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Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway

Chinese Journal of Natural Medicines 2021年第6期19卷 412-421页

作者： YU Jiu-Wang li sha BAO li-Dao WANG Lu Department of Pharmacy Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059China Mongolia Medical School Inner Mongolia Medical UniversityHohhot 010110China

Although the etiology of sciatica remains uncertain,there is increasing evidence that the disease process of sciatica is associated with the levels of inflammatory ***,an alkaloid isolated from Piper nigrum,has previously been demonstrated to inhibit inflammation and analgesic *** purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine,so as to play a therapeutic role in *** EliSA experiment,we confirmed that four inflammatory factors(IL-1β,TNF-α,IL-10,TGF-β1)can be used as evaluation indexes of *** differentially expressed miRNA was screened as miR-520a,by microarray technology,and the downstream target of miR-520a was P65 by ***-time fluorescence quantitative PCR confirmed that the expression of miR-520a was negatively correlated with pro-inflammatory cytokines,positively correlated with anti-inflammatory cytokines and negatively correlated with p65 expression at mRNA *** expression of p65 was positively correlated with pro-inflammatory cytokines and negatively correlated with anti-inflammatory cytokines at the protein level verified by EliSA and Western *** staining analysis showed that the nerve fibers were repaired by piprine,the vacuoles were significantly reduced,and the degree of nerve fiber damage was also *** analysis showed that the expression of p65 decreased after administration of ***-luciferase reporter gene assay confirmed that the luciferase signal decreased significantly after cotransfection of miR-520a mimics and p653'UTR recombinant *** sum up,in the rat model of non-compressed lumbar disc herniation,piperine plays a significant role in ***-520a can specifically and directly target P65,and piperine can promote the expression of miR-520a,then inhibit the expression of p65,down-regulate the pro-inflammatory

关键词： Piperine Sciatica miR-520a P65 Inflammatory factor

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Two-phase sink vortex suction mechanism and penetration dynamic characteristics in ladle teeming process

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Journal of Iron and Steel Research International 2017年第7期24卷 669-677页

作者： Da-peng Tan Ye-sha Ni li-bin Zhang Key Laboratory of E & M Ministry of Education & Zhejiang ProvinceZhejiang University of Technology

At the late stage of continuous casting（CC）ladle teeming,sink vortex can suck the liquid slag into tundish,and cause negative influences on the cleanliness of molten *** address this issue,a twophase fluid mechanical modeling method for ladle teeming was ***,a dynamic model for vortex suction process was built,and the profiles of vortex flow field were ***,based on the level set method（LSM）,a two-phase 3Dinterface coupling model for slag entrapment was ***,in combination with high-order essentially non-oscillatory（ENO）and total variation diminishing（TVD）methods,a LSM-based numerical solution method was proposed to obtain the 3Dcoupling evolution regularities in vortex suction *** results show that the vortex with higher kinetic energy can form an expanded sandglass-shape region with larger slag fraction and lower rotating velocity;there is a pressure oscillation phenomenon at the vortex penetration state,which is caused by the energy shock of two-phase vortex penetration coupling.

关键词： Ladle teeming Sink vortex Suction mechanism Two-phase coupling Level set method Pressure oscillation

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Factors influencing hysteresis characteristics of concrete dam deformation

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Water Science and Engineering 2017年第2期10卷 166-174页

作者： Jia-he Zhang Jian Wang li-sha Chai College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China lixi Barrage Irrigation Management Office of Guangzhou City Guangzhou 510890 China

Thermal deformation of a concrete dam changes periodically, and its variation lags behind the air temperature variation. The lag, known as the hysteresis time, is generally attributed to the low velocity of heat conduction in concrete, but this explanation is not entirely sufficient. In this paper, analytical solutions of displacement hysteresis time for a cantilever beam and an arch ring are derived. The influence of different factors on the displacement hysteresis time was examined. A finite element model was used to verify the reliability of the theoretical analytical solutions. The following conclusions are reached:(1) the hysteresis time of the mean temperature is longer than that of the linearly distributed temperature difference;(2) the dam type has a large impact on the displacement hysteresis time, and the hysteresis time of the horizontal displacement of an arch dam is longer than that of a gravity dam;(3) the reservoir water temperature variation lags behind of the air temperature variation, which intensifies the differences in the horizontal displacement hysteresis time between the gravity dam and the arch dam;(4) with a decrease in elevation, the horizontal displacement hysteresis time of a gravity dam tends to increase, whereas the horizontal displacement hysteresis time of an arch dam is likely to increase initially, and then decrease; and(5) along the width of the dam, the horizontal displacement hysteresis time of a gravity dam decreases as a whole, while the horizontal displacement hysteresis time of an arch dam is shorter near the center and longer near dam surfaces.

关键词： Concretedam Displacement Hysteresis Temperature Analytical solution

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Eyes of diff ering colors in Alvinocaris longirostris from deep-sea chemosynthetic ecosystems: genetic and molecular evidence of its formation mechanism

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Journal of Oceanology and limnology 2021年第1期39卷 282-296页

作者： Qian XIN Min HUI Chaolun li Zhongli sha Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China

Coloration is an important phenotypic trait for multiple adaptive *** is interesting to fi nd white-eye(AW)and orange-eye(AO)phenotypes in the shrimp Alvinocaris longirostris inhabiting the deep-sea cold seep and hydrothermal vent areas of the northwestern Pacifi *** comparative transcriptome analyses,1491 diff erentially expressed genes(DEGs)were identified between AW and *** them,many DEGs were associated with immunity,antioxidation,and detoxifi *** signifi cant enzyme encoding genes,xanthine dehydrogenase,and tryptophan oxidase involved in pigment biosynthesis pathways were up-regulated in AW and AO,respectively,which might be related to the diff erences of white and orange eye ***,single nucleotide polymorphism(SNP)calling detected that genotypes of 28 SNP distributing in 14 unigenes were completely diff erent between AW and ***,there were three and two non-synonymous mutations in immune genes crustin Pm5 and antimicrobial peptide,*** indicate that the diff erence in eye color is probably resulted from immune response to variable micro-environmental stressors encountered in the dispersal process of the shrimps,such as symbiotic microbes,pathogens,and toxic substances,and might be genetically fi xed at *** suggested pathway preliminarily explained the formation mechanism of diff erent eye phenotypes in Alvinocaridid shrimps,providing a basis for further study on adaptive evolution of eyes in deep-sea chemosynthetic faunas.

关键词： alvinocaridid shrimps cold seep and hydrothermal vent diff erentially expressed genes eye color single nucleotide polymorphism(SNP)mutation transcriptome

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Involvement of glucose transporter 4 in ovarian development and reproductive maturation of Harmonia axyridis(Coleoptera:Coccinellidae)

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Insect Science 2022年第3期29卷 691-703页

作者： Yan li sha-sha Wang Su Wang Shi-Gui Wang Bin Tang Fang liu College of Horticulture and Plant Protection Yangzhou UniversityYangzhouJiangsu225009China College of life and Environmental Sciences Hangzhou Normal UniversityHangzhouZhejiang310036China Institute of Plant and Environment Protection Beijing Academy of Agricultural and Forestry SciencesBeijing100097China

Glucose is vital to embryogenesis,as are glucose *** transporter 4(Glut4)is one of the glucose transporters,which is involved in rapid uptake of glucose by various cells and promotes glucose *** energy metabolism in insect reproduction is well known,the molecular mechanism of Glut4 in insect reproduction is poorly *** suspect that Glut4 is involved in maintaining glucose concentrations in the ovaries and affecting vitellogenesis,which is critical for subsequent oocyte maturation and insect *** axyridis(Pallas)is a model organism for genetic research and a natural enemy of insect *** studied the influence of the Glut4 gene on the reproduction and development of *** using RNA interference *** transcription quantitative polymerase chain reaction analysis revealed that HaGlut4 was most highly expressed in *** of the HaGlut4 gene reduced the transcript levels of HaGlut4,and the weight and number of eggs produced significantly *** addition,the transcript levels of vitellogenin receptor and vitellogenin in the fat bodies and the ovaries of *** decreased after the interference of Glut4,and decreased the triglyceride,fatty acid,total amino acid and adenosine triphosphate content of *** resulted in severe blockage of ovary development and reduction of yolk formation;there was no development of ovarioles in the developing *** changes indicate that a lack of HaGlut4 can impair ovarian development and oocyte maturation and result in decreased fecundity.

关键词： glucose transporter 4(Glut4) Harmonia axyridis RNai reproduction vitellogenin

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REDUCED AUGMENTED LAGRANGIAN BI-CONJUGATE GRADIENT METHOD FOR IMPACT-CONTACT PROBLEMS

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Acta Mechanica Solida Sinica 1998年第3期11卷 241-252页

作者： li Nansheng sha Desong Sun Huanchun Dalian Univ Technol Dept Engn Mech Dalian 116023 Peoples R China

To avoid the numerical oscillation of the penalty method andnon-compatibility with ex- plicit operators of conventional Lagrangemultiplier methods used in transient contact problems to en- forcesurface contact conditions, a new approach to enforcing surfacecontact constraints for the tran- sient nonlinear finite elementproblems, referred to as 'the reduced augmented Lagrangianbi-conjugate gradient method (ALCG)', is developed in this *** on the nonlinear constrained optimization theory and iscompatible with the explicit time integration scheme, this approachcan also be used in implicit scheme naturally.

关键词： impact-contact problems contact constraints explicit scheme

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Stochastic uncertain lubrication in gear transmission subjected to tribodynamic loading

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Friction 2024年第8期12卷 1741-1756页

作者： Zhou CHEN Haiming sha Sheng li Zheming TONG Shuiguang TONG State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China School of Mechanical Engineering Zhejiang UniversityHangzhou 310027China Wright State University 3640 Colonel Glenn HighwayDaytonOH 45435USA

A stochastic uncertain tribodynamic model is established for a spur gear pair for the first *** stochastic uncertainty of pinion rotation speed propagated to lubrication performance is *** probability density function of the minimum lubricant film thickness hmin evolves over time periodically at interval of an engagement *** between abrupt increase in meshing force and amplification of hmin uncertainty is *** and reliable lubrication performance can be achieved by suppressing the hmin uncertainty and decreasing the lubrication failure *** can be done by increasing lubricant viscosity,and decreasing input torque and uncertainty level of input rotation *** work lays a solid foundation for robust and reliability based optimization for tribodynamic gear system.

关键词： stochastic uncertainty gears elastohydrodynamic lubrication(EHL) tribodynamics

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AMPK controls sucrose taste sensitization in Drosophila

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Journal of Genetics and Genomics 2023年第1期50卷 50-53页

作者： Yun Hu Zhi-Ying liu sha-sha li An-Qi li Qiao-Ping Wang Lab of Metabolism and Aging School of Pharmaceutical Sciences(Shenzhen)Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China

Sweet taste perception is critical for animals and *** an evolutionary perspective,sweet taste plays a key role in identifying carbohydrates *** taste perception in mammals is not fixed but is plasticity in the context of diets(Maliphol et al.,2013;Bartolotto,2015;Wise et al.,2016).However,so far it remains incomplete clear how diets affect sweet taste sensitivity.

关键词： Sweet taste incomplete

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Effects of sludge characteristics on electrical resistance and energy consumption during electro-dewatering process

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Journal of Environmental Sciences 2021年第3期33卷 339-350页

作者： li sha Xiaoyan Yu Zhangxiang Wu Xingxin liu Shuting Zhang School of Environmental Science and Engineering Tianjin UniversityTianjin 300354China School of Environmental and Safety Engineering Taiyuan Institute of TechnologyTaiyuan 030008China

The increase of electrical resistance(ER)and energy consumption(EC)during the later stage of dewatering is a major problem hindering the development of electro-dewatering(EDW)*** the variations of sludge characteristics are significant during the EDW process,the relationships between sludge characteristics and ER and EC during EDW remain *** this study,the effects of moisture content(MC),thickness,pH,conductivity,zeta potential,temperature,and gas volume on the ER and EC during the EDW process were statistically investigated using correlation and multiple linear regression ***,the results showed that the ER of the sludge near the anode was primarily affected by pH,whereas the sludge near the cathode was primarily affected by the MC and ***,sludge temperature and conductivity were the most reliable indicators to predict the EC near the anode and cathode,*** results of this study provide theoretical guidance useful for solving the increase of ER and EC during the later stage of the EDW process.

关键词： Sludge Electro-dewatering Electrical resistance Energy consumption Multiple linear regression

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Evolution of helium bubbles in nickel-based alloy by post-implantation annealing

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Chinese Physics B 2021年第8期30卷 55-60页

作者： Rui Zhu Qin Zhou li Shi li-Bin Sun Xin-Xin Wu sha-sha Lv Zheng-Cao li Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(Ministry of Education) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Beam Technology Ministry of EducationCollege of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China

Nickel-based alloys have been considered as candidate structural materials used in generation IV nuclear reactors serving at high *** the present study,alloy 617 was irradiated with 180-keV helium ions to a fluence of 3.6×10^(17) ions/cm^(2) at room *** the cross-section transmission electron microscopy(TEM)image,numerous over-pressurized helium bubbles in spherical shape are observed with the actual concentration profile a little deeper than the SRIM predicted ***-implantation annealing was conducted at 700℃for 2 h to investigate the bubble *** long-range migration of helium bubbles occurred during the annealing process,which makes the bubbles of the peak region transform into a faceted shape as *** the coarsening mechanism of helium bubbles at different depths is discussed and related to the migration and coalescence(MC)*** the diffusion of nickel atoms slowed down by the alloy elements,the migration and coalescence of bubbles are suppressed in alloy 617,leading to a better helium irradiation resistance.

关键词： helium bubble coarsening mechanism nickel-based alloy

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