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Succinylation modification:a potential therapeutic target in stroke

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Neural Regeneration Research 2024年第4期19卷 781-787页

作者： Jie lian Wenwu Liu Qin Hu Xiaohua Zhang Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of Medicine Department of Diving and Hyperbaric Medicine Naval Medical CenterNaval Medical University

Stroke is a leading cause of mortality and disability *** cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain *** mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of ***,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ***,the role of succinylation modification in cell metabolism after stroke and its regulation are not well *** aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after *** also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of *** succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by *** evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic ***,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic *** between succinylation and desuccinylation has been implicated in the pathophysiology of *** agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke ***,their therapeutic efficacy in stroke patients should be validated.

关键词： mitochondria metabolism neuroprotection sirtuin 5 stroke succinylation modification

An improved algorithm for retrieving thin sea ice thickness in the Arctic Ocean from SMOS and SMAP L-band radiometer data

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Acta Oceanologica Sinica 2024年第3期43卷 127-138页

作者： lian He Senwen Huang Fengming Hui Xiao Cheng School of Geospatial Engineering and Science Sun Yat-Sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-Sen University) Ministry of EducationZhuhai 519082China

The aim of this study was to develop an improved thin sea ice thickness(SIT)retrieval algorithm in the Arctic Ocean from the Soil Moisture Ocean Salinity and Soil Moisture Active Passive L-band radiometer *** SIT retrieval algorithm was trained using the simulated SIT from the cumulative freezing degree days model during the freeze-up period over five carefully selected regions in the Beaufort,Chukchi,East Siberian,Laptev and Kara seas and utilized the microwave polarization ratio(PR)at incidence angle of 40°.The improvements of the proposed retrieval algorithm include the correction for the sea ice concentration impact,reliable reference SIT data over different representative regions of the Arctic Ocean and the utilization of microwave polarization ratio that is independent of ice *** relationship between the SIT and PR was found to be almost stable across the five selected *** SIT retrievals were then compared to other two existing algorithms(i.e.,UH_SIT from the University of Hamburg and UB_SIT from the University of Bremen)and validated against independent SIT data obtained from moored upward looking sonars(ULS)and airborne electromagnetic(EM)induction *** results suggest that the proposed algorithm could achieve comparable accuracies to UH_SIT and UB_SIT with root mean square error(RMSE)being about 0.20 m when validating using ULS SIT data and outperformed the UH_SIT and UB_SIT with RMSE being about 0.21 m when validatng using EM SIT *** proposed algorithm can be used for thin sea ice thickness(<1.0 m)estimation in the Arctic Ocean and requires less auxiliary data in the SIT retrieval procedure which makes its implementation more practical.

关键词： Arctic sea ice sea ice thickness remote sensing Soil Moisture Active Passive(SMAP) Soil Moisture Ocean Salinity and Soil(SMOS)

A Novel Multi-Stream Fusion Network for Underwater Image Enhancement

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China Communications 2024年第2期21卷 166-182页

作者： Guijin Tang lian Duan Haitao Zhao Feng Liu Jiangsu Key Laboratory of Image Processing and Image Communication Nanjing University of Posts and TelecommunicationsNanjing 210003China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Due to the selective absorption of light and the existence of a large number of floating media in sea water, underwater images often suffer from color casts and detail blurs. It is therefore necessary to perform color correction and detail restoration. However,the existing enhancement algorithms cannot achieve the desired results. In order to solve the above problems, this paper proposes a multi-stream feature fusion network. First, an underwater image is preprocessed to obtain potential information from the illumination stream, color stream and structure stream by histogram equalization with contrast limitation, gamma correction and white balance, respectively. Next, these three streams and the original raw stream are sent to the residual blocks to extract the features. The features will be subsequently fused. It can enhance feature representation in underwater images. In the meantime, a composite loss function including three terms is used to ensure the quality of the enhanced image from the three aspects of color balance, structure preservation and image smoothness. Therefore, the enhanced image is more in line with human visual ***, the effectiveness of the proposed method is verified by comparison experiments with many stateof-the-art underwater image enhancement algorithms. Experimental results show that the proposed method provides superior results over them in terms of MSE,PSNR, SSIM, UIQM and UCIQE, and the enhanced images are more similar to their ground truth images.

关键词： image enhancement multi-stream fusion underwater image

Low-Rank Optimal Transport for Robust Domain Adaptation

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1667-1680页

作者： Bingrong Xu Jianhua Yin Cheng lian Yixin Su Zhigang Zeng IEEE the School of Automation Wuhan University of TechnologyWuhan 430070China Intelligent Transportation Systems Research Center Wuhan University of TechnologyWuhan 430063 Chongqing Research Institute Wuhan University of TechnologyChongqingChina the School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 the Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

When encountering the distribution shift between the source(training) and target(test) domains, domain adaptation attempts to adjust the classifiers to be capable of dealing with different domains. Previous domain adaptation research has achieved a lot of success both in theory and practice under the assumption that all the examples in the source domain are welllabeled and of high quality. However, the methods consistently lose robustness in noisy settings where data from the source domain have corrupted labels or features which is common in reality. Therefore, robust domain adaptation has been introduced to deal with such problems. In this paper, we attempt to solve two interrelated problems with robust domain adaptation:distribution shift across domains and sample noises of the source domain. To disentangle these challenges, an optimal transport approach with low-rank constraints is applied to guide the domain adaptation model training process to avoid noisy information influence. For the domain shift problem, the optimal transport mechanism can learn the joint data representations between the source and target domains using a measurement of discrepancy and preserve the discriminative information. The rank constraint on the transport matrix can help recover the corrupted subspace structures and eliminate the noise to some extent when dealing with corrupted source data. The solution to this relaxed and regularized optimal transport framework is a convex optimization problem that can be solved using the Augmented Lagrange Multiplier method, whose convergence can be mathematically proved. The effectiveness of the proposed method is evaluated through extensive experiments on both synthetic and real-world datasets.

关键词： Domain adaptation low-rank constraint noise corruption optimal transport

Prediction of cell-cell communication patierns of dorsal root ganglion cells: single-cell RNA sequencing data analysis

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Neural Regeneration Research 2024年第6期19卷 1367-1374页

作者： Yanna lian Cheng Wu Li Liu Xiangyao Li National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology Ministry of Education Frontier Science Center for Brain Research and Brain-Machine Integration School of Brain Science and Brain Medicine Zhejiang University International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of Medicine Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicine Zhejiang University 4. Biomedical Sciences College of Medicine and Veterinary Medicine The University of Edinburgh Core Facilities of the School of Medicine Zhejiang University

Dorsal root ganglion neurons transmit peripheral somatic information to the central nervous system, and dorsal root ganglion neuron excitability affects pain perception. Dorsal root ganglion stimulation is a new approach for managing pain sensation. Knowledge of the cell-cell communication among dorsal root ganglion cells may help in the development of new pain and itch management strategies. Here, we used the single-cell RNA-sequencing(scRNA-seq) database to investigate intercellular communication networks among dorsal root ganglion cells. We collected scRNA-seq data from six samples from three studies, yielding data on a total of 17,766 cells. Based on genetic profiles, we identified satellite glial cells, Schwann cells, neurons, vascular endothelial cells, immune cells, fibroblasts, and vascular smooth muscle cells. Further analysis revealed that eight types of dorsal root ganglion neurons mediated proprioceptive, itch, touch, mechanical, heat, and cold sensations. Moreover, we predicted several distinct forms of intercellular communication among dorsal root ganglion cells, including cell-cell contact, secreted signals, extracellular matrix, and neurotransmitter-mediated signals. The data mining predicted that Mrgpra3-positive neurons robustly express the genes encoding the adenosine Adora2b(A2B) receptor and glial cell line-derived neurotrophic factor family receptor alpha 1(GFRα-1). Our immunohistochemistry results confirmed the coexpression of the A2B receptor and GFRα-1. Intrathecal injection of the A2B receptor antagonist PSB-603 effectively prevented histamine-induced scratching behaviour in a dose-dependent manner. Our results demonstrate the involvement of the A2B receptor in the modulation of itch sensation. Furthermore, our findings provide insight into dorsal root ganglion cell-cell communication patterns and mechanisms. Our results should contribute to the development of new strategies for the regulation of dorsal root ganglion excitability.

关键词： cell-cell communications CellChat dorsal root ganglion scRNA-Seq database

Morphogenesis and Molecular Phylogeny of a Marine Urostylid Ciliate Apokeronopsis wrighti(Protista, Ciliophora, Hypotrichia)

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Journal of Ocean University of China 2024年第4期23卷 1067-1075页

作者： lian Chunyu LI Ping ZHANG Tengteng SHAO Chen Department of Zoology College of Life SciencesShaanxi Normal UniversityXi’an 710119China Powerchina Northwest Engineering Corporation Limited Xi’an 710065China

Hypotrichs are one of the highly differentiated ciliated lineages which play important roles in ecological, environmental,evolutionary and basic biological studies. In the present study, we investigated the living characteristics, infraciliature, nuclear apparatus, ontogenesis and phylogenetic position of a marine hypotrichous ciliate, Apokeronopsis wrighti Long et al., 2008, which was isolated from coastal waters in Shenzhen, China. The new isolate resembles the type population in terms of morphological characteristics, morphometrics, and SSU rRNA gene sequence that is with a 99.7% similarity. Ontogenesis of A. wrighti is characterized by oral primordium for the proter as well as marginal and dorsal kineties anlagen in both filial products formed de novo, and the cirral row arranged along the paroral and endoral arises from several anterior frontoventral-transverse cirral streaks. Phylogenetic analyses based on SSU and concatenated gene data suggest that five species of Apokeronopsis form a monophyletic clade, and the genus Apokeronopsis is closely related to Thigmokeronopsis and Metaurostylopsis.

