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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen li.Leilei li.ng Baoshan Zhang yi.Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse appli.ation scenarios is increasingly demanded,which faces significant challenges due to confli.ting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices reali.e a near-perfect stealth capabili.y in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it deli.ers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformabili.y,self-cleaning capabili.y(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its appli.abili.y and durabili.y in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Mali.ious Document Detection Based on GGE Visuali.ation

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Computers, Materials & Continua 2025年第1期82卷 1233-1254页

作者： Youhe Wang yi.Sun Yujie li.Chuanqi Zhou Henan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

With the development of anti-virus technology,mali.ious documents have gradually become the main pathway of Advanced Persistent Threat(APT)attacks,therefore,the development of effective mali.ious document classifiers has become particularly ***,detection methods based on document structure and behavioral features encounter challenges in feature engineering,these methods not only have li.ited accuracy,but also consume large resources,and usually can only detect documents in specific formats,which lacks versatili.y and *** address such problems,this paper proposes a novel mali.ious document detection method-visuali.ing documents as GGE images(Grayscale,Grayscale matrix,Entropy).The GGE method visuali.es the original byte sequence of the mali.ious document as a grayscale image,the information entropy sequence of the document as an entropy image,and at the same time,the grayscale level co-occurrence matrix and the texture and spatial information stored in it are converted into grayscale matrix image,and fuses the three types of images to get the GGE color *** Convolutional Block Attention Module-EfficientNet-B0(CBAM-EfficientNet-B0)model is then used for classification,combining transfer learning and applyi.g the pre-trained model on the ImageNet dataset to the feature extraction process of GGE *** shown in the experimental results,the GGE method has superior performance compared with other methods,which is suitable for detecting mali.ious documents in different formats,and achieves an accuracy of 99.44%and 97.39%on Portable Document Format(PDF)and office datasets,respectively,and consumes less time during the detection process,which can be effectively appli.d to the task of detecting mali.ious documents in real-time.

关键词： Mali.ious document visuali.ation EfficientNet-B0 convolutional block attention module GGE image

Small extracellular vesicles derived from cerebral endotheli.l cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： yi.Zhang Zhongwu li. Michael Chopp Michael Millman Yanfeng li.Pasquale Cepparulo Amy Kemper Chao li.li.Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeli.g is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endotheli.l cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carryi.g reduced miR-27a aboli.hed 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially locali.ed to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internali.ation of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeli.g cerebral endotheli.l cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Longitudinal assessment of peripheral organ metaboli.m and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli.li.Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi.Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Cli.ical Research Center for Metaboli. Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metaboli. dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metaboli.m,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metaboli.m and the gut microbiota in amyloid precursor protein-presenili. 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metaboli. disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metaboli.m in APP/PS1 *** findings suggest that alterations in peripheral organ metaboli.m and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis li.er-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metaboli.m spleen-brain axis

PI3K/AKT signali.g and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong li. Xiaoli. li.Xiaowei Zhou Wei Chen Aidong Wen Minna li. yi.Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signali.g pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signali.g pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signali.g pathways in ischemic stroke,with a focus on the PI3K/AKT signali.g *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signali.g pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endotheli.l NOS signali.g pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signali.g pathway,providing new possibili.ies for the treatment and rehabili.ation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signali.g pathway and their cli.ical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidyli.ositol 3-kinase protein kinase B therapeutics

Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng li.Chunyan Chen Zhenyang li.Peng yi.Haihan Zou Gao Deng Ming Fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang li. School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibili.y and variable resistance has promising appli.ations in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change ampli.ude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probabili.y and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic li.uid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of li.uid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam li.uid metal Electromagnetic interference shielding

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi.Wang Yuning li.Yakun Gu Wei Ma Yuyi.g Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia li. Department of Cli.ical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlyi.g cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density li.oprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted li.id metaboli.m 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density li.oprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Appli.ation of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo Sun Huijun Wang yi.Zheng Siyu Zhou Huixin li.Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are appli.d to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple li.ear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： yi.gjie Zhao yi.heng Sun Chaoxin Pei Xing yi. Xinyi.li.yi.Hao Mengru Zhang Meng Yuan Jingli. Zhou Yu Chen Yanli. Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabili.yhinders further ***,all-inorganic perovskites possessexcellent thermal stabili.y,but black-phase all-inorganic perovskite filmusually requires high-temperature anneali.g steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yi.lding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fideli.y imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian li.Wen yi.XiangHui Xue Jie Zeng HaiLun Ye JianYuan Wang JinSong Chen Na li.TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studyi.g the dynamics and cli.ate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal ampli.udes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of ali.nment in tidal *** investigation includes variances and covariances of tidal ampli.udes,which demonstrate remarkable consistency across measurements from both *** finding highli.hts clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,vali.ating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides