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Negative Effects of Oxytetracycline on Wheat (Triticum aestivum L.) Growth, Root Activity, Photosynthesis, and Chlorophyll Contents

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Agricultural Sciences in China 2011年第10期10卷 1545-1553页

作者： li zhao-jun xie Xiao-yu ZHANG Shu-qing liANG Yong-chao Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences~Key Laboratory of Crop Nutritionand Fertilization Ministry of Agriculture Beijing 100081 P.R.China

A solution culture experiment was performed to investigate the effects of oxytetracycline （OTC） on wheat （Triticum aestivum L.） growth, chlorophyll contents, and photosynthesis at five levels of 0, 10, 20, 40, and 80 mmol L-1 OTC. OTC is toxic to wheat. The wheat growth, especially wheat root was significantly decreased. Further OTC also significantly decreased root activity, chlorophyll contents, and photosynthetic parameters except for intercellular CO2 concentrations. The different responses of indicators such as root number, root activity and so on to OTC were also observed. The IC50 values for the tested indicators to OTC ranged from 7.1 to 113.4 mmol L-1 OTC. The order of indicator sensitivity to OTC was root number stomatal conductance chlorophyll a total chlorophyll photosynthetic rates total surface area transpiration rate chlorophyll b fresh weight of root dry weight of root total length dry weight of shoot = fresh weight of shoot total volume. The root number was more sensitive than other indicators with the IC50 value of 7.1 mmol L-1 OTC, and could be taken as the sensitive indicator to predict the hazards of OTC to wheat.

关键词： OTC wheat growth root morphological characteristics chlorophyll contents photosynthesis

In-situ Enhanced Toughening of Poly（ethylene terephthalate）/elastomer Blends via Gamma-Ray Radiation at Presence of Trimethylolpropane Triacrylate

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Chinese Journal of Chemical Physics 2016年第6期29卷 703-709,I0001,I0002页

作者： li-zhao xie Le-chen Chen Mo-zhen Wang Qi-chao Wu Xiao Zhou Xue-wu Ge CASKeyLaboratoryofSoftMatterChemistry DepartmentofPolymerScienceandEngineeringUniversityofScienceandTechnologyofChinaHefei230026China GuangdongTiananNewMaterialCo. Ltd.Foshan528000China

Gamma-ray radiation has always been a convenient and effective way to modify the inter- facial properties in polymer blends. In this work, a small amount of trimethylolpropane triacrylate （TMPTA） was incorporated into poly（ethylene terephthalate）（PET）/random terpolymer elastomer （ST2000） blends by melt-blending. The existence of TMPTA would induce the crosslinking of PET and ST2000 molecular chains at high temperatures of blend- ing, resulting in the improvement in the impact strength but the loss in the tensile strength. When the PET/ST2000 blends were irradiated by gamma-ray radiation, the integrated me- chanical properties could be enhanced significantly at a high absorbed dose. The irradiated sample at a dose of 100 kGy even couldn＇t be broken under the impact test load, and at the same time, has nearly no loss of tensile strength. Based on the analysis of the impact- fractured surface morphologies of the blends, it can be concluded that gamma-ray radiation at high absorbed dose can further in situ enhance the interfacial adhesion by promoting the crosslinking reactions of TMPTA and polymer chains. As a result, the toughness and strength of PET/ST2000 blend could be dramatically improved. This work provides a facial and practical way to the fabrication of polymer blends with high toughness and strength.

关键词： Toughened PET blend Interracial interaction Gamma-ray radiation Radia- tion crosslink Trimethylolpropane triacrylate

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao zhao Xuelin Wang Hui Guo Zhenjia xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

聚合物模板微球表面电性对中空二氧化硅微球形貌的影响

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高分子学报 2017年第5期27卷 785-792页

作者：段国伟谢李昭赵驰汪谟贞葛学武中国科学院软物质化学重点实验室中国科学技术大学高分子科学与工程系合肥230026

分别以过硫酸钾和偶氮二异丁基脒盐酸盐为引发剂,以聚乙烯吡咯烷酮(PVP)为分散剂,在水中引发苯乙烯聚合制备了2种表面分别带负电性和正电性基团的聚苯乙烯(PS)模板微球.在氨水催化下,利用正硅酸乙酯的水解缩合,形成PS/SiO_2复合微球,去... 详细信息

分别以过硫酸钾和偶氮二异丁基脒盐酸盐为引发剂,以聚乙烯吡咯烷酮(PVP)为分散剂,在水中引发苯乙烯聚合制备了2种表面分别带负电性和正电性基团的聚苯乙烯(PS)模板微球.在氨水催化下,利用正硅酸乙酯的水解缩合,形成PS/SiO_2复合微球,去除模板后得到中空SiO_2微球,并对其进行FTIR、电子显微镜、TGA以及氮气吸附等分析表征.结果表明,PS模板微球表面的电性决定了OH-的分布,从而导致PS模板微球表面SiO_2壳层不同的形成机制.当以表面带负电的PS微球为模板时,可得到树莓状的中空SiO_2微球;而以表面带正电的PS微球为模板时,得到是表面光滑的,具有介孔结构的中空SiO_2微球.

