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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue li yang DI Lei cheng Ranran liU lijuan li Hongmei li Yi TANG Zhangrui yan Yongming LU Tao FU Rong cheng Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

Generation and regulation of electromagnetic pulses generated by femtosecond lasers interacting with multitargets

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Nuclear Science and Techniques 2024年第1期35卷 96-107页

作者： Ya-Dong Xia De-feng Kong Qiang-You He Zhen Guo Dong-Jun Zhang Tong yang Hao cheng Yu-Ze li yang yan Xiao liang Ping Zhu xing-Long Xie Jian-Qiang Zhu Ting-Shuai li Chen lin Wen-Jun Ma Xue-Qing yan State Key Laboratory of Nuclear Physics and Technology and Key Laboratory of HEDP of the Ministry of EducationCAPTPeking UniversityBeijing 100871China Beijing Laser Acceleration Innovation Center Beijing 101407China Institute of Guangdong Laser Plasma Technology Guangzhou 510540China National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and FineChinese Academy of SciencesShanghai 201800China school of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

Ultrashort and powerful laser interactions with a target generate intense wideband electromagnetic pulses(EMPs).In this study,we report EMPs generated by the interactions between petawatt(30 fs,1.4×10^(20) W/cm^(2))femtosecond(fs)lasers with metal flat,plastic flat,and plastic nanowire-array(NWA)*** analyses are conducted on the EMPs in terms of their spatial distribution,time and frequency domains,radiation energy,and *** results indicate that EMPs from metal targets exhibit larger amplitudes at varying angles than those generated by other types of targets and are enhanced significantly for NWA *** a plastic target holder and increasing the laser focal spot can significantly decrease the radiation energy of the ***,the composite shielding materials indicate an effective shielding effect against *** simulation results show that the NWA targets exert a collimating effect on thermal electrons,which directly affects the distribution of *** study provides guidance for regulating EMPs by controlling the laser focal spot,target parameters,and target rod material and is beneficial for electromagnetic-shielding design.

关键词： Electromagnetic pulses Laser plasma interaction Electromagnetic shielding Electron distribution

Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease:Mechanism,clinical evidence,and prospect

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World Journal of Gastroenterology 2024年第8期30卷 833-842页

作者： Xiao-Xia Qiu Sheng-li cheng yan-Hui liu Yu li Rui Zhang Nan-Nan li Zheng li Research and Education Department Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Anhui Provincial Hospital The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina Department of Clinical Pharmacy Anhui Provincial Children’s HospitalHefei 230000Anhui ProvinceChina Department of Pharmacy Taihe County People’s Hospital of Anhui ProvinceFuyang 236600Anhui ProvinceChina Department of Pharmacy The Second People’s Hospital of HefeiHefei Hospital Affiliated to Anhui Medical UniversityHefei 230000Anhui ProvinceChina university of Science and Technology of china The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells College of Health SciencesSchool of Life SciencesJiangsu Normal UniversityXuzhou 221000Jiangsu ProvinceChina

The population of non-alcoholic fatty liver disease(NAFLD)patients along with relevant advanced liver disease is projected to continue growing,because currently no medications are approved for *** microbiota transplantation(FMT)is believed a novel and promising therapeutic approach based on the concept of the gut-liver axis in liver *** has been an increase in the number of pre-clinical and clinical studies evaluating FMT in NAFLD treatment,however,existing findings diverge on its ***,we briefly summarized the mechanism of FMT for NAFLD treatment,reviewed randomized controlled trials for evaluating its efficacy in NAFLD,and proposed the prospect of future trials on FMT.

关键词： Non-alcoholic fatty liver disease Fecal microbiota transplantation Randomized controlled trial Mechanism Efficacy

A peak enhancement of frequency response of waveguide integrated silicon-based germanium avalanche photodetector

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Journal of Semiconductors 2024年第7期45卷 61-68页

作者： linkai Yi Daoqun liu Wenzheng cheng Daimo li Guoqi Zhou Peng Zhang Bo Tang Bin li Wenwu Wang yan yang Zhihua li Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China school of Electronic Electrical and Communication Engineering University of Chinese Academy of SciencesBeijing 100049China

Avalanche photodetectors(APDs) featuring an avalanche multiplication region are vital for reaching high sensitivity and responsivity in optical transceivers. Waveguide-coupled Ge-on-Si separate absorption, charge, and multiplication(SACM)APDs are popular due to their straightforward fabrication process, low optical propagation loss, and high detection sensitivity in optical communications. This paper introduces a lateral SACM Ge-on-Si APD on a silicon-on-insulator(SOI) wafer, featuring a 10 μm-long, 0.5 μm-wide Ge layer at 1310 nm on a standard 8-inch silicon photonics platform. The dark current measures approximately 38.6 μA at-21 V, indicating a breakdown voltage greater than-21 V for the device. The APDs exhibit a unitgain responsivity of 0.5 A/W at-10 V. At-15 V, their responsivity reaches 2.98 and 2.91 A/W with input powers of-10 and-25 dBm, respectively. The device's 3-dB bandwidth is 15 GHz with an input power of-15 dBm and a gain is 11.68. Experimental results show a peak in impedance at high bias voltages, attributed to inductor and capacitor(LC) circuit resonance, enhancing frequency response. Furthermore, 20 Gbps eye diagrams at-21 V and-9 dBm input power reveal signal to noise ratio(SNRs) of 5.30. This lateral SACM APD, compatible with the stand complementary metal oxide semiconductor(CMOS) process,shows that utilizing the peaking effect at low optical power increases bandwidth.

