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3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing

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Bio-Design and Manufacturing 2024年第2期7卷 137-152页

作者： Xiaoyuan Wang Zixian liu Qianqian Duan Boye Zhang Yanyan Cao Zhizhong shen Meng li Yanfeng Xi Jianming Wang shengbo Sang Shanxi Key Laboratory of Micro Nano Sensors and Artificial Intelligence Perception College of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China Shanxi Institute of 6D Artificial Intelligence Biomedical Science Taiyuan 030031China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China Department of Pathology Shanxi Provincial Cancer HospitalTaiyuan 030024China General Hospital of Taiyuan Iron and Steel Company Taiyuan 030809China

Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted *** address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of *** GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 *** analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the *** with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and ***,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three *** addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude *** evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was *** research therefore acts as a foundation for the application of 3DP-7721 models in drug devel

关键词： 3D bioprinting Hepatoma tumor models Drug screening Antitumor drug development

Reconciled estimation of Antarctic ice sheet mass balance and contribution to global sea level change from 1996 to 2021

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Science China Earth Sciences 2024年第11期67卷 3562-3578页

作者： Rongxing li Guojun li Gang HAI Huan XIE Yuan CHENG Wei CHEN Xiangbin CUI Minghu DING Chunchun GAO Tong HAO Changqing KE Chuanjin li Jin li Yan liU Jiangjun RAN Jiawen REN Qiang shen Yunzhong shen Hongling SHI Songyun WANG Zemin WANG Jingang ZHAN Baojun ZHANG Min ZHONG Chunxia ZHOU Center for Spatial Information Science and Sustainable Development Applications Tongji University College of Surveying and Geo-informatics Tongji University Institute for the Conservation of Cultural Heritage School of Cultural Heritage and Information Management Shanghai University College of Resource Environment and Tourism Hubei University of Arts and Science Polar Research Institute of China State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences College of Geodesy and Geomatics Shandong University of Science and Technology School of Geography and Ocean Science Nanjing University Shanghai Astronomical Observatory Chinese Academy of Sciences State Key Laboratory of Remote Sensing Science Faculty of Geographical Science Beijing Normal University Department of Earth and Space Sciences Southern University of Science and Technology State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences Center for Space Research University of Texas at Austin Chinese Antarctic Center of Surveying and Mapping Wuhan University School of Geospatial Engineering and Science Sun Yat-sen University

The Antarctic Ice Sheet（AIS） has been losing ice mass and contributing to global sea level rise（GSLR）. Given its mass that is enough to cause ～58 m of GSLR, accurate estimation of mass balance trend is critical for AIS mass loss monitoring and sea level rise forecasting. Here, we present an improved approach to reconciled solutions of mass balance in AIS and its regions from multiple contributing solutions using the input-out, altimetric, and gravimetric methods. In comparison to previous methods, such as IMBIE 2018, this approach utilizes an adaptive data aggregation window to handle the heterogeneity of the contributing solutions, including the number of solutions, temporal distributions, uncertainties, and estimation techniques. We improved the regression-based method by using a two-step procedure that establishes ensembled solutions within each method（input-output, altimetry, or gravimetry） and then estimates the method-independent reconciled solutions. For the first time, 16contributing solutions from 8 Chinese institutions are used to estimate the reconciled mass balance of AIS and its regions from1996 to 2021. Our results show that AIS has lost a total ice mass of ～3213±253 Gt during the period, an equivalent of～8.9±0.7 mm of GSLR. There is a sustained mass loss acceleration since 2006, from 88.1±3.6 Gt yr-1during 1996–2005 to 130.7 ±8.4 Gt yr-1during 2006–2013 and further to 157.0±9.0 Gt yr-1during 2014–2021. The mass loss signal in the West Antarctica and Antarctic Peninsula is dominant and clearly presented in the reconciled estimation and contributing solutions, regardless of estimation methods used and fluctuation of surface mass balance. Uncertainty and challenges remain in mass balance estimation in East Antarctica. This reconciled estimation approach can be extended and applied for improved mass balance estimation in the Greenland Ice Sheet and mountain glacier regions.

