检索结果-南通市图书馆

Prognosis of hepatocellular carcinoma with bile duct tumor thrombus after R0 resection:a matched study

Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 626-632页

作者： Ding-Ding Wang li-qun wu Zu-Sen Wang Division of Hepatobiliary Pancreatic Surgery The Affiliated Hospital of Qingdao University

BACKGROUND： Hepatocellular carcinoma （HCC） with bile duct tumor thrombus （BDTT） is rare. The present study aimed to determine post-surgical prognoses in HCC patients with BDTT, as outcomes are currently unclear. METHODS： We compared the prognoses of 110 HCC patients without BDTT （group A） to 22 cases with BDTT （group B）. The two groups were matched in age, gender, tumor etiology, size, number, portal vascular invasion, and TNM stage. Additionally, 28 HCC patients with BDTT were analyzed to identify prognostic risk factors. RESULTS： The 1-, 3-, and 5-year overall survival rates were 90.9%, 66.9%, and 55.9% for group A and 81.8%, 50.0%, and 37.5% for group B, respectively. The median survival time in groups A and B was 68.8 and 31.4 months, respectively （P=0.043）. The patients for group B showed higher levels of serum total bilirubin, alanine aminotransferase and gammaglutamyl transferase, a larger hepatectomy range, and a higher rate of anatomical resection. In subgroup analyses of patients with BDTT who underwent R0 resection, TNM stage Ⅲ-Ⅳ was an independent risk factor for overall survival; these patients had worse prognoses than those with TNM stage Ⅰ-Ⅱ after R0 resection （hazard ratio=6.056, P=0.014）. Besides, univariate and multivariate analyses revealed that non-R0 resection and TNM stage Ⅲ-Ⅳ were independent risk factors for both disease-free survival and overall survival of 28 HCC patients with BDTT. The median overall survival time of patients with BDTT who underwent R0 resection was longer than that of patients who did not undergo R0 resection （31.0 vs 4.0 months, P=0.007）.CONCLUSIONS： R0 resection prolonged survival time in HCC patients with BDTT, although prognosis remains poor. For such patients, R0 resection is an important treatment that determines long-term survival.

关键词： hepatocellular carcinoma bile duct tumor thrombus prognosis recurrence R0 resection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Children with type 1 diabetes in COVID-19 pandemic:Difficulties and solutions

引用

World Journal of Clinical Pediatrics 2022年第5期11卷 408-418页

作者： Yue Shi li-qun wu Peng Wei Ze-Huan liao Second Clinical Medical College Beijing University of Chinese MedicineBeijing 100078China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Department of Microbiology Tumor and Cell BiologyKarolinska InstitutetStockholm 17177Sweden

Children/adolescents with type 1 diabetes(T1D)require holistic approach and continuous ***,the coronavirus disease 2019(COVID-19)pandemic has made challenges for the T1D children and their caregivers,professionals,and the healthcare *** minireview aims to consolidate and discuss the difficulties and solutions of children with type 1 diabetes in the COVID-19 pandemic.T1D has been the most common type of diabetes in children and adolescents and the last decades has seen a rapid increase in the prevalence of T1D in youths worldwide,which deserves a public concern particularly in the COVID-19 *** reported in previous studies,T1D is a risk factor related to severe cases,while the virus may induce new-onset diabetes and serious ***,restriction strategies influence medical availability and lifestyle,impact glycemic control and compilation management,and thus pose stress on families and health providers of youths with T1D,especially on those with certain fragile ***,special treatment plans are required for children provided by caregivers and the local health *** health tools such as improved medical devices and telemedicine service,as well as a combined support may benefit in this *** minireview emphasises that continued medical access and support are required to prevent deteriorated condition of children and adolescents with diabetes throughout this ***,strategies are supposed to be formulated to mitigate the difficulties and stress among this group,particularly in the most at-risk *** solutions in this minireview may help individuals and the health system to overcome these problems and help youths with T1D in better diabetes management during such emergency situations.

