检索结果-南通市图书馆

Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer:Integrating Bioinformatics Analysis with Experimental Confirmation

引用

Current Medical Science 2024年第3期44卷 529-544页

作者： Yan-min liU Tie-cheng YANG Xiao-chang FANG li-jie YANG li-wen shi Hua-qiao WANG Ting-ting DOU lin SHU Tian-liang CHEN Jun HU Xiao-ming YU Xuan-fei li Department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China Department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China Department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and *** We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western *** experiments were conducted in vitro to investigate the effects of SLC9A2 on tumor growth and *** We found 130 DEGs,with 45 up-regulated and 85 down-regulated in *** analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter *** pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling *** identified 10 hub genes:CXCL1,SLC26A3,CXCL2,MMP7,MMP1,SLC9A2,SLC4A4,CLCA1,CLCA4,and *** enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of *** expression analysis revealed that CXCL1,CXCL2,MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2,SLC26A3,and ZG16 were expressed at lower *** analysis revealed that 5 key genes were significantly associated with the prognosis of *** mRNA and protein expression levels of SLC9A2 were markedly reduced in CRC tissues and cell ***,SLC9A2 overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and *** blotting analysis revealed tha

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乙烯-醋酸乙烯共聚物改性研究进展

引用

高分子通报 2024年第5期37卷 593-602页

作者：李世文程键安亚非晏超李庭轩李倩李化毅江苏科技大学材料科学与工程学院镇江212100 中国科学院化学研究所北京100190 首都师范大学化学系北京100048

乙烯-醋酸乙烯共聚物(EVA)具有优异的柔韧性、耐腐性、加工性、绿色环保,广泛应用于薄膜、热熔胶、黏合剂、电线电缆等领域。然而,EVA存在粘度低、热性能和力学性能差等缺点,限制了其发展和应用。因此,制备性能优良的新型改性EVA材料成... 详细信息

乙烯-醋酸乙烯共聚物(EVA)具有优异的柔韧性、耐腐性、加工性、绿色环保,广泛应用于薄膜、热熔胶、黏合剂、电线电缆等领域。然而,EVA存在粘度低、热性能和力学性能差等缺点,限制了其发展和应用。因此,制备性能优良的新型改性EVA材料成为近年来的研究热点。本综述回顾了近年来关于EVA不同改性方法的研究进展,对化学改性和物理改性两方面进行了重点介绍,分析了不同改性方法的优势和短板,最后对EVA改性方法及研究方向进行展望。

关键词： EVA 化学改性物理改性接枝改性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于双激光视觉成像与BP算法的微小位移测量

引用

激光与红外 2024年第4期54卷 542-549页

作者：李世雯路恩会郭耀村朱兴龙扬州大学机械工程学院江苏扬州225127 湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

针对现有单激光视觉微位移测量方法中利用的图像特征信息不丰富,导致测量结果不精确的问题,本文提出了一种直射与斜射结合的双激光微小位移测量方法,配合BP(Back Propagation)神经网络实现位移的高精度测量。论文采用透镜成像和小孔成... 详细信息

针对现有单激光视觉微位移测量方法中利用的图像特征信息不丰富,导致测量结果不精确的问题,本文提出了一种直射与斜射结合的双激光微小位移测量方法,配合BP(Back Propagation)神经网络实现位移的高精度测量。论文采用透镜成像和小孔成像的原理对双激光模型进行理论分析,使用ZEMAX对测距模型进行数值模拟,以验证所提方法的理论可行性与优越性;其次,根据数值模拟结果设计并搭建实验平台进行图像采集实验,提取一系列图像特征作为BP网络的输入,以位移参数为输出,构建位移预测模型。实验结果表明,相比单激光模型,本文提出的双激光位移模型有更高的测量精度,引入BP神经网络后,测量准确度达到99以上。本文为微小位移高精度测量提供了新方法与新思路。

关键词：双激光测距位移测量 ZEMAX仿真 BP神经网络

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cold-state spout-fluidizing characteristics of high-carbon ferromanganese powders

引用

International Journal of Minerals,Metallurgy and Materials 2011年第6期18卷 741-747页

作者： Jin Chen wen-li shi Jing Zhao Wan-ming lin Ke liu College of Materials Science and Engineering Taiyuan University of Technology Taiyuan 030024 China Xiangtan Science and Technology Co. Ltd. Xiangtan 411100 China

The spout-fluidizing characteristics of high-carbon ferromanganese powders with different sizes and masses were studied via a plexiglass spout-fluidized bed with an inner diameter of 30 mm and a height of 1000 *** relationships between bed voidage and such parameters as bed height,particle size,fluidizing air velocity,and air flow were *** results show that the powder material with high density can be fluidized in the spout-fluidized bed where the particle size is a key factor influencing the quality of fluidization.

