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Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： Wei zhou Maiying Fan Xiang li Fang Yu En zhou Xiaotong Han Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China Department of Otolaryngology-head and Neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BACKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(ICU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETCM *** targets related to PLA and sepsis were retrieved from the GeneCards,PharmGKB,DisGeNet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

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Multiscale causes of the 2022 Yangtze mega-flash drought under climate change

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Science China Earth Sciences 2024年第8期67卷 2649-2660页

作者： Xing YUAN Yumiao WANG Shiyu zhou Hua li Chenyuan li School of Hydrology and Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China

The 2022 Yangtze mega-flash drought is characterized by strong intensity and rapid development both in time and space,accompanied by a persistent anticyclonic circulation ***,the causes of the extreme event remain elusive given the multiscale nature of *** we presented a brief overview for the oceanic and terrestrial causes of the megaflash drought during the summer of 2022,and estimated the risk in a changing *** the soil moisture percentile as the drought index,it was found that the drought expanded to the entire Yangtze River basin within two months,with 80%of basin under severe drought conditions at the end of *** the intensity and onset speed of the 2022 mega-flash drought were ranked as the first during the past 62 years,with return periods of 86 and 259 years,*** results of composite analysis showed that the spring La Ni?a can facilitate the abrupt change from a wet/normal condition in May–June to drought in July–August over the Yangtze River basin,which was beneficial for the increase of flash drought intensity and onset speed *** analysis through the linear regression also indicated that the unprecedented intensity was associated with the negative phase of the Pacific Decadal *** by a coupling strength index for soil moisture and vapor pressure deficit,it was found that there was a strong land-atmosphere coupling over the Yangtze River basin during July–August *** attribution by using CMIP6 climate models suggested that land-atmosphere coupling increased the risks of flash drought intensity and onset speed like 2022 by 61%±6%and 64%±7%under natural climate forcings,and the synergy of coupling and anthropogenic climate change would increase the risks by 75%±22%and 85%±12%.Our findings emphasized the role of landatmosphere coupling combined with anthropogenic climate change in intensifying flash droughts.

关键词： Flash drought Yangtze River basin Land-atmosphere coupling Climate change Attribution

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Multiplexed manipulation of orbital angular momentum and wavelength in metasurfaces based on arbitrary complex-amplitude control

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light(Science & Applications) 2024年第5期13卷 930-940页

作者： Guoli He Yaqin Zheng Changda zhou Siyang li Zhonghong Shi Yanhui Deng Zhang-Kai zhou State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Due to its unbounded and orthogonal modes,the orbital angular momentum(OAM)is regarded as a key optical degree of freedom(DoF)for future information processing with ultra-high capacity and *** the manipulation of OAM based on metasurfaces has brought about great achievements in various fields,such manipulation currently remains at single-DoF level,which means the multiplexed manipulation of OAM with other optical DoFs is still lacking,greatly hampering the application of OAM beams and advancement of *** order to overcome this challenge,we propose the idea of multiplexed coherent pixel(MCP)for *** approach enables the manipulation of arbitrary complex-amplitude under incident lights of both plane and OAM waves,on the basis of which we have realized the multiplexed DoF control of OAM and *** a result,the MCP method expands the types of incident lights which can be simultaneously responded by metasurfaces,enriches the information processing capability of metasurfaces,and creates applications of information encryption and OAM *** findings not only provide means for the design of high-security and high-capacity metasurfaces,but also raise the control and application level of OAM,offering great potential for multifunctional nanophotonic devices in the future.

关键词： momentum offering overcome

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CVTD: A Robust Car-Mounted Video Text Detector

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Computers, Materials & Continua 2024年第2期78卷 1821-1842页

作者： Di zhou Jianxun Zhang Chao li Yifan Guo Bowen li Department of Computer Science and Engineering Chongqing University of TechnologyChongqingChina College of Information and Engineering Jingdezhen Ceramic UniversityJingdezhenChina

Text perception is crucial for understanding the semantics of outdoor scenes,making it a key requirement for building intelligent systems for driver assistance or autonomous *** information in car-mounted videos can assist drivers in making ***,Car-mounted video text images pose challenges such as complex backgrounds,small fonts,and the need for real-time *** proposed a robust Car-mounted Video Text Detector(CVTD).It is a lightweight text detection model based on ResNet18 for feature extraction,capable of detecting text in arbitrary *** model efficiently extracted global text positions through the Coordinate Attention Threshold Activation(CATA)and enhanced the representation capability through stacking two Feature Pyramid Enhancement Fusion Modules(FPEFM),strengthening feature representation,and integrating text local features and global position information,reinforcing the representation capability of the CVTD *** enhanced feature maps,when acted upon by Text Activation Maps(TAM),effectively distinguished text foreground from non-text ***,we collected and annotated a dataset containing 2200 images of Car-mounted Video Text(CVT)under various road conditions for training and evaluating our model’s *** further tested our model on four other challenging public natural scene text detection benchmark datasets,demonstrating its strong generalization ability and real-time detection *** model holds potential for practical applications in real-world scenarios.

关键词： Deep learning text detection Car-mounted video text detector intelligent driving assistance arbitrary shape text detector

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Manganese oxide and derivative-modified materials in advanced oxidation processes:A review of modification enhancement and activation mechanisms

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Chinese Chemical Letters 2024年第3期35卷 40-51页

作者： Si Sun Shuang Song Shuai Yang Yong-li He Yang Shi Peng zhou Zhao-kun Xiong Yang liu Heng Zhang Ye Du Chuan-Shu He Bo lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaSichuanChengdu 610054China

Manganese oxides(MNO_(x)),as low-toxicity and high-abundance catalysts,have been demonstrated to hold great promise for application in advanced oxidation processes(AOPs).However,further application of this material is restricted due to its unsatisfactory oxidant activation ***,recently remarkable research on deep activation mechanisms and modification of MNO_(x)have been undertaken to improve its ***,modification enhancement mechanisms of MNO_(x)to efficiently degrade various organic contaminants were discussed and highlighted,including metal doping,coupling with other metal oxides,composite with carbonaceous material,and compounding with other *** activation mechanisms of different MNO_(x)and derivative-modified material(such as doped MNO_(x),metal oxide-MNO_(x)hybrids,and MNO_(x)-carbonaceous material hybrids)were summarized in great details,which was specifically categorized into both radical and non-radical *** effects of pH,inorganic ions,and natural organic matter on degradation reactions are also ***,future research directions and perspectives are presented to provide a clear interpretation on the MNO_(x)initiated AOPs.

关键词： Manganese oxide Derivative-modified materials Modification enhancement mechanisms Advanced oxidation process Activation mechanism

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A reweighted damped singular spectrum analysis method for robust seismic noise suppression

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Petroleum Science 2024年第3期21卷 1671-1682页

作者： Wei-lin Huang Yan-Xin zhou Yang zhou Wei-Jie liu Ji-Dong li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China SINOPEC Petroleum Exploration and Production Research Institute Beijing102206China SINOPEC Geophysical Research Institute Nanjing211103jiangsuChina

(Multichannel)Singular spectrum analysis is considered as one of the most effective methods for seismic incoherent noise *** utilizes the low-rank feature of seismic signal and regards the noise suppression as a low-rank reconstruction ***,in some cases the seismic geophones receive some erratic disturbances and the amplitudes are dramatically larger than other *** presence of this kind of noise,called erratic noise,makes singular spectrum analysis(SSA)reconstruction unstable and has undesirable effects on the final *** robustify the low-rank reconstruction of seismic data by a reweighted damped SSA(RD-SSA)*** incorporates the damped SSA,an improved version of SSA,into a reweighted *** damping operator is used to weaken the artificial disturbance introduced by the low-rank projection of both erratic and random *** central idea of the RD-SSA method is to iteratively approximate the observed data with the quadratic norm for the first iteration and the Tukeys bisquare norm for the rest *** RD-SSA method can suppress seismic incoherent noise and keep the reconstruction process robust to the erratic *** feasibility of RD-SSA is validated via both synthetic and field data examples.

关键词： Singular spectrum analysis Damping operator Seismic erratic noise Seismic signal processing Robust low-rank reconstruction

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Evolutionary mechanisms and practical significance of reproductive success and clonal diversity in unisexual vertebrate polyploids

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Science China(life Sciences) 2024年第3期67卷 449-459页

作者： Meng Lu li zhou Jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Hubei Hongshan Laboratorythe Innovation Academy of Seed DesignInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

Unisexual reproduction is generally relevant to polyploidy, and unisexual vertebrates are often considered an evolutionary “dead end” due to the accumulation of deleterious mutations and absence of genetic diversity. However, some unisexual polyploids have developed strategies to avoid genomic decay, and thus provide ideal models to unveil unexplored evolutionary mechanisms, from the reproductive success to clonal diversity creation. This article reviews the evolutionary mechanisms for overcoming meiotic barrier and generating genetic diversity in unisexual vertebrates, and summarizes recent research advancements in the polyploid Carassius complex. Gynogenetic gibel carp(Carassius gibelio) is a unique amphitriploid that has undergone a recurrent autotriploidy and has overcome the bottleneck of triploid sterility via gynogenesis. Recently, an efficient strategy in which ploidy changes, including from amphitriploid to amphitetraploid, then from amphitetraploid to novel amphitriploid, drive unisexual-sexual-unisexual reproduction transition and clonal diversity has been *** on this new discovery, multigenomic reconstruction biotechnology has been used to breed a novel strain with superior growth and stronger disease resistance. Moreover, a unique reproduction mode that combines both abilities of ameiotic oogenesis and sperm-egg fusion,termed as ameio-fusiongensis, has been discovered, and it provides an efficient approach to synthesize sterile allopolyploids. In order to avoid ecological risks upon escape and protect the sustainable property rights of the aquaculture seed industry, a controllable fertility biotechnology approach for precise breeding is being developed by integrating sterile allopolyploid synthesis and gene-editing *** review provides novel insights into the origin and evolution of unisexual vertebrates and into the attempts being made to exploit new breeding biotechnologies in aquaculture.

