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A facile and efficient method for hydroxylation of azabenzanthrone compounds

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Chinese Chemical Letters 2011年第1期22卷 41-44页

作者： Fang Xian Ning Xiang Weng Shi liang Huang Li Jun gu Zhi Shu Huang lian quan gu School of Pharmaceutical sciences Sun Yat-Sen University Guangzhou 51006 China

A novel and facile method of introducing 4-hydroxyl group into the aromatic ring of azabenzanthrone compounds was carried out by reacting azabenzanthrone compounds with hydrazine hydrate or hydroxylamine hydrochloride and sodium hydroxide in diethylene glycol （DEG） solvent. The mechanism of reaction may involve an amino intermediate and follow a hydroxyl substitution process.

关键词： Azabenzanthrone Hydroxylation Hydrazine hydrate Hydroxylamine hydrochloride Sodium hydroxide

A new approach to the facile synthesis of 2-substituted-quinazolin-4(3H)-ones

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Chinese Chemical Letters 2011年第8期22卷 951-953页

作者： Bin Wang Zeng Li Xiao Ning Wang Jia Heng Tan lian quan gu Zhi Shu Huang School of Pharmaceutical Sciences Sun Yat-sen University Guanzhou 510006 China Department of Chemistry and Lithe Science Xiangnan University Chenzhou 423000 China

A new approach to the facile synthesis of 2-substituted-quinazolin-4（3H）-ones and its derivatives using the condensation reaction of substituted 2-aminobenzamide and orthoesters is reported.

关键词： Quinazolin-4(3H)-ones Synthesis Aminobenzamide Orthoester

Synthesis of new 2-aryl-6-styryl-2,3-dihydropyridin-4(1H)-one derivatives from curcuminoids

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Chinese Chemical Letters 2009年第11期20卷 1291-1295页

作者： Ying Peng Huo Xu Qiu Wei Yan Shao Lin Kun An Xian Zhang Bu lian quan gu School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou 51006 China

Series of new 2-aryl-6-styry1-2,3-dihydropyridin-4（1H）-one derivatives were synthesized in acceptable to good yields by treatment of the curcuminoids with aqueous ammonia, the mechanism was proposed. By modification of the primary products, total 13 new compounds were obtained. The structures of all products were elucidated by spectroscopy analysis including HR-MS, 1H NMR and ^13C NMR.

关键词： Dihydropyridinone Curcumin Aqueous ammonia

The Reaction of Tanshinones with Amines

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Chinese Chemical Letters 2003年第6期14卷 557-560页

作者： Lin Kun AN Xian Zhang BU Hai Qiang WU Xin Dong guO Lin MA lian quan gu School of Chemistry and Chemical Engineering Sun Yat-Sen UniversityGuangzhou 510275

The reaction of cryptotanshinone and tanshinone IIA with several biogenic amine metabolites involved in the pathogenic pathways of HE were investigated and eight 1,2,3,4- tetrahydrophenanthrene derivatives, 2-6 and 8-... 详细信息

关键词： Cryptotanshinone tanshinone IIA biogenic amines.

Unexpected Synthesis of 2,2'-[1-(4-Methoxyphenoxy)propane-2,2-diyl]bis(5-methoxy-3-methylbenzofuran)

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Chinese Chemical Letters 2005年第12期16卷 1581-1583页

作者： Yu Dong SHEN Hai Qiang WU Lin Kun AN Zhi Shu HUANG Xian Zhang BU lian quan gu School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080

A new bisbenzofuran analogue Ⅶ was achieved unexpectedly in one step procedure from 1-（4-methoxyphenoxy）acetone Ⅰ by using Amberlyst 15 resin as catalyst in excellent yield. The structure was elucidated by spectro... 详细信息

关键词： Benzofuran Amberlyst 15 resin cyclization

Design and efficient synthesis of novel haptens and complete antigens for the AOZ,a toxic metabolite of furazolidone

