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家庭同步赋能教育对青中年宫颈癌根治术患者术后病耻感家庭功能及生活质量的影响

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中国妇幼保健 2024年第3期39卷 527-530页

作者：池佳妮应林平李旭艳温州市中心医院妇科浙江温州325000

目的探讨家庭同步赋能教育对青中年宫颈癌患者术后病耻感的影响。方法选取2021年7月—2022年6月在温州市中心医院行宫颈癌根治术治疗的青中年宫颈癌患者88例,根据时间顺序分为对照组(2021年7—12月期间,42例)与研究组(2022年1—6月期... 详细信息

目的探讨家庭同步赋能教育对青中年宫颈癌患者术后病耻感的影响。方法选取2021年7月—2022年6月在温州市中心医院行宫颈癌根治术治疗的青中年宫颈癌患者88例,根据时间顺序分为对照组(2021年7—12月期间,42例)与研究组(2022年1—6月期间,46例)。对照组患者及其家庭成员在术后给予常规健康教育干预,研究组患者及其家庭成员在术后给予家庭同步赋能教育,时间3个月。采用社会影响量表(SIS)、家庭功能评定量表(FAD)、生活质量核心问卷(QLQ-C30)对干预前及干预后6个月时的病耻感、家庭功能及生活质量进行评估。结果两组患者干预前SIS评分比较,差异无统计学意义(P>0.05),干预后评分低于干预前,且研究组低于对照组(P0.05),干预后评分低于干预前,且研究组低于对照组(P0.05),干预后功能领域、症状领域、6种症状评分均低于干预前,且研究组低于对照组,干预后总体健康状况评分高于干预前,且研究组高于对照组(P<0.05)。结论家庭同步赋能教育有助于降低青中年宫颈癌患者术后病耻感,改善家庭功能及提高生活质量。

关键词：家庭同步赋能教育宫颈癌病耻感青中年

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32例Mirizzi综合征的诊治分析

医师在线 2024年第3期14卷 54-56页

作者：吴昆霖季卫奔李延旭吴巍扬州大学医学院扬州大学附属医院肝胆外科江苏扬州225000

目的探讨Mirizzi综合征的临床特点及诊治经验。方法回顾性分析32例Mirizzi综合征患者的临床资料,总结病例的临床症状、影像学特点及诊治经验。结果32例患者中,Ⅰ型患者22例(68.8%),Ⅱ型患者7例(21.9%),Ⅲ型患者2例(6.5%),Ⅳ型患者1例(3.... 详细信息

目的探讨Mirizzi综合征的临床特点及诊治经验。方法回顾性分析32例Mirizzi综合征患者的临床资料,总结病例的临床症状、影像学特点及诊治经验。结果32例患者中,Ⅰ型患者22例(68.8%),Ⅱ型患者7例(21.9%),Ⅲ型患者2例(6.5%),Ⅳ型患者1例(3.2%)。其中,3例患者行ERCP+鼻胆管引流,其余患者均行手术治疗。术后无二次手术患者,均痊愈出院。结论Mirizzi综合征的术前诊断仍较困难,需根据术中具体分型及患者的腹部情况作出相应的治疗方案,从而减少术后并发症,改善患者的预后。

关键词： Mirizzi综合征胆囊结石腹腔镜开腹

Random gradient-free method for online distributed optimization with strongly pseudoconvex cost functions

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Control Theory and Technology 2024年第1期22卷 14-24页

作者： Xiaoxi yan Cheng li Kaihong Lu Hang xu School of Electrical and Information Engineering Jiangsu UniversityZhenjiang212013JiangsuChina College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao266590ShandongChina

This paper focuses on the online distributed optimization problem based on multi-agent systems. In this problem, each agent can only access its own cost function and a convex set, and can only exchange local state information with its current neighbors through a time-varying digraph. In addition, the agents do not have access to the information about the current cost functions until decisions are made. Different from most existing works on online distributed optimization, here we consider the case where the cost functions are strongly pseudoconvex and real gradients of the cost functions are not available. To handle this problem, a random gradient-free online distributed algorithm involving the multi-point gradient estimator is proposed. Of particular interest is that under the proposed algorithm, each agent only uses the estimation information of gradients instead of the real gradient information to make decisions. The dynamic regret is employed to measure the proposed algorithm. We prove that if the cumulative deviation of the minimizer sequence grows within a certain rate, then the expectation of dynamic regret increases sublinearly. Finally, a simulation example is given to corroborate the validity of our results.

