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Syntheses,Structure and Biological Activities of 2-(1H-Benzo [1,2,3]triazole-1-yl)-1-(3-methyl-4-bromobiphenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone

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Chemical Research in Chinese Universities 2007年第1期23卷 120-122页

作者： ZHANG Shu-sheng WAN jun li xue-mei li Chun-li XU liang-zhong College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

1,2,4-Triazole derivatives represent an interesting class of heterocyclic compounds and have become the most with rapidly expanding group of antifungal compounds the advantages of toxicity, high oral bioavailability, and broad spectrum of activity against several fun- gi, including most yeasts and folanentous fungi . The triazole fungicides are agrochemicals that are used world wide in the agricultural industry because of their wide spectrum of action, A variety of benzotriazoles exhibit growth-inhibiting activities against some microorganisms and other derivatives possessing anti-inflammatory properties.

关键词： Triazole derivative Cyrstal structure Biological activity

Metabolic Regulation of Mammary Gland Epithelial Cells of Dairy Cow by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第7期10卷 1106-1116页

作者： TONG Hui-li GAO xue-jun li Qing-zhang liU Jie li Nan WAN Zhong-ying Key Laboratory of Dairy Science Ministry of Education/Life College Northeast Agricultural University Harbin 150030 P.R.China

In previous experiment, we isolated a compound dibutyl phthalate （DBP） from Vaccaria segetalis which had galactopoietic function on mammary gland epithelial cells of dairy cow （DCMECs）. In this experiment, we ascertained the metabolic regulation function of DBP on DCMECs. Many genes related to lactation including Stat5, AMPK, b-casein, Glut1, SREBP-1, PEPCK, and ACC were detected by real-time PCR. Furthermore, Stat5 and AMPK were detected by Western blot and immunofluorescence co-localization, respectively. The results showed that DBP stimulates the expression of Stat5 and p-Stat5, thus activates Stat5 cell signal transduction pathway and stimulates b-casein synthesis. DBP also raises the activities of Glut1 and AMPK to stimulate glucose uptake and glycometabolism and activates the expression of AMPK downstream target genes PEPCK and ACC and expression of SREBP-1 to stimulate milk fat synthesis. In addition, the activities of HK, G-6-PDH, ICDH, ATPase, and energy charges were stimulated by DBP to increase the energy metabolism level of DCMECs. The results showed DBP stimulates energy metabolism related to galactopoietic function in DCMECs.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cell metabolic regulation

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Turbulent Agglomeration of Microparticles in a Cylinder Wake Flow Using LES-DEM:Focusing on the Effect of the Reynolds Number

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Journal of Thermal Science 2025年第1期34卷 34-49页

作者： WANG Shuang MU lin li xue XIE jun DONG Ming School of Energy and Power Engineering Dalian University of Technology School of Optical Information and Energy Engineering Wuhan Institute of Technology School of Energy and Environment Shenyang Aerospace University

Turbulent agglomeration is viewed as a promising technology for enhancing fine particle removal *** better understand particle transport,agglomeration behaviors,and fluid-particle interactions,we numerically explored these phenomena under cylindrical vortex wake influence using a coupled large eddy simulation and discrete element method（LES-DEM） *** validity of the LES approach was verified by comparison with available direct numerical simulation（DNS） *** adopted the Johnson-Kendall-Roberts（JKR） contact model for particle-particle *** particle dispersion and agglomeration characteristics of particles with different diameters（dp=2-20 μm） in the laminar and transition of shear layer（TrSL） flow regimes were *** particles were concentrated at the vortex centers,while larger particles accumulated around the *** agglomeration efficiency exhibited an M-shaped profile spanwise（y-direction）.With increasing Reynolds number,the agglomeration efficiency and turbulence intensity *** particle agglomeration efficiency peaks at a certain Reynolds ***,at higher Reynolds numbers,reducing the residence time of particles in the flow field decreases the agglomeration efficiency.

