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Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st international Symposium on Microsomes and Drug Oxidations(MDO)

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Acta Pharmaceutica Sinica B 2017年第2期7卷 241-248页

作者： Ai-Ming Yu Magnus ingelman-Sundberg Nathan j.Cherrington Lauren M.Aleksunes ulrich M.Zanger Wen Xie Hyunyoung jeong Edward M.Morgan Peter j.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David j.Waxman li Wang Xiao-bo Zhong Department of Biochemistry and Molecular Medicine School of MedicineUniversity of California at Davis Department of Physiology and Pharmacology Karolinska Institutet Department of Pharmaceutical Sciences College of PharmacyUniversity of Arizona Department of Pharmacology and Toxicology School of PharmacyRutgers University Dr. Margarete Fischer-Bosch-institute of Clinical Pharmacology Eberhard Karls university Center of Pharmacogenomics and Department of Pharmaceutical Sciences School of PharmacyUniversity of Pittsburgh Department of Pharmacy Practice School of PharmacyUniversity of Illinois at Chicago Department of Pharmacology School of MedicineEmory University Department of Microbiology and immunology and the George William Hooper Research Foundation University of California at San Francisco Department of Environmental and Occupational Health Sciences University of Washington Department of Chemistry University of North Carolina at Chapel Hill Department of Biology and Bioinformatics Program Boston University Department of Physiology and Neurobiology University of Connecticut Department of Pharmaceutical Sciences School of PharmacyUniversity of Connecticut

Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision *** the 21 st international Symposium on Microsomes and Drug Oxidations held in Davis,California,uSA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug *** drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were *** addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were *** findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.

关键词： Drug metabolism and toxicity Genetics Epigenetics Gut microbiota Long non-coding RNAs Disease Personalized medication

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通道高度对翼型翅片印刷电路板换热器流动传热性能的影响

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动力工程学报 2024年第6期44卷 837-843,871页

作者：李德波靳万龙陈兆立陈智豪宋景慧雷贤良邓磊车得福南方电网电力科技股份有限公司广州510080 西安交通大学动力工程多相流国家重点实验室西安710049

基于通道几何尺寸对印刷电路板换热器(PCHE)流动与传热特性的影响,采用数值方法研究了通道高度对翼型翅片PCHE流动传热性能的影响。结果表明:通道高度显著影响PCHE的紧凑性、阻力与传热性能;在相同雷诺数条件下(R_(e)=6000~14000),随着... 详细信息

基于通道几何尺寸对印刷电路板换热器(PCHE)流动与传热特性的影响,采用数值方法研究了通道高度对翼型翅片PCHE流动传热性能的影响。结果表明:通道高度显著影响PCHE的紧凑性、阻力与传热性能;在相同雷诺数条件下(R_(e)=6000~14000),随着通道高度H的减小(通道高度与横向节距之比H/S_(T)=0.12~0.60),范宁摩擦因子f先降低后升高,H/S T=0.24翼型翅片通道的f最低;H/S_(T)=0.24~0.60翼型翅片通道的柯尔本-j因子j几乎相同,H/S_(T)=0.12翼型翅片通道的j有所增加;j/f适合于评价不同高度翼型翅片通道的综合性能,以j/f作为综合性能评价指标时,H/S_(T)=0.24翼型翅片通道的综合性能最佳。

关键词：印刷电路板换热器通道高度翼型翅片流动传热性能综合性能评价指标

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Probing star formation and feedback using CCOSMA and archival data in the CFG028.68–0.28 quasi-sinusoidal filament

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Research in Astronomy and Astrophysics 2019年第12期19卷 305-317页

作者： jin-Long Xu jirgen Stutzki Yuefang Wu Xin Guan jun-jie Wang M.Miller Yang Chen Sheng-li Qin jun-Zhi Wang Chang-Chun Ning Danzengluobu Tian-Lu Chen Nai-Ping Yu Chuan-Peng Zhang Xiao-Lan liu jian-Bin L Karl jacobs urs uGraf Gang Xu Nan li Guo-Yin Zhang and Qi Wu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China i.Physikalisches institut Universitat zu KolnZilpicher Str.7750937 KolnGermany Department of Astronomy Peking UniversityBeijing 100871China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan ProvinceKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Tibet university LhasaTibet 850000China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China NAOC-Tu j.i.t Center for Astrophysics Lhasa 850000China

