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Telithromycin versus clarithromycin for the treatment of community-acquired respiratory tract infections： a meta-analysis of randomized controlled trials

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Chinese Medical Journal 2013年第11期126卷 2179-2185页

作者： li Xiu-min WANG feng-chun YANG feng JIN Ying-hua Department of Pharmacy Military General Hospital of Beijing PLABeijing 100700 China

Background The emergence of bacterial resistance to commonly used antibiotics, such as macrolides, is complicating the management of respiratory tract infections （RTIs）. Telithromycin, a ketolide antimicrobial structurally related to macrolides, is approved for the treatment of community-acquired RTIs, and shows lower pathogen resistance rates. The purpose of this study was to compare the efficacy and safety of telithromycin with clarithromycin, a macrolide routinely used as therapy for RTIs. Methods We performed a meta-analysis of relevant randomized-controlled trials （RCTs） identified in PubMed, the Cochrane library, Embase, CNKI and VIP databases. The primary efficacy outcome was clinical treatment success assessed at the test-of-cure time in the per-protocol population, and the primary safety outcome was drug related adverse effects. Results Seven RCTs, involving 2845 patients with RTIs, were included in the meta-analysis. Oral telithromycin and clarithromycin showed a similar clinical treatment success in modified intention to treat and per-protocol population （cure and improvement）（odds ratios （ORs）： 0.84, 95% confidence intervals （C/）： 0.64-1.11 and OR： 1.14, 95% CI： 0.71-1.85, respectively）. Similar findings were obtained for secondary efficacy outcomes： clinical treatment success at a late post- therapy visit （OR： 0.92, 95% CI： 0.57-1.48） and microbiological treatment success at the test-of-cure time （OR： 1.14; 95% CI： 0.71-1.85）. The safety outcome analysis indicated telithromycin had a similar risk of drug-related adverse effect and serious adverse effect with clarithromycin. Conclusions Our findings indicate that oral telithromycin and clarithromycin have similar treatment efficacy and adverse effect. The advantages of lower antimicrobial resistance rates, once-daily short-duration dosing and reported lower health- care costs make oral telithromycin a useful option for the empiric management of mild-to-moderate RTIs.

关键词： telithromycin clarithromycin community-acquired respiratory tract infections meta-analysis

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Soil Organic Carbon,Carbon Fractions and Nutrients as Affected by Land Use in Semi-Arid Region of Loess Plateau of China

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Pedosphere 2010年第2期20卷 146-152页

作者： liU Xun,li feng-min,liU Da-Qian and SUN Guo-Jun Key Laboratory of Arid and Grassland Ecology of the ministry of Education,School of life Sciences,Lanzhou University,Lanzhou 730000 (China) [a] Key Laboratory of Arid and Grassland Ecology of the ministry of Education School of Life Sciences Lanzhou University Lanzhou 730000 (China)

Cropland (CP),native grassland (NG) and two shrub land treatments which were converted from cropland in 1985:seabuckthorn (Hippophae rhamnoides L.) (ST),and branchytamarisk (Tamarix ramosissima) (BT) were investigated to evaluate effects of land use conversion on soil organic carbon (SOC) and soil nutrients in the semi-arid region of the Loess Plateau of *** organic carbon (TOC),light fraction organic carbon (LFOC),heavy fraction organic carbon (HFOC),total N (TN),nitrate nitrogen (NO 3-N) and nitrite nitrogen (NO 2-N),ammonium nitrogen (NH + 4-N),total P,and available P (AP) were *** results showed that SOC in NG,ST and BT were 12.7%,27.7% and 34.8% higher than that of the cropland,***,light fraction (LF) dry matter,ratio of TOC to TN (C/N) and the ratio of TOC to AP (C/P) were higher in the shrub land or native grassland than in the *** had the highest TN,the sum of NO 3-N and NO 2-N,TP and AP due to the use of chemical *** significantly correlated with LFOC,HFOC and C/*** significantly correlated with dry matter of the LF and C/***,the sum of NO 3-N and NO 2-N and AP were significantly negatively correlated with TOC and ***,land use conversion from cropland to shrub land,or maybe grassland,contributed to SOC sequestration and improved soil nutrients stabilization.