关键词： discrete element method large eddy simulation microparticle particle agglomeration

Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5683-5688页

作者： liang liu Xing-Jie Shen li-jun xue Shu-Kun Yao Jing-Yu Zhu Department of Gastroenterology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250011Shandong ProvinceChina Department of Gastroenterology Jinan Central HospitalCheeloo College of MedicineShandong UniversityJinan 250011Shandong ProvinceChina Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Submucosal hematoma(SH)is one of the rare causes of upper gastrointestinal *** a rare and critical disease in clinical practice,it should be paid more attention to by clinicians to avoid missed diagnosis and *** of the esophageal submucosal hematomas have clear causes,including retrosternal pain,dysphagia,***,we report a rare case of SH extending from the hypopharynx to the lower esophagus caused by oral administration of hirudin and panax notoginseng powder,with atypical clinical *** a long submucosal hematoma has rarely been *** SUMMARY The patient was a 60-year-old male with a history of gastritis,hypertension,coronary heart disease,and coronary stent *** patient developed chest tiredness and heartburn after taking 10 capsules of a homemade mixture of hirudin and notoginseng powder in the previous 2 *** did not have hematemesis or black *** and chest computed tomography confirmed the diagnosis of SH,which ranged from the pharynx to the lower esophagus and was 35-40 cm in *** the diagnosis was confirmed,we performed active conservative treatment on the patient,and the patient recovered well and remained asymptomatic during the 26-mo *** SH is rare,and cases with atypical clinical symptoms may lead to misdiagnosis and missed *** of this disease can lead to serious clinical *** therapy is effective and the prognosis is good.

关键词： Submucosal hematoma Hypopharynx lower esophagus hirudin and panax notoginseng powder Gastroscopy Computed tomography Case report

Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells

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World Journal of Clinical Cases 2016年第8期4卷 248-252页

作者： Ru-Ying Fan Xiao-Wei Wang li-jun xue Ran An Jian-Qiu Sheng Department of Gastroenterology Beijing Military General Hospital Department of Pathology Beijing Military General Hospital

Cronkhite-Canada syndrome(CCS) is a rare but serious protein-losing enteropathy, but little is known about the mechanism. Further more, misdiagnosis is common due to non-familiarity of its clinical manifestation. A 40-year-old male patient was admitted to our hospital because of diarrhea and hypogeusia associated with weight loss for 4 mo. On physical examination, skin pigmentation, dystrophic nail changes and alopecia were noted. He had no alike family history. Laboratory results revealed low levels of serum albumin(30.1 g/L, range: 35.0-55.0 g/L), serum potassium(2.61 mmol/L, range: 3.5-5.5 mmol/L) and blood glucose(2.6 mmol/L, range: 3.9-6.1 mmol/L). The erythrocyte sedimentation rate was elevated to 17 mm/h(range: 0-15 mm/h). X-ray of chest and mandible was normal. The endoscopic examination showed multiple sessile polyps in the stomach, small bowel and colorectum. Histopathologic examination of biopsies obtained from those polyps showed hyperplastic change, cystic dilatation and distortion of glands with inflammatory infiltration, eosinophilic predominance and stromal edema. Immune staining for IgG 4 plasma cells was positive in polyps of stomach and colon. The patient was diagnosed of CCS and treated with steroid, he had a good response to steroid. Both histologic findings and treatment response to steroid suggested an autoimmune mechanism underling CCS.

关键词： Gastrointestinal polyposis Cronkhite-Canada syndrome IgG4 plasma cells Autoimmune mechanism

Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats

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World Journal of Gastroenterology 2020年第46期26卷 7299-7311页

