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International Journal of Mental Health Promotion 2022年第6期24卷 975-988页

作者： li-yu song Graduate Institute of Social Work National Chengchi UniversityTaipei City11605TaiwanChina

This study explores the meaning of the use of community psychiatric rehabilitation(CPR)services to gain knowledge to improve services and shed more light on how to facilitate *** topics explored included:the motivation for participation,perception and expectation towards CPR,the interactions with professionals in the CPR Center,and the feelings towards activities.A qualitative approach was adopted,and 30 consumers were interviewed face-to-face by using semi-structured interview *** were analyzed using the open coding method of grounded *** consumer accounts provided information on the eight aspects of CPR *** findings revealed that the CPR Center created a lifeworld,a friendly place similar to home with structure and *** relationship was the key change agent for *** professionals adopted recovery-oriented approach to empower participants by giving opportunities and *** essential ingredients of this lifeworld covered rehabilitation goals,physical exercises,psychological impact,social interactions,learning,and economic *** services were venues for interpersonal interactions and provided structure for daily life,which helped consumers reach their rehabilitation goals and brought existential meaning to their ***,the accounts also revealed negative phenomena in the CPR *** were made to improve services.

关键词： Community psychiatric rehabilitation persons with psychiatric disability meaning recovery service utilization rehabilitation goal

Two new prenylflavonoids from Epimedium sutchuenense

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Chinese Chemical Letters 2009年第7期20卷 842-844页

作者： Chang yuan yu li Na song Guang Chen College of life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

Two new prenylflavonoids, named sutchuenmedin A （1） and sutchuenmedin B （2）, were isolated from the 70% EtOH extract of Epimedium sutchuenense. Their structures were determined from spectral analysis. C 2009 Guang... 详细信息

关键词： Epimedium sutchuenense Flavonoids Sutchuenmedin A Sutchuenmedin B

Coarsening and Age Hardening Behaviors of γ' Particles in GH742 During High Temperature Treatment

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Journal of Iron and Steel Research International 2009年第5期16卷 81-86页

作者： li Hong-yu song Xi-ping WANG Yan-li CHEN Guo-liang State Key Lab for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

The coarsening and ageing hardening behaviors of γ′ particles in superalloy GH742 have been investigated by field emission scanning electron microscopy （FESEM）, coarsening kinetics calculation and microhardness testing when ageing at 1 050, 950 and 900 ℃ for different time. The cube of γ′ particle size and ageing time follows a linear law as predicted by LSW theory. The particle size distributions give better fit to the LSW theoretical distribution. The activation energy for γ′ coarsening is accurately determined to have 245. 06±14.42 kJ/mol when considering the effect of temperature on the solution concentrations in matrix. Based on the activation energy, the coarsening kinetics of γ′ particle is predicted as r^-t^3=7.35×10^15 Ce/T exp -（245060±14420）/RT *** microhardness studies indicate that microhardness decreases rapidly with increasing the ageing temperature and it has a maximum value corresponding to a critical particle size beyond which the microhardness increase stalls with increasing the ageing time.

关键词： superalloy γ′ particle coarsening kinetics activation energy microhardness

Exploring the Experiences of Personal Recovery among Mental Health Consumers and Their Caregivers Receiving Strength- Based Family Interventions

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International Journal of Mental Health Promotion 2023年第8期25卷 915-925页

作者： li-yu song Su-ting Hsu Graduate Institute of Social Work Taipei City11605Taiwan Department of Community Psychiatry Kaohsiung Municipal Kai-Syuan Psychiatric HospitalKaohsiung City802511Taiwan

