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AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

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中国组织工程研究 2025年第17期29卷 3537-3547页

作者： Yu Yangyi Song Zhuoyue lian qiang Ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of Orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of Orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin O and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

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Solitary Wave and Non-traveling Wave Solutions to Two Nonlinear Evolution Equations

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Communications in Theoretical Physics 2005年第3X期44卷 479-482页

作者： YAN Zhi-lian LIU Xi-qiang School of Mathematical Sciences Liaocheng University Liaocheng 252059 China

By applying the extended homogeneous balance method, we find some new explicit solutions to two nonlinear evolution equations, which include n-resonance plane solitary wave and non-traveling wave solutions.

关键词： approximate equations for long water waves variant Boussinesq equations non-traveling wave solution solitary wave solution

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Symmetry Reductions and Explicit Solutions for a Generalized Zakharov-Kuznetsov Equation

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Communications in Theoretical Physics 2006年第1期45卷 29-32页

作者： YAN Zhi-lian LIU Xi-qiang School of Mathematical Sciences Liaocheng University Liaocheng 252059 China

Two types of symmetry of a generalized Zakharov-Kuznetsov equation are obtained via a direct symmetry method. By selecting suitable parameters occurring in the symmetries, we also find some symmetry reductions and new... 详细信息

关键词： generalized Zakharov-Kuznetsov equation symmetry explicit solution

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The evolution of investments decision mode in China's telecommunication

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 122-128页

作者： ZHANG Ai-hua ZHAO lian-qiang SHU Hua-ying Key Laboratory of Information Management and Information Economics Beijing University of Posts and Telecommunications. Beijing 100876 China

This essay analyzes the data of Chinese telecommunication market, telecommunication investments and investment benefits over the past 20 years. On the basis of these data, the essay reviews Chinese changing telecommunication policies and discusses the major events in the course of China＇s telecommunication development. It is argued that telecommunication policies, regime backgrounds and market demand characteristics have a significant impact on investment decision mode in telecommunication industry. The evolution of network investments decision mode in China＇s telecommunication has corresponded to the transformation of these key factors. Considering the special events in the development of Chinese telecommunication as divisions, the essay discusses three stages of the evolution of investments decision mode in China＇s tel With the firm environment and problems that Chinese telecommunication operators have been facing since 2000 analyzed, it is demonstrated that Chinese telecommunication operators should change their mode of investment decision into the ＂profit-oriented investment decision mode＂ in order to achieve a high growth performance in the capital market,. This investment decision mode will result in increase of the investment profit with limited investment capital. The main procedure of profit-oriented investment decision mode is set out, which is abstracted to a mathematical model eventually.

关键词： China's telecommunication investment decision mode evolution stage key factor investment profit

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Best bounds on the distance between 3-direction quartic box spline surface and its control net

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Applied Mathematics(A Journal of Chinese Universities) 2013年第2期28卷 147-157页

作者： ZENG Xiao-ming ZHOU Guo-rong YANG lian-qiang Department of Mathematics Xiamen University School of Mathematics Anhui University

We present the best bounds on the distance between 3-direction quartic box spline surface patch and its control net by means of analysis and computing for the basis functions of 3-direction quartic box spline *** the local bounds and the global bounds are given by the maximum norm of the first differences or second differences or mixed differences of the control points of the surface patch.

关键词： Box spline bound parametric surface basis function differences of control point.

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Turbulence and mixing in a freshwater-influenced tidal bay: Observations and numerical modeling

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Science China Earth Sciences 2015年第7期58卷 2049-2058页

作者： lian qiang LIU ZhiYu Department of Physical Oceanography College of Ocean & Earth Sciences Xiamen University State Key Laboratory of Marine Environmental Science Xiamen University

In situ observations and numerical simulations of turbulence are essential to understanding vertical mixing processes and their dynamical controls on both physical and biogeochemical processes in coastal embayments. Using in situ data collected by bottom-mounted acoustic Doppler current profilers(ADCPs) and a free-falling microstructure profiler, as well as numerical simulations with a second-moment turbulence closure model, we studied turbulence and mixing in the Xiamen Bay, a freshwater-influenced tidal bay located at the west coast of the Taiwan Strait. Dynamically, the bay is driven predominantly by the M2 tide, and it is under a significant influence of the freshwater discharged from the Jiulong River. It is found that turbulence quantities such as the production and dissipation rates of the turbulent kinetic energy(TKE) were all subject to significant tidal variations, with a pronounced ebb-flood asymmetry. Turbulence was stronger during flood than ebb. During the flooding period, the whole water column was nearly well mixed with the depth-averaged TKE production rate and vertical eddy viscosity being up to 5?10?6 W kg?1 and 2?10?2 m2 s?1, respectively. In contrast, during the ebb strong turbulence was confined only to a 5?8 m thick bottom boundary layer, where turbulence intensity generally decreases with distance from the seafloor. Diagnosis of the potential energy anomaly showed that the ebb-flood asymmetry in turbulent dissipation and mixing was due mainly to tidal straining process as a result of the interaction between vertically shared tidal currents and horizontal density gradients. The role of vertical mixing in generating the asymmetry was secondary. A direct comparison of the modeled and observed turbulence quantities confirmed the applicability of the second-moment turbulence closure scheme in modeling turbulent processes in this weakly stratified tidally energetic environment, but also pointed out the necessity of further refinements of the model.