关键词： Type 1 diabetes Pediatrics COVID-19 pandemic Diabetes management Glycemic control Telemedicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression of the bacterial gene in gallbladder carcinoma tissue and bile

引用

Hepatobiliary & Pancreatic Diseases International 2004年第1期3卷 133-135页

作者： Yun Lu Bing-Yuan Zhang Jing-Sen Shi li-qun wu Department of Hepatobiliary-Vascular Surgery Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China. cloudylucn@***

BACKGROUND: The major causive factors of gallbladder carcinoma are very complex. Cholecystitis with gallstone was reported one of the most important factors. Many research revealed that cholecystitis or gallstone can give rise to epithelial hyperplasia of gallbladder mucusa or canceration secondarily. In this study, 46 patients were detected in order to find the relationship between infection of different bacteria and formation of gallbladder carcinoma.METHODS: Using the common gene primer of bacteria 16S ribosomal RNA (rRNA), we detected bacterial gene fragments of gallbladder carcinoma tissues in 46 patients by polymerase chain reaction (PCR). Relative bile was also detected by PCR in 18 patients who underwent operations, including U-tube drainage (1), right or left biliary tube drainage (4), radical cholecystectomy (9), and cholecystorrhaphy (4). The tissue fragments of gallbladder carcinoma from the remaining 28 patients were paraffin slices.RESULTS: The positive rate of bacterial DNA in gallbladder carcinoma tissue was 78.3% (36/46). The sequence of 16S ribosomal RNA gene fragments amplified by PCR was approximately 371 base pairs (bp). Multiple kinds of standard bacterial gene fragments obtained from 36 patients included Colibacillus, ***, Klebsiella, *** and Clostridium, with a positive rate of 78.3% (36/46). Among the 36 patients, 14 patients with gallbladder carcinoma received operation and their relative bile at operation was detected bacterial gene fragments with a positive rate of 77.8% (14/18). This result was close to that in gallbladder carcinoma tissues.CONCLUSIONS: Our results suggested that there might be a relationship between occurrence of gallbladder carcinoma and infection of different kinds of bacteria, especially anaerobic bacteria ***. This reminds us that the gallbladder mucosa stimulated by anaerobic and aerobic bacteria might be the principal cause for the development of carcinoma.

关键词： bacteria gene expression gallbladder carcinoma tissue relative bile

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment of early duodenal fistula after orthotopic liver transplantation: a case report

引用

Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 155-157页

作者： Yun Lu li-qun wu Bing-Yuan Zhang Bin Zhang Jing-Yu Cao Zhong-Yang Shen Department of Hepatobiliary Vascular Surgery Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China. cloudylucn@***

Gastrointestinal fistula as a serious complicationcould lead to imbalance of nutrition or *** fistula after orthotopic liver transplanta-tion is rare and its treatment is complicated. OnApril 28, 2000, we performed orthotopic livertransplantation for a patient at our hospital. Eightdays after operation duodenal fistula developed,but cured after 13-day *** reportA 46-year-old woman weighing 50 kg was admittedto our hospital because of emaciation and yellowishbody skin for over half a year. In 1994, she hadundergone cholecystectomy and choledochoduode-nostomy for cholangitis elsewhere. One month be-

关键词： of is in as case a case report Treatment of early duodenal fistula after orthotopic liver transplantation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of Pulmonary Vein Anatomy on Long-term Outcome of Cryoballoon Ablation for Atrial Fibrillation

引用

Current Medical Science 2018年第2期38卷 259-267页

作者： Shang-wei HUANG Qi JIN Ning ZHANG Tian-you liNG Wen-qi PAN Chang-jian liN Qing-zhi LUO Yan-xin HAN li-qun wu Department of Cardiology Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai20025 China

