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Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities

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Current Medical Science 2020年第3期40卷 434-443页

作者： wei-li gao Xiang-hua li Xin-peng DUN Xiao-kuan JING Ke YANG Yan-kun li School of Pharmacy Hubei University of Science and TechnologyXianning437100China Hubei Key Laboratory of Cardiovascular Cerebrovascular and Metabolic DisordersHubei University of Science and TechnologyXianning437100China Department of Pharmacy Huangshi Central HospitalAfiliated Hospial of Hubei Polytechnic UniversityEdong Healthcare GroupHuangshi435000China

Progressive memory loss and cognitive impairment are the main clinical manifestations of Alzheimer’s disease(AD).Currently,there is no effective drug available for the treatment of *** studies have demonstrated that the cognitive impairment of AD is associated with oxidative stress and the inhibition of AKT and ERK *** seed proanthocyanidin extract(GSPE)has been shown to have strong antioxidant effect and can protect the nervous system from oxidative stress *** study aimed to investigate the protective effect of GSPE on the cognitive and synaptic impairments of AD using a sporadic AD rat model induced by intracerebroventricular(ICV)injection of streptozotocin(STZ)(ICV-STZ).Rats were treated with GSPE(50,100,or 200 mg/kg every day)by intragastrical(ig.)administration for continuous 7 weeks,and ICV-STZ(3 mg/kg)was performed on the first day and third day of week *** and memory abilities were assessed by the Morris water maze(MWM)test at week *** behavioral test,hippocampal long-term potentiation(LTP)was recorded,and the levels of malondialdehyde(MDA),superoxide dismutases(SOD),glutathione(GSH)and the protein expression of AKT and ERK were measured in the hippocampus and cerebral cortex of *** study revealed that ICV-STZ significantly impaired the working learning ability and hippocampal LTP of rats,significantly increased the levels of MDA,and decreased the activity of SOD and GSH in the hippocampus and cerebral *** contrast,GSPE treatment prevented the impairment of cognitive function and hippocampal LTP induced by ICV-STZ,decreased the level of MDA,and increased the level of SOD and ***,Western blot results showed that GSPE treatment could prevent the loss of AKT and ERK activities in the hippocampus and cerebral cortex induced by *** findings demonstrate that GSPE treatment could ameliorate the impairment of cognitive ability and hippocampal synaptic plasticity in a rat model of sporadic AD

关键词： grape seed proanthocyanidin extract Alzheimer’s disease cognitive ability synaptic plasticity oxidative stress AKT/ERK signaling

Synthesis of diethers derived from furoin by phase transfer catalysis under microwave irradiation

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Chinese Chemical Letters 2007年第7期18卷 791-794页

作者： Feng Zhang Ya Zhuo li Da wei gao Ji Kui Sun Yu Min Zhang College of Chemistry Jilin University Changchun Jilin 130012 China

A series of new diethers were obtained by alkylation of furoin under microwave irradiation （MWI） in phase transfer catalysis （PTC） conditions. The products of alkyl halides were synthesized in good yields （〉75%） within a few minutes, and the products of dihalides were synthesized in fair yields （about 45%）. The yields are dramatically improved compared to conventional heating under the same conditions, in spite of similar profiles of rising in temperature.

关键词： Microwave irradiation Furoin Phase transfer catalysis O-Alkylation

Effects of microwave post-treatments on leaching resistance of ACQ-D treated Chinese fir

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Forestry Studies in China 2010年第1期12卷 1-8页

作者： YU li-li gao wei CAO Jin-zhen TANG Zhen-zhong College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

In order to improve the leaching resistance of active ingredient-copper in ammoniacal copper quat-type D （ACQ-D） treated Chinese fir （Cunninghamia lanceolata Hook.）, microwave post-treatments were carried out. The percentages of leached copper from ACQ-D treated Chinese fir with different microwave post-treatments were obtained after leaching tests by analyzing the copper retention in treated wood. The fixation mechanism of copper in the treated wood was determined with the help of SEM and FTIR spectra, while the valence conversion of copper after microwave post-treatments was studied by UV spectroscopy. Our experimental results show that the percentage of leached copper was reduced significantly after microwave post-treatment over time. This development was reinforced by allowing even more time for the treatment as well as with an increase in the power of microwave post-treatment. The leaching resistance of copper in wrapped samples was better than that in unwrapped samples, which is attributed to the combined effects of temperature and moisture content. Compared with air-dried samples, the valence conversion in the samples with microwave post-treatments changed slightly, which demonstrates that microwave post-treatments cannot impair the natural decay resistance of ACQ-D treated wood. SEM and FTIR spectra showed the presence of crystal particles formed by chemical reactions between copper and wood ingredients in wood cell walls and wood pits. Only a small amount of copper reacted with cellulose, while lignin and hemicellulose were the major bonding sites for copper in wood. Given the experimental results of mechanical properties, microwave post-treatments had a slight effect on the compression strength parallel to the grain and on the erystallinity of ACQ-D treated Chinese fir.

