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Evapotranspiration of an oasis-desert transition zone in the middle stream of Heihe River, Northwest China

Journal of Arid Land 2014年第5期6卷 529-539页

作者： liwen zhao WenZhi zhao Linze Inland River Basin Research Station Chinese Ecosystem Network Research Key Laboratory of Ecohydrology of Inland River Basin Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences

As a main component in water balance, evapotranspiration is of great importance for water saving and irrigation-measure making, especially in arid or semiarid regions. Although studies of evapotranspiration have been conducted for a long time, studies concentrated on oasis-desert transition zone are very limited. On the basis of the meteorological data and other parameters（e.g. leaf area index（LAI）） of an oasis-desert transition zone in the middle stream of Heihe River from 2005 to 2011, this paper calculated both reference（ET0） and actual evapotranspiration（ETc） using FAO56 Penman-Monteith and Penman-Monteith models, respectively. In combination with pan evaporation（Ep） measured by E601 pan evaporator, four aspects were analyzed：（1） ET0 was firstly verified by Ep;（2） Characteristics of ET0 and ETc were compared, while the influencing factors were also analyzed;（3） Since meteorological data are often unavailable for estimating ET0 through FAO56 Penman-Monteith model in this region, pan evaporation coefficient（Kp） is very important when using observed Ep to predict ET0. Under this circumstance, an empirical formula of Kp was put forward for this region;（4） Crop coefficient（Kc）, an important index to reflect evapotranspiration, was also analyzed. Results show that mean annual values of ET0 and ETc were 840 and 221 mm, respectively. On the daily bases, ET0 and ETc were 2.3 and 0.6 mm/d, respectively. The annual tendency of ET0 and ETc was very similar, but their amplitude was obviously different. The differences among ET0 and ETc were mainly attributed to the different meteorological variables and leaf area index. The calculated Kc was about 0.25 and showed little variation during the growing season, indicating that available water（e.g. precipitation and irrigation） of about 221 mm/a was required to keep the water balance in this region. The results provide an comprehensive analysis of evapotranspiration for an oasis-desert transition zone in the middle stream of Heihe

关键词： evapotranspiration pan evaporation water requirement arid region oasis-desert transition zone

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High ecostoichiometric stability and accumulating SiO_(2) and NO_(3)^(-) as main physiological adaptive mechanisms for reed to adverse environments

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Research in Cold and Arid Regions 2024年第5期16卷 250-258页

作者： JianJun Kang Fan Yang DongMei Zhang liwen zhao Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Linze Inland River Basin Research StationChinese Ecosystem Research NetworkNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China Minqin National Studies Station for Desert Steppe Ecosystem Gansu Desert Control Research InstituteWuweiGansu 733000China

Previous studies have shown that nutrients accumulation played important roles in resisting to stress resistance of *** study examined the ecostoichiometric internal stability(EIS)of nutrients accumulation and,concomitantly identified the main resistant regulating substances and their contributions to stress resistance of reed(Gramineae)in arid desert ***(digging method)and soil samples(quartering method))obtained from sand dune(SD),desert steppe(DP),interdune lowland(IL),saline meadow(SM)and wetland(W)habitats were brought back to the lab for nutrients *** indicated that soil nutrients differed obviously,while reed maintained relatively stable ratios of SiO_(2):N,N:K,and P:K when the eco-environments changed in different ***,reed exhibits common adaptive characteristics by mainly accumulating large amounts of SiO_(2)(122.6–174.0 g/kg)and NO_(3)^(-)(166.1–216.6 g/kg),as well as moderate levels of soluble sugar(SS:24.0–55.0 g/kg),which are mainly stored in leaves for stress *** contribution of ions to stress resistance was 80.03%–91.15%(with SiO_(2)and NO_(3)^(-)accounting for 54.91%–63.10%),whereas the contribution of solutes was only 8.85%–19.97%(with SS contributing to 5.14%–10.91%)in different *** findings suggest that maintaining relatively high EIS,while still accumulating SiO_(2)and NO_(3)^(-)as main physiological regulators might be an effective strategy for reed to positively respond to adverse habitats,which provide a strong theoretical basis and technical reference for searching useful methods for restoration and reconstruction of the degraded ecosystems in desert oasis regions.