关键词： Multi-agent system Online distributed optimization Pseudoconvex optimization Random gradient-free method

Spherical Confinement Generates Entropic Force to Accelerate Polymer Chain Detachment

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Chinese Journal of Polymer Science 2024年第3期42卷 407-416,I0010页

作者： Yu-Shan Zheng Jian-Ping Zhou yan xu Kai li Mechanical Engineering Xinjiang UniversityUrumqi 830002China

To understand the dynamic process of polymer detachment, it is necessary to determine the mean detachment time of a single breakable link, which is modeled as a spring. Normally, this time can be viewed as the escape of a Brownian particle from the potential well of the spring. However, as the free dangling length of the polymer chain increases, the conformational entropy of the chain is affected by geometric confinement. It means that the wall exerts a repulsive force on the chain, resulting in accelerated link detachment from a macroscopic perspective. In this work, we investigate the effect of entropy on the detachment rate in the case where the substrate is spherical. We demonstrate that spherical confinement accelerates chain detachment both inside and outside the sphere. An analytical expression for the mean detachment time of breakable links is given, which includes an additional pre-factor that is related to the partition function. Additionally, we analyze the expressions for entropic forces inside the sphere, outside the sphere, and on a flat wall, comparing their magnitudes to explain the difference in mean detachment time.

关键词： Polymer detachment Breakable link Entropic force Mean first passage time

劳动教育融入人体及动物生理学专业课程教学的实践探索

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安徽农业科学 2024年第12期52卷 261-263,267页

作者：李旭艳蒋湘蒲小秋付娜张洪军岭南师范学院广东湛江524048 湛江第一中学广东湛江524048

积极探索劳动教育与专业课程的渗透融合是新时代教学改革的要求,是实现立德树人根本任务的途径之一。人体及动物生理学是生物科学专业的必选课程,充分挖掘课程的劳动教育元素,通过田间劳动、参与式实验课程等方式渗透劳动实践内容,探索... 详细信息

积极探索劳动教育与专业课程的渗透融合是新时代教学改革的要求,是实现立德树人根本任务的途径之一。人体及动物生理学是生物科学专业的必选课程,充分挖掘课程的劳动教育元素,通过田间劳动、参与式实验课程等方式渗透劳动实践内容,探索劳动教育融入专业课程的有效途径,引导学生全面发展。

关键词：专业课程人体及动物生理学劳动教育实践探索

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Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

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China Foundry 2024年第3期21卷 248-256页

作者： Gui-quan Wang Zhuo xu Zhong-li liu Xiang Chen yan-xiang li School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake *** this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical *** graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of *** peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction *** morphology of thermal cracks and 3D profiles of the worn surfaces were also *** is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue *** of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal *** the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

关键词： compacted graphite iron brake disc thermomechanical properties thermal fatigue wear

lipid nanovehicles overcome barriers to systemic RNA delivery: lipid components, fabrication methods, and rational design

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Acta Pharmaceutica Sinica B 2024年第2期14卷 579-601页