关键词： cropland heavy fraction organic carbon light fraction organic carbon native grassland shrub land

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Effect of Long-Term Fertilization on Soil Productivity and Nitrate Accumulation in Gansu Oasis

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Agricultural Sciences in China 2006年第1期5卷 57-67页

作者： YANG Sheng-mao li feng-min SUO Dong-rang GUO Tian-wen WANG Jian-guo SONG Bing-ling JIN Shao-ling Institute of Soil and Fertilizer Gansu Academy of Agricultural Sciences Lanzhou 730070 P.R.China The Key Laboratory of Arid and Grassland Agroecology Lanzhou University Ministry of Education Lanzhou 730000 P.R.China Institute of Agricultural Sciences of Zhangye Prefecture Zhangye 734000 PR China

A long-term （1982-2001） field experiment was conducted in a calcareous soil under wheat （Triticum aestivum L.）-wheat （Triticum aestivum L.）-maize （Zea mays L.） rotation system at Zhangye, Gansu Province, China to determine the effects of long-term fertilization on crop yield, nutrients interactions, content and accumulation of nitrate-N in soil profiles. Twenty- four plots in a split-plot factorial with a combination of eight treatments （from nitrogen （N）, phosphorus （P）, potassium （K） and farmyard manure （M） applications） and 3 replications were selected. Main treatments were M and without M, and the sub-treatments were no-fertilizer （CK）, N, NP and NPK. When P and K fertilizers were part of treatments, their ratio to N was 1N：0.22P：0.42K. All M, P and K fertilizers were applied as the basal dressing. The grain yield was harvested each experimental period and straw yield for the period from 1988 to 1997. After crop harvest in 2000, the soil was sampled from the 0-20, 20-60, 60-100, 100-140 and 140-180 cm depths to determine NO3^--N content. Maize yield of CK in 2000 was only 28.2% of that in 1984, and wheat in 2001 was 25.7% of that observed in 1982. Average impact of fertilizers on grain yield decreased in the order of N 〉 M 〉 P 〉 K. Yield response to N and P fertilizers increased with progress of the experiment. The impact of K fertilizer showed no increase in grain yield during the initial 6 years （1982-1987）, moderate increase in the next 5 years （1988-1992）, and considerable increase in the last 9 years （1993-2001）. The straw yield trend was similar to grain yield. Accumulation and distribution of NO3^--N in soil was significantly affected by annual fertilizations. mineral fertilizers （NP and NPK） led to NO3^- -N accumulation in most subsoil layers, with major impact in the 20-140 cm depth. The combination of mineral fertilizers and farmyard manure （MNP and MNPK） reduced soil NO3^--N accumulation in comparison to mineral fertilizers, It can be argued that long

关键词： long-term fertilization accumulation of nitrate-N crop yields nutrients interactions farmyard manure Nbalance sheet Zhangye Oasis

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Gender differences are associated with the clinical features of systemic lupus erythematosus

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Chinese Medical Journal 2012年第14期125卷 2477-2481页

作者： DING Yan HE Jing GUO Jian-ping DAI Yi-jun li Chun feng min li Ru li Zhan-guo Department of Rheumatology & Immunology Peking UniversityPeople's Hospital Beijing 100044 China

Background Systemic lupus erythematosus （SLE） mostly occurred in young women. This study was undertaken to investigate the different clinical characteristics of SLE between male and female patients, and to identify the sex hormone levels and clinical outcomes of different gender in SLE patients. Methods Of the 516 SLE patients admitted to the Peking University People＇s Hospital from January 2008 to December 2010, 58 were male and 458 were female. Clinical manifestations, laboratory profiles and disease activity scores were evaluated in male and female patients. Sex hormones levels were also compared among male patients. Results The median age at SLE onset in male and female patients was 27.2 and 28.6 years, respectively. Compared with female patients, at onset of SLE, male patients showed higher rates of serious renal disease （58.6% vs. 47.2%, P=0.064）, neuropsychiatric SLE （20.7% vs. 12.0%, P=0.055）, and a higher incidence of anti-ds-DNA （25.9% vs. 16.8%, P=0.069）, anti-Sm （17.2% vs. 8.7%, P=0.002）, anti-Ro （46.6% vs. 28.4%, P=0.004）, anti-UIRNP （29.3% vs. 15.3%, P=0.010）, anticardiolipin antibody （25.9% vs. 11.4%, P=0.004）, and decreased C3 levels （67.2% vs. 49.8%, P=-0.009）. Systemic lupus erythematosus disease activity index （SLEDAI） scores were higher in men than in women （16.8 vs. 12.8, P=0.038）. Of the 58 male patients, 24 had not received aggressive treatment during the three months prior to the study. Levels of testosterone and dihydroepiandrosterone （DHEA） were lower in male SLE patients than in male healthy controls （P=0.004 and P=0.006, respectively）. Low serum testosterone was an independent risk factor for the development of lupus nephritis （P=-0.043）. Male patients with elevated serum prolactin were at increased risk of developing neuropsychiatric manifestations of SLE （P=0.081）. Conclusion Early recognition of risk factors and appropriate intervention are essential, which might lead to high disease activity and serious systemic damage in male SLE pat

