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Bloodletting Acupuncture at Jing-Well Points Alleviates Myocardial Injury in Acute Altitude Hypoxic Rats by Activating HIF-1 α/BNIP3 Signaling-Mediated Mitochondrial Autophagyand Decreasing Oxidative Stress

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Chinese Journal of Integrative Medicine 2023年第2期29卷 170-178页

作者： WANG Chao li meng-xin li Yun-di li Yong-ping Department of Traditional Chinese Medicine Medical Institute of Qinghai UniversityXining 810000China

Objective: To explore the protective effect and possible mechanisms of bloodletting acupuncture at Jing-well points(BAJP) pre-treatment on acute hypobaric hypoxia(AHH)-induced myocardium injury rat. Methods:Seventy-five rats were randomly divided into 5 groups by a random number table: a control group(n=15), a model group(n=15), a BAJP group(n=15), a BAJP+3-methyladenine(3-MA) group(n=15), and a BANA(bloodletting at nonacupoint;tail bleeding, n=15) group. Except for the control group, the AHH rat model was established in the other groups, and the corresponding treatment methods were adopted. Enzyme-linked immunosorbent assay(EliSA) was used to detect creatine kinase isoenzyme MB(CK-MB) and cardiac troponins I(CTn I) levels in serum and superoxide dismutase(SOD) and malondialdehyde(MDA) levels in myocardial tissue. Hematoxylin-eosin(HE)staining was used to observe myocardial injury, and terminal deoxynucleotidyltransferase-mediated d UTP-biotin nick end labeling(TUNEL) staining was used to observe cell apoptosis. Transmission electron microscopy detection was used to observe mitochondrial damage and autophagosomes in the myocardium. The mitochondrial membrane potential of the myocardium was analyzed with the fluorescent dye JC-1. Mitochondrial respiratory chain complex(complex Ⅰ, Ⅲ, and Ⅳ) activities and ATPase in the myocardium were detected by mitochondrial respiratory chain complex assay kits. Western blot analysis was used to detect the autophagy index and hypoxia inducible factor-1α(HIF-1α)/Bcl-2 and adenovirus E1B 19k Da-interacting protein 3(BNIP3) signaling. Results:BAJP reduced myocardial injury and inhibited myocardial cell apoptosis in AHH rats. BAJP pretreatment decreased MDA levels and increased SOD levels in AHH rats(all P<0.01). Moreover, BAJP pretreatment increased the mitochondrial membrane potential(P<0.01), mitochondrial respiratory chain complex(complexes Ⅰ, Ⅲ, and Ⅳ)activities(P<0.01), and mitochondrial ATPase activity in AHH rats(P<0.05). The re

关键词： acute hypobaric hypoxia bloodletting acupuncture at Jing-well points autophagy myocardium injury mitochondrial damage Chinese medicine

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Bloodletting Acupuncture at Jing-Well Points on Hand Induced Autophagy to Alleviate Brain Injury in Acute Altitude Hypoxic Rats by Activating PINK1/Parkin Pathway

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Chinese Journal of Integrative Medicine 2023年第10期29卷 932-940页

作者： li Yong-ping li meng-xin WANG Chao li Yun-di SA Yu-ping GUO Yi Medical College of Qinghai University Xining810001China Qinghai Provincial Key Laboratory of Traditional Chinese Medicine Research for Glucolipid Metabolic Diseases Xining810001China Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin301617China