We have performed a multi-wavelength study toward a quasi-sinusoidal filament(CFG028.68–0.28). A new large-scale ^12CO j = 3-2 map was obtained from the China-Cologne Observation for Sub Millimeter Astronomy(CCOSMA) 3m radio telescope. Based on the ATLASGAL catalog, we have identified 27 dust clumps in the filament. Through the relationship between the mass and radius of these clumps, 67% of these clumps are dense and massive enough to potentially form massive stars. The obtained CFE is ~11% in the filament. The filament has a linear mass density of ~305 M⊙pc^-1, which is smaller than its critical mass to length ratio. This suggests that the external pressure from the neighboring H Ⅱ regions may help prevent the filament from dispersing under the effects of turbulence. Comparing the energy injection from outflows and H Ⅱ regions in the filament, the ionization feedback from the H Ⅱ regions can help maintain the observed turbulence.

关键词： stars:formation stars:early-type iSM:HⅡregions iSM:individual(CFG028.68-0.28,iRDC G28.53-0.25,and N49)

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A novel trigger algorithm for wide-field-of-view imaging atmospheric Cherenkov technique experiments

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Nuclear Science and Techniques 2022年第3期33卷 22-28页

作者： Guang-Guang Xin Hao Cai Yi-Qing Guo Tian-Lu Chen Cheng liu Xiang-li Qian School of Physics and Technology Wuhan UniversityWuhan 430072China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China School of intelligent Engineering Shandong Management UniversityJinan 250357China

The high-altitude detection of astronomical radiation(HADAR)experiment is a new Cherenkov observation technique with a wide field of view(FoV),aimed at observing the prompt emissions ofγ-ray bursts(GRBs).The bottleneck for this type of experiment can be found in determining how to reject the high rate of nightsky background(NSB)noise from random *** this work,we propose a novel method for rejecting noise,which considers the spatial properties of GRBs and the temporal characteristics of Cherenkov *** space coordinates,the map between the celestial sphere and the fired photomultiplier tubes(PMTs)on the telescope's camera can be expressed as f(δ(i,j))=δ'(i',j'),which means that a limited number of PMTs is selected from one *** the temporal scale,a 20-ns time window was selected based on the knowledge of Cherenkov *** allowed integration of the NSB for a short time ***,the angular resolution and effective area at 100 GeV in the HADAR experiment were obtained as 0.2°and 10^(4)m^(2),*** method can be applied to all wide-FoV experiments.

关键词： iACTs Wide field of view(FoV) γ-ray burst Cherenkov radiation

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The exhumation history of collision-related mineralizing systems in Tibet:insights from thermal studies of the Sharang and Yaguila deposits,central Lhasa

The exhumation history of collision-related mineralizing sys...

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中国科学院地质与地球物理研究所2015年度（第15届）学术年会

作者： junxing Zhao Kezhang Qin Guangming li Mingjian Cao Noreen j.Evans Brent i.A.Mc innes jinxiang li Bo Xiao Lei Chen Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Sciences john De Laeter Center for isotope Research Department of Applied Geology/Applied PhysicsCurtin University Key Laboratory of Continental Collision and Plateau uplift Institute of Qinghai–Tibetan Plateau ResearchChinese Academy of Sciences MRL Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences

The large,newly discovered Sharang porphyry Mo deposit and nearby Yaguila skarn Pb–Zn–Ag(–Mo) deposit reside in the central Lhasa terrane,northern Gangdese metallogenic belt,*** mineral chronometers(zircon u–Pb,sericiteAr–Ar,and zircon and apatite(u–Th)/He) reveal that ore-forming porphyritic intrusions experienced rapid cooling(N 100 °C/Ma) during a monotonic magmatic–hydrothermal *** magmatic–hydrothermal ore-forming event at Sharang lasted .0 Myr(.8 Myr for cooling from N 900 to 350 °C and .0 Myr for cooling from 350 to 200 °C) whereas cooling was more prolonged during ore formation at Yaguila(.8 Myr from N 900 to500 °C and a maximum of 6 Myr from N 900 to 350 °C).All porphyritic intrusions in the ore district experienced exhumation at a rate of 0.07–0.09 mm/yr(apatite He ages between 7 and 30 Ma).Combined with previous studies,this work implies that uplift of the eastern section of the Lhasa terrane expanded from central Lhasa(37–30 Ma)to southern Lhasa(15–12 Ma) at an increasing exhumation *** available geochronologic data reveal that magmatic–hydrothermal–exhumation activities in the Sharang–Yaguila ore district occurred within four periods of magmatism with related *** porphyry-type Mo mineralization was associated with Late Cretaceous–Eocene felsic porphyritic intrusions in the central Lhasa terrane,resulting from Neotethyan oceanic subduction and india–Asia continental collision.

