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Metamorphopsia after surgery for rhegmatogenous retinal detachment

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 168-177页

作者： Han-Tao Zhou zhong lin National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

Improvements in surgical techniques have led to 90% success in the surgical repair of rhegmatogenous retinal detachment(RRD).However,anatomical reattachment of the retina does not ensure complete recovery of visual *** incidence of metamorphopsia remains the most common postoperative complaint,from 24% to 88.6%.Currently,the risk factors of metamorphopsia are categorized into macular involvement,retinal shift,outer retinal folds,subretinal fluid,secondary epiretinal membrane,outer retinal layer damage,and surgical *** associations of metamorphopsia with postoperative best-corrected visual acuity and postoperative vision-related quality of life were still *** most popular methods for assessment of metamorphopsia remain the Amsler grid and *** treatments cannot progress beyond the management of negative visual sensations,through methods such as occlusion therapy and aniseikonia-correcting *** main treatment approach involves RRD prevention and the management of risk factors that can lead to postoperative metamorphopsia after RRD *** research concerning metamorphopsia treatment,further upgrades of auxiliary inspection methods,and more accurate microstructural assessments are needed to address this common complication.

关键词： retinal detachment rhegmatogenous retinal detachment metamorphopsia visual distortion

Low-concentration atropine(0.01%)on quantitative contrast sensitivity function in Chinese children with myopia

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 117-124页

作者： Yu-Hao Ye Yi-Yong Xian Fang Liu zhong-lin Lyu Xing-Tao Zhou Jing Zhao Department of Ophthalmology and Optometry Eye&ENT Hospital of Fudan UniversityShanghai 200031China NHC Key Laboratory of Myopia(Fudan University) Key Laboratory of MyopiaChinese Academy of Medical SciencesShanghai 200000China Shanghai Research Center of Ophthalmology and Optometry Shanghai 200000China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000).Shanghai 200030 China Division of Arts and Sciences NYU ShanghaiShanghai 200000China Center for Neural Science and Department of Psychology New York UniversityNew York 10012USA NYU-ECNU Institute of Brain and Cognitive Science NYU ShanghaiShanghai 200000China

AIM:To investigate the effect of 0.01%low-concentration atropine(LA)on quantitative contrast sensitivity function(qCSF)in children with ***:This paired case-control study included 90 eyes of 58 children who were sex-,age-,and refractionmatched and equally divided into two groups:the 0.01%LA group had undergone 6mo use of daily 0.01%atropine and control group was naïve to *** ophthalmic examinations and qCSF test without refractive correction were *** groups were compared in monocular and binocular qCSF parameters,including the area under logCSF,CSF acuity,and contrast sensitivity(CS)at 1.0-18.0 cycle per degree(cpd).RESULTS:In the monocular comparison,the CSF acuity of the LA group was significantly higher than that of the control group(7.58±5.51 vs 6.37±4.22 cpd,Plinder group,the CS at high spatial frequencies(12.0 and 18.0 cpd)were significantly higher in the LA group than in the control group(all P<0.05).In the binocular test,CSF acuity and CS at 12.0 cpd were significantly higher in the LA group than in the control group(10.95±7.00 vs 8.65±5.12 cpd;0.17±0.33 vs 0.06±0.16,respectively;both P<0.05).CONCLUSION:Use of LA may result in improved CS in children with early onset myopia.

关键词： low-concentration atropine myopia quantitative contrast sensitivity function Chinese children

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN lin zhong LUJI HUANG FU CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CAlin ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Decoding ripple formation in single-layer transition metal chalcogenide lateral heterojunctions towards novel optoelectronic properties

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Nano Research 2025年第2期18卷 443-454页

作者： Haitao Yu Mingzi Sun Xiao Wu Zhiguo Xing Jiahao Kou Shipeng Liang Bolong Huang zhong lin Wang CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong 999077China Research Centre for Carbon-Strategic Catalysis The Hong Kong Polytechnic UniversityHong Kong 999077China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332USA

For the ultrathin two-dimensional(2D)materials and lateral heterojunction,the formation of unstable but elastic ripples is commonly observed but is rarely studied,especially their correlations with different material *** fil the knowledge gap in this field,thiswork systematicallyexplores transitionmetal dichalcogenides(TMDCs)in a single component and lateral heterojunction with a series of ripple *** ripple formation energy is quantitatively classified into the initial elastic strain stage and fracture threshold stage based on Fermi-like *** structures reveal that the formation of ripples is accompanied by electron accumulations from flat surfaces to *** comparing the unilateral,decaying,and bilateral ripples in 2D lateral heterojunction,we confirm that Fermi-like distribution is still valid regardless of the shape of the ripples,where the thermodynamic and electronic properties are modulated by ripples-induced uneven *** main features of optical properties are not affected while the sensitivity to ripple-induced strains is *** importantly,the phonon properties further demonstrate the potential of ripples in promoting thermal conductivity,which are strongly correlated with the optical branch of anion *** work provides important theoretical guidance for the design and optimization of high-performance optoelectronic devices based on TMDC heterojunctions.

关键词： transition metal calcogenide lateral heterojunctions ripples optoelectronic properties two-dimensional(2D)materials

Dynamically self-adjustable liquid-liquid and self-adaptive softcontact solid-solid triboelectric nanogenerator for wave energy harvesting

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Nano Research 2025年第1期18卷 404-414页

作者： Yong Long Bingqi Zhao Jianan Niu Yuxiu Liu Wei Sha Jiangwen Wang zhong lin Wang Weiguo Hu Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Water wave energy exhibits great potential toalleviate the global energy crisis. However, harvesting andutilizing wave energy are challenging due to its irregularity,randomness, and low frequency. Triboelectric nanogenerators(TENGs) have gained significant attention for harvesting waveenergy with high efficiency. This study presents a novelellipsoidal, pendulum-like TENG integrating both liquid-liquid(L-L) and solid-solid (S-S) triboelectricity (LS-TENG). Thisinnovative design enables continuous wave energy harvestingand self-powered marine environment monitoring under variousconditions, including temperature, humidity, and light intensity. The binary immiscible liquids within the LS-TENG’s innersoft balloon create dynamic, and self-adjustable L-L contact interfaces, significantly increasing the L-L contact area andenhancing L-L contact electrification (CE). The unique self-adaptive, soft S-S contact increases the S-S contact areacompared to traditional hard point contact, better adapting to the irregular movements of waves and promoting efficient S-SCE. The LS-TENG achieves highly efficient wave energy harvesting by coupling L-L and S-S CE. Furthermore, the uniquesoft contact design protects the S-S interfaces from mechanical wear and damage during long-term work. The LS-TENG’snovel structure provides an innovative and effective way for water wave energy harvesting.

关键词： self-adaptive soft-contact solid-solid liquid-liquid self-adjustable triboelectric nanogenerator

Self-powered tactile sensor for real-time recognition of Morse code based on machine learning

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Nano Research 2025年第2期18卷 760-768页

作者： Shenxing Tan Yang Jiang Xujiang Chao Fei Liang Ripeng Li Tao Jiang Hai-Dong Yu zhong lin Wang Guangzhou Institute of Blue Energy Guangzhou 510555China Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi'an 710072China Beijing Key Laboratory of Micro-Nano Energy and Sensor Center for High-Entropy Energy and SystemsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China School of Computer Science(National Pilot Software Engineering School) Beijing University of Posts and TelecommunicationsBeijing 100876China