Objective: To explore the protective effect of bloodletting acupuncture at twelve Jing-well points on hand(BAJP) on acute hypobaric hypoxia(AHH)-induced brain injury in rats and its possible ***: Seventy-five Sprague Dawley rats were divided into 5 groups by a random number table(n=15),including control, model, BAJP, BAJP+3-methyladenine(3-MA), and bloodletting acupuncture at non-acupoint(BANA, tail tip blooding) groups. After 7-day pre-treatment, AHH models were established using hypobaric oxygen chambers. The levels of S100B, glial fibrillary acidic protein(GFAP), superoxide dismutase(SOD), and malondialdehyde(MDA) in serum were measured by enzyme-linked immunosorbent assay. Hematoxylin-eosin staining and the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling method were used to assess hippocampal histopathology and apoptosis. Transmission electron microscopy assay was used to observe mitochondrial damage and autophagosomes in hippocampal tissues. Flow cytometry was used to detect mitochondrial membrane potential(MMP). The mitochondrial respiratory chain complexes Ⅰ, Ⅲ and Ⅳ activities and ATPase in hippocampal tissue were evaluated, respectively. Western blot analysis was used to detect the protein expressions of Beclin1, autophagy protein 5(ATG5), microtubule-associated protein 1 light chain 3 beta(LC3B), phosphatase and tensin homolog induced kinase 1(PINK1), and Parkin in hippocampal tissues. The mRNA expressions of Beclin1, ATG5 and LC3-Ⅱ were analyzed by quantitative real-time polymerase chain reaction. Results: BAJP treatment reduced hippocampal tissue injury and inhibited hippocampal cell apoptosis in AHH rats. BAJP reduced oxidative stress by decreasing S100B, GFAP and MDA levels and increasing SOD level in the serum of AHH rats(P<0.05 or P<0.01). Then, BAJP increased MMP, the mitochondrial respiratory chain complexes Ⅰ, Ⅲ and Ⅳ activities, and the mitochondrial ATPase activity in AHH rats(all P<0.01). BAJP improve

关键词： acute hypobaric hypoxia bloodletting acupuncture at Jing-well points mitochondrial autophagy PINK1/Parkin signaling mitochondrial damage Chinese medicine

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Improved BP Neural Network for Transformer Fault Diagnosis

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Journal of China University of Mining and Technology 2007年第1期17卷 138-142页

作者： SUN Yan-jing ZHANG Shen MIAO Chang-xin li Jing-meng School of Information and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The back propagation (BP)-based artificial neural nets (ANN) can identify complicated relationships among dissolved gas contents in transformer oil and corresponding fault types, using the highly nonlinear mapping nature of the neural nets. An efficient BP-ALM (BP with Adaptive Learning Rate and Momentum coefficient) algorithm is proposed to reduce the training time and avoid being trapped into local minima, where the learning rate and the momentum coefficient are altered at iterations. We developed a system of transformer fault diagnosis based on Dissolved Gases Analysis (DGA) with a BP-ALM algorithm. Training patterns were selected from the results of a Refined Three-Ratio method (RTR). Test results show that the system has a better ability of quick learning and global convergence than other methods and a superior performance in fault diagnosis compared to convectional BP-based neural networks and RTR.

关键词： transformer fault diagnosis back-propagation artificial neural network momentum coefficient

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DJ1 Ameliorates AD-like Pathology in the Hippocampus of APP/PS1 Mice

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Biomedical and Environmental Sciences 2023年第11期36卷 1028-1044页

作者： PENG Yang Yang li meng xin li Wen Jie XUE Yuan MIAO Yu Fan WANG Yu lin FAN Xiao Chen TANG Lu Lu SONG Han Lu ZHANG Qian li xing Department of Nutrition and Food Hygiene College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina

Objective To explore whether the protein Deglycase protein 1(DJ1)can ameliorate Alzheimer’s disease(AD)-like pathology in Amyloid Precursor Protein/Presenilin 1(APP/PS1)double transgenic mice and its possible mechanism to provide a theoretical basis for exploring the pathogenesis of *** Adeno-associated viral vectors(AAV)of DJ1-overexpression or DJ1-knockdown were injected into the hippocampus of 7-month-old APP/PS1 mice to construct models of overexpression or *** were divided into the AD model control group(MC),AAV vector control group(NC),DJ1-overexpression group(DJ1+),and DJ1-knockdown group(DJ1-).After 21 days,the Morris water maze test,immunohistochemistry,immunofluorescence,and western blotting were used to evaluate the effects of DJ1 on *** DJ1+overexpression decreased the latency and increased the number of platform traversals in the water maze ***1-cells were cured and atrophied,and the intercellular structure was relaxed;the number of age spots and the expression of AD-related proteins were significantly ***1+increased the protein expression of Nuclear factor erythroid 2-related factor 2(NRF2),heme oxygenase-1(HO-1),light chain 3(LC3),phosphorylated AMPK(p-AMPK),and B cell lymphoma-2(BCL-2),as well as the antioxidant levels of total superoxide dismutase(T-SOD),total antioxidant capacity(T-AOC),and Glutathione peroxidase(GSH-PX),while decreasing the levels of Kelch-like hydrates-associated protein 1(Keap1),mammalian target of rapamycin(mTOR),p62/sequestosome1(p62/SQSTM1),Caspase3,and malondialdehyde(MDA).Conclusion DJ1-overexpression can ameliorate learning,memory,and AD-like pathology in APP/PS1 mice,which may be related to the activation of the NRF2/HO-1 and AMPK/mTOR pathways by DJ1.

关键词： Alzheimer's disease DJ1 NRF2/HO-1 Oxidative stress AMPK/mTOR Autophagy Apoptosis

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期68卷 350-359页

作者： Can Zhu Yiyang Wang Lei meng Beibei Qiu Jing li Shucheng Qin Ke Hu xin Jiang Wenbin Lai Minchao liu Zhe liu Chenxing Lu Jinyuan Zhang Yongfang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

关键词： D-A copolymer, hole transport materials, bifunctional bridge capping layer, passivation perovskite solar cells

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The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao lingyan meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

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Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： xin li Yibo ZHOU Tao ZHAO xingjian HE Yanhong PAN State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University Institute of Palaeontology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian hair, as a key feature related to endothermy, physical protection, and camouflage, has a long geohistorical record that dates back even to the Mesozoic. However, the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time. To address this, we conducted taphonomic experiments to simulate the transformation process of black hair. The changes in the morphological structure, microscopic characteristics, and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy, Fourier transform infrared(FTIR) spectroscopy, and Raman spectroscopy. Our results revealed that damage to the morphology of hair began at a mild temperature(150–175°C), and hair transformed into a fluid-like mass at a relatively high temperature(200°C). In addition, the morphological structure of melanosomes had relatively greater preservation potential than keratins did, and the microscopic features of melanosomes were persistently stable. The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased. Although the chemical signals were not lost completely, the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200°C), whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable, even at high temperatures(>200°C). These results were confirmed by principal component analysis(PCA) and principal component analysis linear discriminant analysis(PCA–LDA). In addition, the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid), which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy

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超声图像神经分割方法研究

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北京邮电大学学报 2018年第1期41卷 115-120页

作者：徐晨阳李梦昕杨娟北京邮电大学通信软件工程中心

为了提升超声图像中的神经分割效果,提出了一种新的网络结构残差U型网络.相比于现有的U-net网络,残差U型网络加深了网络结构,提高了网络的表达能力;通过对每层参数进行规范化处理,减少了训练时间,提高了神经分割效果.实验结果表明,残差... 详细信息

为了提升超声图像中的神经分割效果,提出了一种新的网络结构残差U型网络.相比于现有的U-net网络,残差U型网络加深了网络结构,提高了网络的表达能力;通过对每层参数进行规范化处理,减少了训练时间,提高了神经分割效果.实验结果表明,残差U型网络在分割效果上比U-net网络提升了约13%,比Seg Net网络提升了约7%.

关键词：深度学习神经分割卷积神经网络

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Airborne laser communication technology and flight test

Airborne laser communication technology and flight test

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国防光电子论坛空间光信息与组网技术及应用研讨会

作者： li-xin meng li-zhong ZHANG Xiao-ming li Ying-chao li Hui-lin JIANG Fundamental Science on Space-Ground Laser Communication Technology Laboratory

Reconnaissance aircraft is an important node of the space-air-ground integrated information network, on which equipped with a large number of high-resolution surveillance equipment, and need high speed communications equipment to transmit detected information in real time. Currently RF communication methods cannot meet the needs of communication bandwidth. Wireless laser communication has outstanding advantages high speed, high capacity, security, etc., is an important means to solve the high-speed information transmission of airborne platforms. In this paper, detailed analysis of how the system works, the system components, work processes, link power and the key technologies of airborne laser communication were discussed. On this basis, a prototype airborne laser communications was developed, and high-speed, long-distance communications tests were carried out between the two fixed-wing aircraft, and the airborne precision aiming, atmospheric laser communication impacts on laser communication were tested. The experiments ultimately realize that, the communication distance is 144 km, the communication rate is 2.5Gbps. The Airborne laser communication experiments provide technical basis for the application of the conversion equipment.

关键词： Airborne laser communication flight test atmospheric APT

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High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi li Yabo Xie Qiancheng Chen xin Zhang Jian-Rong li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

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