检索结果-南通市图书馆

Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan Wang yun-Qing zhou li-Juan Luo Cui-Jin Wang Nan Shen Hao li Ji-Wen Wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1

Absorption characteristics,model,and molecular mechanism of hydrogen sulfide in morpholine acetate aqueous solution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第2期66卷 125-135页

作者： Hongwei Jin yun Teng Kangkang li zhou Feng Zhonghao li Shiqi Qu Hongzhi Xia Huanong Cheng Yugang li Xinshun Tan Shiqing Zheng College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

The solubility of H_(2)S was measured in solutions of N-butyl-N-methylmorpholine acetate([Bmmorp][Ac])containing 20%-40%(mass)water at experimental temperatures ranged from 298.15 to 328.15 K and pressures up to 320 k *** total solubility of H_(2)S increased with higher temperatures,lower pressures,and reduced water *** reaction equilibrium thermodynamic model was used to correlate the solubility *** results indicate that the chemical reaction equilibrium constant decrease with increasing water content and temperature,whereas Henry constant increase with increasing water content and *** with other ionic liquids,H_(2)S exhibits a higher physical absorption enthalpy and a lower chemical absorption enthalpy in[Bmmorp][Ac]aqueous *** suggests that[Bmmorp][Ac]has a strong physical affinity for H_(2)S and low energy requirement for *** chemical methods were used to investigate the molecular mechanism of H_(2)S absorption in ionic *** interaction energy analysis revealed that the binding of H_(2)S with the ionic liquid in a1:2 ratio is more *** analyses by the methods of the interaction region indicator and the atoms in molecules were conducted to the interactions between H_(2)S and the ionic liquid.

关键词： Ionic liquid Hydrogen sulfide Model Solubility Molecular mechanism

Remarkably Enhanced Methane Sensing Performance at Room Temperature via Constructing a Self-Assembled Mulberry-like ZnO/SnO2 Hierarchical Structure

在线全文

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第3期7卷 341-348页

作者： Xun li Tian Tan Wei Ji Wanling zhou Yuwen Bao Xiaohong Xia Zhangfan Zeng yun Gao Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science &EngineeringHubei University School of Artificial Intelligence Hubei University

Development of metal oxide semiconductors-based methane sensors with good response and low power consumption is one of the major challenges to realize the real-time monitoring of methane *** this work,a selfassembled mulberry-like ZnO/SnO2hierarchical structure is constructed by a two-step hydrothermal *** resultant sensor works at room temperature with excellent response of～56.1% to 2000 ppm CH4at 55%relative *** is found that the strain induced at the ZnO/SnO2interface greatly enhances the piezoelectric polarization on the ZnO surface and that the band bending results in the accumulation of chemically adsorbed O2-ions close to the interface,leading to significant improvement in the sensing performance of the methane gas sensor at room temperature.

关键词： heterojunction methane sensor oxygen vacancy piezoelectric polarization ZnO/SnO2 hierarchical structure

Universal paradigm of ternary metacomposites with tunable epsilon-negative and epsilon-near-zero response for perfect electromagnetic shielding

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 796-809页

作者： yun-Peng Qu yun-Lei zhou Yang Luo Yao liu Jun-Fei Ding Yan-li Chen Xiu Gong Jing-liang Yang Qiong Peng Xiao-Si Qi College of Physics Guizhou UniversityGuiyang550025China Hangzhou Institute of Technology Xidian UniversityHangzhou311231China Department of Materials ETH Zurich8093ZurichSwitzerland Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan250061China

CaCu_(3)Ti_(4)O_(12)(CCTO)ceramic nanocomposites incorporating graphene–carbon black(GRCB)fillers were fabricated by spark plasma sintering *** percolative effects of conductive GRCB fillers on dielectric response of GRCB/CCTO ternary metacomposites were systematically *** weakly real permittivity(ε′)-negative response(ε′~−1×10^(2))was achieved which originated from weakly low-frequency plasmonic state of free carriers within constructed GRCB *** enhancing three-dimensional GRCB network,the plasma frequency of metacomposites increased while the damping factor ***,theε′-negative values of metacomposites were tuned from−10^(2) to−10^(4) orders of magnitude andε′-near-zero(ENZ)frequencies from~142 to~340 MHz which substantially benefited from the moderate carrier concentration of GRCB dual *** Drude model and equivalent circuit models were adopted to demonstrate dielectric and electrical *** obtained metacomposites show strong EM shielding effect along with enhanced plasmonic oscillation and even better achieving perfect EM shielding effect in ENZ *** work achieves the tunableε′-negative andε′-near-zero response and more importantly clarifies its regulation mechanism in ceramic-based ternary metacomposites,which opens up the possibility of designing high-performance EM shielding materials based on metacomposites.

