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For LEO Satellite Networks: Intelligent Interference Sensing and Signal Reconstruction Based on Blind Separation Technology

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China Communications 2024年第2期21卷 85-95页

作者： Chengjie li lidong zhu Zhen Zhang The Key Laboratory for Computer Systems of State Ethnic Affairs Commission School of Computer Science and Technology(Southwest Minzu University)Chengdu 610000China National Key Laboratory of Science and Technology on Communications(University of Electronic Science and Technology of China) Chengdu 610000China College of Computer Science(Sichuan University) Chengdu 610000China

In LEO satellite communication networks,the number of satellites has increased sharply, the relative velocity of satellites is very fast, then electronic signal aliasing occurs from time to time. Those aliasing signals make the receiving ability of the signal receiver worse, the signal processing ability weaker,and the anti-interference ability of the communication system lower. Aiming at the above problems, to save communication resources and improve communication efficiency, and considering the irregularity of interference signals, the underdetermined blind separation technology can effectively deal with the problem of interference sensing and signal reconstruction in this scenario. In order to improve the stability of source signal separation and the security of information transmission, a greedy optimization algorithm can be executed. At the same time, to improve network information transmission efficiency and prevent algorithms from getting trapped in local optima, delete low-energy points during each iteration process. Ultimately, simulation experiments validate that the algorithm presented in this paper enhances both the transmission efficiency of the network transmission system and the security of the communication system, achieving the process of interference sensing and signal reconstruction in the LEO satellite communication system.

关键词： blind source separation greedy optimization algorithm interference sensing LEO satellite communication networks signal reconstruction

Global practical stabilization of the double integrator system with an imperfect sensor and subject to a bounded disturbance

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Control Theory and Technology 2024年第3期22卷 468-478页

作者： Zhiyuan zhu Yuanlong li Zongli lin Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information Processing of Ministry of EducationShanghai 200240China Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaP.0.Box 400743CharlottesvilleVA 22904-4743USA

This paper is concerned with global practical stabilization of the double integrator system with an imperfect sensor and subject to an additive bounded output *** imperfect sensor nonlinearity possesses the nonlinear characteristics of saturation and dead *** of the presence of output dead zone and the additive disturbance,the states cannot be expected to driven into an arbitrarily small neighborhood of the *** solve the global practical stabilization problem,we proposes a low gain-based linear dynamic output feedback law,under which the first state enters and remains in a bounded set whose size is depended on the bound of disturbance and the range of dead zone and the second state enters and remains in a pre-specified arbitrarily small set,both in finite *** results illustrate the effectiveness of our proposed control method.

关键词： Output saturation Disturbance rejection Output dead zone Low gain feedback-linear output feedback Practical stabilization

TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG xin ZHANG Zhao-xin li li-fei HE Feng CHEN Ming-long liU Ying-ze HUANG Jian-mei MO Kong-lan LUO Juan-juan XIAO Feng zhu Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of Molecular Medicine in liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

Notch signaling pathway in cancer:from mechanistic insights to targeted therapies

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2527-2563页

作者： Qingmiao Shi Chen Xue Yifan Zeng xin Yuan Qingfei Chu Shuwen Jiang Jinzhi Wang Yaqi Zhang Danhua zhu Lanjuan li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Notch signaling,renowned for its role in regulating cell fate,organ development,and tissue homeostasis across metazoans,is highly conserved throughout *** Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences,typically necessitating receptor-ligand interaction to initiate classical Notch signaling *** evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer *** of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies,closely linked to cancer proliferation,invasion,and ***,the Notch signaling pathway contributes to maintaining stem-like properties in cancer cells,thereby enhancing cancer *** regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive ***,the Notch signaling pathway is implicated in conferring chemoresistance to tumor ***,a comprehensive understanding of these biological processes is crucial for developing innovative therapeutic strategies targeting Notch *** review focuses on the research progress of the Notch signaling pathway in cancers,providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence and progression of ***,the review summarizes pharmaceutical clinical trials targeting Notch signaling for cancer therapy,aiming to offer new insights into therapeutic strategies for human malignancies.

关键词： Notch invasion involvement

Decoding m^(6)A mRNA methylation by reader proteins in liver diseases

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Genes & Diseases 2024年第2期11卷 711-726页

作者： lijiao Sun xin Chen Sai zhu Jianan Wang Shaoxi Diao Jinyu liu Jinjin Xu Xiaofeng li Yingyin Sun Cheng Huang Xiaoming Meng Xiongwen Lv Jun li Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative DrugsSchool of PharmacyAnhui Medical UniversityHefeiAnhui 230032China The Key Laboratory of Anti-inflammatory and Immune Medicines Anhui Medical UniversityMinistry of EducationHefeiAnhui 230032China Institute for liver Diseases of Anhui Medical University ILD-AMUAnhui Medical UniversityHefeiAnhui 230032China Department of Nephropathy The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230032China

N6-methyladenosine(m^(6)A)is a dynamic and reversible epigenetic *** the most prevalent internal post-transcriptional modification in eukaryotic RNA,it participates in the regulation of gene expression through various mechanisms,such as mRNA splicing,nuclear export,localization,translation efficiency,mRNA stability,and structural *** involvement of m^(6)A in the regulation of gene expression depends on the specific recognition of m^(6)A-modified RNA by reader *** the pathogenesis and treatment of liver disease,studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by m^(6)A modification,in which abnormal expression of reader proteins determines the fate of these gene *** this review,we introduce m^(6)A readers,summarize the recognition and regulatory mechanisms of m^(6)A readers on mRNA,and focus on the biological functions and mechanisms of m^(6)A readers in liver cancer,viral hepatitis,non-alcoholic fatty liver disease(NAFLD),hepatic fibrosis(HF),acute liver injury(Ali),and other liver *** information is expected to be of high value to researchers deciphering the links between m^(6)A readers and human liver diseases.

关键词： IGF2BPs liver diseases m^(6)A modification m^(6)A reader mRNA metabolism YTH domain protein

Evaluation of transmission risk of respiratory particles under different ventilation strategies in an elevator

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Building Simulation 2024年第5期17卷 771-784页

作者： liangyu zhu Xian li Bujin Feng Fan liu School of Civil Engineering and Architecture Linyi UniversityLinyi276000China College of Agriculture Shandong Agricultural UniversityTaian271018China School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200093China

People in elevators are at risk of respiratory infection because the elevator cabin is crowded and has poor *** exhaled particles may be inhaled by the susceptible person,deposited on the surface and suspended in the elevator,which can result in direct and indirect ***,whether the air vent designs adopted in the elevator can effectively reduce the transmission risk of respiratory particles remains *** this study,the dispersion of particles under four common ventilation strategies used in the commercial elevator was investigated by proven computational fluid dynamics(CFD)*** flow field was simulated with the RNG κ-ξ turbulence model and the Lagrangian method was adopted to track particle *** effects of air vent layout and airflow rate on particle transmission were *** found that more than 50% of exhaled particles(average value)were suspended in the cabin and difficult to discharge under the investigated ventilation *** deposited fraction of particles on the susceptible person reached up to 39.14% for infiltration ventilation,which led to a high risk of contact *** the ventilation rate could not significantly reduce the inhalation proportion of particles due to the poor airflow distribution inside the elevator.A more proper ventilation strategy should be explored for the elevator to control transmission risk.

关键词： particle dispersion transmission risk elevator ventilation strategy computational fluid dynamics(CFD)

Fast solution to the free return orbit's reachable domain of the manned lunar mission by deep neural network

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Journal of Systems Engineering and Electronics 2024年第2期35卷 495-508页

作者： YANG Luyi li Haiyang ZHANG Jin zhu Yuehe College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China China Astronauts Research and Training Center Beijing 100094China Hunan Key Laboratory of Intelligent Planning and Simulation for Aerospace Missions Changsha 410073China

It is important to calculate the reachable domain(RD)of the manned lunar mission to evaluate whether a lunar landing site could be reached by the spacecraft. In this paper, the RD of free return orbits is quickly evaluated and calculated via the classification and regression neural networks. An efficient databasegeneration method is developed for obtaining eight types of free return orbits and then the RD is defined by the orbit’s inclination and right ascension of ascending node(RAAN) at the perilune. A classify neural network and a regression network are trained respectively. The former is built for classifying the type of the RD, and the latter is built for calculating the inclination and RAAN of the RD. The simulation results show that two neural networks are well trained. The classification model has an accuracy of more than 99% and the mean square error of the regression model is less than 0.01°on the test set. Moreover, a serial strategy is proposed to combine the two surrogate models and a recognition tool is built to evaluate whether a lunar site could be reached. The proposed deep learning method shows the superiority in computation efficiency compared with the traditional double two-body model.

关键词： manned lunar mission free return orbit reachable domain(RD) deep neural network computation efficiency

Targeting the chromatin structural changes of antitumor immunity

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Journal of Pharmaceutical Analysis 2024年第4期14卷 460-482页

作者： Nian-nian li Deng-xing Lun Ningning Gong Gang Meng xin-ying Du He Wang Xiangxiang Bao xin-yang li Ji-wu Song Kewei Hu Lala li Si-ying li Wenbo liu Wanping zhu Yunlong Zhang Jikai li Ting Yao Leming Mou Xiaoqing Han Furong Hao Yongcheng Hu lin liu Hongguang zhu Yuyun Wu Bin liu Weifang People's Hospital WeifangShandong261000China School of life Sciences Nankai UniversityTianjin300071China Weifang Traditional Chinese Medicine Hospital WeifangShandong261000China Shaanxi Key Laboratory of Sericulture Ankang UniversityAnkangShaanxi725000China Guizhou Education University Guiyang550018China Guizhou Normal University Guiyang550025China School of Medical Imaging Weifang Medical UniversityWeifangShandong261053China Department of Bone and Soft Tissue Oncology Tianjin HospitalTianjin300299China xinqiao Hospital of Army Military Medical University Chongqing400038China Teda Institute of Biological Sciences&Biotechnology Nankai UniversityTianjin300457China

Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of *** defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their ***,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research *** emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.

关键词： Antitumor immunity Chromatin structural Cancer epigenetics DNA methylation Histone modification Chemotherapy

Finite-Time Stabilization for Constrained Discrete-time Systems by Using Model Predictive Control

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1656-1666页

作者： Bing zhu Xiaozhuoer Yuan li Dai Zhiwen Qiang IEEE the Seventh Research Division Beihang UniversityBeijing 100191China the School of Automation Beijing Institute of TechnologyBeijing 100081China

In this paper, a model predictive control(MPC)framework is proposed for finite-time stabilization of linear and nonlinear discrete-time systems subject to state and control constraints. The proposed MPC framework guarantees the finite-time convergence property by assigning the control horizon equal to the dimension of the overall system, and only penalizing the terminal cost in the optimization, where the stage costs are not penalized explicitly. A terminal inequality constraint is added to guarantee the feasibility and stability of the closed-loop *** feasibility can be improved via augmentation. The finite-time convergence of the proposed MPC is proved theoretically,and is supported by simulation examples.

关键词： Constraints deadbeat control finite-time stabilization model predictive control(MPC)