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Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine:A methodological investigation with evidence map

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Journal of Integrative Medicine 2022年第3期20卷 213-220页

作者： Ting-ting Lu Cun-cun Lu Mei-xuan li li-xin ke Hui Cai ke-hu Yang Institution of Clinical Research and Evidence-Based Medicine Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000Gansu ProvinceChina Hepatobiliary and Pancreatic Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

Background:Acupuncture has been widely used to relieve migraine-related ***,the findings of previous systematic reviews(SRs)and meta-analyses(MAs)are still not completely *** quality is also unknown,so a comprehensive study is ***:To evaluate the reporting and methodological quality of these MAs concerning acupuncture for migraine,and summarize evidence about the efficacy and safety of acupuncture for *** strategy:Pub Med,Embase,Cochrane library,China National Knowledge Infrastructure,Chinese Biomedical Databases,Wanfang Data,and VIP databases were searched from inception to September 2020,with a comprehensive search *** criteria:The pairwise MAs of randomized controlled trials(RCTs)concerning migraine treated by acupuncture or acupuncture-based therapies,with a control group that received sham acupuncture,medication,no treatment,or acupuncture at different acupoints were *** extraction and analysis:Two independent investigators screened studies,extracted relevant data,and assessed reporting and methodological quality using Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2009 and A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),then all results were *** correlation test was used to evaluate the correlation between reporting and methodological quality ***:A total of 20 MAs were included in this *** included MAs indicated that acupuncture was efficacious and safe in preventing and treating migraine when compared with control *** was a high correlation between reporting and methodological quality scores(rs=0.87,Plity of the included SRs needs to be improved mainly with regard to protocol and prospective registration,using a comprehensive search strategy,summarizing the strength of evidence body for key outcomes,a full list of excluded studies with reasons for exclusion,reporting of RCTs’fundin

关键词： Migraine Acupuncture Systematic review Meta-analysis AMSTAR 2 PRISMA

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Prevalence of Tuberculosis among Close Contacts of Index Cases in 27 Universities in Beijing,China,2017-2018

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Biomedical and Environmental Sciences 2020年第10期33卷 780-784页

作者： ZHAO Fei ZHANG Zhi Guo MA Shu Bo YANG Zhen HE Yan Ping WANG Lu Qin OWITI Philip MA Chao li Tao DU xin ZHANG Can You CHENG Jun WANG li Xia HE Guang Xue ZHANG Hui li ke xin Clinical Trial Center Beijing HospitalNational Center of Gerontology/Institute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China National Center for TB Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Epidemiology of Microbial Diseases Yale School of Public HealthYale universityNew HavenCTUSA Beijing Changping Institute for Tuberculosis Prevention and Treatment Beijing 102200China The International Union Against Tuberculosis and Lung Disease ParisFrance The National Tuberculosis Leprosy and Lung Disease ProgramNairobiKenya National Immunization Program Chinese Center for Disease Control and PreventionBeijing 102206China Department of Science and Technology Chinese Center for Disease Control and PreventionBeijing 102206China

The World Health Organization(WHO)launched the‘End TB Strategy’,which aims to reduce the mortality and incidence rate of tuberculosis(TB)by 95% and 90% by 2035,respectively,compared with the levels in *** achieve these targets and milestones,the strategy set three pillars and 10 indicators,one of which is systematic screening of contacts and high-risk groups[1].

关键词： mortality tuberculosis Cases

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Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou ke Yajing Zhao xin Min Yanghong li Ruiyu Mi Yangai liu Xiaowen Wu Minghao Fang Zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

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Research trends of uveal melanoma: a bibliometric study and visualization analysis

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TMR Cancer 2021年第2期4卷 12-28页

作者： Hao Wang li-xin ke Cun-Cun Lu Wang li Ya-Min Zhao Ophthalmology Department The Second HospitalLanzhou UniversityLanzhou 730000China The First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080China School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China The First Hospital Lanzhou UniversityLanzhou 730000China School of Public Health Lanzhou UniversityLanzhou 730000China.

Background:Uveal melanoma is the most prevalent intraocular *** preceding decades,many studies have been published on uveal ***,so far,uveal melanoma-related bibliometric studies have not been ***:Uveal melanoma-related articles and reviews published between 2005 and 2019 were retrieved in the Web of Science Core Collection on March 15,*** bibliometric tools(HistCite,VOSviewer,and CiteSpace)were employed to conduct the current ***:A total of 3,404 publications related to uveal melanoma were identified,involving 3015 articles(88.57%)and 389 reviews(11.43%)with 65,429 co-cited references in 9 languages,which were published by 2,875 institutions in 66 countries/*** United States contributed to most publications(n=1427,41.92%),and the Thomas Jefferson University was involved in most of the studies(n=160,5.56%).Investigative Ophthalmology&Visual Science published the majority of the papers(n=175,5.14%),whereas Ophthalmology received the most co-citations(n=7050).Shields CL owned the most publications and co-citations(n=122 and 2151,respectively).Gene and molecular biology aspects,prevalence,the main prognosis factor,and treatment were the intellectual foundations of uveal melanoma *** the field of uveal melanoma,emerging hotspots of uveal melanoma include epidemiologic characteristics,prognosis factors,mechanisms of uveal melanoma development,the use of novel predictive tools,and clinical applications of novel targeted ***:This first bibliometric study focused on the integral tendency of the past 15 years,identified landmark items,and revealed current research hotspots in the field of uveal melanoma,which will provide references for clinicians and researchers,as well as an example of visualization analysis to explore research hotspots in other fields.

关键词： Bibliometric Uveal melanoma HistCite VOSviewer CiteSpace

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期68卷 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu Jing li Shucheng Qin ke Hu xin Jiang Wenbin Lai Minchao liu Zhe liu Chenxing Lu Jinyuan Zhang Yongfang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

关键词： D-A copolymer, hole transport materials, bifunctional bridge capping layer, passivation perovskite solar cells

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Overexpression of p27^(KIP1)induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell line

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World Journal of Gastroenterology 2000年第4期6卷 513-521页

作者： Jiang li xin ke Yang xin xin Yu Meng liang Ge Wen liang Wang Jie Zhang Yun De Hou Department of Pathology,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China State key Laboratory for Molecular Virology and Genetic Engineering,Beijing 100052,China Department of Dermatology,Beijing Hospital,Beijing 100016,China Institute of Radiation Medicine,Beijing 100085,China 第四军医大学陕西西安中国预防医学科学院病毒所北京中国预防医学科学院病毒所分子病毒基因工程国家重点实验室北京北京医院北京解放军军事医学科学院放射医学所北京

AIM We have previously reported that inducible over-expresaion of Bak may prolong cell cycle in G1 phase and lead to apoptosis in HCC-9204 cells. This study is to investigate whether p27KIP1 plays an important role in this process. MEHODS In order to elucidate the exact function of p27KIP1 in this process, a zinc inducible p27KIP1 stable transfectant and transient p27KIP1- GFP fusion transfectant were constructed. The effects of inducible p27KIP1 on cell growth, cell cycle arrest and apoptosis were examined in the mock, control pMD vector, and pMD-KIP1 transfected HCC-9204 cells. RESULTS This p27KIP1-GFP transfectant may transiently express the fusion gene. The cell growth was reduced by 35% at 48 h of p27KIP1 induction with zinc treatment as determined by trypan blue exclusion assay. These differences remained the same after 72 h of p27KIP1 expression, p27KIP1 caused cell cycle arrest after 24 h of induction, with 40% increase in G1 population. Prolonged p27KIP1 expression in this cell line induced apoptotic cell death reflected by TUNEL assay. Fourty-eight h and 72 h of p27KIP1 expression showed a characteristic DNA ladder on agarose gel electrophoresis.

关键词： p27^(KIP1) apoptosis cell cycle inducible expression system carcinoma hepatocellular liver neoplasms

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蒸汽管线裂纹分析

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石油化工设备 2014年第1期43卷 92-94页

作者：李克欣中国石化北京燕山分公司北京102501

针对某再沸器蒸汽入口法兰及管线焊缝多处出现裂纹的问题,通过检验与分析,认为裂纹产生的原因为蒸汽介质碱脆。利用焊接和注入密封剂复合带压堵漏措施进行处理,使用效果良好。

关键词：管线蒸汽裂纹碱脆

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中国参与亚太经济共同体的宏观分析

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财经问题研究 2007年第5期 93-96,F0003页

作者：李克新南开大学经济学院天津300071

在是否要建立“亚太经济共同体”的问题上,亚太经合组织(APEC)成员发生过三次交锋,这显示出APEC要求变革的信息,同时体现了APEC成员在争夺亚太事务主导权以及制定贸易规则上的利益冲突。随着中国内部经济发展水平和外部政治环境的变化,... 详细信息

在是否要建立“亚太经济共同体”的问题上,亚太经合组织(APEC)成员发生过三次交锋,这显示出APEC要求变革的信息,同时体现了APEC成员在争夺亚太事务主导权以及制定贸易规则上的利益冲突。随着中国内部经济发展水平和外部政治环境的变化,中国需要考虑如何在亚太经济一体化的战略决策上采取更加符合国家利益的取向,从而协调与地区内主要国家的双边关系,在经济上使APEC实现利益的最大化,同时在APEC的未来发展方向上掌握主动权。

关键词：亚太经济共同体 APEC 对外经贸政策

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化学药物临床药动学试验样品再分析的一般要求及解读

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中国新药杂志 2014年第12期23卷 1378-1381页

作者：李敏史爱欣李可欣胡欣药物临床风险与个体化应用评价北京市重点实验室北京医院药学部北京100730

化学药物临床药动学试验的生物样品再分析(incurred sample reanalysis,ISR)于1990年水晶城生物分析方法研讨会上首次被提出,经过20余年的发展已成为生物样品分析方法学确证的重要组成部分。2009年欧盟发布的生物分析方法学确证指南、2... 详细信息

化学药物临床药动学试验的生物样品再分析(incurred sample reanalysis,ISR)于1990年水晶城生物分析方法研讨会上首次被提出,经过20余年的发展已成为生物样品分析方法学确证的重要组成部分。2009年欧盟发布的生物分析方法学确证指南、2013年美国FDA发布的生物分析方法学确证指导原则草案均对ISR提出了明确要求,我国2015版药典附录也对ISR提出了相应要求。本文拟重点讨论ISR的试验设计及实施过程中的相关问题,包括ISR策略的背景、ISR的试验设计及ISR的结果评价与分析,以期为临床研究工作者提供参考。

关键词：试验样品再分析试验设计指导原则生物样品分析方法学确证重现性

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新药Ⅰ期临床试验中的加强心电监测的策略探讨

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中国药学杂志 2015年第13期50卷 1153-1155页

作者：薛薇李可欣北京医院药学部药物临床风险与个体化应用评价北京市重点实验室北京100730

目的探讨在Ⅰ期临床试验中加强心电监测的策略,为全面QT/QTc研究(Thorough QT/QTc Study,TQT/QTc)的必要性及新药后续开发策略提供参考。方法参考国内外心脏安全性研究的相关进展,结合全面QT/QTc研究指南,探讨本研究策略。结果本文提出... 详细信息

目的探讨在Ⅰ期临床试验中加强心电监测的策略,为全面QT/QTc研究(Thorough QT/QTc Study,TQT/QTc)的必要性及新药后续开发策略提供参考。方法参考国内外心脏安全性研究的相关进展,结合全面QT/QTc研究指南,探讨本研究策略。结果本文提出并探讨了Ⅰ期试验中加强心电监测的适用范围,分析并阐述方案设计及质量控制的原则与规范。结论新药Ⅰ期临床试验中加强心电监测是依托Ⅰ期临床试验的平台对心脏安全性所进行的初步评价与筛选,在不增加受试者药物暴露的情况下获取及挖掘更多安全性信息,为进一步QT/QTc试验提供依据和参考。

关键词： Ⅰ期临床试验心电监测 QT/QTc研究

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