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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming li Jianfeng li Guoliang Chen tao lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

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西江大桥病害原因分析和维修加固方案设计

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西部交通科技 2018年第10期 121-123页

作者：李远涛广西壮族自治区公路管理局广西南宁530028

桥梁维修加固是延长桥梁寿命、节约建造成本的主要途径。文章以广西藤县西江大桥维修加固工程为实例,介绍了桥梁病害现状和原因,并分析了桥梁重要部分的加固设计措施。西江大桥经加固后各项指标均达到标准要求,取得了较好的经济社会效益... 详细信息

桥梁维修加固是延长桥梁寿命、节约建造成本的主要途径。文章以广西藤县西江大桥维修加固工程为实例,介绍了桥梁病害现状和原因,并分析了桥梁重要部分的加固设计措施。西江大桥经加固后各项指标均达到标准要求,取得了较好的经济社会效益,可为类似工程提供设计参考。

关键词：西江大桥病害检测维修加固设计

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan li Xi liu Wenping liang Yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu tao Wu Dong-Sheng li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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呼吸医师-药师联合门诊工作模式探索与思考

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首都食品与医药 2021年第2期28卷 112-113页

作者：陶丽源马辉北京京煤集团总医院 102300

目的探讨药师在与医师的联合门诊中的工作模式及成效.方法介绍我院呼吸医师-药师联合门诊服务过程中药师的工作内容、职责、流程及成效.结果和结论呼吸科医师-药师联合门诊达到了一个共赢结局,既保障了患者药物治疗的疗效、安全性及依从... 详细信息

目的探讨药师在与医师的联合门诊中的工作模式及成效.方法介绍我院呼吸医师-药师联合门诊服务过程中药师的工作内容、职责、流程及成效.结果和结论呼吸科医师-药师联合门诊达到了一个共赢结局,既保障了患者药物治疗的疗效、安全性及依从性,同时也提高医生门诊工作效率.此外,这种新工作模式也是药师真正融入临床,迅速提高药学服务技能,为患者服务的一个新探索.

关键词：药学门诊药学服务工作模式

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Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

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Neural Regeneration Research 2025年第4期20卷 1015-1030页

作者： Ruoyu Huang Qiuyu Pang Lexin Zheng Jiaxi lin Hanxi li lingbo Wan tao Wang Department of Forensic Science School of Basic Medicine and Biological SciencesSuzhou Medicine College of Soochow UniversitySuzhouJiangsu ProvinceChina

Cholesterol is an important component of plasma membranes and participates in many basic life functions,such as the maintenance of cell membrane stability,the synthesis of steroid hormones,and *** plays a key role in the establishment and maintenance of the central nervous *** brain contains 20%of the whole body’s cholesterol,80%of which is located within myelin.A huge number of processes(e.g.,the sterol regulatory element-binding protein pathway and liver X receptor pathway)participate in the regulation of cholesterol metabolism in the brain via mechanisms that include cholesterol biosynthesis,intracellular transport,and *** brain injuries or diseases involving crosstalk among the processes above can affect normal cholesterol metabolism to induce detrimental ***,we hypothesized that cholesterol-related molecules and pathways can serve as therapeutic targets for central nervous system *** hemorrhage is the most severe hemorrhagic stroke subtype,with high mortality and *** cholesterol levels are associated with the risk of intracerebral ***,secondary pathological changes after intracerebral hemorrhage are associated with cholesterol metabolism dysregulation,such as neuroinflammation,demyelination,and multiple types of programmed cell *** cholesterol accumulation in the brain has been found after intracerebral *** this paper,we review normal cholesterol metabolism in the central nervous system,the mechanisms known to participate in the disturbance of cholesterol metabolism after intracerebral hemorrhage,and the links between cholesterol metabolism and cell *** also review several possible and constructive therapeutic targets identified based on cholesterol metabolism to provide cholesterol-based perspectives and a reference for those interested in the treatment of intracerebral hemorrhage.

关键词： cell death cholesterol metabolism intracerebral hemorrhage myelination therapeutic target

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石化园区给排水系统规划设计

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广州化工 2018年第17期46卷 106-108,113页

作者：陶李园沈浩中国市政工程中南设计研究总院有限公司湖北武汉430010

石化园区的规划具有很强的产业特征,与一般城乡规划有所不同。园区的建设思路应从"产业规划——总体规划——专项规划——控制性详细规划——某项目单项工可"展开。本文分析了石化园区从总体规划到给排水专项规划的设计思路,分别指出了... 详细信息

石化园区的规划具有很强的产业特征,与一般城乡规划有所不同。园区的建设思路应从"产业规划——总体规划——专项规划——控制性详细规划——某项目单项工可"展开。本文分析了石化园区从总体规划到给排水专项规划的设计思路,分别指出了在给水、污水、雨水专项规划中需要区别于城乡规划重点明确的设计要点,以期优化给排水方案,全面满足石化园区在产业发展布局,污染防控及消防安全等方面的要求。

关键词：石化园区分质供水消防系统污水压力管分质收集四级防控

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北京市2005年学生视力不良状况分析

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中国学校卫生 2011年第1期32卷 75-76页

作者：郭欣林晨曦陶立元北京市疾病预防控制中心 100013 北京大学公共卫生学院北京大学第三医院临床流行病研究中心

目的了解北京市学生视力不良情况以及变化趋势,为保护青少年视力提供参考依据。方法按照2005年《全国学生体质与健康调查研究检测细则》的要求,采用整群随机抽样方法,选取北京市6～22岁9 651名学生进行检测。结果 2005年北京市学生视力... 详细信息

目的了解北京市学生视力不良情况以及变化趋势,为保护青少年视力提供参考依据。方法按照2005年《全国学生体质与健康调查研究检测细则》的要求,采用整群随机抽样方法,选取北京市6～22岁9 651名学生进行检测。结果 2005年北京市学生视力不良检出率为55.5%(5 352/9 651),视力不良检出率较2000年提高了17.81个百分点,差异有统计学意义(χ2=534.500,P=0.000)。其中男生为51.2%,女生为59.7%,女生视力不良检出率高于男生(2χ=70.715,P=0.000)。城市学生视力不良检出率为63.4%,乡村学生为44.9%,城市学生高于乡村学生(χ2=328.500,P=0.000)。随着年龄和学段增加,学生视力不良检出率呈增长趋势(2χ趋=1 734.694,P=0.000)。结论北京市学生视力不良检出率随年龄和学段的增加呈持续上升趋势。视力不良防治重点人群为女生和城市学生。

关键词：视力低学生流行病学研究

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