关键词： Zircon u–Pb Sericite40Ar–39Ar Zircon and apatite(u–Th)/He Magmatic–hydrothermal Thermal history Sharang porphyry Mo deposit Yaguila skarn Pb–Zn–Ag(–Mo) deposit Tibet

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The angular distributions of elastic scattering of^12,13C+Zr

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Chinese Physics C 2020年第10期44卷 74-86页

作者： Cui-Hua Rong Gao-Long Zhang lin Gan Zhi-Hong li L.C.Brandao E.N.Cardozo M.R.Cortes Yun-ju li jun Su Sheng-Quan Yan Sheng Zeng Gang lian Bing Guo You-Bao Wang Wei-Ping liu j.Lubian School of Physics Beihang UniversityBeijing 100191China Beijing Advanced innovation Center for Big Data-Based Precision Medicine School of Medicine and EngineeringBeihang Universityand Key Laboratory of Big Data-Based Precision Medicine(Beihang University)Ministry of Industry and Information TechnologyBeijing 100191China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China China institute of Atomic Energy Beijing 102413China instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil instituto de Física Universidade de São PauloBrazil

To obtain the neutron spectroscopic ampli.udes for 90-96Zx overlaps experimental data of elastic scatter-ing with small experimental errors and precise optical potentals were anary exin othe hiohpyecision o3D magneticangular distributions of^12,^13C+^AZr(A=90,91,92,94,96)were measured using the high-precision Q3D magnetic spectrometer in the Tandem *** Sao Paulo potential was used for the optical *** optical mod-el and coupled channel calculations were compared with the experimental *** theoretical results were found tobe very close to the experimental *** addition,the possible effects of the couplings to the inelastic channels of the^AZr targets and 12,13^C projectiles on the elastic scattering were *** was observed that the couplings to the in-elastic channels of the^12,^13C projectiles could improve the agreement with the experimental data,while the inelasticcouplings to the target states are of minor *** effect of the one-neutron stripping in the^13C+^AZr elasticscattering was also *** one-neutron stripping channel in^13C+^AZr was found to be not relevant and did notaffect the elastic scattering angular *** results also show that in the reactions with the considered zir-conium isotopes,the presence of the extra neutron in^13C does not influence the reaction mechanism,which is gov-erned by the collective excitation of the^12C core.

关键词： elastic scattering optical model coupled channel

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Optical polarization characteristics for AlGaN-based light-emitting diodes with AlGaN multilayer structure as well layer

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Chinese Physics B 2021年第4期30卷 535-541页

作者： Lu Xue Yi li Mei Ge Mei-Yu Wang You-Hua Zhu School of information Science and Technology&Tongke School of Microelectronics Nantong UniversityNantong 226019China

The optical properties of AlGaN-based quantum well(QW)structure with two coupled thin well layers are investigated by the six-by-six K-P *** with the conventional structure,the new structure,especially the one with lower Al-content in the barrier layer,can enhance the TE-/TM-polarized total spontaneous emission rate due to the strong quantum confinement and wide recombination *** the conventional QW structure,the reduction of well thickness can lead the degree of polarization(DOP)to decrease and the internal quantum efficiency(iQE)to *** using the coupled thin well layers,the DOP for the structure with high Al-content in the barrier layer can be improved,while the DOP will further decrease with low Al-content in the barrier *** can be attributed to the band adjustment induced by the combination of barrier height and well layer *** iQE can also be further enhanced to 14.8%-20.5%for various Al-content of barrier layer at j=100 A/cm^(2).in addition,the efficiency droop effect can be expected to be suppressed compared with the conventional structure.

关键词： Al Ga N-based quantum well K-P method internal quantum efficiency degree of polarization

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The FAST Galactic Plane Pulsar Snapshot survey:*** design and pulsar discoveries

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Research in Astronomy and Astrophysics 2021年第5期21卷 5-42页