关键词： Metacomposites Ceramic matrix composites Negative permittivity Epsilon-near-zero Electromagnetic shielding

Quasi-shadowing for Z^(d)-actions

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第6期40卷 1563-1580页

作者： Juan PAN Xian Kun REN yun Hua zhou School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

A diffeomorphism is non-uniformly partially hyperbolic if it preserves an ergodic measure with at least one zero Lyapunov *** prove that a C^(1)-smooth Z^(d)-action has the quasishadowing property if one of the genera... 详细信息

关键词： Quasi-shadowing Z^(d)-action non-uniformly partially hyperbolic ergodic measure

Impact of Media Information on Social Response in Disasters:A Case Study of the Freezing‑Rain and Snowstorm Disasters in Southern China in 2008

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2024年第1期15卷 73-87页

作者： Jia He Wenjing Duan Yuxuan zhou yun Su College of Geographic Science and Tourism Xinjiang Normal UniversityUrumqi 830054China Xinjiang Laboratory of Lake Environment and Resources in Arid Zone Urumqi 830054China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster Ministry of EducationBeijing Normal UniversityBeijing 100875China

Disaster information content is an objective mapping of disaster situations,social response,and public *** response to emergency is an important mechanism for implementing and guaranteeing emergency management of major natural hazard-related *** how disaster information content affects social response to emergencies is helpful for managing risk communication and efficient disaster *** on the 2008 freezing-rain and snowstorm disasters in southern China,this study used Python to extract 7,857 case-related media reports and applied natural language processing for text *** used three typical cases to identify and analyze disaster media report content and the relationship between these reports and the social response to the *** categories of disaster response-such as prewarning and forecasting,announcements by the authorities,and social mobilization-appeared in the disaster information in the media,along with disaster impact information,that is,real-time disaster *** response information and an appropriate amount of disaster impact information played important roles in prewarning,disaster relief,public opinion guidance,and social stability maintenance and can serve important functions in communicating with all stakeholders of emergency management,assisting or influencing emergency departments or individuals in decision making,and eliminating "information islands." Empathy caused the general public to become "disaster responders" through receiving *** and an excess of negative information may have a perverse amplification effect on public opinion and increase the unpredictability of the disaster situation and the risk of social crisis.

关键词： Emergency management Freezing-rain and snowstorm disasters Media reports on disasters Social response to emergencies China

Dynamic Offloading and Scheduling Strategy for Telematics Tasks Based on Latency Minimization

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第8期80卷 1809-1829页

作者： Yu zhou yun Zhang Guowei li Hang Yang Wei Zhang Ting Lyu Yueqiang Xu North China Institute of Computing Technology Beijing Beijing100080China School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China

In current research on task offloading and resource scheduling in vehicular networks,vehicles are commonly assumed to maintain constant speed or relatively stationary states,and the impact of speed variations on task offloading is often *** is frequently assumed that vehicles can be accurately modeled during actual motion ***,in vehicular dynamic environments,both the tasks generated by the vehicles and the vehicles’surroundings are constantly changing,making it difficult to achieve real-time modeling for actual dynamic vehicular network *** into account the actual dynamic vehicular scenarios,this paper considers the real-time non-uniform movement of vehicles and proposes a vehicular task dynamic offloading and scheduling algorithm for single-task multi-vehicle vehicular network scenarios,attempting to solve the dynamic decision-making problem in task offloading *** optimization objective is to minimize the average task completion time,which is formulated as a multi-constrained non-linear programming *** to the mobility of vehicles,a constraint model is applied in the decision-making process to dynamically determine whether the communication range is sufficient for task offloading and ***,the proposed vehicular task dynamic offloading and scheduling algorithm based on muti-agent deep deterministic policy gradient(MADDPG)is applied to solve the optimal solution of the optimization *** results show that the algorithm proposed in this paper is able to achieve lower latency task computation ***,the average task completion time of the proposed algorithm in this paper can be improved by 7.6%compared to the performance of the MADDPG scheme and 51.1%compared to the performance of deep deterministic policy gradient(DDPG).

关键词： Component vehicular dynamic task offloading resource scheduling

Anticancer Peptide from Chinese Toad （Bufo Bufo Gargarizans） Skin Enhanced Sensitivity to 5-Fu in Hepatocarcinoma cells （HepG2）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical oncology and cancer researeh 2011年第3期8卷 149-154页

作者： Chuang-xin LU Wen-yu WANG Ning -MA Yao CUI Xiao-yan li yun zhou Oncology Department Henan People＇s Hospital of Zhengzhou University Zhengzhou 450003 Henan Province China

OBJECTIVE To investigate the antiproliferative and apoptogenic activities of peptide extracted from the Chinese toad （Bufo bufo gargarizans） skin （TSP） and its effects on hepatocarcinoma cell line. METHODS M1-F assay was used to detect the effects of TSP （50 lig/mL and 5 ug/mL） on the proliferation and viability of Hepatocarcinoma cell line （HepG2） and liver cell line （L-02）; Flow cytometry was used in DNA content analysis to determine the cell distribution in different phases of cell cycle; Annexin V-FITC/PI stained fluorescence-activated cell sorter （FACS） and transmission electron microscope （TEM） were used to detect the apoptosis of the treated cells. RESULTS TSP could not suppress the proliferation and viability of normal liver L-02 cells, but strongly inhibited the proliferation and viability of HepG2 cells; TSP （50 μg/mL） primarily arrested the HepG2 cells at G1 phase of the cell cycle; TSP （50μg/mL） induced apoptosis in HepG2 cells and enhanced the effects of 5-Fu. CONCLUSION TSP has potent antineoplastic activity against human hepatocarcinoma cells with little toxicity to normal liver cells and can enhance the effects of 5-Fu.

关键词： bufo skins hepatocarcinoma 5-Fu apoptosis

Source apportionment of PM_(2.5)using PMF combined online bulk and single-particle measurements:Contribution of fireworks and biomass burning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 325-336页

作者： Yanjing Zhang Wenshuai li Lei li Mei li Zhen zhou Jianzhen Yu Yang zhou Frontier Science Center for Deep Ocean Multispheres and Earth System(FDOMES)and Physical Oceanography Laboratory Ocean University of ChinaQingdaoShandong 266100China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdaoShandong 266100China Institute of Atmospheric Environment Safety and Pollution Control Jinan UniversityGuangdong 510632China Institute of Environment Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Chemistry Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Environment The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Fireworks(FW)could significantly worsen air quality in short term during *** to similar tracers with biomass burning(BB),the fast and precise qualification of FW and BB is still *** this study,online bulk and single-particle measurements were combined to investigate the contributions of FW and BB to the overall mass concentrations of PM_(2.5)and specific chemical species by positive matrix factorization(PMF)during the Chinese New Year in Hong Kong in February *** combined information,fresh/aged FW(abundant ^(140)K_(2)NO_(3)^(+)and ^(213)K_(3)SO_(4)^(+)formed from ^(113)K_(2)Cl^(+)discharged by fresh FW)can be extracted from the fresh/aged BB sources,in addition to the Second Aerosol,Vehicles+Road Dust,and Sea Salt *** contributions of FW and BB were investigated during three high particle matter episodes influenced by the pollution transported from the Pearl River Delta *** fresh BB/FW contributed 39.2%and 19.6%to PM_(2.5)during the Lunar Chinese New Year ***,the contributions of aged FW/BB enhanced in the last two episodes due to the aging process,evidenced by high contributions from secondary ***,the fresh BB/FW showed more significant contributions to nitrate(35.1%and15.0%,respectively)compared with sulfate(25.1%and 5.9%,respectively)and OC(14.8%and11.1%,respectively)on *** comparison,the aged FW contributed more to sulfate(13.4%).Overall,combining online bulk and single-particle measurement data can combine both instruments’advantages and provide a new perspective for applying source apportionment of aerosols using PMF.

关键词： Source apportionment PMF Online bulk measurements Single particle analysis Fireworks Biomass burning