关键词： Antarctic Ice Sheet Ice mass loss acceleration Sea level rise Reconciled estimation

Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： Ying Lu Se Wang Yifan shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic *** this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond *** addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water *** results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

Sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFC

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Journal of Energy Chemistry 2024年第2期89卷 422-433,I0010页

作者： Bin liu Jiawang li Bowen Yan Qi Wei Xingyu Wen Huarui Xie Huan He Pei Kang shen Zhi Qun Tian Collaborative Innovation Center of Sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina

Transition metal-nitrogen-carbon(M-N-C)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exchange membrane fuel cells(PEMFCs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(S-Fe-N-HC)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as S source and 1,8-diaminonaphthalene(DAN)as N source via an amination *** as-synthesized S-Fe-N-HC features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-S doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-C with soft or graphitic carbon *** unique characteristics endow S-Fe-N-HC with high ORR activity and outstanding durability in 0.5 M H_(2)SO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 ***,its practical PEMFC performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical ***,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near FeN_(4)*** results evidently demonstrate that the dual effect of hard carbon substrate and S doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-C catalysts,providing a new guidance for developing advanced M-N-C catalysts for ORR.

关键词： Transition metal-nitrogen-carbon Oxygen reduction reaction Hard carbon Amide based polymer reaction Proton exchange membrane cells

Exploring Long-Memory Process in the Prediction of Interval-Valued Financial Time Series and Its Application

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Journal of Systems Science & Complexity 2024年第2期37卷 759-775页

作者： shen Tingting TAO Zhifu CHEN Huayou School of Economics Anhui UniversityHefei 230601China Center for Financial and Statistical Research Anhui UniversityHefei 230061China Stony Brook Institute at Anhui University Anhui UniversityHefei 230601China Center for Applied Mathematics Anhui UniversityHefei 230601China

Long-memory process has been widely studied in classical financial time series analysis,which has merely been reported in the field of interval-valued financial time *** aim of this paper is to explore long-memory process in the prediction of interval-valued time series(IvTS).To model the long-memory process,two novel interval-valued time series prediction models named as interval-valued vector autoregressive fractionally integrated moving average(IV-VARFIMA)and ARFIMAX-FIGARCH were *** the developed long-memory pattern,both of the short term and long-term influences contained in IvTS can be *** an application of the proposed models,interval-valued form of WTI crude oil futures price series is *** to current IvTS prediction models,IV-VARFIMA and ARFIMAX-FIGARCH can provide better in-sample and out-of-sample forecasts.

关键词： ARFIMAX-FIGARCH interval-valued time series IV-VARFIMA long-memory process WTI crude oil futures price

H_(∞)/Passive Synchronization of Semi-Markov Jump Neural Networks Subject to Hybrid Attacks via an Activation Function Division Approach

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Journal of Systems Science & Complexity 2024年第3期37卷 1023-1036页

作者： ZHANG Ziwei shen Hao SU Lei School of Electrical and Information Engineering Anhui University of TechnologyMa'anshan 243002China Anhui Province Key Laboratory of Special Heavy Load Robot and School of Electrical and Information Engineering Anhui University of TechnologyMa'anshan243002China

In this work,an H_(∞)/passive-based secure synchronization control problem is investigated for continuous-time semi-Markov neural networks subject to hybrid attacks,in which hybrid attacks are the combinations of denial-of-service attacks and deception attacks,and they are described by two groups of independent Bernoulli *** this foundation,via the Lyapunov stability theory and linear matrix inequality technology,the H_(∞)/passive-based performance criteria for semi-Markov jump neural networks are ***,an activation function division approach for neural networks is adopted to further reduce the conservatism of the ***,a simulation example is provided to verify the validity and feasibility of the proposed method.