关键词： ferromanganese powders fluidity density fluidized beds

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis

引用

Journal of Integrative Plant Biology 2006年第10期48卷 1244-1249页

作者： li-wen Jing shi-Hua Chen Xiao-li Guo Hui Zhang Yan-Xiu Zhao Key Laboratory of Plant Stress Research College of Life Sciences Shandong Normal University Jinan 250014 China

Ablotlc stress, such as salt, drought and extreme temperature, can result in enhanced production of reactive oxygen species （ROS）. Plants have developed both enzymatic ROS-scavenging and non-enzymatic ROS-scavenging systems. The major ROS-scavenging enzymes of plants include superoxide dismutase （SOD）, ascorbate peroxldaae （APX）, catalaae （CAT）, glutathione peroxldaae （GPX） and peroxiredoxina （Prxa）. In the present work, we identified a gene encoding chloroplast-located peroxiredoxin Q, SsPrxQ, from Suaeda salsa L. located at chloroplast. Overexpression of SsPrxQ In Arabidopsis leads to an increase In salt and low-temperature tolerance.

关键词： overexpression peroxiredoxin Q salt and low-temperature tolerance suaeda salsa subcellular localization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solid-phase Decarburization Kinetics of High-carbon Ferromanganese Powders by Microwave Heating

引用

Journal of Iron and Steel Research International 2015年第4期22卷 311-316页

作者： li-na GUO Jin CHEN Jing ZHAO Wan-ming liN wen-li shi Min liANG College of Materials Science and Engineering Taiyuan University of Technology

Solid-phase decarburization of high-carbon ferromanganese powders （HCFPs） was conducted using calcium carbonate powders （CCPs） as a decarburizer by microwave heating. Solid-phase decarburization kinelSics was investi- gated by isothermal method. The results show that the HCFPs show excellent microwave absorption at a higher av- erage heating rate of 80 ℃/min, while CCPs exhibit poor microwave absorption at a lower heating rate of 5--20 ℃/min; the heating characteristics are in-between when HCFPs and CCPs are mixed. The average heating rates of the mix- ture are 32.14, 31.25, 31.43, and 30.77 ℃/rain when the mixture is heated up to 900, 1000, 1100, and 1200 ℃, respectively. The good microwave absorption property of the mixed material lays the foundation for the solid-phase decarburization of HCFPs containing CCPs. Solid-phase decarburization of HCFPs containing CCPs is a first-order reaction by microwave heating. Apparent activation energy of solid-phase decarburization is 55.07 kJ/mol, which is far less than that of ordinary carbon gasification reaction and that of solid-phase decarburization under the same de- carburization condition by conventional heating. It indicates that microwave heating not only produces thermal effect, but also has non-thermal effect.

关键词： high-carbon ferromanganese powder solid-phase decarburization kinetics microwave heating calcium carbonate powder

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer

引用

Current Medical Science 2022年第2期42卷 357-372页

作者： Dan-wen WANG Fei SU li-jie YANG li-wen shi Tie-cheng YANG Hua-qiao WANG Xuan-fei li Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan443071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan443071China Clinical Cancer Study Center of Hubei Provence Wuhan443071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan443071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou730000China

Objective Gastric cancer(GC)is a deadly cancer and a challenging public health problem *** study aimed to analyze potential genes associated with pathogenesis and prognosis of gastric *** This work selected the overlapping differentially expressed genes(DEGs)in GC from four datasets,the GSE29272,GSE29998,GSE54129 and GSE118916 Gene Expression Omnibus *** DEGs were used to carry out comprehensive bioinformatic analysis to analyze the related functions and pathways enriched,the relative expression levels and immune infiltrates,the prognostic characteristics and the interaction *** In total,55 DEGs increased while 98 decreased in their expression *** those DEGs with increased expression,they were mostly concentrated on“focal adhesion”and“ECM-receptor interaction”,whereas DEGs with decreased expression were mostly associated with“gastric acid secretion”and“drug metabolism cytochrome P450”.MCODE and ClueGO results were then integrated to screen 10 hub genes,which were FN1,COL1A1,COL3A1,BGN,TIMP1,COL1A2,LUM,VCAN,COL5A2 and *** analysis revealed that higher expression of the ten hub genes significantly predicted lower overall survival of GC ***1 was most significantly related to neutrophils,CD8+T cells,as well as dendritic cells,while LUM was most significantly related to *** Immunohistochemistry results and functional testing showed that the expression of COL5A2 was elevated in GC and that it might be a key gene in GC tumorigenesis.