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Chinese Chemical Letters 2007年第12期18卷 1490-1492页

作者： Yu Dong Shen Yu Wang Shi Wei Zhang Zhi LiXiao Yuan Ming Sun Xian Zhang Bu lian quan gu Food Quality and Safety Key Laboratory of Department of Education of guangdong Province/Institute of Food Quality and Safety South China Agricultural University Guangzhou 510642 China School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou 510080 China

A good strategy was brought forward for designing efficient haptens and complete antigens for 3-amino-2-oxazolidinone （AOZ）. Haptens designed newly were achieved facilely in good yield by using LiCI-N（Et）3 as new catalysis system, the structure of which was elucidated by spectroscopy analysis, such as NMR and MS. Novel antigens for AOZ were prepared successfully by convenient active ester method. The ratios of haptens 3 and 4 to carrier proteins were proven respectively as 41 ： 1 （5a）, 39：1 （6a）, 11：1 （5b） and 9：1 （6b） by trinitrobenzene sulfonic acid （TNBS） method. The results of indirect competitive ELISA （ic-ELISA） of antiserums indicated that the haptens with a short unsaturated side chain can evoke specific immune response effectively.

关键词： Furazolidone AOZ Antigen Hapten Immunoassay

Synthesis of Phenoxazinone Derivatives and Antiproliferative Activities on Wild-type and Drug-resistant Tumor Cells

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Chinese Chemical Letters 2006年第9期17卷 1141-1144页

作者： Ji Wu RUAN Zhi Shu HUANG Jin Feng HUANG Cui Juan DU Shi liang HUANG Zhi SHI Li Wu FU lian quan gu School of Pharmaceutical Sciences Zhongshan University Guangzhou 510080 Cancer Center Sun Yet-sen UniVersity Guangziaou 510060

A series of novel phenoxazinone derivatives （1-6） were designed and synthesized for evaluating their antitumor activities. The antiproliferative activities of the prepared compounds against representative human neoplastic cell lines were evaluated by MTF assay. The results showed that most of them inhibited cell proliferation in a submicromolar to rnicromolar range. These compounds were also evaluated against KBv200 and MCF-7/Adr cell lines, which overexpress the MDR/P-glycoprotein drug efflux pump responsible for drug resistance, and had a more potential for resisting MDR than their lead compound APO.

关键词： Antitumor phenoxazinones iminoquinones multidrug-resistance.

Synthesis of 2,2'-(Substituted Arylmethylene)bis(1,6,6-trimethyl- 6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione) Derivatives

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Chinese Chemical Letters 2005年第11期16卷 1451-1454页

作者： Jiang Ke QIN Xian Zhang BU Yu Fang WANG Zhi Yun DU Xing Yuan WANG Zhi Shu HUANG Lin MA Lin Kun AN lian quan gu School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510080 School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275

The reactions of tanshinone IIA with aromatic aldehydes have been investigated and several 2, T-（substituted arylmethylene） bis （1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]- furan- 10, 11-dione） derivative... 详细信息

关键词： Tanshinone IIA aromatic aldehydes reaction.

Synthesis of Isoquinoline-1, 3-Dicarboxylic Acid

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Chinese Chemical Letters 1999年第11期10卷 907-910页

作者： Xian Hong YINI Man Ya YANG Hua Hong SHI lian quan gu(Chemistry Department, Zhongshan University. guangzhou 510275)(Chemistry Department, guangxin University for Nationalities, Nanning 530006) Chemistry Department Zhongshan University Guangzhou 510275 China Chemistry Department Guangxin Univ. for Nationalities Nanning 530006 China

Two new compounds, isoquinoline-1, 3-dicarboxyaldehyde and (IDA) were synthesized via 6 or 7 steps starting from benzaldehyde, or prepared via 4 steps starting from allylbenzene.

关键词： Beckman rearrangement reaction intramolecular electrophilic substitution 1,3-dimethyl-isoquinoline derivatives