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Malignant giant cell tumor in the left upper arm soft tissue of an adolescent:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3704-3710页

作者： Wen-Peng Huang li-na zhu Rui li li-Ming li Jian-Bo Gao Department of Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Giant cell tumor of soft tissue(GCT-ST)is an extremely rare low-grade soft tissue tumor that is originates in superficial tissue and rarely spreads ***-ST has unpredictable *** is mainly benign,but may sometimes become aggressive and potentially increase in size within a short period of *** SUMMARY A 17-year-old man was suspected of having a fracture,based on radiography following left shoulder *** month later,the swelling of the left shoulder continued to increase and the pain was *** tomography(CT)revealed a soft tissue mass with strip-like calcifications in the left *** mass invaded the adjacent humerus and showed an insect-like area of destruction at the edge of the cortical bone of the upper *** marrow cavity of the upper humerus was enlarged,and a soft tissue density was seen in the medullary *** CT revealed multiple small nodules beneath the pleura of both lungs.A bone scan demonstrated increased activity in the left shoulder joint and proximal *** mass showed mixed moderate hypointensity and hyperintensity on T1-weighted images,and mixed hyperintensity on T2-weighted fat-saturated *** final diagnosis of GCT-ST was confirmed by *** GCT-STs should be considered in the differential diagnosis of soft tissue tumors and monitored for large increases in size.

关键词： Bone scan Giant cell tumor Soft tissue Tomography X-ray computed Magnetic resonance imaging Case report

The Function of SeMNPV IAP3 in Mammalian Cells

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Virologica Sinica 2008年第3期23卷 183-188页

作者： li-na zhu Chun-lei MEI Zhong-xin ZHANG State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071China Graduate school Chinese Academy of Sciences Beijing 100039 China

The baculoviral inhibitors of apoptosis play a significant role in infectivity and viral host-range, which make them potential candidates for the engineering and improvement of baculovirus insecticidal. The iap3 gene of Spodoptera exigua nucleopolyhedrovirus （SeMNPV）, amplified by PCR, was 939 bp encoding IAP3. The PCR product was cloned into EcoR I/Barn H I of the plasmid pEGFP-C1. GFP was fused to the N-terminaus of IAP3 to study distribution in HEK293. It was observed that the plasmid expressing IAP3 significantly inhibited apoptosis induced by cisplatin in HEK293 cells. We conclude that the IAP3 of SeMNPV is functional in mammalian cells.

关键词： Apoptosis SeMNPV IAP3 HEK293 cells Caspase inhibitor Cisplatin

FcRn inhibitors:a novel option for the treatment of myasthenia gravis

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Neural Regeneration Research 2023年第8期18卷 1637-1644页

作者： li-na zhu Hai-Man Hou Sai Wang Shuang Zhang Ge-Ge Wang Zi-Yan Guo Jun Wu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina

Myasthenia gravis is an acquired,humoral immunity-mediated autoimmune disease characterized by the production of autoantibodies that impair synaptic transmission at the neuromuscular *** intervention-mediated clearance of immunoglobulin G(IgG)was shown to be effective in controlling the progression of the *** neonatal Fc receptor(FcRn)plays a key role in prolonging the serum half-life of *** FcRn to prevent its binding to IgG can accelerate the catabolism of the latter,resulting in decreased levels of IgG,including pathogenic autoantibodies,thereby achieving a therapeutic *** this review,we detail the substantial research progress,both basic and clinical,relating to the use of FcRn inhibitors in the treatment of myasthenia gravis.

关键词： batoclimab clinical trial efgartigimod FcRn FcRn inhibitors immunoglobulin G(IgG) myasthenia gravis nipocalimab rozanolixizumab

Polymorphism of Exon 2 of FSHβ Gene and Its Relationship with Reproduction Performance in Two Goat Breeds

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Agricultural Sciences in China 2010年第6期9卷 880-886页

作者： AN Xiao-peng HAN Dan HOU Jin-xing li Guang WANG Ya-na li ling zhu Guang-qin WANG Jian-gang SONG Yu-xuan CAO Bin-yun College of Animal Science and Technology Northwest Agriculture and Forestry University Yangling 712100 P..R.China

