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The survival and prognostic factors of primary testicular lymphoma- two-decade single-center experience

Asian Journal of Andrology 2018年第6期20卷 615-620页

作者： Run-Zhuo Ma Lei Tian li-yuan tao Hui-Ying He Min li Min Lu Lu-lin Ma Hui Jiang Jian Lu Department of Urology Peking University Third Hospital Beijing 100191 China Department of Hematology Peking University Third Hospital Beijing 100191 China Department of Biostatistics Peking University Third Hospital Beijing 100191 China Department of Pathology Peking University Third Hospital Beijing 100191 China

This study aims to investigate the effect of different local testicular treatments and validate common prognostic factors on primary testicular lymphoma （PTL） patients. We retrospectively reviewed the clinical records of 32 patients from 1993 to 2017 diagnosed with PTL and included 22 patients for analysis. The Kaplan-Meier method, Log-rank test, and multivariate Cox proportional hazard regression analysis were applied to evaluate progression-free survival （PFS）, overall survival （OS）, and determine prognosis predictors. The median follow-up time was 30 months. Median OS and PFS were 96 months and 49 months, respectively. In univariate analysis, advanced Ann Arbor stage （Ill/IV）（P 〈 0.001）, B symptoms （P 〈 0.001）, and extranodal involvement other than testis （P = 0.001） were significantly associated with shorter OS and PFS. In multivariate analysis, Ann Arbor stage was significantly associated with OS （OR = 11.58, P = 0.049）, whereas B symptom was significantly associated with PFS （OR = 11.79, P = 0.049）. In the 10 patients with the systemic usage of rituximab, bilateral intervention could improve median OS from 16 to 96 months （P = 0.032）. The study provides preliminary evidence on bilateral intervention in testes in the rituximab era and validates common prognostic factors for Chinese PTL patients.

关键词： local treatment modalities prognostic factors prophylaxis contralateral orchiectomy prophylaxis contralateral radiotherapy testicular lymphoma

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Prevalence and impact of diabetes in patients with COVID-19 in China

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World Journal of Diabetes 2020年第10期11卷 468-480页

作者： Min Du Yu-Xin lin Wen-Xin Yan li-yuan tao Min liu Jue liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100083China

BACKGROUND Coronavirus disease 2019(COVID-19)is an emerging infectious disease that has spread rapidly around the *** studies have indicated that COVID-19 patients with diabetes are prone to having poor clinical *** To systematically evaluate the prevalence of diabetes among COVID-19 patients in China and its impact on clinical outcomes,including ICU admission,progression to severe cases,or *** We searched studies published in PubMed,Web of Science,and EMBASE from December 1,2019 to March 31,2020 to identify relevant observational study that investigated the prevalence of diabetes among COVID-19 patients or its impact on clinical *** used a random-effects or fixed-effects model to estimate the pooled prevalence of diabetes and risk ratio(RR)and its 95%confidence interval(CI)of diabetes on *** plots were used to evaluate the publication bias and the heterogeneity was evaluated by I2 *** Twenty-three eligible articles including 49564 COVID-19 patients(1573 with and 47991 without diabetes)were finally *** pooled prevalence of diabetes was 10%(95%CI:7%-15%)in COVID-19 *** the subgroup analyses,the pooled prevalence of diabetes was higher in studies with patients aged>50 years(13%;95%CI:11%-16%)than in studies with patients aged≤50 years(7%;95%CI:6%-8%),in severe patients(17%;95%CI:14%-20%)than in non-severe patients(6%;95%CI:5%-8%),and in dead patients(30%;95%CI:13%-46%)than in survivors(8%;95%CI:2%-15%)(P<0.05 for all).Compared with patients without diabetes,the risk of severe cases was higher(RR=2.13,95%CI:1.76-2.56,I2=49%)in COVID-19 patients with *** risk of death was also higher in COVID-19 patients with diabetes(RR=3.16,95%CI:2.64-3.78,I2=34%).However,diabetes was not found to be significantly associated with admission to ICU(RR=1.16,95%CI:0.15-9.11).CONCLUSION Nearly one in ten COVID-19 patients have diabetes in *** is associated with a higher risk of severe illne

