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Efficient and Eco-friendly Process for the Synthesis of Bi(indolyl)methanes Catalyzed by Sodium Hydrogensulfate Monohydrate in Ionic liquid n-Butylpyridinium Tetrafluoroborate

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Chinese Chemical Letters 2006年第6期17卷 723-726页

作者： li Ping ZHANG Yi Qun li Mei yun zhou Department of Chemistry Jinan University Guangzhou 510632

Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridinium tetrafluoroborate （[Bpy]BF4） to afford the corresponding bi（indolyl）methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.

关键词： Bi(indolyl)methane ionic liquid sodium hydrogen sulfate.

Sturge-Weber syndrome： a case report and review of literatures

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Chinese Medical Journal 2010年第1期123卷 117-121页

作者： zhou Jing li Nan-yun zhou Xiao-jun WANG Jian-dong MA Heng-hui ZHANG Ru-song Department of Pathology Nanjing Jinling Hospital ClinicalSchool of Medical College of Nanjing University Nanjing Jiangsu210002 China

Sturge-Weber syndrome （SWS）, or encephalo- trigeminal angiomatosis, is a rare, congenitalneurocutaneous syndrome characterized by unilateral facial cutaneous vascular malformation （nevus flammeus or port-wine stain） in association with ipsilateral leptomeningeal angiomatosis. Prevalence is approximately one per 50 000 live births. Males and females are equally affected and there is no racial bias. 1,2 The common clinical manifestations of SWS include progressive seizures, unilateral cutaneous vascular nevus following the ophthalmic divisions of the trigeminal nerve, ipsilateral glaucoma, contralateral hemiparesis, hemiatrophy, hemianopia and mental retardation. The radiographic hallmark of SWS is ＂tram-line＂ or gyriform calcifications usually involving the occipital and parietal lobes. Histologic studies have revealed that intracranial lesions of SWS display as leptomeningeal angiomatosis, and gyriform calcifications, neuronal loss, astrogliosis in underlying brain tissue.

关键词： Sturge-Weber syndrome encephalotrigeminal angiomatosis pathology, clinical diagnosis, differential

Effects of thrombolytic drugs and a selective endothelin-1 receptor antagonist on acute pulmonary thromboembolism in dogs

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Chinese Medical Journal 2010年第4期123卷 395-400页

作者： HAN li li Qing-yun zhou ling WANG Xi BAO Zhi-yao li Min WAN Huan-ying SHI Guo-chao Department of Respiratory Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Background It has been shown that neurohumoral factors other than mechanical obstruction are involved in the pathophysiology of acute pulmonary thromboembolism （APTE）. The aim of this study was to investigate the effects of thrombolytic drugs, a selective endothelin-1 receptor （ET-1 R） antagonist alone or their combination on APTE in a canine model. Methods Twenty dogs were randomly assigned to five groups： sham, model, urokinase （UK）, BQ123, and combination （UK plus BQ123）. The dogs in the sham group underwent sham surgery. APTE was induced in the other four groups by intravenous injection of autologous blood clots. Dogs in the UK, BQ123 and combination groups received UK, BQ123 （a selective ET-1R antagonist）, or UK plus BQ123, respectively. The dogs in the model group were given saline. Mean pulmonary artery pressure （mPAP）, serum concentrations of ET-1, thromboxane （TXB2）, and tumor necrosis factor （TNF）-α were determined at different time points following the induction of APTE. Results UK and BQ123 alone markedly decreased mPAP in APTE. By comparison, the reduction was more significant in the combination group. Compared with the sham group （（-0.90±0.61） mmHg）, mPAP increased by （7.44±1.04）, （3.42±1.12） and （1.14±0.55） mmHg in the model group, UK alone and BQ123 alone groups, respectively, and decreased by （2.24±0.67） mmHg in the combination group （P 〈0.01）. Serum ET-1 concentrations in the BQ123 and combination groups were （52.95±8.53） and （74.42±10.27） pg/ml, respectively, and were significantly lower than those in the model and UK groups （（84.56±7.44） and （97.66±8.31） pg/ml respectively; P 〈0.01）. Serum TNF-α concentrations were significantly lower in the BQ123 group than in the model, UK and combination groups （P 〈0.05）. Conclusions Our results indicate that the selective ET-1R antagonist BQ123 not only reduces the increase of mPAP and serum ET-1 level, but also inhibits the production of TNF-α, and attenuates the local inflammatory response induced by APTE.

关键词： acute pulmonary thromboembolism thrombolytics endothelin-1 receptor antagonist pulmonary artery pressure

Mechanism of multidrug resistance of human small cell lung cancer cell line H446/VP

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Chinese Medical Journal 2010年第22期123卷 3299-3303页

作者： WANG Yan-ling YAN yun-li zhou Na-jing HAN Shuo ZHAO Jun-xia CAO Cui-li LUE Yu-hong Cell Biology Division Institute of Basic Medicine Hebei Medical University Shijiazhuang Hebei 050017 China

Background Small cell lung cancer （SCLC） is the most aggressive form of lung cancer. This study aimed to investigate the mechanism of human small cell lung cancer cell line resistance to etoposide （VP-16）, H446NP. Methods The cell viability was measured by MTT assay. Immunocytochemistry, reverse transcription-polymerase chain reaction （RT-PCR） and Western blotting methods were used to detect the multidrug resistance gene （MDR1）, bcl-2, bax and the topoisomerase Ⅱ （TopoⅡ） expressions in H446 and H446NP cells after treated with or without VP-16. Results The 50% inhibition concentration （IC50） of VP-16 on H446 cells was 49 mg/L, and 836 mg/L was for H446NP cells. The expressions of MDR1 and bcl-2 were up-regulated, while the amounts of bax and Topo II were reduced in H446NP cells. After treated with 49 mg/L of VP-16, it showed that the drug could significantly inhibit bcl-2 and Topo fl expressions, and increase bax expression in H446 cells compared with that of H446NP cells. Conclusions The H446NP cell was stably resistant to VP-16. The decreased expression of Topo II was correlated with the H446NP multidrug resistance. The elevated expressions of MDR1, and the altered apoptotic pathways also played an important role in VP-16 induced multidrug resistance of SCLC.

