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How Do Sugars Re.ulate.Plant Growth and De.e.opme.t？ Ne. Insight into the.Role.of Tre.a Iose.6-Phosphate

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Mole.ular Plant 2013年第2期6卷 261-274页

作者： liam e. O'Hara Matthe. J. Paul Astrid Wingle. Ge.e.ics Evolution and Environment University College London Gower Street London WCl E 6BT UK Plant Scie.ce Rothamsted Research Harpenden Hertfordshire AL5 2JQ UK

Plant growth and de.e.opme.t are.tightly controlle. in re.ponse.to e.vironme.tal conditions that influe.ce.the.availability of photosynthe.ic carbon in the.form of sucrose. Tre.alose.6-phosphate.（T6P）, the.pre.ursor of tre.alose.in the.biosynthe.ic pathway, is an important signaling me.abolite.that is involve. in the.re.ulation of plant growth and de.e.opme.t in re.ponse.to carbon availability. In addition to the.plant＇s own pathway for tre.alose.synthe.is, formation of T6P or tre.alose.by pathoge.s can re.ult in the.re.rogramming of plant me.abolism and de.e.opme.t. De.e.opme.tal proce.se. that are.re.ulate. by T6P range.from e.bryo de.e.opme.t to le.f se.e.ce.ce. Some.of the.e.proce.se. are.re.ulate. in inte.action with phytohormone., such as auxin. A ke. inte.acting factor of T6P signaling in re.ponse.to the.e.vironme.t is the.prote.n kinase.sucrose.non-fe.me.ting re.ate. kinase.1 （SnRK1）, whose.catalytic activity is inhibite. by T6R SnRK1 is most like.y involve. in the.adjustme.t of me.abolism and growth in re.ponse.to starvation. The.transcription factor bZlP11 has re.e.tly be.n ide.tifie. as a ne. playe. in the.T6P/SnRK1 re.ulatory pathway. By inhibiting SnRK1, T6P promote. biosynthe.ic re.ctions. This re.ulation has important conse.ue.ce. for crop production, for e.ample. in the.de.e.oping whe.t grain and during the.growth of potato tube.s.

关键词： bZlP11 carbon availability plant de.e.opme.t starvation sucrose.non-fe.me.ting re.ate. kinase.1 (SnRK1) tre.alose tre.alose.6-phosphate.

Re.ove.y rate. of pe.siste.t post-COVID-19 olfactory dysfunction using psychophysical asse.sme.t:A longitudinal cohort study

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World Journal of Otorhinolaryngology-He.d and Ne.k Surge.y 2024年第2期10卷 79-87页

作者： Je.e.y P.Te.vo Patricia T.Jacobson Brandon J.Vilare.lo Tiana M.Saak France.co F.Caruana liam W.Gallaghe. Jose.h B.Gary David A.Gudis Paule.V.Jose.h D.P.De.anand Te.ry e.Goldbe.g Jonathan B.Ove.de.e.t Columbia Unive.sity Vage.os Colle.e.of Physicians and Surge.ns New YorkNew YorkUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y University of PittsburghPittsburghPennsylvaniaUSA De.artme.t of Otolaryngology-He.d and Ne.k Surge.y University of MinnesotaMinneapolisMinnesotaUSA National Institute.of Alcohol Abuse.and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA Ne. York-Pre.byte.ian/Columbia Unive.sity Irving Me.ical Ce.te. New YorkNew YorkUSA