关键词： Diabetes COVID-19 Systematic review Meta-analysis

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Features of gastric cancer by anatomic subsite in northern China: A multi-center Health Science Report database study

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2238-2252页

作者： Rui-Ze Qu Yan-Peng Ma Xiao-yuan Bao li-yuan tao Xin Zhou Si-Yi Lu Yi Zhang Bing-Yan Wang Fei li lin Tuo Zhi-Peng Zhang Wei Fu Department of General Surgery Cancer CenterPeking University Third HospitalBeijing 100191China Medical Informatics Center Peking University Health Science CenterBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Department of Hospital Management Peking University Health Science CenterBeijing 100191China

BACKGROUND The features of gastric cancer based on the anatomic site remain unknown in northern China *** To analyze gastric cancer features and associated trends based on the anatomical site in northern China *** This cross-sectional study used incident gastric cancer case data from 10 Peking University-affiliated hospitals(2014 to 2018).The clinical and prevailing local features were *** A total of 10709 patients were enrolled,including antral(42.97%),cardia(34.30%),and stomach body(18.41%)gastric cancer *** in the cardia had the highest male:female ratio,proportion of elderly patients,and patients with complications,including hypertension,diabetes,cerebrovascular,and coronary diseases(Plization rate and cost(each Plity(P=0.046).Anatomical subsite was not linked to postoperative *** The features of gastric cancer based on the anatomical site differ between northern China and other regions,both globally and within the *** factors may account for these differences and should affect policy-making and clinical practice.

关键词： Feature Gastric cancer Anatomical site Northern China

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Nomogram to predict pregnancy outcomes of emergency oocyte freeze-thaw cycles

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Chinese Medical Journal 2021年第19期134卷 2306-2315页

作者： Yang Wang Zi-Ru Niu li-yuan tao Xiao-Ying Zheng Yi-Feng yuan Ping liu Rong li Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China

Background:Existing clinical prediction models for in vitro fertilization are based on the fresh oocyte cycle,and there is no prediction model to evaluate the probability of successful thawing of cryopreserved mature *** research aims to identify and study the characteristics of pre-oocyte-retrieval patients that can affect the pregnancy outcomes of emergency oocyte freeze-thaw ***:Data were collected from the Reproductive Center,Peking University Third Hospital of *** logistic regression model was used to derive the *** model performance was assessed by examining the discrimination and calibration in the development and validation *** ability was assessed using the area under the receiver operating characteristic curve(AUC),and calibration was assessed using the Hosmer–Lemeshow goodness-of-fit test and calibration ***:The predictors in the model of“no transferable embryo cycles”are female age(odds ratio[OR]=1.099,95%confidence interval[CI]=1.003–1.205,P=0.0440),duration of infertility(OR=1.140,95%CI=1.018–1.276,P=0.0240),basal follicle-stimulating hormone(FSH)level(OR=1.205,95%CI=1.051–1.382,P=0.0084),basal estradiol(E2)level(OR=1.006,95%CI=1.001–1.010,P=0.0120),and sperm from microdissection testicular sperm extraction(MESA)(OR=7.741,95%CI=2.905–20.632,Plity,the AUC for the“no transferable embryo cycles”model was 0.799(95%CI:0.722–0.875,Plibration curve showed good calibration for the prediction of no transferable embryo *** predictors in the cumulative live birth were the number of follicles on the day of human chorionic gonadotropin(hCG)administration(OR=1.088,95%CI=1.030–1.149,P=0.0020)and endometriosis(OR=0.172,95%CI=0.035–0.853,P=0.0310).The AUC for the“cumulative live birth”model was 0.724(95%CI:0.647–0.801,Plibration curve showed good cali

关键词： Nomogram Oocyte freeze-thaw In vitro fertilization Pregancy outcome

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Effects of solid solution treatment and cooling on morphology of LPSO phase and precipitation hardening behavior of Mg-Dy-Ni alloy

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Transactions of Nonferrous Metals Society of China 2017年第11期27卷 2381-2389页