Background:This study explored the personal recovery of consumers and their caregivers receiving the strength-based family ***:A three-year project was implemented with 43 dyads from 5 community psychiatric rehabilitation agencies in northern,central,and Southern *** paper presents qualitative analysis with a focus on describing the experiences of personal *** gain a deeper understanding of the participants’personal experiences and perspectives,semi-structured in-depth interviews were conducted on three occasions(six months after the inception of the experiment,18 months after,and when the participants left the services of this study).Over the three occasions,a total of 27 consumers and 28 caregivers were *** analysis was conducted based on grounded ***:Consumers expressed positive experiences in the domain of the recovery process(positive sense of self,taking responsibility,and better coping)and on the objective indicators of recovery(functioning,interpersonal interaction,and family relationship).Caregivers experienced lessened psychological *** also revealed improvements to their sense of self(recovery process)and subjective indicators of recovery outcomes,including feeling empowered and having a better quality of ***,they had better interaction with consumers(objective domain of recovery).Conclusion:These findings suggest that the strength-based perspective is an acceptable,culturally-compatible approach among Chinese mental health consumers and their *** investigators suggest that additional resources would be necessary to support a change in the service system in Taiwan so that family-based services can be provided to promote the recovery of mental health consumers and their family caregivers.

关键词： Recovery strength-based model family caregiver burden psychiatric disability family intervention quality of life

Resynchronization and remultiplexing for transcoding to H.264/AVC

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第Z1期7卷 76-81页

作者： ZHOU Jin XIONG Hong-kai song li yu song-yu Institute of Image Communication and Information Processing Shanghai Jiao Tong University Shanghai 200030 China Institute of Image Communication and Information Processing Shanghai Jiao Tong University Shanghai 200030 China Institute of Image Communication and Information Processing Shanghai Jiao Tong University Shanghai 200030 China Institute of Image Communication and Information Processing Shanghai Jiao Tong University Shanghai 200030 China

H.264/MPEG-4 AVC standard appears highly competitive due to its high efficiency, flexibility and error resilience. In order to maintain universal multimedia access, statistical multiplexing, or adaptive video content delivery, etc., it induces an immense demand for converting a large volume of existing multimedia content from other formats into the H.264/AVC format and vice versa. In this work, we study the remultiplexing and resynchronization issue within system coding after transcoding, aiming to sustain the management and time information destroyed in transcoding and enable synchronized decoding of decoder buffers over a wide range of retrieval or receipt conditions. Given the common intention of multiplexing and synchronization mechanism in system coding of different standards, this paper takes the most widely used MPEG-2 transport stream (TS) as an example, and presents a software system and the key technologies to solve the time stamp mapping and relevant buffer management. The solution reuses previous information contained in the input streams to remultiplex and resynchronize the output information with the regulatory coding and composition structure. Experimental results showed that our solutions efficiently preserve the performance in multimedia presentation.

关键词： Transport stream (TS), Remultiplex, Time stamp, Transcoding, H.264/AVC

Cover a Tree by Induced Matchings

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Journal of Mathematical Research and Exposition 2010年第5期30卷 845-848页

作者： Jing Yong TANG li DONG Xin yu song College of Mathematics and Information Science Xinyan9 Normal University Henan 464000 P. R. China

The induced matching cover number of a graph G without isolated vertices, denoted by imc（G）, is the minimum integer k such that G has k induced matchings M1, M2,..., Mk such that, M1∪M2∪…∪Mk covers V（G）. This paper shows if G is a nontrivial tree, then imc（G） E {△0^＊CG）, △0^＊（G）＋ 1, △0^＊（G）＋ 2}, where △0^＊（G） = max{d0（u）＋ d0（v）： u,v ∈ V（G）,uv ∈ E（G）}.

关键词： induced matching induced matching cover tree.

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期68卷 209-216页

作者： Yixin Yang Wanlei Zhao Ruoxuan Zheng Hongqiang li Wei Chen yu-Fei song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

关键词： reduced graphene oxide polyoxometalates membranes gradient separation nanoparticles

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan li Xi liu Wenping liang yu li liyong Wu Zhe Wang Weihong song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang song Mao Yini li Dongzhen yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron