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抑郁症发生中γ-氨基丁酸与其它相关递质的关系

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生理科学进展 2014年第3期45卷 190-194页

作者：李珍安书成李江娜陕西师范大学生命科学学院西安710062

γ-氨基丁酸(γ-aminobutyric acid,GABA)是哺乳动物中枢神经系统中主要的抑制性神经递质,与焦虑、抑郁、精神分裂等多种神经和精神疾病有关。近年来,越来越多的研究提示,抑郁症的发生与中枢GABA功能缺陷密切相关。但目前基于单胺类递... 详细信息

γ-氨基丁酸(γ-aminobutyric acid,GABA)是哺乳动物中枢神经系统中主要的抑制性神经递质,与焦虑、抑郁、精神分裂等多种神经和精神疾病有关。近年来,越来越多的研究提示,抑郁症的发生与中枢GABA功能缺陷密切相关。但目前基于单胺类递质失调及谷氨酸能神经的研究较多,而对GABA的研究相对较少且比较分散。本文主要通过介绍GABA受体及其作用,以及GABA与5-羟色胺(5-hydroxytryptamine,5-HT)、多巴胺(dopamine,DA)和谷氨酸(glutamic acid,Glu)的相互作用,讨论GABA与抑郁症发生的关系,以期为抑郁症的发生机制与治疗的深入研究提供思路。

关键词： GABA 神经递质抑郁症

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离散事件系统故障的极小观测序列

湖南大学学报（自然科学版） 2016年第4期43卷 147-152页

作者：欧阳丹彤李江娜耿雪娜吉林大学计算机科学与技术学院吉林长春130012 吉林大学符号计算与知识工程教育部重点实验室吉林长春130012

为了提高可诊断离散事件系统故障的在线诊断效率,本文从判定故障发生的可观测事件的角度,提出了故障极小观测序列方法.文中选取有限状态自动机对离散事件系统进行建模.首先,在离线状态下,建立系统的故障模型,以排除对于判定系统故障无... 详细信息

为了提高可诊断离散事件系统故障的在线诊断效率,本文从判定故障发生的可观测事件的角度,提出了故障极小观测序列方法.文中选取有限状态自动机对离散事件系统进行建模.首先,在离线状态下,建立系统的故障模型,以排除对于判定系统故障无关的路径.然后,根据故障模型进一步建立判定系统故障的极小观测序列模型.当离散事件系统在线诊断时,仅需将逐步增加的在线观测事件序列与故障的极小观测序列模型进行比对.若能找到满足该模型的任何一条路径,则说明路径终止状态上故障标签对应的系统故障发生;否则,说明系统无故障发生.文中对可诊断离散事件系统进行实验对比,通过故障的极小观测序列模型能尽快判定有无故障发生,以及发生了哪些故障.该模型能有效地缩小系统在线诊断的时间,提高系统在线诊断的效率.

关键词：离散事件系统故障模型极小观测序列模型故障诊断

Uniaxial Compressive Strength Prediction for Rock Material in Deep Mine Using Boosting-Based Machine Learning Methods and Optimization Algorithms

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 275-304页

作者： Junjie Zhao Diyuan li Jingtai jiang Pingkuang Luo School of Resources and Safety Engineering Central South UniversityChangsha410083China

Traditional laboratory tests for measuring rock uniaxial compressive strength(UCS)are tedious and *** is a pressing need for more effective methods to determine rock UCS,especially in deep mining environments under high in-situ ***,this study aims to develop an advanced model for predicting the UCS of rockmaterial in deepmining environments by combining three boosting-basedmachine learning methods with four optimization *** this purpose,the Lead-Zinc mine in Southwest China is considered as the case *** density,P-wave velocity,and point load strength index are used as input variables,and UCS is regarded as the ***,twelve hybrid predictive models are *** mean square error(RMSE),mean absolute error(MAE),coefficient of determination(R2),and the proportion of the mean absolute percentage error less than 20%(A-20)are selected as the evaluation *** results showed that the hybridmodel consisting of the extreme gradient boostingmethod and the artificial bee colony algorithm(XGBoost-ABC)achieved satisfactory results on the training dataset and exhibited the best generalization performance on the testing *** values of R2,A-20,RMSE,and MAE on the training dataset are 0.98,1.0,3.11 MPa,and 2.23MPa,*** highest values of R2 and A-20(0.93 and 0.96),and the smallest RMSE and MAE values of 4.78 MPa and 3.76MPa,are observed on the testing *** proposed hybrid model can be considered a reliable and effective method for predicting rock UCS in deep mines.