作者： li-tao yuan Guang-li BI yuan-dong li Jing JIANG Yu-xiang HAN Da-qing FANG Ying MA State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology Lanzhou 730050 China College of Materials Science and Engineering Taiyuan University of Science and Technology Taiyuan 030024 China

Effects of solid solution treatment and cooling on the morphology of long period stacking order(LPSO)phase and precipitation hardening behavior of Mg?2Dy?0.5Ni(molar fraction,%)alloy were *** of the as-cast alloy mainly consisted ofα-Mg phase,bamboo-like Mg12DyNi phase with LPSO structure distributed between dendrites and small amounts of cubic Dy *** solid solution treatment at565oC for12h and subsequent different cooling conditions,dot-shaped,block,fine lamellar and rod-shaped LPSO phases precipitate in Mg matrix,*** continuous cooling conditions(furnace and air cooling),the fine lamellar LPSO phase generally forms in grain interior and its volume fraction increases and block LPSO phase coarsens with increasing cooling *** discontinuous cooling conditions(air cooling after furnace cooling to415and265°C),the dot-shaped LPSO grows into the rod-shaped phase,which results in an decrease of cooling hardening behavior of alloy.

关键词： Mg.Dy.Ni alloy LPSO phase microstructure precipitation hardening

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Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis

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Chinese Medical Journal 2019年第5期132卷 577-588页

作者： Lei yuan Yan Zeng Zhong-Qiang Chen Xin-ling Zhang Shuo Mai Pan Song li-yuan tao Department of Orthopedics Peking University Third Hospital Beijing 100191China Department of Urodynamic Center and Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191China

Background: Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic acid (TXA), and epsilon-aminocaproic acid (EACA) are antifibrinolytics currently offered as prophylactic agents to reduce surgery-ass oci a ted blood loss. The aim of this study was to evaluate the efficacy and safety of aprotinin, EACA, and low/high doses of TXA in spinal surgery, and assess the use of which agent is the most optimal intervention using the network meta-analysis (NMA) method. Methods: Five electronic databases were searched, including PubMed, Cochrane library, ScienceDirect, Embase, and Web of Science, from the inception to March 1,2018. Trials that were randomized and compared results between TXA, EACA, and placebo were identified. The NMA was conducted with software R 3.3.2 and STATA 14.0. Results: Thirty randomized controlled trial (RCT) studies were analyzed. Aprotinin (standardized mean difference [SMD]=-0.65, 95% credibility intervals [CrI;-1.25,-0.06]), low-dose TXA (SMD=-0.58, 95% CrI [-0.92,-0.25]), and high-dose TXA (SMD =-0.70, 95% CrI [-1.04,-0.36]) were more effective than the respective placebos in reducing intraoperative blood loss. Low-dose TXA (SMD=-1.90, 95% CrI [-3.32,-0.48]) and high-dose TXA (SMD =-2.31, 95% CrI [-3.75,-0.87]) had less postoperative blood loss. Low-dose TXA (SMD=-1.07, 95% CrI [-1.82,-0.31]) and high-dose TXA (SMD =-1.07, 95% CrI[-1.82,-0.31]) significantly reduced total blood loss. However, only high-dose TXA (SMD =-2.07, 95% CrI [-3.26,-0.87]) was more effective in reducing the amount of transfusion, and was significantly superior to low-dose TXA in this regard (SMD =-1.67, 95% CrI [-3.20,-0.13]). Furthermore, aprotinin (odds ratio [OR]= 0.16, 95% CrI [0.05, 0.54]), EACA (OR = 0.46, 95% CrI [0.22, 0.97]) and high dose of TXA (OR = 0.34, 95% CrI [0.19, 0.58]) had

关键词： Antifibrinolytics Spine surgery Blood loss Transfusion Network meta-analysis

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Comparison of Vaginal Gel and Intramuscular Progesterone for In vitro Fertilization and Embryo Transfer with Gonadotropin-Releasing Hormone Antagonist Protocol

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Chinese Medical Journal 2018年第13期131卷 1557-1561页

作者： Hong-Bin Chi Na-Na liu Rong li li-yuan tao li-Xue Chen Jie Qiao Center for Reproductive Medicine Peking University Third Hospital Beijing 100191 China Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Key Laboratory of Assisted Reproduction Ministry of Education Beijing 100191 China Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191 China

Background： Luteal support is a key to patients undergoing in vitro fertilization and embryo transfer （IVF-ET） with gonadotropin-releasing hormone （GnRH）-antagonist protocol. This study aimed to compare the effect between vaginal progesterone （VP） and intramuscular progesterone （IMP） with GnRH-antagonist protocol alter IVF-ET. Methods： A total of 1760 patients （18 years ≤ age ≤35 years） undergoing IVF-ET with GnRH-antagonist protocol were studied retrospectively between September 2014 and August 2015 in Peking University Third Hospital. In the patients, 1341 patients received VP （VP group） and 419 patients received IMP （IMP group） as luteal support. We compared clinical outcomes between these two groups. The primary objective of the study was the live birth rate. Measurement data between the two groups were conducted using independent samples t-test. The variables in line with non-normal distribution were expressed as median （p25 and p75） and were compared using nonparametric Mann. Whitney U-test. Results： live birth rate in VP group was 38.55%, significantly higher than that in the IMP group, which was 30.79% （x^2 = 8.287, P= 0.004）. The clinical intrauterine pregnancy rate and implantation rate in VP group were also significantly higher than those in the IMP group （clinical intrauterine pregnancy rate 47.35% vs. 41.29%, x^2= 4.727, P = 0.030： implantation rate 30.99% vs. 25.26%, x^2=14.546, P 〈 0.001）. Any statistically significant differences in ectopic pregnancy and abortion rates between two groups were not observed. Conclusion： Luteal support with VP had better clinical outcomes for young women undergoing IVF-ET with GnRH-antagonist protocol.

关键词： Gonadotropin-Releasing Hormone Antagonist Intramuscular Progesterone Undergoing In vitro Fertilization and EmbryoTransfer Vaginal Progesterone

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Evaluation of blood pressure lowering effect by generic and brand-name antihypertensive drugs treatment:a multicenter prospective study in China

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Chinese Medical Journal 2021年第3期134卷 292-301页

作者： Shu-yuan Zhang li-yuan tao Yun-Yun Yang tao Kong Cun-Jin Wu Yang Wang Jing-Zhou Chen Lei Song Yi-Bo Wang Ru-Tai Hui Wei-li Zhang State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China

Background:Generic drugs are bioequivalent to their brand-name counterparts;however,concerns still exist regarding the effectiveness and safety of generic drugs because of small sample sizes and short follow-up time in most *** purpose of this study was to evaluate the long-term antihypertensive efficacy,cost-effectiveness and cardiovascular outcomes of generic drugs compared with brand-name ***:In a multicenter,community-based study including 7955 hypertensive patients who were prospectively followed up for an average of 2.5 years,we used the propensity-score-matching method to match the patients using brand-name drugs to those using generic drugs in a ratio of 1:2,2176 patients using brand-name drugs and 4352 patients using generic ***:There were no significant differences between generic drugs and brand-name drugs in blood pressure(BP)-lowering efficacy,BP control rate,and cardiovascular outcomes including coronary heart disease and *** adjusted mean(95%confidence interval[CI])of systolic BP(SBP)-lowering was-7.9 mmHg(95%CI,-9.9 to-5.9)in the brand-name drug group and-7.1 mmHg(95%CI,-9.1 to-5.1)in the generic drug group after adjusting for age,sex,body mass index,number of antihypertensive drugs and traditionally cardiovascular risk *** patients agedlitating public health benefits,especially in low-

关键词： Brand-name drugs Cost-effectiveness Cardiovascular diseases Generic drugs Hypertension

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Splenic vasculopathy in portal hypertension patients

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World Journal of Gastroenterology 2006年第17期12卷 2737-2741页

作者： tao li Ji-yuan Ni Yan-Wu Qi Hai-Yang li Tong Zhang Zhen Yang Department of Hepatic Surgery Tongji Hosptal Tongji medical College Huazhong University of Science and Technology Wuhan 430030 Hubei province China

AIM： To investigate the interaction between portal hypertension, splanchnic hyperdynamic circulation and splanchnic vasculopathy by observing splenic arterial and venous pathological changes and the role of extracellular matrix in the pathogenesis of portal hypertensive vasculopathy by measuring the expression of type Ⅰ and type Ⅲ procollagen mRNA in splenic venous walls of portal hypertensive patients. METHODS： Morphological changes of splenic arteries and veins taken from portal hypertensive patients （n = 20） and normal controls （n = 10） were observed under optical and electron microscope. Total RNA was extracted and the expression of type Ⅰ and type Ⅲ procollagen mRNA in splenic venous walls of portal hypertensive patients （n= 20） was semi-quantitatively detected using reverse transcription-polymerase chain reaction （RT-PCR）. RESULTS： Under optical microscope, splenic arterial intima was destroyed and internal elastic membrane and medial elastic fibers of the splenic arterial walls were degenerated and broken. Splenic venous intima became remarkably thick. Endothelial cells were not intact with formation of mural thrombus. The tunica media became thickened significantly due to hypertrophy of smooth muscles. Fibers and connective tissues were increased obviously. Under electron microscope, smooth muscle cells of the splenic arteries were degenerated and necrotized. Phenotypes of smooth muscle cells changed from constrictive into synthetic type. Red blood cells and platelets accumulated around the damaged endothelial cells. Synthetic smooth muscle cells were predominant in splenic veins and their cytoplasma had plentiful rough endoplasmic reticulum ribosomes and Golgi bodies. Along the vascular wall, a lot of collagen fibers were deposited, the intima was damaged and blood components accumulated. There was no significant difference in the expression of type Ⅰ procollagen mRNA in splenic venous wall between the patients with portal hypertension and those without

关键词： Portal hypertension Splanchnic hyperdynamic circulation Splanchnic vasculopathy

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Noise exposure assessment with task-based measurement in complex noise environment

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Chinese Medical Journal 2011年第9期124卷 1346-1351页

作者： li Nan YANG Qiu-ling ZENG lin ZHU liang-liang tao li-yuan ZHANG Hua ZHAO Yi-ming Research Center of Clinical Epidemiology Peking University Third Hospital Beijing 100191 China Dongfeng Occupational Disease Prevention and Treatment Institute of Shiyan Shiyan Hubei 442001 China Dongfeng Occupationai Disease Prevention and Treatment Institute of Shiyan Shiyan Hubei 442001 China

Background Task-based measurement （TBM） is a method to assess the eight-hour A-weighted equivalent noise exposure level （LAeq. 8h） besides dosimeter. TBM can be better used in factories by non-professional workers and ***, it is still not clear if TBM is equal or similar with dosimeter for LAeq.8h measurement in general. This study considered the measurement with dosimeter as real personal noise exposure level （PNEL） and assessed the accuracy of TBM by comparing the consistencies of TBM and dosimeter in LAeq.8h *** The study was conducted in one automobile firm among 387 workers who are exposed to unstable *** and TBM were used to compare the two strategies and assess the degree of agreement and causes of disagreement. Worker＇s PNEL was measured via TBM for noise; the real PNEL was also recorded. The TBM for noise was computed with task/position noise levels measured via sound level meter and workers＇ exposure information collected via working diary forms （WDF） filled by participants themselves. Full-shift noise exposure measurement via personal noise dosimeters were taken as the real PNEL. General linear model （GLM） was built to analyze the accuracy of TBM for noise and the source of difference between TBM for noise and real *** The LAeq.8h with TBM were slightly higher than the real PNELs, except the electricians. Differences of the two values had statistical significance in stamping workers （P ＜0.001）, assembly workers （P=0.015） and welding workers （P=0.001）. The correlation coefficient of LAeq.8h with TBM and real PNELs was 0.841. Differences of the two results were mainly affected by real PNEL （F=11.27, P=0.001）; and work groups （F=3.11, P ＜0.001） divided by jobs and workshops were also independent factors. PNEL of workers with fixed task/position （（86.53±8.82） dB（A）） was higher than those without （（75.76±9.92） dB（A））（t=8.84, P ＜0.01）. Whether workers had fixed task/position was another factor on the accuracy of

关键词： task-based measurement noise occupation exposure assessment accuracy feasibility

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