关键词： small cell lung cancer etoposide topoisomerase II, multidrug resistance

Epidermal visualized health monitoring system based on stretchable and washable TPU hybrid conductive microtextiles

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Rare Metals 2024年第7期43卷 3185-3193页

作者： Jing-Bo Yuan Zhi-Hong Feng Dong-Chan li Yang Luo yun-Lei zhou School of Chemical Engineering Hebei University of Technology Engineering Research Center of Chemical Technology for Efficient Utilization of Seawater ResourcesMinistry of EducationTianjin 300401China National Key Laboratory of Application Specific Integrated Circuit Shijiazhuang050000China Department of Materials ETH Zürich8093 ZurichSwitzerland Hangzhou Institute of Technology Xidian UniversityHangzhou 311231China

Electronic textiles,an emerging class of electronic technology,offer exciting opportunities for seamless integration with the human *** applications have been developed based on electronic ***,researches on integrating multiple electronic textilebased devices are still *** this study,we present a system integrated with an electrocardiogram monitoring sensor and an electroluminescence device based on stretchable and washable conductive micro *** signal is acquired by an electrocardiograph amplifier and displayed by a dual-color electroluminescence device based on the processed *** integrated electronic device has excellent moisture permeability and comfort for long-term *** system reported in this study opens a new avenue for the application of electronic textiles in health monitoring,robotic prosthetics,and competitive sports.

关键词： Conductive microtextile Textile composite Electronic textile Electroluminescent displays

Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng Yan yun zhou Peichao Zhang Weidong Hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration

Visibility restoration for real-world hazy images via improved physical model and Gaussian total variation

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Frontiers of Computer Science 2024年第1期18卷 267-269页

作者： Chuan li Enping HU Xinyu ZHANG Hao zhou Hailing XIONG yun liU College of Computer and Information Science Southwest UniversityChongqing 400715China School of Big Data and Intelligent Engineering Chongqing College of International Business and EconomicsChongqing 401520China College of Artificial Intelligence Southwest UniversityChongqing 400715China College of Electronic and Information Engineering Southwest UniversityChongqing 400715China

1 Introduction Under real-world haze conditions,the existence of haze particles in the atmosphere reduces the visibility of captured ***,the noise is inevitably introduced into the degraded image,which further deteriorates the visual quality of the *** enhance the visibility and quality of outdoor real-world hazy images,numerous algorithms have been proposed to remove haze from a single input *** existing methods are broadly lumped into two categories:prior-based methods[1,2]and learning-based methods[3–6].Unfortunately,the widely used atmospheric scattering model and the corresponding haze removal methods fail to take the noise interference into account,which may result in poor visibility restoration performance.

关键词： visibility remove noise

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-Xiao Zheng Zi-An zhou Tiao Feng Hui li Cheng-Hua Sun NüWang Yang Tian Yong Zhao Shu-yun zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome

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Chinese Journal of Natural Medicines 2024年第3期22卷 249-264页

作者： zhou Jiangtao WANG Jun WANG Jiajing li Deyun HOU Jing li Jiankuan BAI yun’e GAO Jianping School of Pharmaceutical Science Shanxi Medical UniversityJinzhong 030600China

Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and *** efficacy of CP-A in treating ulcerative colitis(UC)is,however,not *** study employed an in vitro lipopolysaccharide(LPS)-induced colonic epithelial cell model(NCM460)and an in vivo dextran sulfate sodium(DSS)-induced colitis mouse model to explore CP-A’s protective effects against experimental colitis and its underlying *** monitored the clinical symptoms in mice using various parameters:body weight,disease activity index(DAI),colon length,spleen weight,and histopathological ***,molecular markers were assessed through enzyme-linked immunosorbent assay(EliSA),quantitative real-time polymerase chain reaction(qRT-PCR),immunofluorescence(IF),immunohistochemistry(IHC),and Western blotting *** showed that CP-A significantly reduced reactive oxygen species(ROS),tumor necrosis factor-alpha(TNF-α),and interleukins(IL-6,IL-1β,IL-18)in LPS-induced cells while increasing IL-4 and IL-10 levels and enhancing the expression of Claudin-1,ZO-1,and occludin proteins in NCM460 ***,in vivo findings revealed that CPA administration markedly improved DAI,reduced colon shortening,and decreased the production of myeloperoxidase(MPO),malondialdehyde(MDA),ROS,IL-1β,IL-18,and NOD-like receptor protein 3(NLRP3)inflammasome-associated genes/proteins in UC ***-A treatment also elevated glutathione(GSH)and superoxide dismutase(SOD)levels,stimulated autophagy(LC3B,P62,Beclin-1,and ATG5),and reinforced Claudin-1 and ZO-1 expression,thereby aiding in intestinal epithelial barrier repair in colitis ***,the inhibition of autophagy via chloroquine(CQ)diminished CP-A’s protective impact against colitis in *** findings elucidate that CP-A’s therapeutic effect on experimental colitis possibly involves mitigating intestinal inflammation through autophagymediated N

关键词： Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome Autophagy