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Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease

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Neural Regeneration Research 2010年第22期5卷 1701-1705页

作者： Yangwen Song Xin Chen Chun li nan zhang Traditional Chinese Medicine School Capital Medical University Beijing 100069 China

Extensive iron deposition has been observed in the midbrain substantia nigra （SN） of Parkinson＇s disease （PD） patients, but the mechanisms of iron deposition in the SN remain poorly understood. The present study investigated the relationship between dopaminergic neuronal damage, iron content changes, and divalent metal transporter 1 （DMT1） in the midbrain SN of PD rats to explore the relationship between time of iron deposition and DMT1 expression. Frozen midbrain SN sections from model rats were stained with Perls＇ iron. Results showed massive loss of tyrosine hydroxylase （TH）-positive cells in the SN and increased DMT1 expression in model group rats. No obvious iron deposition was observed in the SN during early stages after damage, but significant iron deposition was detected at 8 weeks post-injury. Results demonstrate that the loss of TH-positive cells in the SN appeared simultaneously with increased DMT1 expression. Extensive iron deposition occurred at 8 weeks post injury, which could be regarded as an early time window of iron deposition.

关键词： Parkinson's disease rotenone iron divalent metal transporter 1 animal models neurodegenerative disease

Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson's disease model rats

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Neural Regeneration Research 2012年第5期7卷 325-331页

作者： Chun li Xin Chen nan zhang Yangwen Song Yang Mu College of Traditional Chinese Medicine Capital Medical University Beijing 100069 China

The present study showed that the latency of rats moving on a vertical grid was significantly prolonged, and the number of rats sliding down from the declined plane was increased remarkably, in rotenone-induced Parkinson＇s disease model rats compared with control rats. The moving latency recovered to normal levels, but the number of slides was significantly increased at 28 days after model establishment. The slope test is a meaningful approach to evaluate the symptoms of Parkinson＇s disease model rats treated with rotenone. In addition, loss of substantia nigral dopaminergic neurons in model rats was observed at 1 day after the model was established, and continued gradually at 14 and 28 days. The expression of tyrosine hydroxylase-positive cells was significantly increased in gastrodin-treated rats at 14 days. Significant numbers of activated microglia cells were observed in model rats at 14 and 28 days; treatment of rats with Madopar at 28 days suppressed microglial activation. Treatment of rats with gastrodin or Madopar at 28 days significantly reduced interleukin-1β expression. The loss of substantia nigral dopaminergic neurons paralleled the microglial activation in Parkinson＇s disease model rats treated with rotenone. The inflammatory factors tumor necrosis factor-a and interleukin-1β are involved in the substantia nigral damage. Gastrodin could protect dopaminergic neurons via inhibition of interteukin-1β expression and neuroinflammation in the substantia nigra.

关键词： gastrodin rotenone neuroinflammation dopamine microglia cells interleukin-1β Parkinson's disease

Atomic modeling for the initial stage of chromium passivation

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International Journal of Minerals,Metallurgy and Materials 2019年第6期26卷 732-739页

作者： li-nan zhang Xi-lin Xiong Yu Yan Ke-wei Gao li-jie Qiao Yan-jing Su Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Corrosion and Protection Center Key Laboratory for Environmental Fracture(MOE)University of Science and Technology BeijingBeijing 100083China SUNCAT Center for Interface Science and Catalysis SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA

The well-known anti-corrosive property of stainless steels is largely attributed to the addition of Cr,which can assist in forming an inert film on the corroding *** maximize the corrosion-resistant ability of Cr,a thorough study dealing with the passivation behaviors of this metal,including the structure and composition of the passive film as well as related reaction mechanisms,is ***,continuous electrochemical adsorptions of OH-groups of water molecules onto Cr terraces in acid solutions are investigated using DFT *** models with various surface conditions are *** is found to begin in the active region,and a fully coated surface mainly with oxide is likely to be the starting point of the passive *** calculated limiting potentials are in reasonable agreement with passivation potentials observed via experiment.