关键词： Uniaxial compression strength strength prediction machine learning optimization algorithm

Cocktail effect of ionic patch driven by triboelectric nanogenerator for diabetic wound healing

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Chinese Chemical Letters 2024年第8期35卷 460-465页

作者： Yixia Zhang Caili Xue Yunpeng Zhang Qi Zhang Kai Zhang Yulin liu Zhaohui Shan Wu Qiu Gang Chen na li Hulin Zhang jiang Zhao Da-Peng Yang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Rehabilitation Science and Engineering University of Health and Rehabilitation SciencesQingdao 266024China School of Materials and Chemical Engineering Quanzhou Normal UniversityQuanzhou 362000China

There is increasing evidence shows that either electrical stimulation(ES)or metal ion is an effective way to accelerate ulcerative wound ***,less attention is paid to investigating the synergistic effect between ***,we explore the combined effects of ES and multiple metal ions on dia-betic wound healing assisted by a triboelectric nanogenerator(TENG).Firstly,the novel Eggshell@CuFe_(2)O_(4)nanocomposites(NCs)are prepared,which show unique structure and intrinsic antimicrobial ***,the as-prepared nanocomposites are embedded in oxidized starch hydrogel to form a mul-tifunctional composite gel,which is further assembled into a wearable ionic triboelectric nanogenerator(iTENG)patch with polydimethylsiloxane(PDMS).It can convert the mechanical energy produced by a human body motion to electric energy and mediate the sequential release of metal ions(Fe^(2+)/Ca^(2+)/Cu^(2+)),thereby resulting in the“cocktail effect”on impaired *** their effects,a satisfying healing re-sult in diabetic mouse is identified,which can effectively accelerate wound healing process by relieving inflammation,promoting angiogenesis and collagen *** work puts forward the cocktail effect of electric simulation coupled with the multiple metal ions,and opens up a new perspective in designing iTENG patch towards repair of hard-to-heal wounds.

关键词： iTENG Cocktail effect CuFe_(2)O_(4) Eggshell Diabetic wound

FPGA-based plasma sterilization device for wound-edge recognition

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nanotechnology and Precision Engineering 2024年第3期7卷 56-70页

作者： Huijuan Lu Xiaorong Tang Minglei li Xueping jiang Wenxiang Xiao Hua li School of life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004People’s Republic of China Guilin URIT MEDICAL Electronic Sales Co. Ltd.Guilin 541004People’s Republic of China

There is a currently a lack of large-area plasma sterilization devices that can intelligently identify the shape of a wound for automatic *** this reason,in this work,a plasma sterilization device with wound-edge recognition was developed using aﬁeld-programmable gate array(FPGA)and a high-performance image-processing platform to realize intelligent and precise sterilization of *** was used to design the mechanical structure of the device,and it was manufactured using 3D *** device used an improvement of the traditional Sobel detection algorithm,which extends the detection of edges in only the x and y directions to eight directions(0○,45○,90○,135○,180○,225○,270○,and 315○),completing the wound-edge detection by adaptive *** device can be controlled according to different shapes of sterilization area to adjust the positioning of a single plasma-jet tube in the horizontal plane for two-dimensional move-ment;the distance between the plasma-jet tube and the surface of the object to be sterilized can be also adjusted in the vertical *** this way,motors are used to move the plasma jet and achieve automatic,efﬁcient,and accurate plasma *** was found that a good sterilization effect could be achieved at both the culture-medium level and the biological-tissue *** ideal sterilization parameters at the culture-medium level were a speed of 2 mm/s and aﬂow rate of 0.6 slm,while at the biological-tissue level,these values were 1 mm/s and 0.6 slm,respectively.

关键词： FPGA Wound-edge recognition Improvement of the Sobel algorithm Plasma Automatic and precise sterilization

Migration and fate of polycyclic aromatic hydrocarbons in bioretention systems with different media:experiments and simulations

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 17-33页

作者： Zhaoxin Zhang Jiake li Zhe liu Yajiao li Bei Zhang Chunbo jiang Institute of Land Engineering and Technology Shaanxi Provincial Land Engineering Construction Group Co.Ltd.Xi’an 710075China State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi’an University of TechnologyXi’an 710048China School of Architecture and Civil Engineering Xi’an University of Science and TechnologyXi’an 710054China College of Landscape Architecture and Art Northwest A&F UniversityYangling 712100China