关键词： Chinese fir (Cunninghamia lanceolata Hook.) ammoniaeal copper quaternary ammonium salts type D (ACQ-D) copper leaching resistance microwave post-treatment

Synchronization Characterization of DC Microgrid Converter Output Voltage and Improved Adaptive Synchronization Control Methods

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Energy Engineering 2025年第2期122卷 805-821页

作者： wei Chen Xin gao Zhanhong wei Xusheng Yang Zhao li School of Electrical Engineering and Information Engineering Lanzhou University of TechnologyLanzhou730050China

This paper deeply introduces a brand-new research method for the synchronous characteristics of DC microgrid bus voltage and an improved synchronous control *** method mainly targets the problem of bus voltage oscillation caused by the bifurcation behavior of DC microgrid ***,the article elaborately establishes a mathematical model of a single distributed power source with hierarchical *** this basis,a smallworld network model that can better adapt to the topology structure of DC microgrids is further ***,a voltage synchronization analysis method based on the main stability function is proposed,and the synchronous characteristics of DC bus voltage are deeply studied by analyzing the size of the minimum non-zero *** view of the situation that the line coupling strength between distributed power sources is insufficient to achieve bus voltage synchronization,this paper innovatively proposes a new improved adaptive controller to effectively control voltage *** the convergence of the designed controller is strictly proved by using Lyapunov’s stability ***,the effectiveness and feasibility of the designed controller in this paper are fully verified through detailed simulation *** comparative analysis with the traditional adaptive controller,it is found that the newly designed controller can make the bus voltages of each distributed power source achieve synchronization more quickly,and is significantly superior to the traditional adaptive controller in terms of anti-interference performance.

关键词： DC microgrid bifurcation small-world network voltage synchronization improved adaptive control

The role of sulfur cycle in new particle formation:Cycloaddition reaction of SO_(3)to H_(2)S

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Journal of Environmental Sciences 2025年第2期148卷 489-501页

作者： Haijie Zhang wei Wang liang Fan Junling li Yanqin Ren Hong li Rui gao Yisheng Xu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Key Laboratory of Cluster Science Ministry of Education of ChinaSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

The chemistry of sulfur cycle contributes significantly to the atmospheric nucleation process,which is the first step of new particle formation(NPF).In the present study,cycloaddition reaction mechanism of sulfur trioxide(SO_(3))to hydrogen sulfide(H_(2)S)which is a typical air pollutant and toxic gas detrimental to the environment were comprehensively investigate through theoretical calculations and Atmospheric Cluster Dynamic Code ***-phase stability and nucleation potential of the product thiosulfuric acid(H_(2)S_(2)O_(3),TSA)were further analyzed to evaluate its atmospheric *** any catalysts,the H_(2)S+SO_(3)reaction is infeasible with a barrier of 24.2 kcal/*** nucleation precursors formic acid(FA),sulfuric acid(SA),and water(H_(2)O)could effectively lower the reaction barriers as catalysts,even to a barrierless reaction with the efficiency of cis-SA>trans-FA>trans-SA>H_(2)***,the gas-phase stability of TSA was investigated.A hydrolysis reaction barrier of up to 61.4 kcal/mol alone with an endothermic isomerization reaction barrier of 5.1 kcal/mol under the catalytic effect of SA demonstrates the sufficient stability of ***,topological and kinetic analysis were conducted to determine the nucleation potential of *** clusters formed by TSA and atmospheric nucleation precursors(SA,ammonia NH_(3),and dimethylamine DMA)were thermodynamically ***,the gradually decreasing evaporation coefficients for TSA-base clusters,particularly for TSA-DMA,suggests that TSA may participate in NPF where the concentration of base molecules are relatively *** present new reaction mechanismmay contributes to a better understanding of atmospheric sulfur cycle and NPF.