关键词： Adaptive strategy Desert oasis Gramineae Nutrients Stoichiometric characteristics

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Improving the mechanical properties and inhibiting strain softening behavior of the biodegradable Zn-0.06Mg alloy via ECAP plus rolling processing

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Progress in Natural Science:Materials International 2024年第1期34卷 45-55页

作者： Chengwei Ji Aibin Ma Jinghua Jiang Dan Song Huan Liu liwen zhao Xuefei Fang College of Mechanics and Materials Hohai University Suqian Institute Hohai University

The practical application of micro-alloying Zn–Mg alloys is limited due to their poor mechanical properties and evident strain softening behavior. Therefore, this paper proposed the utilization of ECAP plus rolling processing as an innovative approach to potentially address these limitations. Herein, effects of ECAP and rolling processing on the microstructures, mechanical properties and strain softening behavior were investigated. It was found that the grain refinement achieved through 1-pass ECAP and 8-pass ECAP processing differed significantly, and subsequent rolling processing can further regulate grain size and dislocation distribution. The 1-pass ECAP plus cold rolling(1p-CR), 1-pass ECAP plus hot-cold rolling(1p-HC), and 8-pass ECAP plus hot-cold rolling(8p-HC) processed alloys exhibited heterostructure characterized by fine grains encircling coarse grains. Additionally, regions with high density dislocations were uniformly distributed alongside regions with low density dislocations. This unique microstructure promoted the accumulation and interaction of dislocation during deformation, resulting in the inhibition of strain softening behavior while maintaining high strength and high elongation. Therefore, the 1p-CR, 1p-HC, and 8p-HC alloys demonstrated excellent formability and mechanical stability while meeting the required mechanical properties for implant materials, which highlight their significant potential for practical applications.

关键词： Zn–Mg alloys ECAP Rolling Mechanical properties Strain softening behavior

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Impact of soil conditions on the physiological characteristics of maize plants in an arid region, Northwest China

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Research in Cold and Arid Regions 2016年第4期8卷 334-342页

作者： liwen zhao ZhiBin He WenZhi zhao Linze Inland River Basin Research Station Chinese Ecosystem Network Research Key Laboratory of Ecohydrology of Inland River Basin Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences

Overuse of irrigation water to ensure the crop yield of maize plants has caused serious water shortage problems in the middle reach of Heihe River, China. Thus, further research on the physiological characteristics, i.e., photosynthetic rate and leaf transpiration rate, are urgently needed to develop an efficient irrigation management system. In this paper, we selected two common soil textures （sandy loam, sand） and three one-time irrigation volumes （60 mm, 20 mm, 0 mm） in order to analyze the impact of soil conditions on the physiological characteristics of maize plants. Physiological and meteorological factors, soil water content and plant growing parameters were synchronously monitored on Jun. 30, Jul. 25 and Aug. 27 of 2012. The results indicate that sandy loam is better than sand for the growth of maize plants and single irrigation may provide limited influence on the physiological characteristics. Thus, increasing irrigation times and decreasing one-time volume is suggested for an efficient irrigation system.

关键词： photosynthesis leaf transpiration water use efficiency maize plant soil water content

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TRIP13:A promising cancer immunotherapy target

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Cancer Innovation 2024年第6期3卷 1-10页

作者： Shengnan Jing Liya zhao liwen zhao Yong‐Jing Gao Tianzhen He Institute of Pain Medicine and Special Environmental Medicine Co‐innovation Center of NeuroregenerationNantong UniversityNantongJiangsuChina

The tumor microenvironment(TME)facilitates tumor development through intricate intercellular signaling,thereby supporting tumor growth and suppressing the immune *** hormone receptor interactor 13(TRIP13),an AAA+ATPase,modulates the conformation of client macromolecules,consequently influencing cellular signaling ***13 has been implicated in processes such as proliferation,invasion,migration,and metastasis during tumor *** studies have revealed that TRIP13 also plays a role in immune response suppression within the ***,inhibiting these functions of TRIP13 could potentially enhance immune responses and improve the efficacy of immune checkpoint *** review summarizes the recent research progress of TRIP13 and discusses the potential of targeting TRIP13 to improve immune‐based therapies for patients with cancer.

关键词： immune responses immune‐based therapies thyroid hormone receptor interactor 13 tumor microenvironment

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Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers

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Acta Pharmaceutica Sinica B 2019年第2期9卷 421-432页

作者： Meng Li liwen zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang Wuya College of Innovation Shenyang Pharmaceutical University School of Chinese Materia Medica Guangzhou University of Chinese Medicine Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University

Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy.

关键词： Docetaxel Nanoassemblies Mono thioether bond Linoleic acid Pharmacokinetics Antitumor efficacy

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混合动力汽车增程器转速控制技术及应用

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防爆电机 2025年第1期60卷 30-32,54页

作者：张炜龙刘旺赵利文石高峰肖伟红张恒熙湖南中车时代电驱科技有限公司湖南株洲412000

为了解决因增程器转速控制波动导致的整车抖动、NVH异响、发电效率低的问题。现设计了一种用于混合动力汽车增程器的转速控制算法,经过台架测试和整车应用表明,所述算法能有效提高混动汽车增程器转速控制性能,满足整车低油耗、强劲动力... 详细信息

为了解决因增程器转速控制波动导致的整车抖动、NVH异响、发电效率低的问题。现设计了一种用于混合动力汽车增程器的转速控制算法,经过台架测试和整车应用表明,所述算法能有效提高混动汽车增程器转速控制性能,满足整车低油耗、强劲动力、静谧平顺的驾驶体验的产品需求。

关键词：混合动力汽车增程器转速控制

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Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1526-1540页

作者： Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu Du Xian Zhang Luwei Han liwen zhao Ligong Lu Hongzhi Du Shengtao Yuan Meixiao Zhan Jiangsu Key Laboratory of Drug Screening China Pharmaceutical UniversityNanjing 210003China Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityJinan UniversityZhuhai 519000China Sanhome Pharmaceutical Co. Ltd.Nanjing 210000China School of Pharmacy Hubei University of Chinese MedicineWuhan 430065China

Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor *** 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor ***,global institutions have been working to develop mIDH2 ***1573 is a novel mIDH2 inhibitor that we independently designed and *** have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and ***,SH1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal *** could also promote the differentiation of mutant AML cell lines and granulocytes in PDX ***,it was confirmed that SH1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue ***,toxicological data showed that SH1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically *** research successfully promoted the approval of SH1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,SH1573 was effective and safe.

关键词： Acute myeloid leukaemia Tumor metabolism Mutant isocitrate dehydrogenase 2(mIDH2) mIDH2 inhibitor SH1573 2-Hydroxyglutarate Differentiation Preclinical efficacy

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苯加氢制环己烯装置能量系统集成及催化剂再生周期优化

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化工学报 2022年第12期73卷 5494-5503页

作者：赵丽文刘桂莲西安交通大学化学工程与技术学院陕西西安710049

苯选择性加氢制环己烯是工业上大规模生产环己烯的最佳方法,该反应的关键在于高活性和高选择性催化剂的选用。受各种因素影响,催化剂活性随生产系统运行时间的延长不断下降,影响反应器参数及换热网络(HEN)集成。从物料平衡和能量平衡出... 详细信息

苯选择性加氢制环己烯是工业上大规模生产环己烯的最佳方法,该反应的关键在于高活性和高选择性催化剂的选用。受各种因素影响,催化剂活性随生产系统运行时间的延长不断下降,影响反应器参数及换热网络(HEN)集成。从物料平衡和能量平衡出发,基于对温焓图的分析构建反应-换热网络耦合模型,揭示催化剂失活对能量系统集成的影响。据该模型分析苯加氢制环己烯生产过程,确定催化剂活性与反应关键参数及换热网络能耗的关系,并以催化剂活性为自变量构建反应-换热网络耦合性能图,直观反映反应转化率、反应器进/出口温度、反应器热负荷、系统能耗、系统运行时间及单位产品成本随催化剂失活的变化趋势。以单位产品平均生产成本为评价指标可以确定,Ru-Zn-B/ZrO_(2)催化剂的最佳再生活性为0.5,最佳再生周期为0.92年。再生周期优化后,单位产品平均生产成本可降低19.9%。

关键词：环己烯集成催化剂活性再生优化

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扰动换热网络负荷迁移规律及瓶颈辨识策略

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化工学报 2023年第11期74卷 4611-4621页

作者：赵丽文刘桂莲西安交通大学化学工程与技术学院陕西西安710049

对于发生源/阱参数变化的换热网络(HEN),提出一种系统的干扰响应/参数调整方法,用于平衡系统盈余热量/冷量,辨识制约能量回收的瓶颈及对应的解瓶颈策略。在拓扑结构分析基础上,枚举可行的响应对象及扰动传播路径,明确换热器的负荷转移... 详细信息

对于发生源/阱参数变化的换热网络(HEN),提出一种系统的干扰响应/参数调整方法,用于平衡系统盈余热量/冷量,辨识制约能量回收的瓶颈及对应的解瓶颈策略。在拓扑结构分析基础上,枚举可行的响应对象及扰动传播路径,明确换热器的负荷转移规律。推导了换热器热阻需求(Rreq)、面积增量(?A)、系统年度总成本(Ct)与热容流率波动系数(α)之间的关系。构建热阻需求变化趋势图和经济变化图,以成本最优为目标,选择最佳的响应对象并确定其热负荷变化值,定位响应变量调整过程中因热阻制约而产生系统用能瓶颈,确定解瓶颈所需的面积增量。该方法无须复杂模拟计算即可确定扰动状态下加热/冷却介质流量需求变化值及各换热设备面积需增量,可以有效指导生产工艺的设计、优化和改造。以苯烷基化生产过程为例展示该方法的应用,当α位于[0.75,0.88]和[0.88,1.35]时,两台加热器分别是最优的响应对象,最大节省年度总成本19400 USD·a^(-1)和24024 USD·a^(-1)。

关键词：换热网络扰动负荷迁移瓶颈解瓶颈

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