关键词： unisexual vertebrates polyploidy reproduction transition clonal diversity precise breeding genomic reconstruction controllable fertility

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Climate change drives flooding risk increases in the Yellow River Basin

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Geography and Sustainability 2024年第2期5卷 193-199页

作者： Hengxing Lan Zheng Zhao Langping li Junhua li Bojie Fu Naiman Tian Ruixun lai Sha zhou Yanbo Zhu Fanyu Zhang Jianbing Peng John J.Clague State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710064China University of Chinese Academy of Sciences Beijing 10049China Yellow River Institute of Hydraulic Research Yellow River Conservancy CommissionZhengzhou 450003China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Earth Surface Processes and Resources Ecology Beijing Normal UniversityBeijing 100875China Key Laboratory of Mechanics on Disaster and Environment in Western China The Ministry of Education of ChinaSchool of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China Department of Earth Sciences Simon Fraser UniversityBurnabyCanada

The Yellow River Basin(YRB)has experienced severe floods and continuous riverbed elevation throughout *** climate change has been suggested to be driving a worldwide increase in flooding ***,owing to insufficient evidence,the quantitative correlation between flooding and climate change remains *** present a long time series of maximum flood discharge in the YRB dating back to 1843 compiled from historical documents and instrument *** in yearly maximum flood discharge show distinct periods:a dramatic decreasing period from 1843 to 1950,and an oscillating gentle decreasing from 1950 to 2021,with the latter period also showing increasing more extreme floods.A Mann-Kendall test analysis suggests that the latter period can be further split into two distinct sub-periods:an oscillating gentle decreasing period from 1950 to 2000,and a clear recent increasing period from 2000 to *** further predict that climate change will cause an ongoing remarkable increase in future flooding risk and an∼44.4 billion US dollars loss of floods in the YRB in 2100.

关键词： Flooding risk Risk management Climate change Flood discharge Extreme precipitation

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Green Synthesis of Iron(Ⅱ,Ⅲ)-polyphenol Nanoparticles and Their Adsorption of Malachite Green

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 1025-1030页

作者：胡玉 zhou Fan ZHANG Nan PAN Xiaobin li Shiying ZHANG Dong li li 张玲帆 Department of Chemistry and Environmental Engineering Hanjiang Normal UniversityShiyan 442000China Shiyan Hydrological and Water Resources Survey Bureau of Hubei Province Shiyan 442000China School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai 200237China

Three kinds of iron nanoparticles(FeNPs)were prepared via green route based on pomegranate(PG),green tea(GT),and mulberry(ML)extracts under ambient *** obtained materials were characterized by scanning electron microscopy(SEM),transmission electronic microscopy(TEM),X-ray energy-dispersive spectrometer(EDS),X-ray diffraction(XRD),fourier transform infrared spectroscopy(FTIR),and X-ray photoelectron spectroscopy(XPS)*** experimental results show that FeNPs were in the form of amorphous iron(Ⅱ,Ⅲ)-polyphenol complex with different dispersity and ***-Fe has the smallest size range of 25-35 nm,PG-Fe has a moderate size-distribution of 30-40 nm,while ML-Fe formed a tuberous net-type with a sheeting ***-Fe displays the highest removal efficiency of 90.2%in 20 min towards cationic dye of malachite green(16.6%by ML-Fe and 69.3%by GT-Fe),which is attributed to its highest polyphenol content,lowest zeta potential,as well as the most Fe^(2+)on the surface of *** removal mechanism was mainly induced by electrostatic adsorption based on pH and zeta potential tests.

关键词： iron nanoparticles pomegranate green tea mulberry adsorption

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Engineering phonon thermal transport in few-layer PdSe_(2)

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Frontiers of physics 2024年第3期19卷 135-141页

作者： Meilin li Huanhuan Sun Jun zhou Yunshan Zhao Phonon Engineering Research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceInstitute of Physics Frontiers and Interdisciplinary SciencesSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China

Engineering phonon transport in low-dimensional materials has great significance not only for fundamental research,but also for thermal management applications of electric ***,due to the difficulties of micro and nano processing and characterization techniques,the work on tuning phonon transport at nanoscale are *** this work,by introducing Ar+plasma,we probed the phonon transport in two-dimensional(2D)layered semiconductor PdSe_(2)under different defect *** using thermal bridge method,the thermal conductivity was measured to decrease by 50%after a certain Ar+irradiation,which implied a possible phase ***,Raman characterizations were performed to show that the Raman sensitive peaks of PdSe_(2)was red-shifted and finally became disappeared with the increase of defect concentration.“Defect engineering”proves be a practical strategy in tuning the phonon thermal transport in low-dimensional materials,thus providing guidance for potential application in designing thermoelectric devices with various emerging materials.

关键词： phonon transport PdSe_(2) defects thermal bridge method

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