Polycyclic aromatic hydrocarbons(PAHs)present significant risks to human health owing to their carcinogenic,teratogenic,and mutagenic *** contamination of surface water with PAHs via runoff has become a prominent source of water *** the capacity of bioretention systems to remove PAHs from runoff is recognized,the dynamics of PAH migration and degradation in these systems are not *** study aims to explain the migration and fate of PAHs in bioretention systems through a series of experiments and model *** study constructed bioretention systems with three different media types and found that these systems achieved PAH load reductions exceeding 92%.Notably,naphthalene(naP),fluoranthene(FLT),and pyrene(PYR)tended to accumulate in the media’s upper layer,at depths of 10 to 40 *** further analyze the migration and fate of PAHs during multi-site rainfall events and across prolonged operation,we applied the HYDRUS-1D model under three distinct *** findings of this study indicated that naP degraded in 40 d,whereas FLT and PYR showed incomplete degradation after 120 *** continuous rainfall events,there was no clear pattern of PAH accumulation;however,FLT and PYR persisted in the bioretention *** combination of experimental and simulation findings highlights the inevitable accumulation of PAHs during extended use of bioretention *** research provides a theoretical basis for improving operational efficiency,advancing PAH degradation in bioretention systems,and reducing their toxicity.

关键词： Bioretention Polycyclic aromatic hydrocarbons HYDRUS-1D Model simulation Migration

Decadal length-of-day and geomagnetic changes imply more complex Earth’s core motions

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Science Bulletin 2024年第13期69卷 2038-2041页

作者： Hao Ding Jiancheng li Weiping jiang Wenbin Shen School of Geodesy and Geomatics Hubei Luojia LaboratoryWuhan UniversityWuhan 430079China GNSS Research Center Wuhan UniversityWuhan 430079China

Since the 1950s,the length-of-day variations(DLOD)of the Earth’s rotation have received extensive attention and research in various fields,including geodynamics,geomagnetism,geodesy,seismology,geology,marine science,environmental science,and even biology and *** the abundance of related studies and notable advancements,the underlying mechanism behind the decadal changes in DLOD remains a persistent unresolved *** essential aspect of investigating this issue lies in its potential to unveil the Earth’s core motions[1,2].Despite the presence of various hypothesized and constructed models about the Earth’s core motions,these models typically exhibit simplicity.

关键词： Earth geology geomagnetic

Oxidative Dehydrogenation of Propane over Supported Nickel Single-Atom Catalyst

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Chinese Journal of Chemistry 2024年第4期42卷 370-376页

作者： Qian Zhang Xunzhu jiang Yangyang li Yuanlong Tan Qike jiang Xiaoyan liu Botao Qiao CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China University of Chinese Academy of Sciences Beijing100049 China Dalian national Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

Oxidative dehydrogenation of propane has been an ever-growing field for propylene production due to its exothermic properties,of which overoxidation is the major drawback,with CO and even CO_(2) as undesired *** the purpose of getting higher propylene selectivity as well as yield,herein,we report Ni single atoms supported on calcium aluminate as an efficient catalyst candidate for propane oxidative *** from higher valence states of Ni1 species,it shows 2—3 times as much propylene selectivity as that of Ni *** 14.2%C_(3)H_(6) yield with 47.3%propylene selectivity has been achieved on Ni single atom catalyst and a good stability during 20 h test can be obtained as well.

关键词： Oxidative dehydrogenation/Nickel Single-atom catalysts Propane Propylene selectivity

Energy release characteristics of PTFE/Al/TiH_(2) reactive jet with different TiH_2 content

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Defence Technology（防务技术） 2024年第9期39卷 168-176页

作者： Chunlan jiang Jingbo Zhang Rong Hu liang Mao Ming li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Titanium hydride(TiH_(2)), a promising high-energy additive, is doped into PTFE/Al to optimize the energy output structure of the reactive jet and strive for better aftereffect damage ability to the target. Six types of PTFE/Al/TiH_(2) reactive liners with different TiH_(2) content are prepared by the molding and sintering method. The energy release characteristics of PTFE/Al/TiH_(2) reactive jet are tested by the transient explosion energy test, and are characterized from pressure and temperature. The reaction delay time,pressure history, and temperature history of the energy release process are obtained, then the actual value of released energy and reaction efficiency of the reactive jet are calculated. The results show that the peak pressure and temperature of the PTFE/Al/TiH_(2) jet initially increase and then decrease with increasing TiH_(2) content. When the TiH_(2) content is 10%, the actual value of released energy and reaction efficiency increased by 24% and 6.4%, respectively, compared to the PTFE/Al jet. The reaction duration of the reactive material is significantly prolonged as the TiH_(2) content increased from 0% to 30%. Finally,combined with the energy release behaviors of PAT material and the dynamic deformation process of liner, the enhancement mechanism of TiH_(2) on energy release of the reactive jet is expounded.

关键词： PTFE/Al/TiH_(2) Reactive materials Shaped charge Impact energy release characteristics