The objectives of the present study were to detect the polymorphism in follicle stimulating hormone beta （FSHβ） gene and investigate the relationship between FSHβ gene and high prolificacy in *** to the sequence of ovine FSHβ gene,two pairs of primers were designed to detect single nucleotide polymorphism of exon 2 of FSHβ gene in two goat breeds,Xinong Saanen dairy goat and Boer goat,by *** least square mean and genetic variance of different genotypes at polymorphic locus were analyzed,and the selection reaction was forecasted by genetic correlation between marker locus and genetic variance of litter size *** was one polymorphic locus occurring in exon 2 （P2） with three genotypes （EE,EF and FF）.In Xinong Saanen dairy goat,EE genotype had significantly higher （P 〈 0.05） litter size than EF and FF genotype in the first to fourth parity and average parity;EF genotype had significantly higher （P 〈 0.05） litter size than FF genotype in the second and average *** Boer goat,EE genotype had significantly higher （P 〈 0.01） litter size than EF and FF genotype in the second to fourth parity and average parity;EF genotype had significantly higher （P 〈 0.05） litter size than FF genotype in average *** Xinong Saanen dairy and Boer goat,the heredity of litter size was mainly influenced by genetic additive effect and the EE genotype is a favorable marker genotype for litter size in these two breeds.

关键词： goat FSHβ polymorphism litter size

Effect of vacuum heat treatment on microstructure and corrosion behavior of HVOF sprayed AICoCrFeNiCu high entropy alloy

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Journal of Iron and Steel Research International 2023年第8期30卷 1550-1561页

作者： Yong-kuan Zhou l Jia-jie Kang Guo Jin Xiu-fang Cui Jie Zhang Guo-zheng Ma Zhi-qiang Fu li-na zhu Ding-shun She Yu-yun Yang School of Engineering and Technology China University of Geosciences(Beijing)Beijing 100083China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212100JiangsuChina Zhengzhou Institute China University of Geosciences(Beijing)Zhengzhou 451283HenanChina College of Material Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001HeilongjiangChina Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK national Key Lab for Remanufacturing Academy of Armored Forces EngineeringBeijing 100072China

To improve the corrosion resistance of coalbed methane drilling equipment,an AICoCrFeNiCu high entropy alloy coating was prepared on the AISI 4135(35CrMo)steel substrate by high velocity oxygen fuel(HVOF)technology,and the coating was subjected to vacuum heat treatment(VHT)at different temperatures(500,700,900 and 1100℃).The corrosion test of the substrate and the coatings after VHT in coalbed methane drilling fluid was carried *** results show that the HVOF sprayed AICoCrFeNiCu high entropy alloy(HEA)coating has a good bonding with the substrate,and the porosity of the coating is about 2.4%.There is partial segregation in the coating,and the coating mainly consists of body-centered cubic *** coating has good thermal stability,and the phase structure and microstructure of the coatings have changed after VHT at different *** with the substrate,the as-sprayed coating has better uniform corrosion resistance,and the corrosion resistance of the coating after VHT is further *** VHT at 500℃,the HVOF-sprayed AICoCrFeNiCu HEA coating has the best corrosion resistance.

关键词： High velocity oxygen fuel AICoCrFeNiCu high entropy alloy coating Vacuum heat treatment Microstructure Corrosion

有机磷酸酯盐与羧酸盐复配成核剂对等规聚丙烯性能的影响

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复合材料学报 2016年第9期33卷 2006-2012页

作者：任娜李效军朱孔营河北工业大学化工学院天津300130 天津大学分析测试中心天津300072

以2,2’-亚甲基-双-(4,6-二叔丁基苯基)磷酸钠(na-11)和双环[2,2,1]-庚烷-2,3-二羧酸钠(naCA)2种成核剂进行复配,研究复配成核剂对等规聚丙烯(iPP)力学性能和结晶行为的影响。采用双螺杆挤出机为共混设备将成核剂与iPP共混,制备了na-11/... 详细信息

以2,2’-亚甲基-双-(4,6-二叔丁基苯基)磷酸钠(na-11)和双环[2,2,1]-庚烷-2,3-二羧酸钠(naCA)2种成核剂进行复配,研究复配成核剂对等规聚丙烯(iPP)力学性能和结晶行为的影响。采用双螺杆挤出机为共混设备将成核剂与iPP共混,制备了na-11/na-CA/iPP复合材料。通过万能材料实验机、XRD、DSC、偏光显微镜(PLM)对其力学性能、结晶形态、微观结构进行了表征。结果表明:na-11和na-CA 2种成核剂复配能够显著提高iPP的拉伸性能和弯曲性能。na-11和na-CA复配成核剂诱导iPP形成α晶体。2种成核剂1∶1复配,添加量为0.4wt%时,iPP的结晶峰温度提高了20.3℃,结晶度提高了8.8%。PLM显示,na-11和na-CA复配成核剂使iPP球晶尺寸明显变小。na-11和na-CA复配成核剂具有很好的成核效果,这2种成核剂对改善聚丙烯的结晶性能和力学性能具有协同效应。

关键词：复配成核剂协同效应等规聚丙烯结晶行为力学性能

Automatic extraction of imaging observation and assessment categories from breast magnetic resonance imaging reports with natural language processing