关键词： systemic lupus erythematosus male lupus, gender

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诚信视角下的商鞅变法

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西北师大学报（社会科学版） 2007年第3期44卷 121-124页

作者：李锋敏兰州城市学院甘肃兰州730070

商鞅以"信"而使民,为"信"而行法,终使秦国有大治。从诚信的视角出发,关注商鞅变法中以法制建立起的诚信体系及其与法制之间的关系,可对商鞅变法的重新认识有所裨益。

关键词：商鞅变法诚信法制

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论北朝寺院经济的资源配置

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西北师大学报（社会科学版） 2008年第3期45卷 56-58页

作者：李锋敏兰州城市学院城市经济与社会管理学院甘肃兰州730070

北朝是佛教寺院经济发展扩张时期,寺院在经济资源的配置方面显示了其积极自主的特点。在经济制度规则的约束下,无论是对于劳动力、土地以及资财等资源的获取,抑或是资源财富的经营活动,都表现出寺院经济发展的多种途径和方式。王权社会... 详细信息

北朝是佛教寺院经济发展扩张时期,寺院在经济资源的配置方面显示了其积极自主的特点。在经济制度规则的约束下,无论是对于劳动力、土地以及资财等资源的获取,抑或是资源财富的经营活动,都表现出寺院经济发展的多种途径和方式。王权社会的国家暴力,依然对寺院经济有着强大的干预能力。研究北朝寺院经济的资源配置情况可以从一个侧面了解北朝经济状况。

关键词：北朝寺院经济资源配置

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Petroleum Hydrocarbon Degradation Potential of Soil Bacteria Native to the Yellow River Delta

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Pedosphere 2008年第6期18卷 707-716页

作者： WANG Zhen-Yu GAO Dong-Mei li feng-min ZHAO Jian XIN Yuan-Zheng S. SIMKINS XING Bao-Shan Key Lab of Marine Environmental Science and Ecology Ministry of Education College of Environmental Science and Engineering Ocean University of China Qingdao 266100 （China） Department of Plant Soil and Insect Sciences University of Massachusetts Amherst MA 01003 （USA）

The bioremediation potential of bacteria indigenous to soils of the Yellow River Delta in China was evaluated as a treatment option for soil remediation. Petroleum hydrocarbon degraders were isolated from contaminated soil samples from the Yellow River Delta. Four microbial communities and eight isolates were obtained. The optimal temperature, salinity, pH, and the ratios of C, N, and P (C:N:P) for the maximum biodegradation of diesel oil, crude oil, n-alkanes, and polyaromatic hydrocarbons by indigenous bacteria were determined, and the kinetics changes in microbial communities were monitored. In general, the mixed microbial consortia demonstrated wider catabolic versatility and faster overall rate of hydrocarbon degradation than individual isolates. Our experimental results demonstrated the feasibility of biodegradation of petroleum hydrocarbon by indigenous bacteria for soil remediation in the Yellow River Delta.

关键词： bioremediation potential contaminated soil petroleum hydrocarbon degradation soil remediation Yellow River Delta

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论我国半干旱地区农业生产力与生态系统可持续发展

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资源科学 1999年第5期21卷 25-30页

作者：李凤民兰州大学干旱农业生态国家重点实验室

我国半干旱地区农业生产力低下和生态环境恶化的根源在于系统内的同化作用被强烈弱化，而异化作用却异常活跃。表现为植被破坏、农业生产力低下、土壤水蚀和风蚀严重、土壤肥力持续下降，扩大开垦面积进一步导致问题的严重化。这两大系... 详细信息

我国半干旱地区农业生产力低下和生态环境恶化的根源在于系统内的同化作用被强烈弱化，而异化作用却异常活跃。表现为植被破坏、农业生产力低下、土壤水蚀和风蚀严重、土壤肥力持续下降，扩大开垦面积进一步导致问题的严重化。这两大系统功能的不协调变化就是所谓的“生态平衡失调”，只有同化作用得到有效提高，才能抑制异化作用的恶性发展。核心就是大幅度提高系统生产力，对以人为中心的生态系统而言，提高农业生产力是生态环境改善和生态系统可持续发展的关键环节。首先改善农田水分状况，在大幅度提高作物单产的基础上，发展以集水技术为基础的生态农业，从而实现农业生态系统的可持续发展。

