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Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis:Implications for bone health

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World Journal of Stem Cells 2024年第4期16卷 389-409页

作者： ling-ling Wang Zhan-Jin lu Shun-Kui luo yun li Zhe Yang Hong-yun lu Department of Gerontology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan Universitythe First Hospital Affiliated with Medical College of Macao University of Science and Technology)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND Osteoporosis(OP)has become a major public health problem *** OP treatments are based on the inhibition of bone resorption,and it is necessary to identify additional treatments aimed at enhancing *** the bone marrow(BM)niche,bone mesenchymal stem cells(BMSCs)are exposed to a hypoxic ***,a few studies have demonstrated that hypoxiainducible factor 2alpha(HIF-2α)is involved in BMSC osteogenic differentiation,but the molecular mechanism involved has not been *** To investigate the effect of HIF-2αon the osteogenic and adipogenic differentiation of BMSCs and the hematopoietic function of hematopoietic stem cells(HSCs)in the BM niche on the progression of *** Mice with BMSC-specific HIF-2αknockout(Prx1-Cre;Hif-2αfl/fl mice)were used for in vivo *** quantification was performed on mice of two genotypes with three interventions:Bilateral ovariectomy,semilethal irradiation,and dexamethasone ***,the hematopoietic function of HSCs in the BM niche was compared between the two mouse *** vitro,the HIF-2αagonist roxadustat and the HIF-2αinhibitor PT2399 were used to investigate the function of HIF-2αin BMSC osteogenic and adipogenic ***,we investigated the effect of HIF-2αon BMSCs via treatment with the mechanistic target of rapamycin(mTOR)agonist MHY1485 and the mTOR inhibitor *** The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention *** vitro,Hif-2αfl/fl mouse BMSCs were cultured and treated with the HIF-2αagonist roxadustat,and after 7 d of BMSC adipogenic differentiation,the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMSCs treated with roxadustat were decreased;in addition,after 14 d of osteogenic differentiation,BMSCs treated with roxadusta

关键词： Hypoxia-inducible factor-2α Bone marrow niche Bone mesenchymal stem cells Osteoporosis Osteogenic/adipogenic differentiation Mechanistic target of rapamycin signaling pathway

Multi-layer network embedding on scc-based network with motif

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Digital Communications and Networks 2024年第3期10卷 546-556页

作者： lu Sun Xiaona li Mingyue Zhang liangtian Wan yun lin Xianpeng Wang Gang Xu Department of Communication engineering Institute of Information Science TechnologyDalian Maritime UniversityDalian116026China Key Laboratory of Big Data Intelligent Computing Chongqing University of Posts and TelecommunicationsChongqing400065China Key Laboratory for Ubiquitous Network and Service Software of liaoning Province DUT School of Software Technology&DUT-RU International School of Information Science and EngineeringDalian University of TechnologyDalian 116620China college of Information and Communication engineering Harbin Engineering UniversityHarbin 150001China School of Information and Communication engineering Hainan UniversityHaikou 570228China State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast UniversityNanjing 210096China

Interconnection of all things challenges the traditional communication methods,and Semantic Communication and Computing(SCC)will become new *** is a challenging task to accurately detect,extract,and represent semantic information in the research of SCC-based *** previous research,researchers usually use convolution to extract the feature information of a graph and perform the corresponding task of node ***,the content of semantic information is quite *** graph convolutional neural networks provide an effective solution for node classification tasks,due to their limitations in representing multiple relational patterns and not recognizing and analyzing higher-order local structures,the extracted feature information is subject to varying degrees of ***,this paper extends from a single-layer topology network to a multi-layer heterogeneous topology *** Bidirectional Encoder Representations from Transformers(BERT)training word vector is introduced to extract the semantic features in the network,and the existing graph neural network is improved by combining the higher-order local feature module of the network model representation network.A multi-layer network embedding algorithm on SCC-based networks with motifs is proposed to complete the task of end-to-end node *** verify the effectiveness of the algorithm on a real multi-layer heterogeneous network.

关键词： Semantic communication and computing Multi-layer network Graph neural network Motif

Copper-based electro-catalytic nitrate reduction to ammonia from water:Mechanism,preparation,and research directions

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Environmental Science and Ecotechnology 2024年第4期20卷 42-62页

作者： Jinshan Wei Yi li Hexing lin Xihui lu Chucheng Zhou Ya-yun li Shenzhen Key Laboratory of Special Functional materials&Shenzhen engineering Laboratory for Advance Technology of Ceramics College of Materials Science and EngineeringShenzhen UniversityShenzhen518060PR China

Global water bodies are increasingly imperiled by nitrate pollution,primarily originating from industrial waste,agricultural runoffs,and urban *** escalating environmental crisis challenges traditional water treatment paradigms and necessitates innovative ***-catalysis,especially utilizing copper-based catalysts,known for their efficiency,cost-effectiveness,and eco-friendliness,offer a promising avenue for the electro-catalytic reduction of nitrate to *** this review,we systematically consolidate current research on diverse copper-based catalysts,including pure Cu,Cu alloys,oxides,single-atom entities,and ***,we assess their catalytic performance,operational mechanisms,and future research directions to find effective,long-term solutions to water purification and ammonia ***-catalysis technology shows the potential in mitigating nitrate pollution and has strategic importance in sustainable environmental *** to the application,challenges regarding complexity of the real water,the scale-up of the commerical catalysts,and the efficient collection of produced NH3 are still *** reseraches of catalyst specially on long term stability and in situ mechanisms are proposed.

关键词： Water treatment Nitrate removal Electrocatalysis Cu catalysts Ammonia synthesis

Doping engineering of iron oxide nanoparticles towards high performance and biocompatible T_(1)-weighted MRI contrast agents

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Rare Metals 2024年第1期43卷 298-308页

作者： Xue Xu Ping-li Dong Yu-yun Chai Run Yang Zhen-Hui Ma Chi-Chong lu Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Extremely small-sized iron oxide nanoparticles(IONPs) are of great interest in magnetic resonance imaging(MRI) due to their biosafety as an alternative to clinical gadolinium(Ⅲ) complexes-based contrast *** when the particle size is less than 10 nm,it has strong diffusion ability and deep penetration distance in tumor *** doping can significantly enhance the T_(1)contrast effect of nanoparticles by regulating the surface exposed ***,the nucleation and growth processes of multi-component synthesis systems are complex and difficult to be accurately controlled,leading to great challenges in the synthesis of ultra-small-sized nanoparticles with different components and ***,extremely smallsized superparamagnetic gadolinium-doped iron oxide nanoparticles(GdIONPs,Gd_(x)Fe_(3-x)O_(4) NPs) with adjustable doping amount and controllable size in the range of 3.5-7.5 nm were synthesized by thermal ***,as-synthesized GdIONPs were surface modified with a highly water-soluble and biocompatible carboxyl-polyethylene glycol-phosphoric acid ligand with high binding ***_(0.65)Fe_(2.35)O_(4) NPs exhibited very high r_(1) relaxivity of 10.6 mmol^(-1)·L·s^(-1) in terms of all metal concentrations and 49.0 mmol^(-1)·L·s^(-1) in terms of gadolinium alone,respectively,3 and 14 times higher than clinical T_(1) contrast agents(Gd-DTPA).GdIONPs can continuously obtain high resolution images of blood vessels,and can be used as an efficient and multifunctional contrast agent for MR T_(1)*** stable and efficient doping strategy provides an easy and effective method to individually optimize the magnetic properties of complex oxides and their relaxation effects for a variety of biomedical applications.

关键词： Iron oxide nanoparticles Small size Magnetic resonance imaging Substitutional doping Gd dopant

Influence of cerium and yttrium addition on strength and electrical conductivity of pure aluminum alloys

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Journal of Rare Earths 2024年第3期42卷 600-611,I0006页

作者： Guojian lin lu li Zhengwei Guo Xianjun Jia Xiao Wang Zhentao Yuan Guoxing Zhang yun Zhan Quan Shan Zulai li Faculty of materials Science and engineering Kunming University of Science and TechnologyKunming650093China Research Center for Analysis and Measurement Kunming University of Science and TechnologyKunming650093China City college Kunming University of Science and TechnologyKunming650051China

To develop pure aluminum alloys with high conductivity and strength, Al-0.2Ce and Al-0.2Ce-0.1Y alloys were prepared by rolling and annealing processes in this study. The effects of trace rare earth elements on the strength and electrical conductivity of the pure aluminum alloys were investigated. It is revealed that the addition of Ce and Y to pure aluminum can effectively enhance the strength and electrical conductivity of the alloys. In Al-0.2Ce, the addition of Ce can effectively refine the grain size of a-Al, with an average grain size of 90.68 μm in the as-cast state. The grain size of the alloy is further reduced to 87.55 μm by the simultaneous addition of Y. The synergistic addition of Ce and Y changes the properties of the alloy. The addition of Ce and Y also produces the Al_(11)Ce_(3) and Al_(3)Y second phases, which have coherent relationship with a-Al. The two-dimensional mismatch degree was calculated to be only 4.43%and 0.85%, respectively, which can provide a certain amount of nucleation substrate for a-Al in the incubation stage. The interfacial match between the L1_(2)structure of Al_(3)Y and a-Al was calculated using first-principles simulations. The results indicate that Al_(3)Y has a strong bonding effect with a-Al. Nanoscale second phases at grain boundaries can be effective in reducing resistivity due to dislocation *** second phases with better matching interfaces to the substrate have no positive effect on the scattering motion of electrons.

关键词： Pure aluminum Rare earths Impurity purification First-principles calculations Strength-conductivity contradiction

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting

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Frontiers in Energy 2024年第3期18卷 378-389页

作者： Zhao-ting SHANG Tang-ming li Bing-qian HU Min liU Wang-ting lu Fan YU yun ZHENG Key Laboratory of Optoelectronic Chemical materials and Devices of Ministry of Education College of Optoelectronic Materials and TechnologyJianghan UniversityWuhan 430056China Institute of New Energy materials and engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Department of Chemical engineering University of WaterlooWaterlooOntario N2L 3G1Canada

The use of two-dimensional(2D)layered metal-organic frameworks(MOFs)as self-sacrificial templates has been proven to be a successful method to create high-efficiency Selenium(Se)-containing electrocatalysts for overall water ***,two strategies are then utilized to introduce Se element into the Co–Fe MOF,one being the etching of as-prepared MOF by SeO_(2) solution,and the other,the replacing of SCN−with SeCN−as the construction *** electrochemical activity of the pristine 2D MOF and their calcinated derivatives for catalyzing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is evaluated and further *** is found that the effect of introducing Se on improving electrochemical catalytic activity is significant for the HER ***,the calcinated derivative in the replacing method exhibits an overpotential of 235 mV for HER and 270 mV for OER at a current density of 10 mA/*** comparing the two methods of introducing Se element into MOF,similar electrocatalytic activity can be achieved on the their calcinated *** high electrochemical performance of 2D CoFe-MOF derivatives may be resulted from the unique 2D hierarchical porous structure and strong synergistic effect between different components in the material.

关键词： 2D MOF selenium(Se)-containing materials hydrogen evolution reaction(HER) oxygen evolution reaction(OER)

聚乙烯醇纤维掺量对高延性地聚合物混凝土早期抗裂和收缩性能影响

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大连理工大学学报 2024年第1期64卷 74-81页

作者：李杉周郑州卢亦焱王喆安俊澎武汉大学土木建筑工程学院湖北武汉430072

研究了聚乙烯醇(PVA)纤维掺量对高延性地聚合物混凝土早期塑性收缩开裂、干燥收缩和自生收缩的影响.结果表明,与地聚合物混凝土相比,掺PVA纤维的高延性地聚合物混凝土抗开裂性能和抗收缩性能显著提高,PVA纤维体积掺量为2%的地聚合物混... 详细信息

研究了聚乙烯醇(PVA)纤维掺量对高延性地聚合物混凝土早期塑性收缩开裂、干燥收缩和自生收缩的影响.结果表明,与地聚合物混凝土相比,掺PVA纤维的高延性地聚合物混凝土抗开裂性能和抗收缩性能显著提高,PVA纤维体积掺量为2%的地聚合物混凝土抗开裂和抗收缩性能最好.基于试验结果,建立了收缩预测模型,该模型能够一定程度反映地聚合物混凝土早期收缩特征.

关键词：地聚合物混凝土高延性塑性收缩开裂干燥收缩自生收缩收缩预测模型

New material of Coniopteris simplex from the Middle Jurassic of the Ordos Basin,Inner Mongolia,china and implications on its spatio-temporal distribution and paleogeography

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Journal of Palaeogeography 2024年第2期13卷 199-211页

作者： yun-Feng li Chang-lu Zhang Fei liang Xiao Tan Fan-Hao Gong Chun-lin Sun Tao li Yu-ling Na Research Center of Paleontology and Stratigraphy Jilin UniversityChangchun 130026Jilin ProvinceChina college of Earth Sciences Jilin UniversityChangchun 130061Jilin ProvinceChina college of Paleontology Shenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Key Lab of Evolution of Past life in NE Asia Ministry of Natural ResourcesShenyang Normal UniversityShenyang 110034Liaoning ProvinceChina Shenyang Center of Geological Survey China Geological SurveyShenyang 110034Liaoning ProvinceChina

Coniopteris simplex is a common component in many Jurassic ***,due to morphological variations in sterile fronds and incomplete preservation of reproductive organs,its classification has been controversial for a long ***,we present new material collected from the Middle Jurassic Yan’an Formation in the Ordos Basin,Inner *** new material reveals important morphological characters,including hemi-dimorphic fronds,two forms of sterile pinnae,short-stalked sori and sporangia on fertile fronds,annulus of sporangium composed of about 30 cells,in situ rounded triangular spores with protruded suture,and the lips of trilete laesura encircled by one or two rows of small *** on these observations,we emended the diagnosis of this common *** spatio-temporal distribution of Coniopteris simplex shows that the iconic species was restricted to the paleolatitudes ranging from 19.5°N to 48.9°N in the Northern Hemisphere during the Early—Late Jurassic,mainly distributed in the tropical to paratropical zones,and the paleolongitude ranging from 9.6°E to 129.3°E,which may be limited by the opening of the Viking Corridor and the splitting of the Central Atlantic Ocean.

关键词： Coniopteris simplex Yan'an Formation Middle Jurassic Inner Mongolia Paleogeography

Dynamic Event-Triggered Quadratic Nonfragile Filtering for Non-Gaussian Systems:Tackling Multiplicative Noises and Missing Measurements

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1127-1138页

作者： Shaoying Wang Zidong Wang Hongli Dong yun Chen Guoping lu college of Science Shandong University of AeronauticsBinzhou 256603China college of Electrical engineering and Automation Shandong University of Science and TechnologyQingdao 266590 Department of Computer Science Brunel University LondonUxbridge UB83PHUK Artificial Intelligence Energy Research Institute Northeast Petroleum UniversityDaqing 163318 Heilongjiang Provincial Key Laboratory of Networking and Intelligent Control Northeast Petroleum UniversityDaqing 163318China School of Automation Hangzhou Dianzi UniversityHangzhou 310018China School of Electrical engineering Nantong UniversityNantong 226019China

This paper focuses on the quadratic nonfragile filtering problem for linear non-Gaussian systems under multiplicative noises,multiple missing measurements as well as the dynamic event-triggered transmission *** multiple missing measurements are characterized through random variables that obey some given probability distributions,and thresholds of the dynamic event-triggered scheme can be adjusted dynamically via an auxiliary *** attention is concentrated on designing a dynamic event-triggered quadratic nonfragile filter in the well-known minimum-variance *** this end,the original system is first augmented by stacking its state/measurement vectors together with second-order Kronecker powers,thus the original design issue is reformulated as that of the augmented ***,we analyze statistical properties of augmented noises as well as high-order moments of certain random *** the aid of two well-defined matrix difference equations,we not only obtain upper bounds on filtering error covariances,but also minimize those bounds via carefully designing gain ***,an example is presented to explain the effectiveness of this newly established quadratic filtering algorithm.

关键词： filtering quadratic bounds