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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin zhang Haobang liang Bei Hu Longlong ren Yanjuan liu Yuhu zhang Chengbo Dai Hejun Wu Weifeng li Xin li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang Shuo li Fu Tang Jingkai zhang Yuetong Kang Hean zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na li Yue-Yue ren Ying Tang Qi Yang Tian-Tian Meng Song li Jing zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu liu Michael Chopp Michael Millman Yanfeng li Pasquale Cepparulo Amy Kemper Chao li li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Genetic Analysis of Major and Minor Gene(s) Resistant to Stripe Rust in Important Resource Wheat line Jinghe891-1

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Agricultural Sciences in China 2002年第4期1卷 364-369页

作者： XU Shi-chang, zhang Jing-yuan, ZHAO Wen-sheng, WU li-ren zhang Ji-xin and YUAN Zhen-dong( Institute of Plant Protection , Chinese Academy of Agricultural Sciences , Beijing 100094 , P. R . China Institute of Crop Science, Beijing Academy of Agricultural and Forestry Science, Beijing 100089 , P. R . China ) Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100094 P. R . China Institute of Crop Science Beijing Academy of Agricultural and Forestry Science Beijing 100089 P.R. China

Inheritance of line Jinghe891-l resistant to pathotype of Puccinia striiformis in two patterns of temperature (Normal: day 18℃ /night 10℃ , High: day 24℃ /night 15℃ )was studied in this paper. The results showed that there were at least two pairs of dominant major genes and one pair of recessive minor genes in Jinghe 891-1. The two pairs of major genes that conferred resistance to CY31 were allelic or linked closely with resistance gene in Jubilejna Ⅱ , Kangyin655 and T. spelta Album. They were novel resistance genes and were inherited in a repeated or independent mode. The minor genes, which could modify the major genes, were sensitive to temperature and conferred resistance to all pathotypes of Puccinia striiformis in China. It is recommended that this line can be used as an important resource stock.

关键词： Wheat Wheat resistance to Puccinia striiformis Major gene(s) Minor gene(s) Genetic analysis

“21世纪海上丝绸之路”之4个主要东盟国家人文环境风险评估

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海洋通报 2016年第6期35卷 617-624页

作者：杨理智张韧白成祖黎鑫刘君解放军理工大学气象海洋学院海军92962部队气象台成都军区测绘信息中心

在"21世纪海上丝绸之路"重大战略设想提出的背景下,针对东盟国家在海上丝绸之路中的重要性及其因社会制度、发展水平等导致的人文环境的不确定性,开展了菲律宾、马来西亚、新加坡、印度尼西亚等4个东盟国家人文环境风险分析,引入了云模... 详细信息

在"21世纪海上丝绸之路"重大战略设想提出的背景下,针对东盟国家在海上丝绸之路中的重要性及其因社会制度、发展水平等导致的人文环境的不确定性,开展了菲律宾、马来西亚、新加坡、印度尼西亚等4个东盟国家人文环境风险分析,引入了云模型的理论方法,针对4个东盟国家的4类主要的人文环境风险——国家政局、经济状况、军事实力、政治结盟及其综合人文环境风险进行了定量化评估。研究结果表明,4个评估目标国家综合人文环境风险并不高,但个别国家的某一类或几类人文环境风险偏高,值得针对性的给予关注。

关键词： 21世纪海上丝绸之路风险评估云模型人文环境东盟国家

RNAi-Mediated Knocking Down of Rlpk2 Gene Retarded Soybean Leaves Senescence

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RNAi-Mediated Knocking Down of Rlpk2 Gene Retarded Soybean L...

Low Correspondence of EGFR Mutations in Tumor Tissue And Paired Serum of Non-Small-Cell Lung Cancer Patients

2005年全国植物生长物质研讨会

作者： Xiaoping li, Rui Gan, Yuanyuan Ma, Pengli li liweng zhang, ren zhang, Ningning Wang (Department of Botany and Ecology, Nan Kai University, Tianjin 300071 Department of Biological Sciences, University of Wollongong, NSW2522, Australia)

＜正＞Receptor protein kinases comprise multigene families. They are plasma membrane-bound and play an important role in the perception and transmittance of external signals. Many signals are perceived by the extracellular domains of receptor protein kinases and are transduced by activation of intracellular kinase domains. Receptor protein kinases in animals autophosphorylate either on tyrosine residues or on serine and/or threonine residues. Plant counterparts, receptor-like protein kinases （RLKs）, have topological features of the animal receptor protein kinases but contain sequence motifs characteristic of serine/threonine kinases. Plant RLK gene families participate in wide spectra of cellular responses.

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来源： cnki会议评论

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Chinese Journal of Cancer Research 2010年第1期22卷 27-31页

作者： Guo-hong Song,Jun ren,li-jian zhang,li-jun Di, Yan-hua Yuan,Jing Yu,Jun Jia Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Medical Oncology,Peking University School of Oncology,Beijing Cancer Hospital & Institute,Beijing 100142,China DepartmentofMedicalOncology PekingUniversitySchoolofOncologyBeijingCancerHospital&InstituteBeijing100142China

Objective： Epidermal growth factor receptor （EGFR） mutations are strong determinants of tumor response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer （NSCLC） patients. The aim of this study was to evaluate the correspondence between EGFR mutations in non-small-cell lung cancer tissues and in circulating DNA. Methods： The research was conducted in 50 non-small-cell lung cancer patients who had undergone curative surgery, and in whom both serum and neoplastic tissues were available. Meanwhile sera of 33 cases of advanced NSCLC patients were also analyzed. DNA were extracted from each sample. Mutations of EGFR in exonl8-21 were examined by PCR amplification method and direct sequencing. Results： EGFR mutations were detected in 15 （30%） of 50 neoplastic tissue samples, 6 cases were in-frame deletion del E746-A750 in exonl9, 9 cases were substitution in exon 21 （all were L858R except one was L861Q）, but no mutated DNA resulted in paired serum circulating DNA samples of 50 resectable patients. As the 33 advanced NSCLC patients, EGFR mutations were detected in only 2 serum circulating DNA samples, all were L858R mutation in exon 21. Conclusion： These data indicated that it was difficult to identify EGFR mutations in circulating DNA of NSCLC patients. The use of EGFR mutation in serum as a clinical method for decision making of TKI therapy is unsatisfactory.

关键词： Circulating DNA Epidermal growth factor receptor (EGFR) Mutation Non-small-cell lung cancer (NSCLC)

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高超声速飞行器再入段的动力学建模与仿真

系统仿真学报 2009年第2期21卷 534-537页

作者：李菁菁任章黎科峰张庆振刘存佳北京航空航天大学

高超声速飞行器的动力学建模对于进行控制系统的设计和仿真来说是非常重要的。与传统的飞行器相比,由于其飞行的速度和高度跨度大、变化快,高超声速飞行器的飞行动力学特性相当复杂。为了研究高超声速飞行器的一些本质的动力学特性,选... 详细信息

高超声速飞行器的动力学建模对于进行控制系统的设计和仿真来说是非常重要的。与传统的飞行器相比,由于其飞行的速度和高度跨度大、变化快,高超声速飞行器的飞行动力学特性相当复杂。为了研究高超声速飞行器的一些本质的动力学特性,选择再入段进行分析,建立了再入段的高超声速动力学模型。利用风洞实验数据,建立了空气动力学数据库,并且对模型进行了不确定性分析。在模型的基础上,讨论了高超声速飞行器再入段的控制系统的设计方法。最后,在MATLAB/SIMULNK中进行了控制系统仿真,仿真结果表明在60公里到着陆点控制系统能够很好地控制动力学模型跟踪制导指令。

关键词：动力学建模高超声速飞行器再入段空气动力学数据库控制系统仿真