of TPR, Raman, XPS and ESR. It was found that the octahedral Mo species in oxidized Co-Mo/MgO（x）-Al2O3 catalyst and the contents of Mo^5＋, Mo^4＋, S^2- and S^2-2 species in the functioning catalysts increased with increasing the Mg/Al atom ratio of the support under the studied experimental conditions. This is favorable for the formation of the active Co-Mo-S phase of the catalysts. Catalytic performance testing results showed that the catalysts Co-Mo/MgO-Al2O3 with the Mg/Al atom ratio of the support in the range of 0.475-0.525 exhibited optimal catalytic activity for the reaction.

关键词： Co-Mo catalyst reduction sulfidation mixed support water gas shift

基于互联网的自我管理模式在稳定期慢性阻塞性肺疾病患者中的应用效果分析

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中外医疗 2024年第23期43卷 140-143页

作者：佘世秀王莲顾花武威市中医医院肺病科甘肃武威733000 武威市中医医院风湿骨病一科甘肃武威733000 武威市中医医院老年病科甘肃武威733000

目的探讨对处于稳定期慢性阻塞性肺疾病(简称慢阻肺)患者采用基于互联网的自我管理模式的临床效果。方法随机选取2020年7月—2022年8月武威市中医医院收治的90例稳定期慢阻肺患者为研究对象,依据不同护理方法分为观察组和对照组,每组45... 详细信息

目的探讨对处于稳定期慢性阻塞性肺疾病(简称慢阻肺)患者采用基于互联网的自我管理模式的临床效果。方法随机选取2020年7月—2022年8月武威市中医医院收治的90例稳定期慢阻肺患者为研究对象,依据不同护理方法分为观察组和对照组,每组45例。观察组接受基于互联网的自我管理模式,对照组采用传统的护理模式。对比两组患者的护理质量、遵医行为评分与自我效能感评分、生活质量评分、护理依从性。结果观察组的遵医行为评分、自我效能感评分均高于对照组,差异有统计学意义(P均<0.05);观察组的生活质量各项评分均高于对照组,差异有统计学意义(P均<0.05);观察组的护理满意度95.56%(43/45)高于对照组的82.22%(37/45),差异有统计学意义(χ^(2)=4.050,P<0.05)。结论基于互联网的自我管理模式能够提供个性化的健康护理服务,可提高患者的生活质量和自我效能感,并有较高的遵医行为和护理满意度。

关键词：稳定期慢性阻塞性肺疾病基于互联网的自我管理模式护理质量自我效能遵医行为

Some Recent Advances on SpectralMethods for Unbounded Domains

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Communications in Computational Physics 2009年第2期5卷 195-241页

作者： Jie Shen Li-lian wang Department of Mathematics Purdue UniversityWest LafayetteIN47907USA Division of Mathematical Sciences School of Physical and Mathematical SciencesNanyang Technological University637616Singapore

We present in this paper a unified framework for analyzing the spectral methods in unbounded domains using mapped Jacobi,Laguerre and Hermite functions.A detailed comparison of the convergence rates of these spectral methods for solutions with typical decay behaviors is carried out,both theoretically and computationally.A brief review on some of the recent advances in the spectral methods for unbounded domains is also presented.

关键词： Spectral method unbounded domain orthogonal polynomials rational functions Hermite functions Laguerre functions

基于模糊层次分析法的联合防空武器装备效能评估

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信息工程大学学报 2024年第5期25卷 620-623页

作者：赵杰马超王练周旗开军事科学院北京100080 32147部队陕西宝鸡721000 31567部队北京100080

联合防空武器装备是现代防空作战的核心战斗力,对联合防空武器装备效能进行客观精准的评估,能够为优化联合防空武器装备效能、提升联合防空作战能力提供有益的借鉴和参考。将层次分析法和模糊综合评估法相结合,建立评估指标体系,运用层... 详细信息

联合防空武器装备是现代防空作战的核心战斗力,对联合防空武器装备效能进行客观精准的评估,能够为优化联合防空武器装备效能、提升联合防空作战能力提供有益的借鉴和参考。将层次分析法和模糊综合评估法相结合,建立评估指标体系,运用层次分析法确立指标权重,运用模糊综合评估法进行模糊隶属函数处理的步骤实施评估,实现定性分析和定量分析的有机结合。评估结果能够以具体数字直观反映联合防空武器装备的实际效能,为部队有针对性地推动联合防空武器装备体系建设提供了科学依据。

关键词：联合防空武器装备评估作战效能

Numerical Simulation of Coal Floor Fault Activation Influenced by Mining

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Journal of China University of Mining and Technology 2006年第4期16卷 385-388页

作者： wang lian-guo MIAO Xie-xing School of Sciences China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

By means of the numerical simulation software ANSYS, the activation regularity of coal floor faults caused by mining is simulated. The results indicate that the variation in horizontal, vertical and shear stresses, as well as the horizontal and vertical displacements in the upper and the lower fault blocks at the workface are almost identical. Influ- enced by mining of the floor rock, there are stress releasing and stress rising areas at the upper part and at the footwall of the fault. The distribution of stress is influenced by the fault so that the stress isolines are staggered by the fault face and the stress is focused on the rock seam around the two ends of the fault. But the influence in fault activation on the upper or the lower fault blocks of the workface is markedly different. When the workface is on the footwall of the fault, there is a horizontal tension stress area on the upper part of the fault; when the workface is on the upper part of the fault, it has a horizontal compressive stress area on the lower fault block. When the workface is at the lower fault block, the maximum vertical displacement is 5 times larger then when the workface is on the upper fault block, which greatly in- creases the chance of a fatal inrush of water from the coal floor.

关键词： mining fault activation: simulation

基于河流生态修复的乡村河流廊道景观设计研究

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环境科学与管理 2024年第9期49卷 159-162页

作者：杨倩袁涛王炼吴小青江苏建筑职业技术学院江苏徐州221116

随着人类活动的加剧,乡村河流的污染问题日益严峻。因此,文章提出基于河流生态修复的乡村河流廊道景观设计研究。以沙河为例,考虑到沙河水质污染严重,通过人工曝气法对水质进行处理。同时考虑到泄洪问题,对河道进行拓宽和蜿蜒特征恢复... 详细信息

随着人类活动的加剧,乡村河流的污染问题日益严峻。因此,文章提出基于河流生态修复的乡村河流廊道景观设计研究。以沙河为例,考虑到沙河水质污染严重,通过人工曝气法对水质进行处理。同时考虑到泄洪问题,对河道进行拓宽和蜿蜒特征恢复的处理;并通过设置生态小岛,为水生动植物提供生存环境。为减少水土流失,研究通过种植植被来对河岸土壤进行固定。上述手段在保证当地居民生活需求前提下,恢复沙河流域的生态环境,实现人与自然的和谐相处,为乡村河流廊道的生态修复提供合适的参考。

关键词：乡村河流廊道生态修复景观设计