关键词： 18S rRNA gene Apokeronopsis ciliated protists multi-gene ontogenesis systematics Urostylida

A comprehensive research on wear resistance of GH4169 superalloy in longitudinal-torsional ultrasonic vibration side milling with tool wear and surface quality

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Chinese Journal of Aeronautics 2024年第4期37卷 556-573页

作者： Baoqi CHANG Zhaoxi YI Fen ZHANG lian DUAN Ji-an DUAN School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China State Key Laboratory of High Performance and Complex Manufacturing Central South UniversityChangsha 410083China School of Physics and Electronics Central South UniversityChangsha 410083China

To improve the service and machining performance of the workpiece, the tool wear mechanisms, surface machining quality, and wear resistance in conventional side milling(CSM)and longitudinal-torsional ultrasonic vibration side milling(LTUVSM) of GH4169 superalloy at different cutting lengths are investigated systematically. Tool wear mechanisms are revealed and the correlation between machined surface quality with tool wear is analyzed correspondingly. Tool wear patterns mainly include adhesive wear, diffusion wear, abrasive wear, and chipping *** surface quality is achieved in LTUVSM due to a maximum reduction of flank wear bandwidth and wear rate by 71.9% and 71.5%, respectively, compared to CSM. The friction coefficient,initial wear stage time, and wear volume of dry sliding wear were measured to evaluate the workpiece wear resistance. The maximum reductions in friction coefficient and wear volume in LTUVSM are 18.2% and 15.8% compared to CSM. The regular ultrasonic vibration textures suppress the friction and the growth of contact nodes in the contact area, decreasing the degree of surface wear, which is demonstrated by a 38.8% increase in initial wear stage time compared to *** conclusion, the workpiece in LTUVSM exhibits higher wear resistance because of the improvement of tool wear and the guarantee of surface quality.

关键词： Dry sliding wear Surface quality Tool wear Ultrasonic vibration Wear resistance

Influence of Incomplete Soil Plugs on Bearing Capacities of Bucket Foundations in Clay

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China Ocean Engineering 2024年第1期38卷 144-155页

作者： LI Hui-shan LIU Run YANG Xu lian Ji-jian State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Institute of Marine Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China

Due to the uneven seabed and heaving of soil during pumping,incomplete soil plugs may occur during the installation of bucket foundations,and the impacts on the bearing capacities of bucket foundations need to be *** this paper,the contact ratio(the ratio of the top diameter of the soil plug to the diameter of the bucket)and the soil plug ratio(the ratio of the soil heave height to the skirt height)are defined to describe the shape and size of the incomplete soil ***,finite element models are established to investigate the bearing capacities of bucket foundations with incomplete soil plugs and the influences of the contact ratios,and the soil plug ratios on the bearing capacities are *** results show that the vertical bearing capacity of bucket foundations in homogeneous soil continuously improves with the increase of the contact ***,in normally consolidated soil,the vertical bearing capacity barely changes when the contact ratio is smaller than 0.75,while the bearing capacity suddenly increases when the contact ratio increases to 1 due to the change of failure *** contact ratio hardly affects the horizontal bearing capacity of bucket ***,the moment bearing capacity improves with the increase of the contact ratio for small aspect ratios,but hardly varies with increasing contact ratio for aspect ratios larger than ***,the reduction coefficient method is proposed based on this analysis to calculate the bearing capacities of bucket foundations considering the influence of incomplete soil *** comparison results show that the proposed reduction coefficient method can be used to evaluate the influences of incomplete soil plug on the bearing capacities of bucket foundations.

关键词： bucket foundation incomplete soil plug uniaxial bearing capacity contact ratio soil plug ratio

A novel triple periodic minimal surface-like plate lattice and its data-driven optimization method for superior mechanical properties

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 217-238页

作者： Yanda WANG Yanping lian Zhidong WANG Chunpeng WANG Daining FANG State Key Laboratory for Turbulence and Complex Systems&Center for Applied Physics and Technology College of EngineeringPeking UniversityBeijing 100871China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China

Lattice structures can be designed to achieve unique mechanical properties and have attracted increasing attention for applications in high-end industrial equipment,along with the advances in additive manufacturing(AM)*** this work,a novel design of plate lattice structures described by a parametric model is proposed to enrich the design space of plate lattice structures with high connectivity suitable for AM *** parametric model takes the basic unit of the triple periodic minimal surface(TPMS)lattice as a skeleton and adopts a set of generation parameters to determine the plate lattice structure with different topologies,which takes the advantages of both plate lattices for superior specific mechanical properties and TPMS lattices for high connectivity,and therefore is referred to as a TPMS-like plate lattice(TLPL).Furthermore,a data-driven shape optimization method is proposed to optimize the TLPL structure for maximum mechanical properties with or without the isotropic *** this method,the genetic algorithm for the optimization is utilized for global search capability,and an artificial neural network(ANN)model for individual fitness estimation is integrated for high efficiency.A set of optimized TLPLs at different relative densities are experimentally validated by the selective laser melting(SLM)fabricated *** is confirmed that the optimized TLPLs could achieve elastic isotropy and have superior stiffness over other isotropic lattice structures.

关键词： lattice structure triple periodic minimal surface(TPMS) plate lattice structural optimization machine learning