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Microdeletion on xq27.1 in a Chinese VACTERL-li.e Family with Kidney and Anal Anomali.s

Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： li.Min ZHANG Yu Lan ZHANG Kai li.li.Ping Ping LYU Yu Han li.NG Ya Xin YU Yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-li.e association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-li.e *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-li.ked microdeletion in two li.ing affected individuals,harboring a 196–380 kb microdeletion on xq27.1,which was identified by famili.l exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-li.e cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in xq27.1 could be a possible cause of the VATER/VACTERL-li.e ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-li.ked

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DISCRETIZATION OF JUMP STOCHASTIC DIFFERENTIAL EQUATIONS IN TERMS OF MULTIPLE STOCHASTIC INTEGRALS

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Journal of Computational Mathematics 1998年第4期16卷 375-384页

作者： li. CW Wu, SC li., xq City Univ Hong Kong Dept Math Hong Kong Hong Kong Acad Sinica Inst Appl Math Beijing 100080 Peoples R China Acad Sinica Lab Management Decis & Informat Syst Beijing 100080 Peoples R China

In the Stratonovich-Taylor and Stratonovich-Taylor-Hall discretization schemes for stochastic differential equations (SDEs), there appear two types of multiple stochastic integrals respectively. The present work is to approximate these multiple stochastic integrals by converting them into systems of simple SDEs and solving the systems by lower order numerical schemes. The reli.bili.y of this approach is clarified in theory and demonstrated in numerical examples. In consequence, the results are appli.d to the strong discretization of both continuous and jump SDEs.

关键词： Brownian motion Poisson process stochastic differential equation multiple stochastic integral strong discretization

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De Novo Design and Synthesis of Four-Heli. Bundle Peptides

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Chinese Chemical Letters 1996年第9期7卷 809-811页

作者： li. xq Miao, ZW Luo, Y li. CX Tang, YQ BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

Two peptides (li.2 and li.9) designed to form four-heli. bundle were synthesized by stepwise soli. phase peptide synthesis (SPPS) using Fmoc strategy, purified by reversed phase high performance li.uid chromatography ... 详细信息

关键词： 4-HEli. BUNDLE COILED-COIL PROTEINS PREDICTION STABIli.Y MODEL

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Synthesis and Crystal Structure of (CO) 5ReSnMe 2Re(CO) 5

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Chinese Journal of Structural Chemistry 1999年第2期18卷 39-43页

作者： li. J li., H Song, xq Kai, L Yin, N Nankai Univ State Key Lab Elementoorgan Chem Tianjin 300071 Peoples R China Nankai Univ Inst Elementoorgan Chem Tianjin 300071 Peoples R China

The crystal structure of the title complex (CO) 5ReSnMe 2Re(CO) 5, (C 12 H 6O 10 Re 2Sn, M r =801.27), has been determined by single crystal X ray diffraction. The crystal is monocli.ic with space group P2 1/n (NO.14), a=10.587(2), b=12.392(2), c = 14.594(3) , β = 100.59(3)°, V = 1882(1) 3, D x = 2.828 g·cm -3 , F(000)=1432, μ =14.3759mm -1 , Z =4, and final R =0 0440 and R w =0 0483 for 1954 reflections ( I≥3σ(I )). In the complex the Sn atom is connected to two methyl groups and two Re atoms which are in sli.htly distorted tetrahedral arrangement. The Re atom is coordinated by five carbonyl li.ands and one Sn atom, forming an octahedral structure.

关键词： metal carbonyl cluster Re complex synthesis crystal structure

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New records of submarine hydrothermal activity in middle part of the Okinawa Trough

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Chinese Science Bulletin 1997年第7期42卷 574-577页

作者： Zhao, YY Zhai, SK li. RZ li. FY Gao, AG He, LJ Wang, ZG Zhu, xq Institute of Oceanology Chinese Academy of Sciences Qingdao China Institute of Geochemistry Chinese Academy of Sciences Guiyang China

THE hydrothermal activity area investigated is located at the middle of the trough (126°50′—127°30′E; 27°20′—27°50′N). Some surface sediment samples and core samples were collected, with other samples from non-hydrothermal activity area (128°20′—129°10′E; 30°30′—31°40′N) in the north of the trough for comparison. Analyses for elements and

关键词： hydrotKermal activity chemical elements the Okinawa Trough.

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Transjugular intrahepatic portosystemic shunt vs endoscopic therapy in preventing variceal rebleeding

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World Journal of Gastroenterology 2012年第48期18卷 7341-7347页

作者： Hui Xue Meng Zhang Jack xq Pang Fei Yan Ying-Chao li.li.ng-Shan Lv Jia Yuan Muna Pali.he Wei-Zhi li.Zhi-Lun Wang Department of Gastroenterology First Affiliated Hospital of Xi'an Jiaotong University Department of Gastroenterology Central Hospital of Nanyang City Faculty of Publi. Health School of MedicineXi' an Jiaotong University