关键词： Activation function division approach deception attacks denial-of-service attacks H_(∞)/passive synchronization semi-Markov jump neural networks

Large-scale interplant exchange of macromolecules between soybean and dodder under nutrient stresses

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Plant Diversity 2024年第1期46卷 116-125页

作者： Jingxiong Zhang Shalan li Wenxing li Zerui Feng Shuhan Zhang Xijie Zheng Yuxing Xu Guojing shen Man Zhao Guoyan Cao Xuna Wu Jianqiang Wu Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan and Center for life Science School of Life SciencesYunnan UniversityKunming 650500China

Parasitic plants and their hosts communicate through haustorial *** deficiency is a common stress for plants,yet little is known about whether and how host plants and parasites communicate during adaptation to such nutrient *** this study,we used transcriptomics and proteomics to analyze how soybean(Glycine max)and its parasitizing dodder(Cuscuta australis)respond to nitrate and phosphate deficiency(-N and-P).After-N and-P treatment,the soybean and dodder plants exhibited substantial changes of transcriptome and proteome,although soybean plants showed very few transcriptional responses to-P and dodder did not show any transcriptional changes to either-N ***,large-scale interplant transport of mRNAs and proteins was *** the mobile mRNAs only comprised at most 0.2%of the transcriptomes,the foreign mobile proteins could reach 6.8%of the total proteins,suggesting that proteins may be the major forms of interplant ***,the interplant mobility of macromolecules was specifically affected by the nutrient regimes and the transport of these macromolecules was very likely independently *** study provides new insight into the communication between host plants and parasites under stress conditions.

关键词： Cuscuta Mobile molecules Nutrient deficiency Host plant-parasitic plant interaction Interplant transport Systemic signaling

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

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Bone Research 2024年第2期12卷 390-406页

作者： Xinshu Zhang Yao Xiao Bo Hu Yanhao li Shaoyang Zhang Jian Tian Shuo Wang Zaijin Tao Xinqi Zeng Ning-Ning liu Baojie li shen liu Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RdShanghai 200233PR China Section of Spine Surgery Department of OrthopaedicsChangzheng HospitalNaval Medical UniversityShanghai 200003PR China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200241PR China Department of Orthopaedics Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityWuxi 214062PR China State Key Laboratory of Systems Medicine for Cancer Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China

Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe *** are widely recognized as a fibrotic trigger during peritendinous adhesion ***,different clusters of macrophages have various functions and receive multiple regulation,which are both still *** our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon *** transcriptomes of over 74000 human single cells were *** results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion ***,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human ***,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages *** together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their *** results provide potential therapeutic targets against human tendon adhesion.

关键词： tendon analysis landscape

An Asynchronous Variational Integrator for Contact Problems Involving Elastoplastic Solids

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Acta Mechanica Solida Sinica 2024年第2期37卷 305-315页

作者： Zongwu Niu Zixiao Wang Yongxing shen University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai200240China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai200240China Department of Biostatistics Johns Hopkins Bloomberg School of Public HealthBaltimoreMaryland21205USA

Simulations of contact problems involving at least one plastic solid may be costly due to their strong nonlinearity and requirements of *** this work,we develop an explicit asynchronous variational integrator(AVI)for inelastic non-frictional contact problems involving a plastic *** AVI assigns each element in the mesh an independent time step and updates the solution at the elements and nodes *** asynchrony makes the AVI highly efficient in solving such bi-material *** advantage of the AVI,the constitutive update is locally performed in one element at a time,and contact constraints are also enforced on only one *** time step of the contact element is subdivided into multiple segments,and the fields are updated *** a contact event,only one element involving a few degrees of freedom is considered,leading to high *** proposed formulation is first verified with a pure elastodynamics benchmark and further applied to a contact problem involving an elastoplastic solid with non-associative volumetric *** numerical results indicate that the AVI exhibits excellent energy behaviors and has high computational efficiency.

关键词： Asynchronous variational integrator Plasticity Contact Computational efficiency Finite element method