作者： j.L.Han Chen Wang P.F.Wang Tao Wang D.j.Zhou jing-Hai Sun Yi Yan Wei-Qi Su Wei-Cong jing Xue Chen X.Y.Gao li-Gang Hou jun Xu K.j.Lee Na Wang Peng jiang Ren-Xin Xu jun Yan Heng-Qian Gan Xin Guan Wen-jun Huang jin-Chen jiang Hui li Yun-Peng Men Chun Sun Bo-jun Wang H.G.Wang Shuang-Qiang Wang jin-Tao Xie Heng Xu Rui Yao Xiao-Peng You D.j.Yu jian-Ping Yuan Rai Yuen Chun-Feng Zhang Yan Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST NAOCChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China Kavli institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy Peking UniversityBeijing 100871China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Department of Astronomy Guangzhou UniversityGuangzhou 510006China School of Physical Science and Technology Southwest UniversityChongqing 400715China

Discovery of pulsars is one of the main goals for large radio *** Five-hundredmeter Aperture Spherical radio Telescope(FAST),that incorporates an L-band 19-beam receiver with a system temperature of about 20 K,is the most sensitive radio telescope utilized for discovering *** designed the snapshot observation mode for a FAST key science project,the Galactic Plane Pulsar Snapshot(GPPS)survey,in which every four nearby pointings can observe a cover of a sky patch of 0.1575 square degrees through beam-switching of the L-band 19-beam *** integration time for each pointing is 300 seconds so that the GPPS observations for a cover can be made in 21 *** goal of the GPPS survey is to discover pulsars within the Galactic latitude of±10∘from the Galactic plane,and the highest priority is given to the inner Galaxy within±5∘.up to now,the GPPS survey has discovered 201 pulsars,including currently the faintest pulsars which cannot be detected by other telescopes,pulsars with extremely high dispersion measures(DMs)which challenge the currently widely used models for the Galactic electron density distribution,pulsars coincident with supernova remnants,40 millisecond pulsars,16 binary pulsars,some nulling and mode-changing pulsars and rotating radio transients(RRATs).The follow-up observations for confirmation of new pulsars have polarization-signals recorded for polarization profiles of the ***-detection of previously known pulsars in the survey data also leads to significant improvements in parameters for 64 *** GPPS survey discoveries are published and will be updated at http://***/GPPS/.

关键词： pulsars:general

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Hamiltonicity in 2-Connected Claw-Free Graphs

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新疆大学学报(自然科学版)(中英文) 1996年第3期 22-32页

作者： li Mingchu (Department of Mathematics, Wayne State university, Detroit,Mi 48202 u.S.A)

Ｈａｍｉｌｔｏｎｉｃｉｔｙｉｎ２－ＣｏｎｎｅｃｔｅｄＣｌａｗ－ＦｒｅｅＧｒａｐｈｓ￥ＬｉＭｉｎｇｃｈｕ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓ，ＷａｙｎｅＳｔａｔｅＵｎｉｖｅｒｓｉｔｙ，Ｄｅｔｒｏｉｔ，ＭＩ４... 详细信息

Ｈａｍｉｌｔｏｎｉｃｉｔｙｉｎ２－ＣｏｎｎｅｃｔｅｄＣｌａｗ－ＦｒｅｅＧｒａｐｈｓ￥ＬｉＭｉｎｇｃｈｕ（ＤｅｐａｒｔｍｅｎｔｏｆＭａｔｈｅｍａｔｉｃｓ，ＷａｙｎｅＳｔａｔｅＵｎｉｖｅｒｓｉｔｙ，Ｄｅｔｒｏｉｔ，ＭＩ４８２０２Ｕ．Ｓ．Ａ）Ａｂｓｔｒａｃ...

关键词： connected claw-free cycle of length

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人口结构空间特性的ESDA分析——基于山东省的实证研究

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青岛大学学报（自然科学版） 2018年第1期31卷 142-149页

作者：刘璐逯进青岛大学经济学院青岛266061

通过构建山东省2003~2014年17市人口结构综合指数,讨论了山东省人口结构空间分布模式及其内在机理。研究结果显示,总体上山东省人口结构全域自相关特性不显著,其空间分布趋向于离散、随机的分布模式;而局域空间自相关分析却表现出人口... 详细信息

通过构建山东省2003~2014年17市人口结构综合指数,讨论了山东省人口结构空间分布模式及其内在机理。研究结果显示,总体上山东省人口结构全域自相关特性不显著,其空间分布趋向于离散、随机的分布模式;而局域空间自相关分析却表现出人口结构空间分布的异质性特点,其中以济青都市圈所辖城市为主的核心地带大都显示为负的空间自相关性,而外围地带大都显示出正的空间自相关性。这提示核心地带对其他地区的正向溢出效应并未完全发挥,而外围地带低值与低值的集聚现象未得到根本性的改变,人口转型面临困境。

关键词：人口结构空间特征 ESDA

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