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Efficacy and safety of ulinastatin in the treatment of septic shock:a systematic review and meta-analysis

Medical Data Mining 2024年第1期7卷 1-9页

作者： Chao Tong Aheyeerke Halengbieke Teng-Rui Cao Xin Huang jia-Lu Luo jia-Xin li Xue-Tong Ni Feng Sun Xing-Hua Yang School of Public Health Capital Medical UniversityBeijing 100069China Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijing 100191China

Background:Septic shock is a common systemic inflammatory response syndrome for critical patients in the intensive care *** is currently used for the treatment of septic *** study sought to evaluate the efficacy and safety of ulinastatin in the treatment of septic shock ***:Three English databases(Embase,Medline,and Cochrane library)and four Chinese databases(China National Knowledge Infrastructure,Wanfang data,SinoMed,and VIP)were searched for published randomized controlled *** 16.0 software was used to conduct the ***:A total of 48 articles were included(Chinese article 47,1 in English).The results show that the treatment of ulinastatin could reduce mortality(risk ratio=0.63,95%confidence interval(CI)(0.55,0.72)),multiple organ dysfunction syndrome(risk ratio=0.6,95%CI(0.53,0.68)),length of intensive care unit stay(mean difference(MD)=-3.92,95%CI(-4.65,-3.18)),length of hospital stay(MD=-4.39,95%CI(-6.63,-2.15))and decrease Acute Physiology and Chronic Health Evaluation II score(MD=-4.55,95%CI(-5.63,-3.47))and Sequential Organ Failure Assessment score(MD=-2.02,95%CI(-2.59,-1.44))with Plinastatin reduces case mortality rate,multiple organ dysfunction syndrome,length of intensive care unit stay,and length of hospital stay and decreases Acute Physiology and Chronic Health Evaluation II score and Sequential Organ Failure Assessment ***,it also lowers TNF-α,Interleukin-6,C reactive protein,hypersensitive C-reactive protein,and procalcitonin levels in the body.

关键词： effectiveness meta-analysis randomized controlled trial septic shock ulinastatin

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Dissolution behavior,thermodynamic and kinetic analysis of malonamide by experimental measurement and molecular simulation

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Chinese Journal of Chemical Engineering 2023年第1期53卷 260-269页

作者： Peng Yang Shengzhe jia Yan Wang Zongqiu li Songgu Wu Jingkang Wang Junbo Gong School of Chemical Engineering and Technology State Key Laboratory of Chemical EngineeringTianjin UniversityTianjin 300072China School of Pharmaceutical Sciences(Shandong Analysis and Testing Center) Qilu University of Technology(Shandong Academy of Sciences)Jinan 250014China

In this study,the solid structure,dissolution behavior,thermodynamic properties and nucleation kinetics of malonamide were ***,the Hirshfeld surface analysis and molecular electrostatic potential surface were plotted to reveal the percentage contribution of various intermolecular contacts and location of the strongest hydrogen ***,the solubility of malonamide in 12 solvents was determined by dynamic method at temperatures from 278.15 K to 318.15 *** thermodynamic models were applied to analyze solubility *** addition,the thermodynamic properties were calculated to further analyze and discuss the dissolution behavior of ***,the physicochemical properties of solvents were explored to express the solvent *** results illustrate“like dissolves like”,“mass transfer”and“solvent–solute interaction”rules play the synergistic effects on the dissolution *** molecular dynamic simulation,including radial distribution function analysis and solvent free energy,was used to further explain the dissolution *** last,the nucleation rate and effective interfacial energy in methanol solvent was measured and calculated to reveal the nucleation behaviour.

关键词： Malonamide Solubility Thermodynamic properties Molecular simulation Nucleation rate

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Enhancement of electrical conductivity and electromagnetic interference shielding performance via supercritical CO_(2) induced phase coarsening for double percolated polymer blends

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Nano Research 2023年第1期16卷 613-623页

作者： Fangfang Zou Xia liao Pengwei Song Shaozhe Shi jia Chen Xiaohan Wang Guangxian li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

The electrical conductivity of conductive polymer composites(CPCs)with a classical double percolated structure is highly connected to the phase ***,lots of conductive fillers,which are added to guarantee CPCs’electrical conductivity,caused increased viscosity and limited phase coarsening in traditional atmosphere ***,a novel processing method of supercritical carbon dioxide(scCO_(2)),assisted phase coarsening for polylactide acid(PLA)/polystyrene(PS)/multi-wall carbon nanotube(MWCNT)composites was *** was first proved that obviously coarsened conductive network of double percolation after scCO_(2) annealing was achieved,which benefited from CO_(2) plasticized polymer chains and thus decreased ***,the electrical properties and electromagnetic interference(EMI)shielding performance of the composites were significantly *** percolation threshold of PLA/PS/MWCNT composites decreased from 0.31 wt.%to 0.16 wt.%,and EMI shielding effectiveness increased from 32.8 to 37.4 dB at 5 wt.%MWCNT *** work provides a simple,green,and effective way of post-processing to tailor the phase structure via varying conditions of annealing medium such as temperature,CO_(2) pressure,and time,and gains CPCs with improved electrical conductivity and EMI shielding performance.

关键词： double-percolated structure supercritical carbon dioxide annealing

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Cenozoic plants from Tibet:An extraordinary decade of discovery,understanding and implications

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Science China Earth Sciences 2023年第2期66卷 205-226页

作者： Zhekun ZHOU jia liU linlin CHEN Robert A.SPICER Shufeng li jian HUANG Shitao ZHANG Yongjiang HUANG linbo jia Jinjin HU Tao SU CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla666303China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming650204China School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China State Key Laboratory of Paleobiology and Stratigraphy Nanjing Institute of Geology and PaleontologyChinese Academy of SciencesNanjing210008China

Plant fossils play an important role in understanding landscape evolution across the Tibetan Region,as well as plant diversity across wider eastern *** the last decade or so,paleobotanical investigations within the Tibet Region have led to a paradigm shift in our understanding of how the present plateau formed and how this affected the regional climate and *** is because:(1)Numerous new taxa have been *** all the Cenozoic records of new plant fossil species reported from the Tibet(Xizang)Autonomous Region 45 out of 63(70%)were documented after *** these,many represent the earliest records from Asia,or in some cases worldwide,at the genus or family level.(2)These fossils show that during the Paleogene,the region now occupied by the Tibetan Plateau was a globally significant floristic exchange *** on paleobiogeographic studies,grounded by fossil evidence,there are four models of regional floristic migration and exchange,i.e.,into Tibet,out of Tibet,out of India and into/out of Africa.(3)Plant fossils evidence the asynchronous formation histories for different parts of the Tibetan *** most of the Paleogene,there was a wide east-west trending valley with a subtropical climate in central Tibet bounded by high(>4 km)mountain systems,but that by the early Oligocene the modern high plateau had begun to form by the rise of the valley *** reconstructions using radiometrically-dated plant fossil assemblages in southeastern Tibet show that by the earliest Oligocene southeastern Tibet(including the Hengduan Mountains)had reached its present elevation.(4)The coevolution between vegetation,landform and paleoenvironment is evidenced by fossil records from what is now the central Tibetan *** the Paleocene to Pliocene,plant diversity transformed from that of tropical,to subtropical forests,through warm to cool temperate woodland and eventually to deciduous shrubland in response to landscape evolution from a seas

关键词： Tibetan Plateau Cenozoic Paleobotany Flora Central valley Biodiversity

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High-rate sodium metal batteries enabled by trifluormethylfullerene additive

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Nano Research 2022年第8期15卷 7172-7179页

作者： Pengju li Xiaobo Huang Zhipeng jiang Han Zhang Pengwei Yu Xing Lu jia Xie State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Sodium metal is a promising anode for sodium batteries due to its high theoretical capacity and low ***,the serious Na dendrite growth and low Coulombic efficiency,especially at high current densities/cycling capacities,severely limit the application of sodium metal ***,trifluoromethylfullerene,C_(60)(CF_(3))_(6),is designed as an electrolyte additive to enable the high-rate cycling of sodium metal anodes with high Coulombic *** CF3 groups contribute to the formation of stable NaF-rich solid electrolyte interface layer,while C_(60)cages induce the uniform distribution of sodium ions and promote the formation of smooth and compact ***,Na||Cu cell with C_(60)(CF_(3))_(6)can be cycled at 2 mA·cm^(−2)and 10 mAh·cm^(−2)over 180 cycles with an average Coulombic efficiency of 99.9%,and Na||Na cell can be cycled at 10 mA·cm^(−2)over 600 ***,Na||NaV2(PO_(4))_(3)@C full cell exhibits high capacity retention of 84%over 2,000 cycles at 20 C(~3 mA·cm^(−2)).

关键词： sodium metal anode fullerene trifluormethylfullerene high rate electrolyte additive

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Performance of the Large Field of View Airborne Infrared Scanner and its application potential in land surface temperature retrieval

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Frontiers of Earth Science 2023年第2期17卷 378-390页

作者： Chao WANG Zhiyuan li Xiong XU Xiangsui ZENG jia li Huan XIE Yanmin JIN Xiaohua TONG College of Surveying and Geo-informatics Tongji UniversityShanghai 200092China Shanghai Key Laboratory for Planetary Mapping and Remote Sensing for Deep Space Exploration Tongji UniversityShanghai 200092China Frontiers Science Center for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China

The Large Field of View Airborne Infrared Scanner is a newly developed multi-spectral instrument that collects images from the near-infrared to long-wave infrared *** data can be used for land surface temperature(LST)retrieval and environmental *** data application,quality assessment is an essential procedure for a new *** this paper,based on the data collected by the scanner near the Yellow River in Henan Province,the geometric and radiometric qualities of the images are first *** absolute geolocation accuracy of the ten bands of the scanner is approximately 5.1 *** ground sampling distance is found to be varied with the whisk angles of the scanner and the spatial resolution of the *** band-to-band registration accuracy between band one and the other nine bands is approximately 0.25 *** length and angle deformations of the ten bands are approximately 0.67%and 0.3°,*** signal-to-noise ratio(SNR)and relative radiometric calibration accuracy of bands 4,9,and 10 are relatively better than those of the other ***,the radiative transfer equation(RTE)method is used to retrieve the LST from the data of the *** of in situ samples are collected to evaluate the retrieved *** the samples with unreasonable retrieved LST,the bias and RMSE between in situ LST measured by CE312 radiometer and retrieved LST are−0.22 K and 0.94 K,and the bias and RMSE are 0.27 K and 1.59 K for the InfReC R500-D thermal imager,***,the images of the Large Field of View Airborne Infrared Scanner yield a relatively satisfactory accuracy for both LST retrieval and geometric and radiometric qualities.

关键词： Large Field of View Airborne Infrared Scanner quality assessment thermal infrared remote sensing land surface temperature retrieval

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坤安乐汤联合芬吗通治疗围绝经期女性睡眠障碍随机对照研究

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中国中西医结合杂志 2024年第1期44卷 25-30页

作者：盛少琴董沈怡范梦梦万闻婧刘佳俐金雪静徐晶浙江中医药大学第二临床医学院杭州310053 浙江省杭州市妇产科医院妇科杭州310008 杭州师范大学临床医学院杭州311121 浙江省嘉兴市妇幼保健院产科浙江314050 杭州市余杭区第二人民医院妇幼保健中心杭州311121 杭州市临安区第一人民医院妇科杭州311300

目的观察坤安乐汤联合芬吗通治疗围绝经期女性睡眠障碍的临床疗效。方法267例均为在浙江中医药大学附属第二医院、杭州市妇产科医院更年期门诊就诊伴有睡眠障碍的围绝经期女性患者,符合纳入标准150例,按随机数字表法分为3组(中医组、西... 详细信息

目的观察坤安乐汤联合芬吗通治疗围绝经期女性睡眠障碍的临床疗效。方法267例均为在浙江中医药大学附属第二医院、杭州市妇产科医院更年期门诊就诊伴有睡眠障碍的围绝经期女性患者,符合纳入标准150例,按随机数字表法分为3组(中医组、西医组、中西医组),每组50例,中医组予坤安乐汤口服,西医组予芬吗通口服,中西医组予坤安乐汤+芬吗通口服。治疗3个月后观察3组患者匹兹堡睡眠质量指数(PSQI)、改良Kupperman评分、血糖、肝功能[谷丙转氨酶(ALT)、谷草转氨酶(AST)]、肾功能[肌酐(Cr)]、血脂[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、性激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))]等变化。结果142例患者完成随访,其中中医组46例,西医组48例,中西医组48例。治疗3个月后,3组患者的PSQI较治疗前均降低,与其余两组比较,中西医组入睡加快、早醒延迟、夜间苏醒次数减少、总睡眠时间延长(P0.05)。结论坤安乐汤联合芬吗通治疗有效缓解女性围绝经期睡眠障碍。

关键词：围绝经期睡眠障碍坤安乐汤芬吗通中药复方中西医结合

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微生物燃料电池催化转化甲烷的研究进展

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现代化工 2024年第7期44卷 36-40页

作者：李鑫钰张超包朋飞刘嘉欣卢静侯彬中北大学环境与安全工程学院山西太原030051

介绍了甲烷的来源和现有催化转化方法,通过对微生物燃料电池催化转化甲烷机理的概述和影响因素的归纳分析,综述了微生物燃料电池催化转化甲烷的研究现状,并且对存在的问题和未来的研究方向进行了总结和展望。

关键词：微生物燃料电池甲烷催化电能

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急性脑缺血/再灌注后小鼠皮层和海马部位神经细胞损伤的动态表征

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中国药理学通报 2024年第9期40卷 1708-1718页

作者：李彤白家鸣施懿峻闻彩名崔琳杨静娴肖洪贺辽宁中医药大学药学院辽宁大连116600

目的动态表征急性脑缺血/再灌注(ischemia/reperfusion,I/R)后小鼠皮层和海马部位神经细胞的损伤情况。方法取体质量为25~28 g的雄性C57BL/6J小鼠,线栓法阻断小鼠的大脑中动脉,1 h后进行再灌注,制备急性I/R损伤小鼠模型。实验为Sham组、... 详细信息

目的动态表征急性脑缺血/再灌注(ischemia/reperfusion,I/R)后小鼠皮层和海马部位神经细胞的损伤情况。方法取体质量为25~28 g的雄性C57BL/6J小鼠,线栓法阻断小鼠的大脑中动脉,1 h后进行再灌注,制备急性I/R损伤小鼠模型。实验为Sham组、I/R-6 h组、I/R-24 h组和I/R-72 h组。采用Longa神经功能评分评估各时间点小鼠的神经功能;TTC染色检测脑梗死体积;苏木精-伊红染色观察脑组织病理损伤;尼氏染色检测神经细胞损伤;免疫荧光组织化学染色检测星形胶质细胞和小胶质细胞的活化情况,以及成熟神经元的损伤情况;透射电镜检测海马神经元的线粒体损伤;Western blot检测线粒体分裂-融合相关蛋白p-Drp1/Drp1、Mff、Fis1和OPA1的表达情况。结果随着脑I/R时间的延长,小鼠的神经功能损伤、脑梗死体积,皮层和海马部位的神经细胞损伤、胶质细胞活化、神经元缺失、线粒体损伤逐渐加重;线粒体分裂相关蛋白表达逐渐增加,而线粒体融合相关蛋白表达逐渐降低。结论随着脑I/R时间的延长,胶质细胞活化、神经元缺失、线粒体损伤等神经病理损伤逐渐加重,这可能与线粒体动力学失衡有关。

关键词：缺血/再灌注损伤动态表征神经元星形胶质细胞小胶质细胞线粒体

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固体火箭发动机中最终凝相产物特性分析

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火箭推进 2024年第3期50卷 90-101页

作者：刘梦莹徐晨恩黄河峡蔡佳刘筑李世鹏南京航空航天大学能源与动力学院江苏南京210016 南京工业职业技术大学航空工程学院江苏南京210023 空间物理重点实验室北京100076 北京理工大学宇航学院北京100086

铝颗粒的加入可以有效提高固体推进剂的能量特性,但也带来了两相流比冲损失、熔渣沉积和喷管烧蚀加剧等消极影响,因此,对固体火箭发动机最终凝相产物特性展开研究对评估和提升固体火箭发动机性能具有重要意义。以燃烧终产物为主要研究对... 详细信息

铝颗粒的加入可以有效提高固体推进剂的能量特性,但也带来了两相流比冲损失、熔渣沉积和喷管烧蚀加剧等消极影响,因此,对固体火箭发动机最终凝相产物特性展开研究对评估和提升固体火箭发动机性能具有重要意义。以燃烧终产物为主要研究对象,搭建了基于粒度分析仪的高温高速颗粒特性动态测量系统,对AP/HTPB含铝复合推进剂开展了高温高压下固体火箭发动机试验研究,获得了排气羽流中燃烧终产物分布特性,包括燃烧终产物粒径、均值粒径及颗粒种类等随时间的变化规律,为全面了解凝相产物粒度分布特性提供试验和数据支撑。根据发动机燃烧室压力分布趋势,将固体火箭发动机的工作过程划分为3个阶段(阶段①~③),研究表明:阶段①排气羽流中固体颗粒包括黑火药和推进剂两种燃烧产物,黑火药的随机燃烧特性、燃烧室压力和温度的突升会共同影响该阶段的燃烧终产物分布特性;阶段②燃烧稳定性最高,且该阶段不同时刻燃烧终产物粒径具有较为一致的分布特性,可采用特征模式描述阶段②燃烧终产物的粒径分布;阶段③燃烧终产物粒径分布离散度小于阶段①,该阶段燃烧室压力和温度的突降会影响燃烧终产物分布特性;燃烧室压力和温度突变会改变燃烧终产物模态、峰值粒径及均值粒径等分布特性,不同类型颗粒质量分数随发动机工作阶段的变化而变化。

关键词：固体火箭发动机含铝复合推进剂凝相产物粒径分布动态粒径测量

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