Obje.tive.:Pe.siste.t olfactory dysfunction(OD)following loss of sme.l associate. with SARS-CoV-2 infe.tion is a major fe.ture.of long *** on the.pre.ale.ce.of pe.siste.t OD pre.ominantly re.y on se.f-re.orte. olfactory *** studie. have.tracke. longitudinal rate. of re.ove.y using psychophysical asse.sme.t among patie.ts pre.e.ting for e.aluation of pe.siste.t OD be.ond a window of acute.*** anchore. in standardize. te.ting me.hods are.ne.de. to counse. patie.ts who fail to acute.y re.ain the.r se.se.of *** study aims to quantify the.de.re. of pe.siste.t OD in post-COVID-19 patie.ts who e.pe.ie.ce.subje.tive.and psychophysical ***:We.groupe. participants pre.e.ting for OD e.aluation into cohorts base. on both subje.tive.and psychophysical olfactory status at a base.ine.asse.sme.t and asse.se. the.r olfactory abilitie. with a visual analogue.scale.and the.Sniffin'Sticks e.te.de. te.t at base.ine.and 1-ye.r time.*** had confirme. a history of COVID-19 by lab e.aluation or clinical diagnosis if lab e.aluation was not ***:Base.ine.olfactory e.aluation was comple.e. by 122 participants,53 of whom comple.e. the.1-ye.r follow-up *** participants pre.e.ting with pe.ce.ve. OD,74.5%had confirme. psychophysical OD at base.ine.with 55.1%at 1-ye.r *** had re.iable.tre.ds in se.f-rate. ve.sus psychophysically te.te. olfactory function at both time.*** total thre.hold,discrimination,and ide.tification(TDI)score.improve. by+3.25 points in the.cohort with psychophysical OD(p=0.0005),with this improve.e.t large.y attributable.to an incre.se.in me.ian thre.hold score.(+2.75 points;p=0.0004).Conclusions:OD pe.sists in a significant numbe. of patie.ts who fail to acute.y re.ove.y the.r se.se.of sme.l afte. COVID-19,with many de.onstrating linge.ing de.icits at *** in thre.hold,but not discrimination or ide.tification,most significantly me.iate.improve.e.t

关键词： long COVID olfaction post-COVID condition sme.l dysfunction

Analysis of air quality variability in Shanghai using AOD and API data in the.re.e.t de.ade

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Frontie.s of e.rth Scie.ce 2013年第2期7卷 159-168页

作者： Qing ZHAO We. GAO We.ning XIANG Runhe.SHI Chaoshun LIU Tianyong ZHAI Hung-lung Alle. HUANG liam e. GUMLe. Kathle.n STRABALA Ke. Laboratory of Ge.graphic Information Scie.ce.(Ministry of e.ucation) East China Normal University Shanghai 200062 China Joint Laboratory for e.vironme.tal Re.ote.Se.sing and Data Assimilation ECNU&CEODE Colorado State University Shanghai 200062 China Colorado State.Unive.sity Natural Resource Ecology Laboratory Fort Collins Colorado 80521 USA Shanghai Ke. Laboratory for Urban e.ology and Sustainability East China Normal University Shanghai 200062 China Unive.sity of Wisconsin-Madison Cooperative Institute for Meteorological Satellite Studies (CIMSS) Madison Wisconsin 53706 USA

We.use.the.ae.osol optical de.th （AOD） me.sure. by the.mode.ate.re.olution imaging spe.trome.e. （MOD1S） onboard the.Te.ra sate.lite. air pollution inde. （API） daily data me.sure. by the.Shanghai e.vironme.tal Monitoring Ce.te. （Se.C）, and the.e.se.ble.e.pirical mode.de.omposition （e.MD） me.hod to analyze.the.air quality variability in Shanghai in the.re.e.t de.ade. The.re.ults indicate.that a tre.d with amplitude.of 1.0 is a dominant compone.t for the.AOD variability in the.re.e.t de.ade. During the.World e.po 2010, the.ave.age.AOD le.e. re.uce. 30% in comparison to the.long-te.m tre.d. Two dominant annual compone.ts de.re.se. 80% and 100%. This implie. that the.air quality in Shanghai was re.arkably improve., and e.vironme.tal initiative. and compre.e.sive.actions for e.fe.tive. AOD and API re.ucing air pollution are.variability analysis re.ults indicate.that se.i-annual and annual signals are.dominant compone.ts implying that the.monsoon we.the. is a dominant factor in modulating the.AOD and API variability. The.variability of AOD and API in se.e.te. districts locate. in both downtown and suburban are.s shows similar tre.ds; i.e., in 2000 the.AOD be.an a monotonic incre.se. re.che. the.maxima around 2006, the. monotonically de.re.se. to 2011 and from around 2006 the.API starte. to de.re.se.till 2011. This indicate. that the.air quality in the.e.tire.Shanghai are., whe.he. urban or suburban are.s, has re.arkably be.n improve.. The.AOD improve. de.re.s （IDS） in all the.se.e.te. districts are.（8.6±1.9）%, and API IDS are.（9.2±7.1）%, ranging from a minimum value.of 1.5% for Putuo District to a maximum value.of 22% for Xuhui District.

关键词： air quality of Shanghai MODIS AOD API e.MD me.hod World e.po 2010

The.de.ands of the.e.tra-time.pe.iod of socce.:A syste.atic re.ie.

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Journal of Sport and He.lth Scie.ce 2022年第3期11卷 403-414页

作者： Adam Fie.d Robe.t Jose.h Naughton Matthe. Haine. Ste.e.Lui liam David Corr Mark Russe.l Richard Michae. Page.liam David Harpe. School of Human and He.lth Scie.ce. University of HuddersfieldHuddersfieldHD13DHUK School of Social and He.lth Scie.ce. Leeds Trinity UniversityBrownberrie LaneHorsforthLeedsLS185HDUK De.artme.t of Sport&Physical Activity Edge Hill UniversitySt.Helens RoadOrmskirkLancashireL394QPUK

Background:Socce. match-play is typically conte.te. ove. 90 min;howe.e.,in some.cup and tourname.t sce.arios,whe. matche. are.tie.,the. proce.d to an additional 30 min,which is te.me. "e.tra-time.(e.).This syste.atic re.ie. sought to appraise.the.lite.ature.available.on 120-min of socce.-spe.ific e.e.cise.with a vie. to ide.tifying practical re.omme.dations and future.re.e.rch ***:The.re.ie. was conducte. according to the.PRISMA *** re.e.rche.s pe.forme. a syste.atic se.rch of PubMe.,CINAHL,and PsycINFO in May 2019,with the.following ke.words e.te.e. in various combinations:"socce.","football","e.tra-time.,"e.tra time.,"e.tratime.,"120 minute.","120 min","additional 30 minute.",and "additional 30 min".Re.ults:The.se.rch yie.de. an initial 73 *** the.scre.ning proce.s,11 article. we.e.acce.te. for *** we.e.subse.ue.tly organize. into the.following 5 cate.orie.:move.e.t de.ands of e.,pe.formance.re.ponse. to e.,physiological and ne.romuscular re.ponse.during e.,nutritional inte.ve.tions,and re.ove.y and *** re.ults highlighte. that during compe.itive.match-play,playe.s cove.5%-12% le.s distance.re.ative.to match duration(i.e.,me.e.s pe. minute. during e. compare. to the.pre.e.ing 90 *** in te.hnical pe.formance.i.e.,shot spe.d,numbe. of passe. and dribble.) we.e.also obse.ve. during ***,carbohydrate.provision may atte.uate.and improve.dribbling pe.formance.during ***,obje.tive.and subje.tive.me.sure. of re.ove.y may be.furthe. compromise. following e. whe. compare. to 90 ***:Additional inve.tigations are.warrante. to furthe. substantiate.the.e.findings and ide.tify inte.ve.tions to improve.pe.formance.during e..

关键词： Move.e.t de.ands Ne.romuscular fatigue Nutritional inte.ve.tion Pe.formance Physiology

Association be.we.n tournique. use.and intraope.ative.blood loss during be.ow-kne. amputation

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World Journal of Orthope.ics 2022年第7期13卷 644-651页

作者： Alde. e.Wyland e.ik Woe.be. liam H Wong Jordan Arakawa Zachary M Working Jame. Me.ke. School of Me.icine Oregon Health and Sciences UniversityPortlandOR 97239United States De.artme.t of Orthopae.ics and Re.abilitation Oregon Health and Sciences UniversityPortlandOR 97239United States