作者： li-jun xue Ju-Qiang Han Yuan-Chen Zhou Hong-Ye Peng Teng-Fei Yin Kai-Min li Shu-Kun Yao School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Department of Hepatology The Seventh Medical Center of PLA General HospitalBeijing 100700China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)has become one of the most common chronic liver diseases in the *** our early clinical data and questionnaire analysis of NAFLD,it was found that the body mass index of some patients did not meet the diagnostic criteria for overweight or *** consumption of high-temperature-processed foods such as fried food,hot pot and barbecue is closely related to the occurrence of nonobese *** the intake of this kind of food can reduce disease severity and improve *** To explore the untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease in Sprague-Dawley rats induced by high-temperatureprocessed *** Fifty-four male Sprague-Dawley rats were divided into three groups:The control group received a standard diet;the nonfried soybeans(NDFS)group received 60%NDFS and 40%basic feed and the dry-fried soybeans(DFS)group received 60%DFS and 40%basic *** rats were sacrificed at week 4,8,and 12 in each *** food intake,body weight,Lee’s index,liver index,serological index and hepatic histopathology were *** metabolomics characteristics were used to analyze the changes in liver metabolites of rats at week *** between metabolites and pathology scores between the DFS and control groups and between the DFS and NDFS groups were *** selected some of the metabolites,both within the pathway and outside of the pathway,to explain preliminarily the difference in liver pathology in the three groups of *** There were no statistically significant differences in the food intake,body weight,Lee's index or serological index between the DFS group and the control group(P>0.05).At week 8 and week 12,the steatosis scores in the DFS group were significantly higher than those in the other two groups(Pliver index of the DFS group was the lowest(NDFS group vs DFS group,P<0.05).The fibrosis score in the DFS group was sign

关键词： Nonobese nonalcoholic fatty liver disease High-temperature-processed feed Mild steatosis and early fibrosis Untargeted metabolomics characteristics Animal models Novel pathogenesis for nonalcoholic fatty liver disease

FOXO1 inhibition potentiates ischemic angiogenesis in diabetes via suppression of ROCK1/drp1-mediated mitochondrial fission

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中国药理学与毒理学杂志 2019年第10期 924-925页

作者： SHI Yun-di WU Pin li xue-jun TIE Lu Department of Pharmacology School of Basic Medical Sciences Peking University Peking University

OBJECTIVE Diabetes-induced endothelial cell(EC) dysfunction and neovascularization impairment constitute vascular complications with limited treatment regimens. Transcription factor FOXO1 is a key angiogenic regulator and plays a pathologic role in progression of diabetes. The present study was designed to determine the involvement of FOXO1 in impaired EC function and post-ischemic neovascularization in diabetes and investigate underlying mechanisms. METHODS and RESILTS FOXO1-selective inhibitor AS1842856 improved blood flow recovery and capillary density in ischemic hindlimb,and rescued the delay of wound closure with a concomitant augmentation of mean perfusion rate in diabetic mice. In vitro, treatment with AS1842856 abrogated high glucose-induced apoptosis and ameliorated capillary tube formation in human umbilical vein endothelial cells(HUVECs). FOXO1 inhibition relieved alterations in mitochondrial networks and significantly suppressed the overproduction of mitochondrial reactive oxygen species(mt ROS) induced by high glucose in ECs. Expression of dynamin-relatedprotein-1(Drp1) and phosphorylation at Ser616, a protein required for mitochondrial fission, were enhanced by hyperglycemia, which could be neutralized by FOXO1 inhibition. Moreover, the transcription of Rhoassociated coiled-coil containing protein kinase 1(ROCK1),which phosphorylates Drp1 at Ser616, was shown by luciferase assay to be directly regulated by *** FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for complications of diabetes.

关键词： diabetes mitochondria

The genomic,transcriptomic,and immunological profiles of perineural invasion in pancreatic ductal adenocarcinoma

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Science China(life Sciences) 2023年第1期66卷 183-186页

作者： Shu-Heng Jiang Rong-Kun li De-jun liu jun-li xue Min-Hao Yu Shan Zhang li-Min liu jun-Feng Zhang Rong Hua Yong-Wei Sun Xu Wang Qin Yang Zhi-Gang Zhang State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Institute of Oncology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001China Department of Biliary-Pancreatic Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200217China Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Gastrointestinal Surgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200217China Department of Oral Pathology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011China State Key Laboratory of Oncogenes and Related Genes Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Institute of Precision Medicine Shanghai 200125China

Dear Editor,Cancer neuroscience is an emerging topic in cancer research(Monje et al.,2020;Shi et al.,2022).Perineural invasion(PNI),defined as the neoplastic invasion of tumor cells into or surrounding the different layers of nervous fibers(epineural,perineural,and endoneural spaces of the neuronal sheath),is associated with aggressive tumor behavior.

关键词： invasion neural

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