AIM:To compare early use of transjugular intrahepatic portosystemic shunt(TIPS) with endoscopic treatment(ET) for the prophylaxis of recurrent variceal ***:In-patient data were collected from 190 patients between January 2007 and June 2010 who suffured from variceal *** who were older than 75 years;previously received surgical treatment or endoscopic therapy for variceal bleeding;and compli.ated with hepatic encephalopathy or hepatic cancer,were excluded from this ***-five cases lost to follow-up were also *** analysis was done in 126 eli.ible *** them,64 patients received TIPS(TIPS group) while 62 patients received endoscopic therapy(ET group).The relevant data were collected by patient review or telephone *** occurrence of rebleeding,hepatic encephalopathy or other compli.ations,survival rateand cost of treatment were compared between the two ***:During the follow-up period(median,20.7 and 18.7 mo in TIPS and ET groups,respectively),rebleeding from any source occurred in 11 patients in the TIPS group as compared with 31 patients in the ET group(Kaplan-Meier analysis and log-rank test,P = 0.000).Rebleeding rates at any time point(6 wk,1 year and 2 year) in the TIPS group were lower than in the ET group(Bonferroni correction α' = α/3).Eight patients in the TIPS group and 16 in the ET group died with the cumulative survival rates of 80.6% and 64.9%(Kaplan-Meier analysis and log-rank test c2 = 4.864,P = 0.02),*** was no significant difference between the two groups with respect to 6-wk survival rates(Bonferroni correction α' = α/3).However,significant differences were observed between the two groups in the 1-year survival rates(92% and 79%) and the 2-year survival rates(89% and 64.9%)(Bonferroni correction α' = α/3).No significant differences were observed between the two treatment groups in the occurrence of hepatic encephalopathy(12 patients in TIPS group and 5 in ET gr

关键词： Transjugular intrahepatic portosystemic shunt Portal hypertension Rebleeding Endoscopicvariceal li.ation Cyanoacrylate

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Fluoride in Tea and Its Risk Assessment

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茶叶 2013年第4期39卷 515-518页

作者： li.NN li.ng YR Zheng xq Zhejiang University Tea Research Institute

Tea plant absorbs from soil a large amount of fluorine(F) which is accumulated in leaf,resulting in elevated F concentration in *** is a controversial topic whether the fluoride in tea is associated with *** research advances in F variation of various kinds of tea,factors influencing F level in tea and the associated health risk assessment were reviewed in the present *** F level in tea increases with the maturity of the tea *** tea had a high F content because it was prepared using mature shoots and old tea leaves as raw *** low grade UK supermarket economy teas contained elevated F comparable to the Chinese brick *** F level is also affected by tea cultivar,soil condition,tea processing method and tea infusion preparation method.

关键词：健康风险评估茶叶经济氟中毒茶树品种土壤条件制备方法加工方法氟含量

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Fine mapping of the powdery mildew resistance gene Pmxq-0508 in bread wheat

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The Crop Journal 2024年第4期12卷 1176-1184页

作者： Zejun Qian Guohao Han Ningning Yu Cheng li. Ran Han Paula E.Jameson Jiaojiao Wang Ya Zhao Bei Xiao Ruishan li. Jiadong Zhang Yuli.Jin Hongjie li.Pengtao Ma Yantai Key Laboratory of Characteristic Agricultural Biological Resources Conservation and Germplasm Innovative Utili.ation College of Life SciencesYantai UniversityYantai 264005ShandongChina Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021HebeiChina Crop Research Institute Shandong Academy of Agriculture SciencesJinan 250100ShandongChina School of Biological Sciences University of CanterburyChristchurch 8140CanterburyNew Zealand The National Engineering Laboratory of Crop Molecular Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

In a wheat breeding li.e xq-0508 showing consistent resistance to powdery mildew disease,a recessive gene,designated Pmxq-0508,was identified and mapped to a distal region on chromosome arm *** three resistance-associated genes in this region,one encoding a protein kinase was selected as the primary candidate for *** closely li.ked DNA markers developed in the study could be used for marker-assisted selection for powdery-mildew resistance in breeding programs.

关键词： Wheat powdery mildew Pmxq-0508 BSR-Seq Fine mapping Marker-assisted selection

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基于聚合物膜片和光纤复合结构的局部放电声传感器

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传感器与微系统 2024年第7期43卷 92-96页

作者：李如锋杨军李春海国网雄安新区供电公司河北保定070001 武汉大学电气工程学院湖北武汉430072 石家庄科林电气股份有限公司河北石家庄050000

本文提出了一种基于聚合物膜片和单模—多模—单模光纤复合结构的用于局部放电探测的声传感器。将长度为5cm的多模光纤植入单模光纤之间作为声敏感单元。当光从单模光纤进入多模光纤时,会激发光纤内的高阶模式形成干涉,以实现声传感,并... 详细信息

本文提出了一种基于聚合物膜片和单模—多模—单模光纤复合结构的用于局部放电探测的声传感器。将长度为5cm的多模光纤植入单模光纤之间作为声敏感单元。当光从单模光纤进入多模光纤时,会激发光纤内的高阶模式形成干涉,以实现声传感,并将该光纤串入聚合物膜片中,用于改善其灵敏度。实验结果表明:该传感器在空气中的声传感灵敏度可达-30.8 dBm(0 dBm定义为1 V/μBar)。根据IEC 60270标准分别在空气和油介质中对传感器进行了局部放电声传感测试证明了该方案的可行性。由于其结构简单、成本低廉和不受电磁干扰等优点,该传感器有望在电力设备局部放电检测等领域得到应用。

关键词：局部放电光纤传感声传感聚合物膜片

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Co-administration of interleukins 7 and 15 with DNA vaccine improves protective immunity against Toxoplasma gondii

Co-administration of interleukins 7 and 15 with DNA vaccine ...

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第五届全国人畜共患病学术研讨会

作者： Chen J li.ZY Petersen E li. WG Zhu xq State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences Ningbo University School of Medicine Department of Infectious Diseases and Cli.ical Microbiology Institute for Clinical MedicineFaculty of Health SciencesAarhus University Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou University College of Veterinary Medicine

Toxoplasma gondii is an obli.atory intracellular parasite,which can infect all warm-blooded animals including ***,including IL-15 and IL-7,play a critical role in the regulation of the homeostasis of naive and memory T ***-administration the DNA vaccine with cytokines may improve its ***-7 and IL-15 from splenic tissues of Kunming mice were cloned,and eukaryotic plasmid pVAX-IL-7-IL-15 was *** mice were

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