Developing lightweight,green,and flexible wearable electronics with high sensitivity and multifunctional sensing capabilities is of important significance in the field of outdoor sports,such as mountaineering,animal tracking and *** work proposes a silk fibroin fibers-based triboelectric nanogenerator(SF TENG)to harvest tiny energy from human fingertip tapping and act as a self-powered tactile *** SF-TENG adopts a green,efficient,and low-cost fabrication strategy,in which a breathable and electropositive silk fibroin fiber membrane and a silver conductive layer are prepared by electrostatic spinning and magnetron sputtering,and combined with a conductive cloth and a breathable tape to form a flexible sensor that can be attached to a human *** thin and soft portable TENG device,having a thickness of only 0.3 mm and a mass of 354 mg at the dimension of 4.5 cm×4.5 cm,can generate a maximum power density of 1.0 mW·m^(–2).Furthermore,the SF-TENG has excellent sensitivity of 1.767 mV·Pa^(–1) with good cyclic *** superior sensing characteristics provide new avenues for Morse code applications toward outdoor wearable autonomous *** proposed SF-TENG offers promising solutions in multi-scenario outdoor sport,human-machine interface interaction,and security systems.

关键词： flexible electronics triboelectric nanogenerator silk fibroin Morse code translation

Microdroplet splitting and mixing by portable triboelectric nanogenerator

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Nano Research 2025年第2期18卷 741-750页

作者： Qi Gao Qin Xiang Wenkai Liu Mengru Ding Wei Long Jianlong Wang Xiaojun Cheng Hengyu Li zhong lin Wang Tinghai Cheng Guangzhou Institute of Blue Energy Knowledge CityHuangpu DistrictGuangzhou 510555China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Faculty of Mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China

Theadvancementofdigital microfluidics technology has been pivotal in academic research andengineering ***,the prevailing limitation is that traditional voltage sources generate an excess of Joule heat,adversely impacting droplet ***,the power supply equipment required by digital microfluidics limits its ***,we propose a self-powered microdroplet manipulation(SMDM)via triboelectric nanogenerator(TENG),which presents a capability for spliting and mixing different kinds of ***,SMDM is based on the electroosmotic flow principle,thereby enabling droplet spliting in the range of from 2 to 630μ***,for droplet spliting in the range of from 5 to 60μL,the TENG only requires a power output ranging from 2.704 to 6.084 *** addition,SMDM demonstrates proficiency in droplet mixing,which achieves complete mixing of 10μL droplets in 60 s and 30μL droplets in a mere 53 ***,leveraging the strengths of the TENG,a self-powered microdroplet manipulated system is designed for digital *** carries significant advantages over the traditional voltage source,including self-powered,low-Joule heat,increased safety and enhanced *** research provides a new solution for portable applications of digital microfluidics.

关键词： triboelectric nanogenerator microdroplet manipulation digital microfluidics droplet splitting droplet mixing

REVIEW OF SOME RESEARCHES ON NANO-AND SUBMICRON BROWNIAN PARTICLE-LADEN TURBULENT FLOW

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Journal of Hydrodynamics 2012年第6期24卷 801-808页

作者： lin Jian-zhong HUANG Li-zhong China Jiliang University Department of Mechanics Zhejiang University

The study of nano- and submicron Brownian particle-laden turbulent flow has wide industrial applicability and hence has received much attention. The purpose of the present paper is to provide and review some researches in this field. The topics are related to the universality, particularity, complexity and importance of nano- and submicron Brownian particle-laden turbulent flow, the models of particle general dynamical equation, the collision behavior of particles. Finally, several open research issues are identified.

关键词： particle-laden flow nano-particle submicron particle Brownian turbulence

Mixed Rescaling Model and Direct Photon Production

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Chinese Physics Letters 1996年第3期13卷 165-167页

作者： lin zhong-jin Department of Physics Xiamen UniversityXiamen 361005 CCAST(World Loboratory) P.O.Box 8730Beijing 100080

Using the mixed rescaling model,the main features of the European Muon Collaboration eifec t can be *** the ratio of cross sections,free proton(p)-bound nucleon of Iron(Fe)to free proton-free proton,for large-P_(T) di... 详细信息

关键词： scaling explained free