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烟草microRNA171c的功能分析

植物科学学报 2016年第5期34卷 775-780页

作者：张力沙爱华长江大学主要粮食作物产业化湖北省协同创新中心湖北荆州434025

MicroRNA是一类长度为20~24碱基的非编码小RNA,调控植物多种生理代谢途径。MicroRNA171（miR171）在拟南芥、大麦和水稻中通过负调控SCL靶基因使植物表现出分枝结构变化和其他一些发育表型,还可调控拟南芥叶绿素的合成代谢。但其他植物m... 详细信息

MicroRNA是一类长度为20~24碱基的非编码小RNA,调控植物多种生理代谢途径。MicroRNA171（miR171）在拟南芥、大麦和水稻中通过负调控SCL靶基因使植物表现出分枝结构变化和其他一些发育表型,还可调控拟南芥叶绿素的合成代谢。但其他植物miR171的功能仍然未知。为了探明烟草miR171c的功能,本研究根据烟草miR171c序列设计了靶基因模拟物STTM171,通过病毒表达载体在烟草中进行表达,抑制miR171c的活性后观察植物表型变化。结果表明在病毒表达STTM171烟草中,植株出现顶端优势丧失、茎干增多等表型。荧光定量PCR检测到STTM171过表达植株miR171c表达量下降,两个推测的SCL靶基因TC134811和TC127385表达量上升,表明miR171c可能在烟草和拟南芥等植物中的功能比较保守,可以通过调控可能的靶基因SCL来调节植物的生长发育。

关键词：烟草 microRNA171 靶基因模拟物病毒表达载体

miR-15a and miR-16 affect the angiogenesis of multiple myeloma by targeting VEGF

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miR-15a and miR-16 affect the angiogenesis of multiple myelo...

中华医学会血液学分会第十三届全国血栓与止血学术会议暨“血栓栓塞性疾病（血栓与止血）基础与临床研究进展”

作者： Chun-yan Sun Xiao-mei She You Qin Zhang-bo Chu Lei Chen MD Lu Zhang li-sha ai Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Background:Deregulated microRNAs and their roles in cancer development have attached much *** microRNAs,miR-15a and miR-16,which act as putative tumor suppressor by targeting the oncogene BCL2,have been implicated in cell cycle,apoptosis and proliferation. Methods:In the present study,we investigated the possible role of miR-15a/miR-16 in the angiogenesis of multiple myeloma(MM).Using a stem-loop quantitative reverse transcription-PCR, we analyzed miR-15a/miR-16 expressions in bone marrow samples from newly diagnosed MM patients and a panel of MM cell *** transfection,western blotting analysis and assay of

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数媒时代焦虑、抑郁与社会比较的关系

心理科学进展 2025年第1期33卷 92-106,I0001-I0007页

作者：赵立白莎首都经济贸易大学工商管理学院北京100070

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。... 详细信息

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。研究发现,消极社会比较(传统上行比较和下行同化比较)可能会引发焦虑和抑郁,社交网络平台对此负面影响具有催化作用;而情绪比较和下行对比比较可以缓解焦虑和抑郁,网络健康社区促进了情绪比较的积极作用的发挥。研究推进了社会比较理论在情绪情感领域的应用,确定了焦虑、抑郁与网络健康社区可供性的关联,也为网络社区服务、运营和设计的原则提供参考和借鉴以帮助个体应对心理健康问题。研究还指出焦虑、抑郁和社会比较关系后续研究的可能路径和方向。

关键词：社会比较焦虑抑郁社交网络平台网络健康社区

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, Yu-Ze Wang, Yu-Chang liu, Ting-Ting Zhao, Quan-liang li, Chen-sha Cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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尿路感染中肠球菌的分布及耐药性分析

中华医院感染学杂志 2017年第4期27卷 743-745,761页

作者：田鹏鹏朱丽莎马青艾彪田甜长江大学附属第一医院检验科湖北荆州434000 长江大学附属第一医院眼科湖北荆州434000

目的探讨尿标本中肠球菌的分布特点和耐药性。方法选取2014年1月-2015年12月2 872例尿路感染患者,对尿液病原菌进行鉴定及药物敏感性试验,耐药率分析采用χ~2检验或Fisher精确概率检验。结果 2 872例尿标本中分离病原菌2 872株,革兰阴性... 详细信息

目的探讨尿标本中肠球菌的分布特点和耐药性。方法选取2014年1月-2015年12月2 872例尿路感染患者,对尿液病原菌进行鉴定及药物敏感性试验,耐药率分析采用χ~2检验或Fisher精确概率检验。结果 2 872例尿标本中分离病原菌2 872株,革兰阴性菌2 053株,占71.5%;革兰阳性菌749株,占26.1%;真菌70株,占2.4%,检出病原菌最多的前5位依次为大肠埃希菌1 399株、粪肠球菌304株,肺炎克雷伯菌171株、屎肠球菌109株、铜绿假单胞菌94株,依次占比为48.7%、10.6%、6.0%、3.8%、3.3%;男性、女性、门诊、住院、泌尿科、肾内科患者分离的病原菌分别占34.5%、65.5%、4.1%、95.9%、39.7%、23.4%,屎肠球菌对青霉素、氨苄西林、环丙沙星、左氧氟沙星、红霉素等耐药率很高,均在80%以上;粪肠球菌对红霉素耐药率最高,对青霉素、氨苄西林、呋喃妥因耐药率很低,粪肠球菌对青霉素、氨苄西林、高浓度庆大霉素、环丙沙星、左氧氟沙星、红霉素、呋喃妥因等耐药率显著低于屎肠球菌;未发现对万古霉素、替考拉宁及利奈唑胺耐药的肠球菌。结论尿路感染以大肠埃希菌、肠球菌最常见,肠球菌耐药情况严重,不同肠球菌种间耐药性差异明显,应根据鉴定及药敏结果合理使用抗菌药物。

关键词：尿路感染肠球菌耐药性

磷霉素对尿路感染患者肠杆菌科细菌的敏感性分析

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中华医院感染学杂志 2017年第12期27卷 2664-2667页

作者：田鹏鹏朱丽莎马青艾彪龙聪长江大学附属第一医院检验科湖北荆州434000

目的了解磷霉素对尿路感染患者肠杆菌科细菌的敏感性,指导临床合理用药。方法对2016年1-9月医院尿路感染患者清洁中段尿标本进行培养,共分离出肠杆菌科病原菌678株,使用BD-phoenix-100对尿路感染患者中段尿分离肠杆菌科细菌进行鉴定和... 详细信息

目的了解磷霉素对尿路感染患者肠杆菌科细菌的敏感性,指导临床合理用药。方法对2016年1-9月医院尿路感染患者清洁中段尿标本进行培养,共分离出肠杆菌科病原菌678株,使用BD-phoenix-100对尿路感染患者中段尿分离肠杆菌科细菌进行鉴定和药敏试验及产超广谱β-内酰胺酶(ESBLs)的检测,磷霉素药敏试验采用纸片扩散法测定,结果按CLSI 2015年版标准判断;应用WHONET 5.6软件分析分离株的分布和耐药情况。结果共分离678株肠杆菌科细菌,以大肠埃希菌为主,共510株占75.2%;肠杆菌科细菌对磷霉素的敏感率为92.3%;大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌中产ESBLs检出率分别为41.4%、38.2%、6.1%;产ESBLs大肠埃希菌、肺炎克雷伯菌对磷霉素的敏感率分别为94.3%、9.5%。结论尿路感染病原菌以大肠埃希菌、肺炎克雷伯菌为主,磷霉素对尿路感染病原菌(包括产ESBLs细菌)具有较好的敏感性,可作为临床首选的经验用药。

关键词：磷霉素尿路感染肠杆菌科超广谱β-内酰胺酶敏感性

急诊介入治疗合并院前心脏骤停急性心肌梗死临床疗效分析

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中国卫生标准管理 2017年第8期8卷 34-35页

作者：乔龙买买提力.艾沙新疆克拉玛依市独山子人民医院急救中心新疆克拉玛依833600 新疆医科大学第一附属医院神经外科新疆乌鲁木齐830054

目的探讨分析合并院前心脏骤停急性心肌梗死运用急诊介入治疗的临床疗效。方法在本院合并院前心脏骤停急性心肌梗死患者中选取100例,随机分为观察组和对照组,每组50例,观察组给予急诊介入治疗,对照组给予溶栓治疗,观察对比临床疗效。结... 详细信息

目的探讨分析合并院前心脏骤停急性心肌梗死运用急诊介入治疗的临床疗效。方法在本院合并院前心脏骤停急性心肌梗死患者中选取100例,随机分为观察组和对照组,每组50例,观察组给予急诊介入治疗,对照组给予溶栓治疗,观察对比临床疗效。结果观察组的总有效率为92%,对照组的总有效率为70%,差异有统计学意义(P<0.05)。结论用急诊介入治疗合并院前心脏骤停急性心肌梗死效果良好。

关键词：急诊介入治疗心脏骤停急性心肌梗死疗效

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu liu sha-sha Cui Ting-Ting li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

OKMC simulation of vacancy-enhanced Cu solute segregation affected by temperature/irradiation in the Fe–Cu system

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Nuclear Science and Techniques 2022年第11期33卷 158-169页

作者： Zi-Qin Shen Jie Gao sha-sha Lv liang Chen Dong-Yue Chen De-Sheng ai Zheng-Cao li Key Lab of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Nuclear and New Energy Institute Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Beam Technology Ministry of EducationCollege of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Engineering and Management The University of TokyoTokyo 113-8656Japan

The effects of annealing and irradiation on the evolution of Cu clusters in a-Fe are investigated using object kinetic Monte Carlo *** our model,vacancies act as carriers for chemical species via thermally activated diffusion jumps,thus playing an important role in solute *** the end of the Cu cluster evolution,the simulations of the average radius and number density of the clusters are consistent with the experimental data,which indicates that the proposed simulation model is applicable and *** the simulation of the annealing process,it is found that the evolution of the cluster size roughly follows the 1/2 time power law with the increase in radius during the growth phase and the 1/3 time power law during the coarsening *** addition,the main difference between neutron and ion irradiation is the growth and evolution process of the copper-vacancy *** aggregation of vacancy clusters under ion irradiation suppresses the migration and coarsening of the clusters,which ultimately leads to a smaller average radius of the copper *** proposed simulation model can supplement experimental analyses and provide a detailed evolution mechanism of vacancy-enhanced precipitation,thereby providing a foundation for other elemental precipitation research.

关键词： Object kinetic Monte Carlo Irradiation effect Solute segregation Reactor pressure vessel