关键词： tidal bay turbulent mixing second-moment turbulence closure model turbulent kinetic energy dissipation rate vertical eddy viscosity

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Hierarchical Switching Control of Multiple Models Based on Robust Control Theory

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自动化学报 2006年第3期32卷 411-416页

作者： GAO FENG LI Ke-qiang lian Xiao-Min State Key Laboratory of Automotive Safety and Energy Tsinghua University Beijing 100084

A new hierarchical switching control system of multiple models based on robust control theory is designed for some plant with large uncertainties. The model set and controller set are designed by robust control theory and the characteristics of robust control system are taken into account. A new kind of switching index function by estimating uncertainty is designed. Furthermore, stability of the closed system is analyzed by the small gain theorem in the sense of exponentially weighted L2 norm. And simulation is done on a plant with both parameter uncertainty and un-modeled dynamics. Both theoretical analysis and simulation results show that this new hierarchical switching control system can control the plant with large uncertainties effectively and has good performance of tracking and stability.

关键词：多模式控制开关控制自动化系统鲁棒控制

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第四系上更新统黏土的改良研究

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铁道工程学报 2013年第4期30卷 30-35,115页

作者：马连强铁道第三勘察设计院集团有限公司天津300251

研究目的:运用不同配比的石灰、水泥和固化剂、粉煤灰对第四系上更新统黏土进行改良,获取所得到的颗粒级配的变化,塑限、液限、塑性指数的变化,胀缩特性的变化,击实试验参数的变化以及强度和水稳性的变化,得到经改良处理后,能够达到作... 详细信息

研究目的:运用不同配比的石灰、水泥和固化剂、粉煤灰对第四系上更新统黏土进行改良,获取所得到的颗粒级配的变化,塑限、液限、塑性指数的变化,胀缩特性的变化,击实试验参数的变化以及强度和水稳性的变化,得到经改良处理后,能够达到作为客运专线填料的要求。研究结论:(1)下蜀黏土是一种工程性质比较特殊的填料,其含水量对土体强度、动模量有非常显著的影响;(2)在下蜀黏土中掺入一定比例的生石灰、熟石灰、普通硅酸盐水泥、土壤固化剂可达到提高土的强度和水稳性,降低土的压缩性和胀缩性,但单纯掺合粉煤灰不能达到这些目的;(3)下蜀黏土填料改良研究对南方地区客运专线填料选择具有较高参考价值。

关键词：第四系上更新统塑性指数客运专线

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Coordinated Control of Sliding Mode and Hamiltonian for PWM Rectifier

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International Journal of Plant Engineering and Management 2018年第1期23卷 44-52页

作者： LI lian-qiang GAO Jun-wei Qingdao University Shandong Qingdao 266071China

Aiming at the PWM rectifier control strategy of sliding mode control, steady state performance weak Hamiltonian control dynamic tracking performance is poor, the coordinated compound control is proposed, the feedback linearization controller and sliding mode controller Hamiltonian system is obtained, and the design of a coordinated control strategy. In order to verify the accuracy of this method, MATLAB/Simulink is used for simulation analysis. The simulation results show that the composite control can achieve the coordinated dynamic rapid tracking and constant DC output and unit power factor operation, and satisfy the control requirements of the rectifier, effectively reducing the disturbance effect on the system. Compared with Hamiltonian control, the proposed method combines the advantages of the two methods, which have the fast tracking performance and excellent steady-state characteristics, and the research prospect is broad.

关键词： PWM rectifier Hamiltonian control sliding mode variable structure feedback linearization coordinated control

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Time-Resolved Radiography using Chirp-Pulse Proton Beams

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Chinese Physics Letters 2011年第3期28卷 136-139页

作者： TENG Jian ZHAO Zong-Qing ZHU Bin HONG Wei CAO Lei-Feng ZHOU Wei-Min SHAN lian-qiang GU Yu-Qiu Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900

Protons accelerated by the target normal sheath acceleration(TNSA)mechanism have a wide energy spectrum and are called chirp-pulse *** numerical simulation of chirp-pulse proton radiography in an implosion process with single shot is carried out using the Monte Carlo *** different methods are *** first method,proton framing radiography,uses a stack of radiochromic film layers as the *** layer deposits protons with energy corresponding to the Bragg peak,which can record the transient state of the implosion *** second method,proton streak radiography,uses an external magnetic field to deflect *** energies correspond to different *** using a slit before the magnetic field,one-dimensional spatial resolution and temporal resolution can be *** method is more suitable for the diagnosis of the implosion process.

关键词： process method resolution

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