关键词： chromium acid solutions passive films interfaces modeling studies

The effect of selected alloying element additions on properties of Mg-based alloy as bioimplants： A literature review

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Frontiers of Materials Science 2013年第3期7卷 227-236页

作者： li-nan zhang Zeng-Tao HOU Xin YE Zhao-Bin XU Xue-ling BAI Peng SHANG Center for Translational Medicine Research and Development Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China

This review investigates the current application limitations of Mg and Mg alloys. The key issues hindering the application of biodegradable Mg alloys as implants are their fast degradation rate and biological consideration. We have discussed the effect of some selected alloying element additions on the properties of the Mg-based alloy, especially the nutrient elements in human （Zn, Mn, Ca, St）. Different grain sizes, phase constituents and distributions consequently influence the mechanical properties of the Mg alloys. Solution strengthening and precipitation strengthening are enhanced by the addition of alloying elements, generally improving the mechanical properties. Besides, the hot working process can also improve the mechanical properties. Combination of different processing steps is suggested to be adopted in the fabrication of Mg-based alloys. Corrosion properties of these *** alloys have been measured in vitro and in vivo. The degradation mechanism is also discussed in terms of corrosion types, rates, by- products and response of the surrounding tissues. Moreover, the clinical response and requirements of degradable implants are presented, especially for the nutrient elements （Ca, Mn, Zn, Sr）. This review provides information related to different Mg alloying elements and presents the promising candidates for an ideal implant.

关键词： magnesium alloy alloying element corrosion biodegradation

Physical modification of polyetheretherketone for orthopedic implants

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Frontiers of Materials Science 2014年第4期8卷 313-324页

作者： Ya-Wei DU li-nan zhang Zeng-Tao HOU Xin YE Hong-Sheng GU Guo-Ping YAN Peng SHANG School of Materials Science and Engineering Wuhan Institute of Technology Wuhan 430073 China Center for Translational Medicine Research and Development Shenzhen Instituies of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China Department of Spine Surgery Shenzhen Second People's Hospital Shenzhen 518035 China

Polyetheretherketone （PEEK） is regarded as one of the most potential candidates for replacing current implant applications. To obtain good bone-implant interfaces, many modification methods have been developed to enable PEEK and PEEK- based composites from bio-inert to bioactive. Among them, physical methods have aroused significant attention and been widely used to modify PEEK for orthopedic implants. This review summarizes current physical modification techniques of PEEK for orthopedic applications, which include composite strategies, surface coating methods and irradiation treatments. The positive consequences of those modification methods will encourage continuing investigations and stimulate the wide range of applications of PEEK-based implants in orthopedics.

关键词： polyetheretherketone (PEEK) modification bioactivity bone-implantinterface

In vitro and in vivo evaluation of bone morphogenetic protein- 2 （BMP-2） immobilized collagen-coated polyetheretherketone （PEEK）

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Frontiers of Materials Science 2015年第1期9卷 38-50页

作者： Ya-Wei DU li-nan zhang Xin YE He-Min NIE Zeng-Tao HOU Teng-Hui ZENG Guo-Ping YAN Peng SHANG Center for Translational Medicine Research and Development Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China School of Materials Science and Engineering Wuhan Institute of Technology Wuhan 430073 China Department of Biomedical Engineering College of Biology Hunan University Changsha 410082 China Department of Spine Surgery Shenzhen Second People's Hospital Shenzhen 518035 China

Polyetheretherketone （PEEK） is regarded as one of the most potential candidates of biomaterials in spinal implant applications. However, as a bioinert material, PEEK plays a limited role in osteoconduction and osseointegration. In this study, recombinant human bone morphogenetic protein-2 （rhBMP-2） was immobilized onto the surface of collagen-coated PEEK in order to prepare a multi-functional material. After adsorbed onto the PEEK surface by hydroph（bic interaction, collagen was cross-linked with N-（3-dimethylaminopropyl）-N＇-ethyl carbodiimide hydrochloride （EDC） and N-hydro xysuccinimide （NHS）. EDCINHS system also contributed to the immobilization of rhBMP- 2. Water contact angle tests, XPS and SEM clearly demonstrated the surface changes. EliSA tests quantified the amount of rhBMP-2 immobilized and the release over a period of 30 d. In vitro evaluation proved that the osteogenesis differentiation rate was higher when cells were cultured on modified PEEK discs than on regular ones. In vivo tests were conducted and positive changes of major parameters were presented. This report demonstrates that the rhBMP-2 immobilized method for PEEK modification increase bioactivity in vitro and in vivo, suggesting its practicability in orthopedic and spinal clinical applications.

关键词： polyetheretherketone (PEEK) spinal implantation bone morphogeneticprotein-2 (BMP-2) collagen surface modification

Melting Evaluation of Phase Change Materials Impregnated into Cascaded Metal Foams with Regionalized Enhancement

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Journal of Thermal Science 2025年第1期34卷 223-241页

作者： WEI Xinyi zhang nan zhang Zhaoli CAO Xiaoling YUAN Yanping School of Mechanical Engineering Southwest Jiaotong University

Metal foam promotes the heat transfer of phase change materials(PCMs) in the penalty of reducing the energy storage density of the composite *** this work,the effects of constant porosity(0.96,0.94,0.92,or 0.90) and pore density(PPI) of metal foam on heat transfer of composite PCMs are *** rate could be enhanced by employing with low porosity copper ***,aiming to the right bottom phase changing "dead region",a regionalized enhancement strategy of cascaded metal foams is *** dynamic melting performances of all the composite PCMs are comprehensively *** results reveal that the cascaded configuration is beneficial for *** show that the horizontal strategy enhances melting performance:a maximum of 17.98% reduction in total melting time could be reached when the rear part porosity is 90%.The energy storage density rate could be raised by 5.48%.Besides,the vertical strategy performs with a better average temperature uniformity of 0.441 and brings a lower temperature in the heated *** sum up,the regionalized enhancement of copper foam provides better performance in the phase change *** shows significant potential for solar heat storage and thermal protection.

关键词： copper metal foam heat transfer enhancement phase change materials regionalized enhancement

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong zhang nan zhang Pinxian Xi * Zhichuan JXu Chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Lung-targeted polyzwitterionic lipid nanoparticles for effective treatment of lung inflammation

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Science China Chemistry 2025年

作者： Wen zhang Jiaxin li nan Wang Muzi li Chen Peng Xinyue zhang Guanghui Ouyang Yan li Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences

lipid nanoparticles (LNPs) are non-viral nucleic acid delivery systems that show great potential in vaccine development and disease treatment. Although LNPs are particularly advantageous for in vivo delivery, the wide application of LNPs is impeded as their systemic delivery of nucleic acid drugs to extrahepatic tissues remains highly challenging. To address this issue, we developed lung-targeted polyzwitterionic LNPs with zwitterionic polymer poly(2-methyacryloyloxyethyl phosphorylcholine)(PMPC) modified 1,2-dimyristoyl-sn-glycerol lipid for the delivery of small interfering RNA (siRNA). Three libraries with 90PMPC-LNPs@siRNA were established. The polyzwitterionic PMPC-LNPs had high siRNA encapsulation efficiency of about90%. The findings revealed that polyzwitterionic PMPC-LNPs@siRNA absorbed protein corona with the main component of Vitronectin, mediating lung-targeted delivery of siRNA. With good cellular uptake and endo/lysosomal escape ability, in vitro and in vivo studies demonstrated that polyzwitterionic PMPC-LNPs with siRNA against tumor necrosis factor-α (TNF-α) could significantly down-regulate the TNF-α in mRNA and protein levels, and improved the pathological features of lung inflammation. Polyzwitterionic PMPC-LNPs@siRNA achieved safe and efficient treatment of lung inflammation. Therefore, this work offered a promising siRNA therapeutic approach for lung diseases.

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