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Chinese Medical Journal 2019年第14期132卷 1673-1680页

作者： Yi liu li-na zhu Qing liu Chao Han Xiao-Dong Zhang Xiao-Ying Wang Department of Radiology Peking University First HospitalBeijing 100034China

Background:Structured reports are not widely used and thus most reports exist in the form of free *** process of data extraction by experts is time-consuming and error-prone,whereas data extraction by natural language processing (NLP) is a potential solution that could improve diagnosis efficiency and *** purpose of this study was to evaluate an NLP program that determines American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) descriptors and final assessment categories from breast magnetic resonance imaging (MRI) ***:This cross-sectional study involved 2330 breast MRI reports in the electronic medical record from 2009 to *** used 1635 reports for the creation of a revised BI-RADS MRI lexicon and synonyms lists as well as the iterative development of an NLP *** remaining 695 reports that were not used for developing the system were used as an independent test set for the final evaluation of the NLP *** recall and precision of an NLP algorithm to detect the revised BI-RADS MRI descriptors and BI-RADS categories from the free-text reports were evaluated against a standard reference of manual human ***:There was a high level of agreement between two manual reviewers,with a κ value of *** all breast imaging reports,the NLP algorithm demonstrated a recall of 78.5% and a precision of 86.1% for correct identification of the revised BI-RADS MRI descriptors and the BI-RADS *** generated the total results in narrow the gap between unstructured report text and structured data,which is needed in decision support and other applications.

关键词： Breast natural Language Processing Magnetic Resonance Imaging Breast Imaging Reporting and Data System

Modification of Maxwell model for conductivity prediction of carbon nanotubes-filled polymer composites with tunneling effect

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 25-36页

作者： Jue zhu Longyuan li Ningtao zhu Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and Pipeline Key Laboratory of Impact and Safety Engineering (Ningbo University) Ministry of Education School of Engineering Computing and Mathematics University of Plymouth Xi'an Zhanshi Testing & Engineering Co.Ltd.

Carbon nanotubes(CNTs) have garnered great attention in recent years due to their outstanding electrical, thermal, and mechanical properties. The incorporation of small amounts of CNTs in polymers can substantially improve the sensitivity of the polymer's electrical conductivity. This paper presents a modified Maxwell model to evaluate the electrical conductivity of CNTs-filled polymer composites by introducing a transition zone to account for the tunneling effect. In this modified Maxwell model, the CNTs-filled polymer composite is modeled as a three-phase composite, consisting of a matrix(polymer), inclusions(CNTs), and a transition zone(tunneling zone). The effective electrical conductivity(EEC) of the composite is calculated based on the volume fractions and electrical conductivities of the matrix, inclusions, and transition zone. The model's validity is confirmed through the use of available test data, which demonstrates its capability to accurately capture the nonlinear conductivity behavior observed in CNTs-polymer composites. This study offers valuable insights into the design of high-performance conductive polymer nanocomposites, and enhances the understanding of electrical conduction mechanisms in CNT-dispersed polymer composites.

关键词： nanoclay

Numerical investigation on threading dislocation bending with Inas/GaAs quantum dots

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Chinese Physics B 2021年第11期30卷 146-150页

作者： Guo-Feng Wu Jun Wang Wei-Rong Chen li-na zhu Yuan-Qing Yang Jia-Chen li Chun-Yang Xiao Yong-Qing Huang Xiao-Min Ren Hai-Ming Ji Shuai Luo State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The threading dislocations(TDs)in GaAs/Si epitaxial layers due to the lattice mismatch seriously degrade the performance of the lasers grown on *** insertion of Inas quantum dots(QDs)acting as dislocation filters is a pretty good alternative to solving this *** this paper,a finite element method(FEM)is proposed to calculate the critical condition for Inas/GaAs QDs bending TDs into interfacial misfit dislocations(MDs).Making a comparison of elastic strain energy between the two isolated systems,a reasonable result is *** effect of the cap layer thickness and the base width of QDs on TD bending are studied,and the results show that the bending area ratio of single QD(the bending area divided by the area of the QD base)is evidently affected by the two ***,we present a method to evaluate the bending capability of single-layer QDs and multi-layer *** the QD with 24-nm base width and 5-nm cap layer thickness,taking the QD density of 10^(11) cm^(-2) into account,the bending area ratio of single-layer QDs(the area of bending TD divided by the area of QD layer)is about 38.71%.With inserting five-layer Inas QDs,the TD density decreases by 91.35%.The results offer the guidelines for designing the QD dislocation filters and provide an important step towards realizing the photonic integration circuits on silicon.

关键词： Inas/GaAs quantum dots threading dislocation finite element method bending area