关键词：中空微球二氧化硅聚苯乙烯模板微球表面电性正硅酸乙酯

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang zhao-Xian li Wei-Qi Zhang Yu-Ying Tan li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of liver Cancer Tianjin First Center HospitalTianjin 300192China Department of liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao li zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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披碱草胚和胚乳的发育

中国草地学报 2016年第6期38卷 98-101页

作者：李造哲谢菲马青枝李月强内蒙古农业大学草原与资源环境学院内蒙古呼和浩特010019 内蒙古阿拉善盟林木种苗站内蒙古巴彦浩特750306 内蒙古农业大学生命科学学院内蒙古呼和浩特010019 内蒙古包头市达茂旗林业局内蒙古014500

采用常规石蜡切片法,对披碱草(Elymus dahuricus Turcz.)胚和胚乳发育过程进行了观察。结果表明:披碱草花后6h卵细胞受精形成合子,合子休眠期长约6h。花后12h,合子进行第一次分裂。花后1d,形成了四细胞原胚,胚胎发生属紫菀型。花后第9d... 详细信息

采用常规石蜡切片法,对披碱草(Elymus dahuricus Turcz.)胚和胚乳发育过程进行了观察。结果表明:披碱草花后6h卵细胞受精形成合子,合子休眠期长约6h。花后12h,合子进行第一次分裂。花后1d,形成了四细胞原胚,胚胎发生属紫菀型。花后第9d,在梨形原胚偏上一侧出现小凹沟,器官开始分化。花后第18d时,胚的结构基本发育成熟。披碱草有异常胚发生的现象。胚乳发育早,胚发育晚,胚乳的类型属于核型胚乳。

关键词：披碱草胚胚乳发育

认知行为疗法对维持性血液透析患者抑郁、焦虑和生活质量影响的系统评价

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中国循证医学杂志 2017年第2期17卷 152-161页

作者：李红王浪赵丽谢兰添陈华更庞晓丽天津中医药大学研究生院天津300193 天津市环湖医院天津300350 天津中医药大学护理学院天津300193

目的系统评价认知行为疗法对维持性血液透析患者抑郁、焦虑和生活质量的影响。方法计算机检索Pub Med、EMbase、Cochrane Central of Registration Controlled Trials(CENTRAL,2016年8期)、Web of Science、CINAHL、Psyco INFO、CBM、CNKI和Wan Fang Data中有关认知行为疗法对维持性血液透析患者抑郁、焦虑和生活质量影响的随机对照试验(RCT),检索时限均为建库至2016年9月1日。由2名研究员独立筛选文献、提取资料、评价纳入研究的偏倚风险并进行交叉核对后,采用Rev Man 5.3软件进行Meta分析。结果共纳入14个RCT,包括1 492例患者。Meta分析结果显示,认知行为疗法在干预≥2个月时能够改善维持性血液透析患者的抑郁[SMD=–0.85,95%CI(–0.96,–0.74),P0.05)。结论认知行为疗法干预≥2个月时对改善维持性血液透析患者的抑郁、焦虑和提高生活质量具有较好的效果,但不足2个月时效果不明显。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。

关键词：认知行为疗法肾透析抑郁焦虑生活质量系统评价 Meta分析随机对照试验

Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease

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Neural Regeneration Research 2025年第3期20卷 613-631页

作者： Yanxin Shen Guimei Zhang Chunxiao Wei Panpan zhao Yongchun Wang Mingxi li li Sun Department of Neurology and Neuroscience Center The First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Cognitive Impairment Center Department of NeurologyThe First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina

Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative stress mediates excessive oxidative responses, and its involvement in Alzheimer's disease pathogenesis as a primary or secondary pathological event is widely accepted. As a member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With the discovery of ferroptosis, the central role of glutathione peroxidase 4 in anti-lipid peroxidation in several diseases, including Alzheimer's disease, has received widespread attention. Increasing evidence suggests that glutathione peroxidase 4 expression is inhibited in the Alzheimer's disease brain, resulting in oxidative stress, inflammation, ferroptosis, and apoptosis, which are closely associated with pathological damage in Alzheimer's disease. Several therapeutic approaches, such as small molecule drugs, natural plant products, and non-pharmacological treatments, ameliorate pathological damage and cognitive function in Alzheimer's disease by promoting glutathione peroxidase 4 expression and enhancing glutathione peroxidase 4 activity. Therefore, glutathione peroxidase 4 upregulation may be a promising strategy for the treatment of Alzheimer's disease. This review provides an overview of the gene structure, biological functions, and regulatory mechanisms of glutathione peroxidase 4, a discussion on the important role of glutathione peroxidase 4 in pathological events closely related to Alzheimer's disease, and a summary of the advances in small-molecule drugs, natural plant products, and non-pharmacological therapies targeting glutathione peroxidase 4 for the treatment of Alzheimer's disease. Most prior studies on this subject used animal models, and relevant clinical studies are lacking. Future clinica

关键词： apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder neuroprotection oxidative stress small-molecule drugs