关键词：半干旱地区农业生产力生态环境可持续发展

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Interventional therapy for chronic simple atherosclerotic occlusive disease of lower extremity

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Journal of Medical Colleges of PLA(China) 2010年第4期25卷 212-219页

作者： liu Yamin Han Hui Qin Hao Yu li Zhang min feng Jun Department of Peripheral Vessels First Affiliated Hospital Xi 'an Jiaotong University Xi 'an 710061 China

Objective： To explore the efficacy of interventional therapy for chronic atherosclerotic occlusive disease of the lower extremity. Methods： Fifty-six cases of simple atherosclerotic occlusive disease of lower extremity were divided into 3 types according to the location of occhision, including 17 cases of abdominal aorta-iliac artery, 18 cases of iliac-femoral artery, and 21 cases of inferior popliteal artery. Catheter and guide wire combined with blunt dissection and subtle banding were used to dredge the occluded vessels, and stents were implanted when interlayer appeared. Results： After the treatment, 46 cases of occlusion were dredged （82.1%）, 6 cases remained occluded with the same symptoms （10.7%）, and 4 cases had severer symptoms （7.1%）. Among the 46 successful cases, there were 16 cases of abdominal aorta-iliac artery （94.1%）, 16 cases of iliac-femoral artery （88.9%） and 14 cases of inferior popliteal artery, artery （66.6%）. There was no statistical difference between the abdominal aorta-iliac artery cases and iliac-femoral artery cases （P〉0.05）, but there was statistical difference between these two types and the inferior popliteal artery cases （P〈0.05）. In the successful cases, 9 cases of abdominal aorta-iliac artery （52.9%）, 10 cases of iliac-femoral artery （55.5%） and 10 cases of inferior popliteal artery （33.3%） had 5-10 cm of occlusion, with no statistical difference between the first two types （P〉0.05）, but with statistical difference between the first two types and the third type （P〈0.05）. Compared with the 14 dredged cases （71.4%）, the 7 cases （33.3%） of inferior popliteal artery cases had richer compensatory circulation （P〈0.05）. Conclusion： It＇s safe and effective to treat simple atherosclerotic occlusive disease of the lower extremity with interventional therapy. The location and length of occlusion and the abundance of compensatory circulation had effect on the therapy.

关键词： Atherosclerosis Lower extremity occlusion Interventional therapy

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溃疡分期对幽门螺杆菌根除率的影响

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胃肠病学 2017年第4期22卷 238-240页

作者：李敏高峰新疆维吾尔自治区人民医院消化科 830001

背景:幽门螺杆菌(Hp)感染与多种胃肠道疾病的发生相关。研究表明,Hp根除率可能受疾病种类、疾病进展阶段的影响。目的:探讨内镜下溃疡分期对Hp根除率的影响。方法:收集2015年1月—2016年7月新疆维吾尔自治区人民医院收治的Hp感染消化性... 详细信息

背景:幽门螺杆菌(Hp)感染与多种胃肠道疾病的发生相关。研究表明,Hp根除率可能受疾病种类、疾病进展阶段的影响。目的:探讨内镜下溃疡分期对Hp根除率的影响。方法:收集2015年1月—2016年7月新疆维吾尔自治区人民医院收治的Hp感染消化性溃疡(PU)患者423例,其中胃溃疡(GU)组133例,十二指肠溃疡(DU)组255例,予14 d含铋剂四联疗法根除Hp治疗。比较不同内镜分期溃疡患者Hp根除率的差异,对Hp根除率影响因素进行单因素分析。结果:GU与DU组间Hp根除率差异无统计学意义(82.7%对83.9%,P>0.05)。GU组活动期溃疡患者根除率显著高于非活动期(89.0%对75.0%,P0.05)。单因素分析显示,溃疡分期与是否能成功根除Hp相关,活动期PU患者根除率显著高于非活动期(87.8%对80.3%,P<0.05)。结论:内镜下溃疡分期与PU尤其是GU患者的Hp根除率有关,在溃疡活动期进行Hp根除治疗能显著提高根除率。

关键词：幽门螺杆菌根除率消化性溃疡内镜溃疡分期

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