关键词： gastric cancer differentially expressed genes bioinformatics analysis prognosis immune infiltrate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interplay between geometric and electronic structures of Pt entities over TiO_(2) for CO oxidation

引用

Science China Chemistry 2024年第2期67卷 705-714页

作者： Xixiong Zhang wen shi Shaobo Han Yong li wenjie Shen School of Chemistry Dalian University of TechnologyDalian116024China State Key Laboratory of Catalysis Dalian Institution of Chemical PhysicsChinese Academy of SciencesDalian116023China

Monodispersed Pt colloids with a mean size of 2 nm were deposited uniformly on the {110} facets of a rod-shaped rutile TiO_(2),forming a well-defined Pt/TiO_(2) *** treatment of this precursor at elevated temperatures re-dispersed the Pt particles into clusters and ***-calcination at 673 K partially oxidized the Pt particle surface,while calcination at 773 K yielded Pt Oxclusters of 1.6 nm in 7–8 atomic *** calcination at 873 K formed a mixture of raft-like PtO_(x) clusters(1.6 nm,1–2 atomic layers) and cationic *** tested for CO oxidation at 373 K,the Pt particles showed a higher activity than the Pt Oxclusters,whereas the cationic single-atoms were much less *** H_(2)-reduction at 473 K converted the partially oxidized Pt particles into the metallic species,but they were encapsulated by TiO_(2)–xoverlayers because of the strong metal–support interactions,which decreased the activity dramatically.H_(2)-reduction of the PtO_(x) clusters at473 K enhanced the fraction of metallic Pt species without changing the size and geometry,and promoted the activity substantially.H_(2)-treatment of Pt single-atoms at 473 K increased the activity only moderately because most Pt species still kept at cationic *** results straightforwardly differentiated the catalytic behavior of Pt particles,clusters and single-atoms at the same metal loading and over the same TiO_(2) support,and further demonstrated that the electronic structures of Pt entities played a decisive role in the catalytic oxidation,in addition to the specified sizes.

关键词： Pt/TiO_(2)catalyst size effect Pt clusters active sites electronic structures CO oxidation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

引用

Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang Zhuo li Tingxia Zhou Ziwang Zhang wen shi Yexiang Tong Jianxin shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of TiO_(2) addition on microstructures and properties of Mgo-Cao refractory aggregates

引用

Journal of Iron and Steel Research International 2024年第6期31卷 1547-1554页

作者： Shuai Zhang Jing-ran Wang Yuan-gao li Feng-you li wen Yan Hui-ying shi The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Joint International Research Laboratory of Refractories and Metallurgy Wuhan 430081HubeiChina Shanxi Luweibao Taigang Refractory Co. Ltd.Taiyuan 030003ShanxiChina

MgO-CaO(40 wt.%CaO)refractory aggregates were prepared using the calcined dolomite and light-burned magnesia fine powder as raw materials and TiO_(2) as *** effect of TiO_(2) on their phase composition,microstructures and properties was investigated by X-ray diffraction and scanning electron *** properties such as bulk density,apparent porosity,relative aggregate tube strength and hydration resistance were also *** results showed that the CaTiO_(3) generated by the reaction between CaO and TiO_(2) was distributed around the CaO grain boundaries and intermittently distributed with MgO,which formed an isolation layer around CaO and greatly improved the hydration ***,the introduction of TiO_(2) promoted sintering and increased the grain size,further improving the strengths and hydration resistance of the *** addition,the most significant enhancement in the hydration resistance and strengths of the samples was achieved when 1.0-2.0 wt.%TiO_(2) was *** this case,the relative strength of aggregate increased from 33.3% to 37.3%-43.1%,and the mass gain after the hydration test decreased from 3.13% to 1.26%-1.45%.

关键词： MgO-CaO refractory aggregate TiO_(2)addition Phase composition Microstructure Hydration resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：