关键词： photodetectors optical communications responsivity 3-dB bandwidth

A double-layer radiative cooling coating that utilizes the refractive index difference between layers to achieve extremely high solar reflectivity

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Science china Technological sciences 2024年第10期67卷 3182-3189页

作者： WANG FuQiang li ChunZhe yanG ZhenNing XIE Weixin li Xiang XU ZengHui yan YuYing cheng ZiMing school of Energy Science and Engineering Harbin Institute of Technology school of New Energy Harbin Institute of Technology at Weihai china Construction Eco-Environmental Protection Technology Co. Ltd. Faculty of Engineering University of Nottingham

Passive daytime radiative cooling（PDRC） technology has great potential in reducing cooling energy consumption. In order to further improve the spectral performance of PDRC coatings, current researchers mostly focus on the selection and size design of functional particles, while ignoring the optical properties enhancement effect caused by the interlayer binder. In this study, based on the principle that the refractive index difference between layers enhanced the backscattering performance of the solar spectrum, we proposed and manufactured a double-layer PDRC coating with polyvinylidene difluoride（PVDF） as the filmforming material in the upper layer and polydimethylsiloxane（PDMS） as the film-forming material in the lower layer, both filled with Al2O3and SiO2particles. The double-layer PDRC coating exhibited excellent spectral performance that a high solar reflectivity of 98% and an emissivity of 0.95 at the “atmospheric window” band. In comparison, the solar spectrum reflectivity of the single-layer PDRC coatings based on PVDF and PDMS of the same thickness was 95% and 94.7%, respectively. Outdoor tests showed that the PDRC coating achieved a temperature decrease of up to 7.1℃ under direct sunlight at noon time. In addition, the PDRC coating had excellent weather resistance, water resistance, and other basic properties. This article opens up a new idea and provides methodological guidance for the design of double-layer PDRC coatings.

关键词： double-layer radiative cooling coating spectral modulation interlayer refractive index solar energy radiative transfer

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The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi feng Xi-Lei Sun Zheng-Hua An Yong Deng cheng-Er Wang Huang Jiang Jun-Jie li Da-li Zhang xin-Qiao li Shao-lin Xiong Chao Zheng Ke Gong Sheng yang Xiao-Jing liu Min Gao Xiang-yang Wen Ya-Qing liu yan-Bing Xu Xiao-Yun Zhao Jia-Cong liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China school of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response light yield nonlinearity

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li chengcheng Gai Danqing xin Yijing Zhao yan Song Yahong cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Targeting colorectal cancer with Herba Patriniae and Coix seed:Network pharmacology,molecular docking,and in vitro validation

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3539-3558页

作者： cheng-Lei Wang Bing-Wei yang xin-yan Wang Xue Chen Wei-Dong li Hao-Yu Zhai Ying Wu Mu-YaoCui Jia-He Wu Qing-Hui Meng Nan Zhang Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China The First Clinical Medical College Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of Scientific Research Management Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China school of Clinical Medicine Qinghai university Xining 810000Qinghai ProvinceChina school of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Herba Patriniae and Coix seed(HC)constitute a widely utilized drug combination in the clinical management of colorectal cancer(CRC)that is known for its diuretic,anti-inflammatory,and swelling-reducing *** its efficacy has been demonstrated in a clinical setting,the active compounds and their mechanisms of action in CRC treatment remain to be fully *** To identify the active,CRC-targeting components of HC and to elucidate the mechanisms of action *** Active HC components were identified and screened using *** for each component were ***-related targets were obtained from human gene *** targets between HC and CRC were identified.A“drug-ingredient-target”network was created to identify the core components and targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were conducted to elucidate the key pathways *** docking between core targets and key components was *** vitro experiments validated core *** Nineteen active components of HC were identified,with acacetin as the primary active *** predictive analysis identified 454 targets of the active compounds in *** mapping with 2685 CRC-related targets yielded 171 intervention targets,including 30 core *** and KEGG analyses indicated that HC may influence the phosphoinositide 3-kinase(PI3K)/Akt signaling *** docking showed that acacetin exhibited an optimal interaction with AKT1,identifying PI3K,AKT,and P53 as key genes likely targeted by HC during CRC *** inhibited HT-29 cell proliferation and migration,as well as promoted apoptosis,in *** blotting analysis revealed increased p53 and cleaved caspase-3 expression and decreased levels of p-PI3K,p-Akt,and survivin,which likely contributed to CRC *** Acacetin,the principal active compound in the HC pair,inhibited the proliferati

关键词： Colorectal cancer Baijiangcao(Herba Patriniae) Yiyiren(Coix seed) Acacetin Proliferation Migration Apoptosis Network pharmacology

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023

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Cancer Communications 2024年第1期44卷 127-172页

作者： feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-yan Cai Yuan-Fang li Xiu-Juan qu Hong Qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang ling-Yu Sun Rong-Bo lin Chang Wang Hao liu Miao-Zhen Qiu Wen-Long Guan Sheng-Xiang Rao Jia-Fu Ji yan xin Wei-Qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-lin Yuan feng Bi Tian-Shu liu Han liang yan-Qiao Zhang Guo-xin li Jun liang Bao-Rui liu lin Shen Jin li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy Center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor Center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in china,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of china,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong yanmei li Ni yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao Shiying li Hong cheng school of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China school of Pharmaceutical sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage