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Oesophageal cancer metastases:An observational study of a more aggressive approach

World Journal of Gastrointestinal Surgery 2022年第9期14卷 997-1007页

作者： Lianne Pickett Mary dunne Orla Monaghan liam Grogan Oscar Breathnach Thomas N Walsh department of Surgery Connolly HospitalBlanchardstownDublin D15 X40DIreland Clinical Trials Resource Unit St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland department of Radiation Oncology St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland department of Medical Oncology Beaumont HospitalDublin D09 V2N0Ireland department of Surgery RCSI BahrainAdliya 15503Bahrain

BACKGROUNd The prognosis for oesophageal carcinoma is poor,but once distant metastases emerge the prognosis is considered *** is no consistent protocol for the early identification and aggressive management of *** To examine the outcome of a policy of active postoperative surveillance with aggressive treatment of confirmed *** A prospectively maintained database of 205 patients diagnosed with oesophageal carcinoma between 1998 and 2019 and treated with curative intent was interrogated for patients with metastases,either at diagnosis or on follow-up surveillance and treated for *** cohort was compared with incomplete clinical responders to neoadjuvant chemoradiotherapy(nCRT)who subsequently underwent surgery on their primary *** survival was estimated using the Kaplan-Meier method,and the log-rank test was used to compare survival differences between *** Of 205 patients,11(5.4%)had metastases treated for cure(82%male;median age 60 years;9 adenocarcinoma and 2 squamous cell carcinomas).All had undergone neoadjuvant chemotherapy or chemoradiotherapy,followed by surgery in all but 1 *** the 11 patients,4 had metastatic disease at diagnosis,of whom 3 were successfully downstaged with nCRT before definitive surgery;2 of these 4 also developed oligometastatic recurrence and were treated with curative *** definitive treatment,7 had treatment for metachronous oligometastatic disease;5 of whom underwent metastasectomy(adrenal×2;lung×2;liver×1).The median overall survival was 10.9 years[95%confidence interval(CI):0.7-21.0 years],which was statistically significantly longer than incomplete clinical responders undergoing surgery on the primary tumour without metastatic intervention[n=62;median overall survival=1.9(95%CI:1.1-2.7;P=0.012].The cumulative proportion surviving 1,3,and 5 years was 100%,91%,and 61%,respectively compared to 71%,36%,and 25%for incomplete clinical responders undergoing surge

关键词： Oesophageal metastases Oligometastases Active surveillance Treatment for cure Metastasectomy Survival

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Loss of two families of SPX domain-containing proteins required for vacuolar polyphosphate accumulation coincides with the transition to phosphate storage in green plants

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Molecular Plant 2021年第5期14卷 838-846页

作者： Long Wang Xianqing Jia Yuxin Zhang Lei Xu Benoit Menand Hongyu Zhao Houqing Zeng liam dolan Yiyong Zhu Keke Yi Key Laboratory of Plant Nutrition and Fertilizers Ministry of Agriculture and Rural AffairsInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Jiangsu Provincial Key Lab for Organic Solid Waste Utilization National Engineering Research Center for Organic-based FertilizersJiangsu Collaborative Innovation Center for Solid Organic Waste Resource UtilizationNanjing Agricultural UniversityNanjing 210095China Aix Marseille Univ CEACNRSBIAMLuminy Plant Genetics and Biophysics TeamMarseille 13009France College of Life and Environmental Sciences Hangzhou Normal UniversityHangzhou 311121China Gregor Mendel Institute of Molecular Plant Biology GmbH Dr.Bohr-Gasse 31030 ViennaAustria

Phosphorus is an essential nutrient for *** is stored as inorganic phosphate(Pi)in the vacuoles of land plants but as inorganic polyphosphate(polyP)in chlorophyte *** it is recognized that the SPX-Major Facilitator Superfamily(MFS)and VPE proteins are responsible for Pi influx and efflux,respectively,across the tonoplast in land plants,the mechanisms that underlie polyP homeostasis and the transition of phosphorus storage forms during the evolution of green plants remain *** this study,we showed that CrPTCI,encoding a protein with both SPX and SLC(permease solute carrier 13)domains for Pi transport,and CrVTC4,encoding a protein with both SPX and vacuolar transporter chaperone(VTC)domains for polyP synthesis,are required for vacuolar polyP accumulation in the chlorophyte Chlamydomonas *** analysis showed that the SPX-SLC,SPX-VTC,and SPX-MFS proteins were present in the common ancestor of green plants(Viridiplantae).The SPX-SLC and SPX-VTC proteins are conserved among species that store phosphorus as vacuolar polyP and absent from genomes of plants that store phosphorus as vacuolar *** contrast,SPX-MFS genes are present in the genomes of streptophytes that store phosphorus as Pi in the *** results suggest that loss of SPX-SLC and SPX-VTC genes and functional conservation of SPX-MFS proteins during the evolution of streptophytes accompanied the change from ancestral polyP storage to Pi storage.

关键词： Chlamydomonas polyphosphate SPX-SLC SPX-VTC vacuolar phosphate plant evolution

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Imaging mechanism for hyperspectral scanning probe microscopy via Gaussian process modelling

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npj Computational Materials 2020年第1期6卷 1477-1483页

作者： Maxim Ziatdinov dohyung Kim Sabine Neumayer Rama K.Vasudevan liam Collins Stephen Jesse Mahshid Ahmadi Sergei V.Kalinin Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Computational Sciences and Engineering division Oak Ridge National LaboratoryOak RidgeTN 37831USA Joint Institute for Advanced Materials Department of Materials Science and EngineeringUniversity of TennesseeKnoxvilleTN 37996USA

We investigate the ability to reconstruct and derive spatial structure from sparsely sampled 3d piezoresponse force microcopy data,captured using the band-excitation(BE)technique,via Gaussian Process(GP)*** for weakly informative priors,GP methods allow unambiguous determination of the characteristic length scales of the imaging process both in spatial and frequency *** further show that BE data set tends to be oversampled in the spatial domains,with~30% of original data set sufficient for high-quality reconstruction,potentially enabling faster BE *** the same time,reliable reconstruction along the frequency domain requires the resonance peak to be within the measured *** behavior suggests the optimal strategy for the BE imaging on unknown ***,we discuss how GP can be used for automated experimentation in SPM,by combining GP regression with non-rectangular scans.

关键词： methods Gaussian weakly

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3d-printed,citrate-based bioresorbable vascular scaffolds for coronary artery angioplasty

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Bioactive Materials 2024年第8期38卷 195-206页

作者： Yonghui ding liam Warlick Mian Chen Eden Taddese Caralyn Collins Rao Fu Chongwen duan Xinlong Wang Henry Ware Cheng Sun Guillermo Ameer Centre for Advanced Regenerative Engineering(CARE) Northwestern UniversityEvanstonIL 60208USA department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA

Fully bioresorbable vascular scaffolds(BVSs)aim to overcome the limitations of metallic drug-eluting stents(dESs).However,polymer-based BVSs,such as Abbott’s Absorb,the only US FdA-approved BVS,have had limited use due to increased strut thickness(157μm for Absorb),exacerbated tissue inflammation,and increased risk of major cardiac events leading to inferior clinical performance when compared to metallic *** we report the development of a drug-eluting BVS(dE-BVS)through the innovative use of a photopolymerizable,citrate-based biomaterial and a high-precision additive manufacturing *** with a clinically relevant strut thickness of 62μm can be produced in a high-throughput manner,*** BVS per minute,and controlled release of the anti-restenosis drug everolimus can be achieved by engineering the structure of polymer coatings to fabricate drug-eluting *** achieved the successful deployment of BVSs and dE-BVSs in swine coronary arteries using a custom-built balloon catheter and BVS delivery system and confirmed BVS safety and efficacy regarding maintenance of vessel patency for 28 days,observing an inflammation profile for BVS and dE-BVS that was comparable to the commercial XIENCE^(TM)dES(Abbott Vascular).

关键词： coronary inflammation balloon

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The evidence for the impact of policy on physical activity outcomes within the school setting: A systematic review

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Journal of Sport and Health Science 2021年第3期10卷 263-276,F0003页

作者： Catherine B.Woods Kevin Volf liam Kelly Blathın Casey Peter Gelius Sven Messing Sarah Forberger Jeroen Lakerveld Joanna Zukowska Enrique Garcıa Bengoechea department of Physical Education and Sport Sciences Health Research InstituteUniversity of LimerickLimerick V94 T9PXIreland Friedrich-Alexander-Universit€at Erlangen-N€urnberg Erlangen 91058Germany Leibniz Institute for Prevention Research and EpidemiologyBIPS Bremen 28359Germany department of Epidemiology and data Science Amsterdam Public Health Research instituteAmsterdam UMCVU University AmsterdamAmsterdam 1081 HVthe Netherlands Upstream Team Amsterdam UMCVU University AmsterdamAmsterdam 1081 HVthe Netherlands Faculty of Civil and Environmental Engineering Gdansk University of TechnologyGdansk 80-213Poland

Background:despite the well-established health benefits of physical activity(PA)for young people(aged 419 years),most do not meet PA *** that support PA in schools may be promising,but their impact on PA behavior is poorly *** aim of this systematic review was to ascertain the level and type of evidence reported in the international scientific literature for policies within the school setting that contribute directly or indirectly to increasing ***:This systematic review is compliant with Preferred Reporting Items for Systematic Review and Meta-Analysis *** databases were searched using key concepts of policy,school,evaluation,and *** title and abstract screening of 2323 studies,25 progressed to data *** quality was assessed using standardized tools,and the strength of the evidence of policy impact was described based on pre-determined codes:positive,negative,inconclusive,or untested ***:Evidence emerged for 9 policy areas that had a direct or indirect effect on PA within the school *** were whole school PA policy,physical education,sport/extracurricular PA,classroom-based PA,active breaks/recess,physical environment,shared use agreements,active school transport,and *** bulk of the evidence was significantly positive(54%),27%was inconclusive,9%was significantly negative,and 11%was untested(due to rounding,some numbers add to 99%or 101%).Frequency of evidence was highest in the primary setting(41%),34%in the secondary setting,and 24%in primary/secondary combined school *** policy area,frequency of evidence was highest for sport/extracurricular PA(35%),17%for physical education,and 12%for whole school PA policy,with evidence for shared use agreements between schools and local communities rarely reported(2%).Comparing relative strength of evidence,the evidence for shared use agreements,though sparse,was 100%positive,while 60%of the evidence for w

关键词： Evaluation Physical activity Policy School Systematic review

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Clinical Significance of Plasma Levels of Soluble Cd40 in Patients with Chronic Lymphocytic Leukemia

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Open Journal of Blood diseases 2013年第1期3卷 1-5页

作者： Barry d. Hock liam J. Fernyhough Sheryl M. Gough Judith L. McKenzie Cancer Genetics Research Group University of Otago Christchurch New Zealand. Haematology Research Group Christchurch Hospital Christchurch New Zealand Pathology department University of Otago Christchurch New Zealand

Cd40 ligation provides signals central to chronic lymphocytic leukemia (CLL) cell survival and proliferation. The release of soluble Cd40 (sCd40) may impact on both these signals and Cd40 targeted therapies. In this study we investigated the prognostic significance of plasma sCd40 inuntreated CLL patients (n = 34). We report that 56% had levels higher than those of normal donors and that elevated levels were associated with significantly shorter treatment free (TFS) and overall survival. In bivariate analysis sCd40 remained a significant marker of TFS independent of Binet staging, Cd38 positivity and lymphocyte count. RT-PCR analysis demonstrated that CLL cells expressed transcripts encoding putative sCd40. These results suggest sCd40 may play a role in CLL progression and that its function, prognostic significance and potential impact on antibody based therapies should be further investigated.

关键词： Cd40 Chronic Lymphocytic Leukemia Survival

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动力有效应力分析述评

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世界地震工程 1980年第2期 36-44页

作者： W.d.liam Finn 王余庆冶研院

一、前言有效应力控制变形是土力学中早已有的基本原理之一,而且在静力问题中已广泛应用有效应力的稳定分析法。可是,由于缺乏予测循环荷载或地震荷载作用下孔

关键词：有效应力分析体积应变塑性变形地震荷载范性变形地震力孔隙水压力孔隙水压循环荷载试验屈服面体积变化屈服轨迹

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Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse

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Protein & Cell 2020年第8期11卷 613-617页

作者： Marcelo Monteiro Pedroso david W.Waite Okke Melse liam Wilson Natasa Mitic Ross P.McGeary Iris Antes Luke W.Guddat Philip Hugenholtz Gerhard Schenk School of Chemistry and Molecular Biosciences The University of QueenslandSt.LuciaQLDBrisbane 4072Australia Australian Centre for Ecogenomics The University of QueenslandSt.LuciaQLDBrisbane 4072Australia Center for Integrated Protein Science Munich at the TUM School of Life Sciences Technische Universit(a)t München85354 FreisingGermany department of Chemistry Maynooth UniversityMaynoothCo.KildareIreland

dear Editor, Antibiotic resistance has emerged as a major threat to global health;multi-drug resistant bacteria already kill more patients in the United States each year than HIV/AIdS, Parkinson's disease, emphysema and homicide combined (Laxminarayan et al., 2013).Among the most effective bacterial resistance mechanisms are β-lactamases, a family of enzymes that are divided into four distinct *** A, C and d (serine-β-lactamases, SBLs) use a catalytic site serine residue to initiate inactivation of the antibiotic, while Class B (metallo-β-lactamases, MBLs) relies on a Zn2+-activated hydroxide (Walsh et al., 2005;Bush and Jacoby,2010;Mitic et al., 2014;Lisa et al., 2017).Clinically relevant inhibitors of Class C and d SBLs are available and in use (e.g., clavulanic acid (CA), drawz et al., 2010), but for MBLs the search for such inhibitors has remained challenging (McGeary et al., 2017).

关键词： hydroxide metallo spectrum

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1976年以来液化势研究的进展

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世界地震工程 1982年第2期 15-26页

作者： W.d.liam Finn 张敏政

引言自从1964年阿拉斯加地震和日本新泻地震地面液化造成大量的破坏以来,地震时饱和砂土的液化已成为土动力学的一个主要课题。Seed 和 Le e开展的循环三轴试验对液化作了定量的研究。受他们的研究所鼓舞,液化研究取得了迅速的发展。在... 详细信息

引言自从1964年阿拉斯加地震和日本新泻地震地面液化造成大量的破坏以来,地震时饱和砂土的液化已成为土动力学的一个主要课题。Seed 和 Le e开展的循环三轴试验对液化作了定量的研究。受他们的研究所鼓舞,液化研究取得了迅速的发展。在以后的十年中,发展了一系列新的

关键词：液化势平均粒径泥沙粒径抗液化强度非均等固结循环应力比孔压比侧限压力体积变化

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地震时地面和土构筑物的永久变形

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世界地震工程 1992年第1期8卷 63-69页

作者： W. d. liam Finn 王天颂

前言多数大地震中,地震引起的地面永久位移是造成震害的一个主要原因。据Youd报告,1964年阿拉斯加地震中约60％的震害直接由地面位移造成。基于震后对有震害与无震害建筑物的调查,Youd指出大多数建筑物能经受50～100mm的不均匀地面位移... 详细信息

前言多数大地震中,地震引起的地面永久位移是造成震害的一个主要原因。据Youd报告,1964年阿拉斯加地震中约60％的震害直接由地面位移造成。基于震后对有震害与无震害建筑物的调查,Youd指出大多数建筑物能经受50～100mm的不均匀地面位移而只产生小的震害;有少数建筑物经受得住1米多位移而无严重震害。由于地面位移而引起的结构震害,取决于位移场的特点。

关键词：地面构筑物变形地震位移

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