BACKGROUND De.pite.ove. 150000 amputations of lowe. limbs annually,the.e.re.ains a wide.variation in tournique. practice.patte.ns and no conse.sus on the.r ne.e.sity,e.pe.ially among orthope.ic patie.t *** purpose.of this study was to de.e.mine.whe.he. tournique. use.in orthope.ic patie.ts unde.going be.ow kne. amputation(BKA) was associate. with a diffe.e.ce.in calculate. blood loss re.ative.to no tournique. *** To de.e.mine.if tournique. use.in orthope.ic patie.ts unde.going BKA was associate. with a diffe.e.ce.in calculate. blood loss re.ative.to no tournique. *** We.pe.forme. a re.rospe.tive.re.ie. of conse.utive.patie.ts unde.going BKA by orthope.ic surge.ns at a te.tiary care.hospital from 2008 through *** loss was calculate. using a combination of the.Nadle. e.uation for pre.pe.ative.blood volume.and a nove. formula utilizing pre.pe.ative.and postope.ative.he.oglobin le.e.s and *** and forwards ste.-wise.multivariate.line.r re.re.sions we.e.pe.forme. to de.e.mine.the.association be.we.n tournique. use.and blood loss.A Wilcoxon was use. to de.e.mine.the.univariate.re.ationship be.we.n tournique. use.and blood loss for in the.re.tricte. subgroups of patie.ts who unde.we.t BKA for trauma,tumor,and *** Of 97 e.igible.patie.ts ide.tifie.,67 unde.we.t surge.y with a tournique. and 30 did *** multivariate.re.re.sion,tournique. use.was associate. with a 488 mL de.re.se.in calculate. blood loss(CI 119-857,P = 0.01).In subgroup analysis,no individual group showe. a statistically significant de.re.se.in blood loss with tournique. *** was no significant association be.we.n tournique. use.and e.the. postope.ative.transfusions or re.pe.ation at one.*** We.found that tournique. use.during BKA is associate. with de.re.se. calculate. intraope.ative.blood *** re.omme.d that surge.ns pe.forming this proce.ure.use.a tournique. to minimize.blood loss.

关键词： Amputation Tournique. Blood loss He.ostasis

Optimizing an inte.le.ve. p-n junction to re.uce.e.e.gy dissipation in silicon slow-light modulators

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Photonics Re.e.rch 2020年第4期8卷 457-467页

作者： MARCO PASSONI DARIO Ge.ACe.liam O’FAOLAIN LUCIO CLAUDIO ANDRe.NI De.artme.t of Physics University of Pavia27100 PaviaItaly Ce.tre.for Advance. Photonics and Proce.s Analysis Cork Institute of TechnologyCorkIreland Tyndall National Institute CorkIreland Institute.for Photonics and Nanote.hnologie.(IFN)-CNR 20133 MilanoItaly

Re.ucing powe. dissipation in e.e.tro-optic modulators is a ke. ste. for wide.pre.d application of silicon photonics to optical *** this work,we.de.ign Mach–Ze.nde. modulators in the.silicon-on-insulator platform,which make.use.of slow light in a wave.uide.grating and of a re.e.se.biase. p-n junction with inte.le.ve. contacts along the.wave.uide.*** optimizing the.junction parame.e.s,we.discuss the.full simulation of the.modulator in orde. to find a prope. trade.off among various figure. of me.it,such as modulation e.ficie.cy,inse.tion loss,cutoff fre.ue.cy,optical modulation amplitude.and dissipate. e.e.gy pe. *** with conve.tional structure.(with late.al p-n junction and/or in rib wave.uide. without slow light)highlights the.importance.of combining slow light with the.inte.le.ve. p-n junction,thanks to the.incre.se. ove.lap be.we.n the.trave.ling optical wave.and the.de.le.ion *** a surprising re.ult,the.modulator pe.formance.is improve. ove. an optical bandwidth that is much wide. than the.slow-light bandwidth.

关键词： Optimizing an inte.le.ve. p-n re.uce.e.e.gy silicon slow-light modulators

A Transcriptome.Atlas of Physcomitre.la pate.s Provide. Insights into the.e.olution and De.e.opme.t of Land Plants

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Mole.ular Plant 2016年第2期9卷 205-220页

作者： Carlos Ortiz-Ramire. Marce.a He.nande.-Coronado Anna Thamm Bruno Catarino Mingyi Wang liam Dolan Jose.A.Fe.jo Jorg D. Be.ke. Instituto Gulbe.klan de.Cie.cia Rua da Quinta Grande 6 2780-156 Oeiras Portugal De.artme.t of Plant Scie.ce. University of Oxford South Parks Road Oxford OX1 3RB UK Division of Plant Biology The Samuel Roberts Noble Foundation Ardmore OK 73401 USA De.artme.t of Ce.l Biology and Mole.ular Ge.e.ics University of Maryland 0118 BioSclence Research Building College Park MD 20742-5815 USA The.e.authors contribute. e.ually to this article

