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Correlation between postoperative chemotherapy regimen and survival in patients with resectable gastric adenocarcinoma accompanied with vascular cancer thrombus

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1618-1628页

作者： Ze-Feng Yang Zhuan-Xia Dong Chen-Jie Dai li-zheng fu Hong-Mei Yu Yu-Sheng Wang Department of Health Statistics School of Public HealthShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Medical University Taiyuan 030001Shanxi ProvinceChina Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment Taiyuan 030001Shanxi ProvinceChina MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Oncology Digestive The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Digestive Oncology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Patients with resectable gastric adenocarcinoma accompanied by vascular cancer thrombus(RGAVCT)have a poor prognosis,with a 5-year survival rate ranging from 18.42%-53.57%.These patients need a reasonable postoperative treatment plan to improve their *** To determine the most effective postoperative chemotherapy regimen for patients with *** We retrospectively collected the clinicopathological data of 530 patients who un-derwent radical resection for gastric cancer between January 2017 and January 2022 and who were pathologically diagnosed with gastric adenocarcinoma with a choroidal cancer ***-thermore,we identified the high-risk variables that can influence the prognosis of patients with RGAVCT by asse-ssing the clinical and pathological features of the patients who met the inclusion *** also assessed the significance of survival outcomes using Mantel-Cox univariate and multivariate *** subgroups of pa-tients with stages Ⅰ,Ⅱ,and Ⅲ disease who received single-,dual-,or triple-drug regimens following surgery were analyzed using SPSS 25.0 and the ggplot2 package in R *** In all,530 eligible individuals with RGAVCT were enrolled in this *** median overall survival(OS)of patients with RGAVCT was 24 months,and the survival rates were 80.2%,62.5%,and 42.3%at 12,24,and 59 months,*** complications,tumor size,T stage,and postoperative chemotherapy were identified as independent factors that influenced OS in patients with RGAVCT according to the Cox multivariate analysis model.A Kaplan-Meier analysis revealed that chemotherapy had no effect on OS of patients with stage Ⅰ or Ⅱ RGAVCT;however,chemotherapy did have an effect on OS of stage Ⅲ *** Ⅲ patients who were treated with chemotherapy consisting of dual-or triple-agent regimens had better survival than those treated with single-agent regimens,and no significant difference was observed in the survival of patients treat

关键词： Vascular cancer embolism Postoperative chemotherapy regimen Gastric adenocarcinoma Risk factors Survival

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指向核心素养的物理实验教学策略研究——以“浮力”实验教学为例

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物理教学探讨 2024年第9期42卷 1-4,9页

作者：王艳芳李正福教育部课程教材研究所课程改革实验研究中心北京100029

物理是一门以实验为基础的自然科学课程。物理实验教学具有重要的教育价值,但也存在一些问题与挑战。物理实验教学要坚持以核心素养为导向,在实验教学设计中明确将核心素养作为重要教学目标,在实验教学实施中将核心素养作为重要学习内容... 详细信息

物理是一门以实验为基础的自然科学课程。物理实验教学具有重要的教育价值,但也存在一些问题与挑战。物理实验教学要坚持以核心素养为导向,在实验教学设计中明确将核心素养作为重要教学目标,在实验教学实施中将核心素养作为重要学习内容,在实验教学评价中将核心素养作为重要维度,推进“教-学-评”相一致的实验教学,切实提高实验教学培养核心素养的效果。

关键词：核心素养实验教学教育价值实施策略

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An Example of Embedded Singular Continuous Spectrum for Discrete Schrödinger Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1837-1849页

作者： zheng Qi fu Xiong li Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

We present an example of a potential such that the corresponding discrete Schrödinger operator has singular continuous spectrum embedded in the absolutely continuous spectrum.

关键词： Sparse potentials singular continuous spectrum Prüfer variables

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PIVAS药师参与静脉用药不良反应主动监测工作模式初探

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中国处方药 2024年第1期22卷 91-94页

作者：秦霞李正富孙帮燕昭通市第一人民医院云南昭通657000

目的探讨静脉药物配置中心(PIVAS)药师参与静脉用药不良反应(ADR)主动监测的工作模式。方法收集2021年所有使用血必净注射液(规格10 ml,天津红日药业股份有限公司)住院患者的用药数据,PIVAS药师参与临床ADR主动监测,建立PIVAS药师参与临... 详细信息

目的探讨静脉药物配置中心(PIVAS)药师参与静脉用药不良反应(ADR)主动监测的工作模式。方法收集2021年所有使用血必净注射液(规格10 ml,天津红日药业股份有限公司)住院患者的用药数据,PIVAS药师参与临床ADR主动监测,建立PIVAS药师参与临床ADR主动监测工作模式。结果收集到2021年使用血必净注射液所有住院患者共计1468例,PIVAS药师参与3例血必净注射液ADR主动监测,PIVAS药师参与临床ADR监测后明显地发现了许多隐藏的和因不合理给药引起的ADR。结论以血必净注射液为例,PIVAS药师在审核静脉用药医嘱基础上参与ADR主动监测,建立PIVAS药师参与静脉用药ADR主动监测工作模式,改变以往被动监测模式使其变为主动监测模式,提高了ADR上报率,降低了医师漏报率,也提高了ADR上报质量,可促进医院ADR监测工作的高效开展。

关键词： PIVAS药师血必净注射液 ADR主动监测工作模式

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地震前兆仪器自动实时监测软件的设计与实现

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内陆地震 2024年第1期38卷 100-104页

作者：白亚东周亚刘哲郑立夫张家口地震监测中心站河北张家口075000 唐山地震监测中心站河北唐山063000 北京市地震局北京100080

为解决台站不同仪器的全自动实时监测和观测资料汇总的问题,设计并开发了一款地震前兆仪器自动实时监测软件-SMS地震仪器运行监测报警系统。基于MATLAB语言对数据处理的优势,结合FTP传输协议和GUI图形界面技术,采用面向对象的模块化程... 详细信息

为解决台站不同仪器的全自动实时监测和观测资料汇总的问题,设计并开发了一款地震前兆仪器自动实时监测软件-SMS地震仪器运行监测报警系统。基于MATLAB语言对数据处理的优势,结合FTP传输协议和GUI图形界面技术,采用面向对象的模块化程序设计方法,实现对观测仪器运行状态及阈值报警、数据备份另存、实时绘图显示等功能。同时该软件操作设置简单,可移植性高,交互性良好,已经在张家口附近多个地震台站得到了成功应用。

关键词：地震前兆仪器实时监测 MATLAB语言

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Exploring Trade-offs in Thermal Interface Materials:The Impact of Polymer-Filler Interfaces on Thermal Conductivity and Thixotropy

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Chinese Journal of Polymer Science 2024年第7期42卷 916-925,I0006页

作者： Bin Zhang zheng-li Dou Yong-zheng Zhang Qiang fu Kai Wu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

Effective thermal transport across solid-solid interfaces which is essential in thermal interface materials(TIMs),necessitates both optimal thixotropy and high thermal *** role of filler surface modification,a fundamental aspect of TIM fabrication,in the influence of these properties is not fully *** study employs the use of a silane coupling agent(SCA)to modify alumina,integrating experimental approaches with molecular dynamics simulations,to elucidate the interface effects on thixotropy and thermal conductivity in polydimethylsiloxane(PDMS)-based *** findings reveal that the variations of SCAs modify both interface binding energy and transition layer *** interface binding energy restricts macromolecular segmental relaxation near the interface,hindering desirable thixotropy and bond line *** the contrary,the thickness of the transition layer at the interface positively influences thermal conductivity,facilitating the transport of phonons between the polymer and ***,selecting an optimal SCA allows a balance between traditionally conflicting goals of high thermal conductivity and minimal bond line thickness,achieving an impressively low interface thermal resistance of just 2.45-4.29 K·mm^(2)·W^(-1)at275.8 kPa.

关键词： Thermal interface material Surface modification Thermal conductivity Thixotropy Interface thermal resistance

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Impact of Local Climate Zones on the Urban Heat and Dry Islands in Beijing:Spatial Heterogeneity and Relative Contributions

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Journal of Meteorological Research 2024年第1期38卷 126-137页

作者： Zuofang zheng fu LUO Nana li Hua GAO Yuanjian YANG Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089

Based on the building height and density data on a 100-m resolution,hourly 2-m temperature and humidity data at83 automatic weather stations,and gridded local climate zone(LCZ)data on a 120-m resolution in urban Beijing in2020,this study first employs the semivariogram combined with building parameters to calculate spatial correlations and has identified an LCZ grid resolution of 500 m suitable for best usage of the available observation ***,how the spatially heterogeneous LCZs affect and contribute to the canopy urban heat island intensity(UHII)and urban dry island intensity(UDII)are quantitatively *** is found that UHII is high in winter and low in summer with a unimodal diurnal variation while UDI is low in winter but high in summer with a bimodal diurnal *** LCZ with compact mid-rise(open high-rise)buildings exhibits the highest UHII(UDII),followed by the compact high-rise(compact low-rise),while the LCZ of scattered trees presents both the lowest UHII and the lowest *** most significant difference in the UHII(UDII)among the nine LCZ types in the urban area of Beijing is2.62℃(1.1 g kg^(-1)).Area-weighted averaging analysis reveals that the open mid-rise LCZ is the most significant contributor to the UHII(UDII),immediately followed by compact mid-rise(open low-rise),with the least contribution from bare rock or paved(scattered trees).The results also indicate that beyond the intrinsic physical properties of the LCZs of a city,their area proportions cannot be overlooked in evaluating their impact on the UHI and *** quantitatively findings could help urban planners to create a livable urban climate and environment by adjusting the relevant land use.

关键词： local climate zone(LCZ) urban heat island(UHI) urban dry island(UDI) distribution pattern contribution rate Beijing

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Ectomycorrhizal fungi and dark septate endophyte inoculation improve growth and tolerance of Pinus tabulaeformis under cadmium stress

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Pedosphere 2024年第2期34卷 473-483页

作者： Yong ZHOU Yanyan zheng Pengwei li lingjie XU Qiang fu College of Landscape Architecture and Tourism Hebei Agricultural UniversityBaoding 071000China

Forest trees can establish symbiotic associations with dark septate endophytes(DSEs)and ectomycorrhizal fungi(ECMF)***,the combined effects of these two fungi on the growth and cadmium(Cd)tolerance of host plants remain largely *** address this knowledge gap,a pot experiment was conducted to examine the effects of the interaction between an ECMF strain(Suillus granulatus)and a DSE strain(Pseudopyrenochaeta sp.)on Pinus tabulaeformis under Cd stress,by assessing plant growth and physiological parameters,nutrient uptake,and soil ***,the colonization rates of both fungal strains were found to increase in response to Cd stress,with the extent of this increase being influenced by the specific fungal species and the Cd level in the *** to the non-inoculation treatment,single inoculation with fungal strain resulted in enhanced biomass,root development,and nutrient contents in *** seedlings under Cd ***,a synergistic effect was observed when these seedlings were co-inoculated with *** and Pseudopyrenochaeta sp.,as indicated by significantly greater measurements in various indicators compared to both the single and non-inoculation *** inoculation effectively regulated the antioxidant defense responses and photosynthesis of *** seedlings subjected to Cd stress,particularly in the co-inoculation *** addition,fungal inoculation facilitated the Cd accumulation in ***,suggesting a promising potential for the implementation of bioremediation strategies in the areas contaminated with heavy *** findings from this study indicate that the utilization of root symbiotic fungi obtained from stress environments could potentially enhance the growth performance and tolerance of *** towards heavy metals,and co-inoculation of both fungal groups may result in even more pronounced synergistic effects on the overall fitness of the plant.

关键词： antioxidant defense response colonization rate fungal inoculation heavy metal tolerance physiological parameter root symbiotic fungi soil property

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Numerical and experimental study of the effects of wind turbine operation on sand-dust transport characteristics

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 97-113页

作者： Gaosheng Ma Hong Han Ye li Deshun li Yan Wang Ning fu Quan zheng Rennian li School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Gansu Provincial Technology Center for Wind Turbines Lanzhou 730050China Key Laboratory of Fluid Machinery and Systems Lanzhou 730050China Multiple function Towing Tank Laboratory State Key Laboratory of Ocean EngineeringSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Given factors such as reduced land availability for onshore wind farms,wind resource enrichment levels,and costs,there is a growing trend of establishing wind farms in deserts,the Gobi,and other arid ***,the relationship between sanddust weather environments and wind turbine operations has garnered significant *** investigate the impact of wind turbine wakes on sand-dust transportation,this study employs large eddy simulation to model flow fields,coupled with an actuator line model for simulating rotating blades and a multiphase particle in cell model for simulating sand *** research focuses on a horizontal axis wind turbine model and examines the motion and spatiotemporal distribution characteristics of four typical sizes of sand particles in the turbine *** findings reveal that sand particles of varying sizes exhibit a spiral settling pattern after traversing the rotating plane of wind turbine blades,influenced by blade shedding vortex and *** particles tend to cluster in the peripheries of the vortex cores of low vorticity in the wind turbine *** rotation of wind turbines generates a wake vortex structure that causes a significant clustering of sand particles at the tip *** the wake distance increases,the particles that cluster at the turbine's tip gradually spread outward to approximately twice the rotor diameter and then begin to mix with the incoming flow *** turbines have a noticeable impact on sand-dust transportation,hindering their movement to a significant *** average sand-blocking rate exhibits a trend of initially increasing and then decreasing as the wake distance *** its peak,the sand-blocking rate reaches an impressive 67.55%.The presence of wind turbines induces the advanced settling of sand particles,resulting in a“triangular”distribution of the deposition within the ground projection area of the wake.

关键词： wind turbine particle transportation actuator line model dry deposition particle clustering

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Constructing hierarchical ZSM-5 coated with small ZSM-5 crystals via oriented-attachment and in situ assembly for methanol-to-aromatics reaction

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 41-53页

作者： Ning Yang Tingjun fu Chuntao Cao Xueqing Wu Huiling zheng Zhong li State Key Laboratory of Clean and Efficient Coal Utilization College of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024China

Developing hierarchical and nanoscale ZSM-5 catalysts for diffusion-limited reactions has received ever-increasing attention. Here, ZSM-5 architecture integrated with hierarchical pores and nanoscale crystals was successfully prepared via in situ self-assembly of nanoparticles-coated silicalite-1. First, the oriented attachment of amorphous nanoparticles on external surface of silicalite-1 was achieved by controlling the alkalinity of Si-Al coating solution. The partial exposure of the external surface of silicalite-1 ensured the uniform removal of silicon in the bulk phase for the creation of hierarchical pores during the subsequent desilication-recrystallization. The uniform removal of silicon species in the bulk phase was mainly due to the synergistic effect of surface protection and alkaline etching, which could be balanced by regulating the relative amount of tetrapropylammonium cation and OH– in desilication-recrystallization solution. Importantly, the removed silicon from silicalite-1 recrystallized and in situ assembled into final ZSM-5 nanocrystals induced by surface Si-Al nanoparticles. The hierarchical pores and nanoscale crystals on this integrated architecture not only promoted the removal of coke precursors from micropores but also provided large external specific surface (91 m^(2)·g^(-1)) for coke deposition. Consequently, a much longer catalytic lifetime was achieved for methanol-to-aromatics reaction compared to conventional hollow structure ZSM-5 (84 h vs 46 h), with relatively high stability.

关键词： hierarchical ZSM-5 nanocrystal integrated architecture diffusion coke

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