Variant pulmonary vein anatomy （PVA） has been reported to influence the recurrence of atrial fibrillation （AF） after radiofrequency ablation. However, the effects of PVA on AF in patients undergoing cryoballoon ablation （CBA） remain unknown. The present study aimed to examine the impact of PVA on the long-term outcome of CBA for AF. A total of 78 patients （mean age 60.7±10.9 years, 64.1% males） with symptomatic and drug-refractory paroxysmal AF were enrolled in the study. Left atrium （LA） and PVA acquired at computed tomography angiography （CTA） were reconstructed with CARTO 3 SYSTEM. Patients were routinely evaluated by 24-hour Holter monitoring following CBA. Cox regression was used to detect the predictors of AF recurrence after CBA. The results showed abnormal PVA in 30 patients （38.5%） and 18 patients （23.1%） had left common PV （LCPV）. Electrical pulmonary vein isolation was achieved in all patients. After a mean follow-up of 689.5±103.8 days, it was found that patients with abnormal PVA had similar AF recurrence rate to those with normal PVA （26.7% vs. 25.0%, P=0.54）, and there was no significant difference in AF recurrence rate between LCPV patients and non-LCPV patients （33.7% vs. 23.3%, P=0.29）. Cox regression analysis showed that AF duration （72.9±9.0 vs. 42.3±43.2 months, HR 1.001; 95%CI 1.003- 1.014; P〈0.001） and cryo-applications of right-side PVs （3.0±1.6 vs. 4.7±1.7, HR 0.661; 95% CI 0.473-0.925; P=0.016） were independent predictors of freedom from AF, but PVA was not identified as a predictor of long-term success. In conclusion, the variant PVA cannot significantly influence the long-term outcome of AF patients undergoing CBA; longer AF duration and less cryo-applications of right-side PVs are associated with higher AF recurrent rate.

关键词： atrial fibrillation pulmonary vein anatomy cryoballoon ablation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts

The effect of pinacidil on postshock activation and ventricu...

引用

中华医学会第十五次全国心血管病学大会

作者： Qi Jin Wei Feng Shen li qun wu Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Aim To determine the postshock activation patterns with both successful and failed shocks in a canine model of ventricular fibrillation, and whether piniacidil, an early after-depolarization (EAD) inhibitor, altered t...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Clinical value of serum CA19-9 levels in evaluating resectability of pancreatic carcinoma

引用

World Journal of Gastroenterology 2008年第23期14卷 3750-3753页

作者： Shun Zhang Yi-Ming Wang Chuan-Dong Sun Yun Lu li-qun wu Department of Hepatobiliary Surgery Affiliated Hospital of Medical College Qingdao University Qingdao 266003 Shandong Province China

AIM:To evaluate the clinical value of serum CA19-9 levels in predicting the respectability of pancreatic carcinoma according to receiver operating characteristic(ROC) curve analysis. METHODS:Serum CA19-9 levels were measured in 104 patients with pancreatic cancer which were possible to be resected according to the imaging. ROC curve was plotted for the CA19-9 levels. The point closest to the upper left-hand corner of the graph were chosen as the cut-off point. The sensitivity,specificity,positive and negative predictive values of CA19-9 at this cut-off point were calculated. RESULTS:Resectable pancreatic cancer was detected in 58(55.77%) patients and unresectable pancreatic cancer was detected in 46(44.23%) patients. The area under the ROC curve was 0.918 and 95% CI was 0.843-0.992. The CA19-9 level was 353.15 U/mL,and the sensitivity and specificity of CA19-9 at this cut-off point were 93.1% and 78.3%,respectively. The positive and negative predictive value was 84.38% and 90%,respectively. CONCLUSION:Preoperative serum CA19-9 level is a useful marker for further evaluating the resectability of pancreatic cancer. Obviously increased serum levels of CA19-9(> 353.15 U/mL) can be regarded as an ancillary parameter for unresectable pancreatic cancer.

关键词： Pancreatic carcinoma Resection Tumor markers CA19-9 Receiver operating characteristic curve

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atrial fibrillation

引用

The Journal of Biomedical Research 2014年第1期28卷 1-17页

作者： Thomas M.Munger li-qun wu Win K.Shen Heart Rhythm Services Division of Cardiovascular DiseasesMayo ClinicRochester Department of Cardiology Rui Jin HospitalShanghai Jiao Tong University of Medicine Division of Cardiovascular Diseases Mayo ClinicPhoenix

Atrial fibrillation is the most common arrhythmia affecting patients today. Disease prevalence is increasing at an alarming rate worldwide, and is associated with often catastrophic and costly consequences, including heart failure, syncope, dementia, and stroke. Therapies including anticoagulants, anti-arrhythmic medications, devices, and non-pharmacologic procedures in the last 30 years have improved patients＂ functionality with the disease. Nonetheless, it remains imperative that further research into AF epidemiology, genetics, detection, and treatments continues to push forward rapidly as the worldwide population ages dramatically over the next 20 years.

关键词： atrial fibrillation arrhythmias cardiac stroke dementia heart failure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of intra-tumor injection of Xiao-Zhi-ling on transplanted hepatoma in rats

引用

World Journal of Gastroenterology 2003年第9期9卷 2121-2124页

作者： Yun Lu li-qun wu Department of Hepato-biliary Vascular Surgery,Medical College,Qingdao University,Qingdao 266003,Shandong Province,China Department of Hepato-biliary Vascular Surgery Medical College Qingdao University 16 Jiangsu Road Qingdao 266003 Shandong Province China. cloudylucn@***

AIM: To study the therapeutic effectiveness of intra-tumorinjection of Xiao-Zhi-ling(XZL) on transplanted hepatomain ***: Sixty rats were divided into 3 groups (groupsS, X and E), 20 in each. Different drugs were injected intothe implanted hepatoma (Group S with 0.2 mi saline ascontrol, group X with 0.2 mi XZL, group E with 0.2 miethanol). After 3 days and 8 days respectively, we detectedthe hepatoma volume (HV), the level of albumin, alanineaminotransferase (ALT), aspartate aminotransferase (AST)and alkaline phosphatase (ALP) in serum, and the expressionof proliferating cell nuclear antigen (PCNA) in ***: The results were obtained after 3 days, the HVsin groups X and E were smaller than those in group S (groupX vs S P=0.010*, group Evs S P=0.002*, P＜0.05). Thelevels of ALT and AST in group S and X were lower thanthose in group E (ALT Group S vs E P=0.019*, group X vsEP=0.003*, P＜0.05; AST group X vs E P=0.002*, P＜0.05).The levels of ALP and PCNA labeling index in group X werelower than those in group S and E (ALP group X vs SP=0.000*, group X vs E P=0.000*. P＜0.05; PCNA group XvsS P=0.008*, group X vsE P=0.048*, P＜0.05). The levelsof creatinine in group S were lower than those in group E(group S vs E P=0.017, P＜0.05). The degree of tumornecrosis in group S was lower than those in groups X and E(group S vsX P=0.006*, group S vs E P=0.006*, P＜0.05).After 8 days, the HVs in groups X and E were smaller thanthose in group S (group X vs S P=0.007*, group Evs SP=0.004*, P＜0.05). The difference of HVs between groupsX and E was not significant. The levels of albumin, ALT, ASTand creatinine in group X were not higher than those inother groups, the levels of ALP and PCNA in group X werelower than those in groups S and E (ALP group X vs EP=0.006* P＜0.05; PCNA group X vsS P=0.044*, group Xvs E P=0.021*, P＜0.05). The degree of tumor necrosis ingroup S was lower than that in groups X and E (group S vsX P=0.001*, group S vs E P=0.002*, P＜0.05).CONCLUSION: The

关键词： Xiao-Zhi-ling注射液中药制剂肝细胞癌肿瘤转移

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生命退化论的哲学视野

引用

医学与哲学（A） 2012年第4期33卷 17-21页

作者：黎群武湖北科技学院湖北咸宁437100

生命退化是指生命系统从有序到无序或从高有序度到低有序度的转化趋势和过程,主要表现为物种数量减少、种群寿命缩短和个体衰老死亡。关于生命退化的原因,自然科学认为是自然规律和天灾人祸使然,宗教神学认为是人的犯罪和神的惩罚所致,... 详细信息

生命退化是指生命系统从有序到无序或从高有序度到低有序度的转化趋势和过程,主要表现为物种数量减少、种群寿命缩短和个体衰老死亡。关于生命退化的原因,自然科学认为是自然规律和天灾人祸使然,宗教神学认为是人的犯罪和神的惩罚所致,哲学认为是自然、社会和神灵的交互影响。生命退化论对人类具有启示和警示的积极作用,可是人们对它一直存在着认识上的误解和价值取向上的误区。

关键词：生命退化,物种数量,种群寿命,衰老,生命哲学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：