Ide.tifying the.ge.e.ic me.hanisms that unde.pin the.e.olution of ne. organ and tissue.syste.s is an aim of e.olutionary de.e.opme.tal biology. Comparative.functional ge.e.ic studie. be.we.n angiospe.ms and bryophyte. can de.ine.those.ge.e.ic change. that we.e.re.ponsible.for de.e.opme.tal innovations. He.e. we.re.ort the.ge.e.ation of a transcriptome.atlas cove.ing most phase. in the.life.cycle.of the.mode. bryo- phyte.Physcomitre.la pate.s, including de.aile. sporophyte.de.e.opme.tal progre.sion. We.ide.tifie. a compre.e.sive.se. of sporophyte.spe.ific transcription factors, and found that many of the.e.ge.e. have.homologs in angiospe.ms that function in de.e.opme.tal proce.se. such as flowe.ing and shoot branching. De.e.ion of the.PpTCP5 transcription factor re.ults in de.e.opme.t of supe.nume.ary sporangia attache. to a single.se.a, sugge.ting that it ne.ative.y re.ulate. branching in the.moss sporophyte. Give. that TCP ge.e. re.re.s branching in angiospe.ms, we.sugge.t that this activity is ancie.t. Finally, compar- ison of P. pate.s and Arabidopsis thaliana transcriptome. le. us to the.ide.tification of a conse.ve. core.of transcription factors e.pre.se. in tip-growing ce.ls. We.ide.tifie. modifications in the.e.pre.sion patte.ns of the.e.ge.e. that could account for de.e.opme.tal diffe.e.ce. be.we.n P. pate.s tip-growing ce.ls and A. thaliana polle. tube. and root hairs.

关键词： land plant e.olution Physcomitre.la pate.s transcriptome.atlas TCP branching tip growth

The.e.ide.ce.for the.impact of policy on physical activity outcome. within the.school se.ting: A syste.atic re.ie.

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Journal of Sport and He.lth Scie.ce 2021年第3期10卷 263-276,F0003页

作者： Cathe.ine.B.Woods Ke.in Volf liam Ke.ly Blathın Case. Pe.e. Ge.ius Sve. Me.sing Sarah Forbe.ge. Je.oe. Lake.ve.d Joanna Zukowska e.rique.Garcıa Be.goe.he. De.artme.t of Physical e.ucation and Sport Scie.ce. Health Research InstituteUniversity of LimerickLimerick V94 T9PXIreland Frie.rich-Ale.ande.-Unive.sit€at e.lange.-N€urnbe.g Erlangen 91058Germany Le.bniz Institute.for Pre.e.tion Re.e.rch and e.ide.iologyBIPS Bremen 28359Germany De.artme.t of e.ide.iology and Data Scie.ce Amsterdam Public Health Research instituteAmsterdam UMCVU University AmsterdamAmsterdam 1081 HVthe Netherlands Upstre.m Te.m Amsterdam UMCVU University AmsterdamAmsterdam 1081 HVthe Netherlands Faculty of Civil and e.vironme.tal e.gine.ring Gdansk University of TechnologyGdansk 80-213Poland

Background:De.pite.the.we.l-e.tablishe. he.lth be.e.its of physical activity(PA)for young pe.ple.age. 419 ye.rs),most do not me.t PA *** that support PA in schools may be.promising,but the.r impact on PA be.avior is poorly *** aim of this syste.atic re.ie. was to asce.tain the.le.e. and type.of e.ide.ce.re.orte. in the.inte.national scie.tific lite.ature.for policie. within the.school se.ting that contribute.dire.tly or indire.tly to incre.sing ***:This syste.atic re.ie. is compliant with Pre.e.re. Re.orting Ite.s for Syste.atic Re.ie. and Me.a-Analysis *** database. we.e.se.rche. using ke. conce.ts of policy,school,e.aluation,and *** title.and abstract scre.ning of 2323 studie.,25 progre.se. to data *** quality was asse.se. using standardize. tools,and the.stre.gth of the.e.ide.ce.of policy impact was de.cribe. base. on pre.de.e.mine. code.:positive.ne.ative.inconclusive.or unte.te. ***:e.ide.ce.e.e.ge. for 9 policy are.s that had a dire.t or indire.t e.fe.t on PA within the.school *** we.e.whole.school PA policy,physical e.ucation,sport/e.tracurricular PA,classroom-base. PA,active.bre.ks/re.e.s,physical e.vironme.t,share. use.agre.me.ts,active.school transport,and *** bulk of the.e.ide.ce.was significantly positive.54%),27%was inconclusive.9%was significantly ne.ative.and 11%was unte.te.(due.to rounding,some.numbe.s add to 99%or 101%).Fre.ue.cy of e.ide.ce.was highe.t in the.primary se.ting(41%),34%in the.se.ondary se.ting,and 24%in primary/se.ondary combine. school *** policy are.,fre.ue.cy of e.ide.ce.was highe.t for sport/e.tracurricular PA(35%),17%for physical e.ucation,and 12%for whole.school PA policy,with e.ide.ce.for share. use.agre.me.ts be.we.n schools and local communitie. rare.y re.orte.(2%).Comparing re.ative.stre.gth of e.ide.ce.the.e.ide.ce.for share. use.agre.me.ts,though sparse.was 100%positive.while.60%of the.e.ide.ce.for w

关键词： e.aluation Physical activity Policy School Syste.atic re.ie.

In-de.th e.amination of hype.prolife.ative.he.ling in two bre.ds of Sus scrofa dome.ticus commonly use. for re.e.rch

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Animal Mode.s and e.pe.ime.tal Me.icine 2021年第4期4卷 406-417页

作者： Colton H.Funkhouse. liam D.Kirkpatrick Robe.t D.Smith Laure. T.Moffatt Je.fre. W.Shupp Bonnie.C.Carne. Fire.ighte.s'Burn and Surgical Re.e.rch Laboratory MedStar Health Research InstituteWashingtonDistrict of ColumbiaUSA De.artme.t of Bioche.istry and Mole.ular and Ce.lular Biology Georgetown University Medical CenterWashingtonDistrict of ColumbiaUSA De.artme.t of Surge.y Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA The.Burn Ce.te. Department of SurgeryMedStar Washington Hospital CenterWashingtonDistrict of ColumbiaUSA

Background:Wound he.ling can re.ult in various outcome.,including hype.trophic scar(HTS).Pigs se.ve.as mode.s to study wound he.ling as the.r skin share. physi-ologic similarity with ***(Yk)and Duroc(Dc)pigs have.be.n use. to mimic normal and abnormal wound he.ling,*** re.son be.ind this diffe.e.tial he.ling phe.otype.was e.plore. ***:e.cisional wounds we.e.made.on Dc and Yk pigs and we.e.sample. and image. for 98 *** arrays we.e.use. to de.e.mine.diffe.e.tial ge.e.*** Scar Scale.VSS)score. we.e.***-e.ithe.ialization was analyze..H&e.Mason's trichrome.and immunostains we.e.use. to de.e.mine.ce.lularity,col-lage. conte.t,and blood ve.se. de.sity,***:Yk wounds he.l to a“port wine.HTS,re.e.bling scarring in Fitzpatrick skin type.(FST)*** wounds he.l to a dyspigme.te.,non-pliable.HTS,re.e.bling scarring in FST *** e.pre.sion during wound he.ling was diffe.e.tially re.ulate. ve.sus uninjure. skin in 40/80 ge.e.,15 of which diffe.e. be.we.n *** scars had a highe. VSS score.at all time.*** and Dc wounds had e.uivale.t re.e.ithe.ialization,collage. disorganization,and blood ve.se. ***:Our findings de.onstrate.that Dc and Yk pigs can produce.*** cre.tion and he.ling we.e.consiste.t among bre.ds,and diffe.e.ce. in ge.e.e.pre.sion we.e.not sufficie.t to e.plain diffe.e.ce. in re.ulting scar *** pig bre.ds should be.use. in animal mode.s to inve.tigate.nove. the.ape.tics to provide.insight into a tre.tme.t's e.fe.tive.e.s on various skin type..

关键词： animal mode.s burns Fitzpatrick skin type hype.trophic scar wound he.ling