关键词： New particle formation(NPF) Atmospheric sulfur cycle Nucleation process Reaction mechanism Hydrogen sulfide(H_(2)S) Atmospheric Cluster Dynamic Code (ACDC)

Vasospastic angina with J waves formation in patients with sudden loss of consciousness

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Journal of Geriatric Cardiology 2015年第3期12卷 313-318页

作者： Dan ZHU Yi-Ming LUO Ke-Hu A ling-Yun ZU Yan-Hui ZHANG li-Jun GUO wei gao Yuan ZHANG Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Department of Cardiology Peking University Third Hospital Beijing China

Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coro- nary soasm are discussed.

关键词： Angina Consciousness loss J wave Osbom wave

Sharp Isolated Toughness Bound for Fractional(k,m)-Deleted Graphs

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 252-269页

作者： wei gao wei-fan WANG Yao-jun CHEN School of Mathematics Hohai UniversityNanjing 210098China Department of Mathematics Zhejiang Normal UniversityJinhua 321004China Department of Mathematics Nanjing UniversityNanjing 210093China

A graph G is a fractional(k,m)-deleted graph if removing any m edges from G,the resulting subgraph still admits a fractional *** k≥2 and m≥1 be ***[2m/k]^(*)=[2m/k]if 2m/k is not an integer,and[2m/k]^(*)=[2m/k]-1 if 2m/k is an *** this paper,we prove that G is a fractional(k,m)-deleted graph if δ(G)≥k+m and isolated toughness meets I(G)>{3-1/m,if k=2 and m≥3,k+[2m/k]^(*)m+1-[2m/k]^(*);***,we show that the isolated toughness bound is tight.

关键词： graph isolated toughness fractional k-factor fractional(k,m)-deleted graph

Existence of Nonnegative Solutions to Singular Semi-positone Problems

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Acta Mathematicae Applicatae Sinica 2002年第3期18卷 523-528页

作者： Hong-zhou Wang, li-hu Deng, wei-gao GeDepartment of Applied Mathematics, Beijing Institute of Technology, Beijing 100081, China Department of Applied Mathematics Beijing Institute of Technology Beijing China

In this paper we study a class of semi-positone singular boundary value problem. With prior bounds estimate and topology degree method, some existence results of nonnegative solution will be shown.

关键词： Semi-positone problem singularity Green function

High potential in synergizing the reduction of dissolved organic carbon concentration and carbon dioxide emissions for submerged-vegetationcovered river networks

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Journal of Environmental Sciences 2025年第5期151卷 298-309页

作者： Qingqian li Ruixia liu Zhangmu Jing Yanjie wei Shengqiang Tu Huibin Yu Hongjie gao Peng Yuan State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental ScienceBeijing 100012China State Environmental Protection Key Laboratory of Estuarine and Coastal Environment Chinese Research Academy of Environmental ScienceBeijing 100012China State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China College of Municipal and Environmental Engineering Shenyang Jianzhu UniversityShenyang 110168China

Various technologies and projects have been explored and developed for the synergetic control of environmental pollution and carbon emissions in aquatic *** submerged vegetation in shallow waters was also expected to achieve this ***,the magnitude and mechanism of carbon dioxide(CO_(2))emission affected by submerged vegetation is not clear enough in complex aquatic *** study investigated the influences of submerged plants on CO_(2)emission,ecosystem metabolism features,and microbial community traits based on observations in river networks on the Changjiang River *** results showed that CO_(2)emission from planted waters accounted for 73%of unplanted ***,planted waters had higher dissolved organic carbon removal capacity in overlying water and higher potential of carbon sequestration in sediment at the same *** distinctions between the two habitats were attributed to(1)improved CO_(2)and bicarbonate consumption in water columns via enhancing photosynthesis and(2)inhibited CO_(2)production by reconstructing the benthic microbial *** eco-advantages were found in planted sediments,such as a high potential of methane oxidation and xenobiotics biodegradation and a low risk of becoming black and *** brief,submerged vegetation is beneficial in promoting pollution removal and carbon retention *** study advances our understanding of the feedback between aquatic metabolism and CO_(2)emission.

关键词： Mitigated CO_(2)emission Submerged vegetation Paired O_(2)-CO_(2)departure Carbon uptake velocity Microbial metabolism pathways The Changjiang River