作者： Jing yan Hao Zhang Guangfeng li Jiacan Su yan Wei Can xu Institute of Translational Medicine Shanghai UniversityShanghai 200444China Institute of Medicine Shanghai UniversityShanghai 200444China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Department of Orthopedics Shanghai Zhongye HospitalShanghai 200941China Organoid Research Center Shanghai UniversityShanghai 200444China Department of Gastroenterology Changhai HospitalShanghai 200433China

lipid nanovehicles are currently the most advanced vehicles used for RNA delivery,as demonstrated by the approval of patisiran for amyloidosis therapy in *** illuminate the unique superiority of lipid nanovehicles in RNA delivery,in this review,we first introduce various RNA therapeutics,describe systemic delivery barriers,and explain the lipid components and methods used for lipid nanovehicle ***,we emphasize crucial advances in lipid nanovehicle design for overcoming barriers to systemic RNA ***,the current status and challenges of lipid nanovehicle-based RNA therapeutics in clinical applications are also *** objective is to provide a comprehensive overview showing how to utilize lipid nanovehicles to overcome multiple barriers to systemic RNA delivery,inspiring the development of more high-performance RNA lipid nanovesicles in the future.

关键词： lipid nanovehicles RNAtherapeutics Barriers to systemicRNA delivery lipid components Fabricationmethods lipid nanovehicledesign Extrahepatictissue targeting Organ tropism

Flow Field Characteristics of Multi-Trophic Artificial Reef Based on Computation Fluid Dynamics

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Journal of Ocean University of China 2024年第2期23卷 317-327页

作者： HUANG Junlin li Jiao li yan GONG Pihai GUAN Changtao XIA xu School of Engineering Ocean University of ChinaQingdao 266100China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesKey Laboratory of Sustainable Development of Marine FisheriesMinistry of Agriculture and Rural AffairsQingdao Key Laboratory for Marine Fish Breeding and BiotechnologyQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

On the basis of computational fluid dynamics,the flow field characteristics of multi-trophic artificial reefs,including the flow field distribution features of a single reef under three different velocities and the effect of spacing between reefs on flow scale and the flow state,were *** indicate upwelling,slow flow,and eddy around a single *** velocity,height,and volume of upwelling in front of a single reef were positively correlated with inflow *** length and volume of slow flow increased with the increase in inflow *** were present both inside and backward,and vorticity was positively correlated with inflow *** between reefs had a minor influence on the maximum velocity and height of *** the increase in space from 0.5 L to 1.5 L(L is the reef lehgth),the length of slow flow in the front and back of the combined reefs increased *** the space was 2.0 L,the length of the slow flow *** four different spaces,eddies were present inside and at the back of each *** maximum vorticity was negatively correlated with space from 0.5 L to 1.5 L,but under 2.0 L space,the maximum vorticity was close to the vorticity of a single reef under the same inflow velocity.

关键词： artificial reef flow field characteristics computation fluid dynamics multi-trophic structure

PDOL-Based Solid Electrolyte Toward Practical Application:Opportunities and Challenges

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Nano-Micro Letters 2024年第7期16卷 109-141页

作者： Hua yang Maoxiang Jing li Wang Hong xu Xiaohong yan Xiangming He Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013People’s Republic of China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084People’s Republic of China

Polymer solid-state lithium batteries(SSLB)are regarded as a promising energy storage technology to meet growing demand due to their high energy density and *** conductivity,interface stability and battery assembly process are still the main challenges to hurdle the commercialization of *** the main component of SSLB,poly(1,3-dioxolane)(PDOL)-based solid polymer electrolytes polymerized in-situ are becoming a promising candidate solid elec-trolyte,for their high ion conductivity at room temperature,good battery elec-trochemical performances,and simple assembly *** review analyzes opportunities and challenges of PDOL electrolytes toward practical application for polymer *** focuses include exploring the polymerization mechanism of DOL,the performance of PDOL composite electrolytes,and the application of ***,we provide a perspective on future research directions that need to be emphasized for commercialization of PDOL-based electrolytes in *** exploration of these schemes facilitates a comprehensive and profound understanding of PDOL-based polymer electrolyte and provides new research ideas to boost them toward practical application in solid-state batteries.

关键词： Poly(1,3-dioxolane) Solid electrolyte Polymerization mechanism Composite electrolyte Practical application