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Prospective study of light dark matter search with a newly proposed DarkSHINE experiment

Science China(Physics,Mechanics & Astronomy) 2023年第1期66卷 124-138页

作者： Jing Chen Ji-yuan Chen jun-Feng Chen Xiang Chen Chang-Bo Fu jun Guo Le He Zheng-Ting He Kim Siang Khaw Jia-lin li liang li Shu li Meng Lv Dan-Ning liu Han-qing liu Kun liu Qi-bin liu Yang liu Ze-Jia Lu Cen Mo Si-yuan Song Xiao-Long wang yu-Feng wang Zhen wang Zi-Rui wang wei-Hao wu Dao Xiang Hai-jun Yang jun-Hua Zhang yu-Lei Zhang Zhi-yu Zhao Xu-liang Zhu Chun-Xiang Zhu Yi-Fan Zhu Tsung-DaoLee Institute Shanghai Jiao Tong UniversityShanghai 201210China Institute of Nuclear and Particle Physics School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai 200240China Center for High Energy Physics Peking UniversityBeijing 10087lChina School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Electronics Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China R&D Center Shanghai Instituteof CeramicsChinese Academyof SciencesShanghai 20189China Key Laboratory of Nuclear Physics and lon-beam Application(MOE) Fudan UniversityShanghai 200443China Institute of Modern Physics Fudan UniversityShanghai 200443China IKey Laboratory for Laser Plasmas(MOE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Zhangjiang Institute for Advanced Study Shanghai JiaoTong UniversityShanghai 200240.China College of literature Scienceand the ArtsUniversity of MichiganAnn Arbor MI 48109-1040USA Deparment of Physics Swiss Federal Institnute of Technology ZurichZurich 8093Swizerland

Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass *** with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass *** have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV *** analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the *** experiment takes advantage of using missing momentum to enhance signal versus background separation *** this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with *** better background estimates,major rare background processes have also been *** paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment *** 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.

关键词： dark matter dark photon electron-on-target experiment

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尘肺病患者门诊与住院服务利用情况及影响因素分析

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现代预防医学 2024年第7期51卷 1193-1198页

作者：喻文鳌魏宇豪周家青周丁子伍东升张勤姜侠廖加强周敏伏代刚彭莉君沈江张本王焕强吕向裴杜文四川大学华西公共卫生学院/华西第四医院华西职业性尘肺病队列工作组中国疾病预防控制中心职业卫生与中毒控制所

目的了解尘肺病患者门诊与住院服务利用情况及其影响因素。方法采取便利抽样方法，在四川大学华西第四医院选取共199名尘肺病患者，使用中国疾病预防控制中心编制的《尘肺病患者就医行为及其影响因素问卷》调查其人群特征、就医行为... 详细信息

目的了解尘肺病患者门诊与住院服务利用情况及其影响因素。方法采取便利抽样方法，在四川大学华西第四医院选取共199名尘肺病患者，使用中国疾病预防控制中心编制的《尘肺病患者就医行为及其影响因素问卷》调查其人群特征、就医行为与影响因素。采用多因素logistic回归模型与多因素poisson回归模型分析患者门诊与住院服务利用的影响因素。结果调查的尘肺病患者两周门诊率为27.6%，一年利用门诊次数中位数为2次；一年住院率为61.8%，对已住院患者，一年住院次数中位数为1次，住院累积天数中位数为30 d；患者平均直观式健康标尺（VAS）得分为（48.3±17.4）分。多因素logistic回归与多因素poisson回归分析显示，已参加基础医保（OR=0.067,95%CI:0.006～0.716）、用药频率更高（OR=0.100,95%CI:0.037～0.269）、VAS得分更低（OR=0.992,95%CI:0.988～0.997）的尘肺病患者利用门诊服务更少，近期出现咳嗽加重（OR=5.530,95%CI:2.446～12.501）、有工伤保险（OR=1.183,95%CI:1.015～1.379）、收入较低（OR=0.980,95%CI:0.965～0.997）的尘肺病患者利用门诊服务更多；已婚（OR=0.063,95%CI:0.005～0.771）、VAS得分更低（OR=8.463,95%CI:3.090～23.248）的尘肺病患者利用住院服务更少；用药频率更高（OR=8.463,95%CI:3.090～23.248）、合并肺心病（OR=1.855,95%CI:1.307～2.634）、获得尘肺赔偿（OR=3.358,95%CI:1.183～9.529）、获得社会救济（OR=1.402,95%CI:1.047～1.877）、更主动与病友交流病情（OR=2.158,95%CI:1.061～4.390）的尘肺病患者利用住院服务更多。结论尘肺病患者门诊与住院利用率均高于全国平均水平。尘肺病患者自身健康状况、经济水平和社会支持水平是影响其就医行为的重要因素。

关键词：尘肺病就医行为住院门诊社会支持

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Effect of vascular endothelial growth factor 165 gene transfection on bone defects and its mRNA expression in rabbits

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Chinese Medical Journal 2007年第13期120卷 1187-1191页

作者： ZHAO Dong-mei wang Hai-bin YANG Jia-feng wu Shi-qing liU jun-li XU Fu-yu QIU li-ping cai Jing-long Department of Orthopaedics Shandong University Jinan 250033 China Department of Plastics Shandong University Jinan 250033 China Second Hospital Key Laboratory of liquid Structure and Heredity of Materials Ministry of Education Shandong University Jinan 250033 China

Background Gene therapy has been a hot spot in repair of bone defects in recent years. This study aimed to construct a recombinant plasmid pcDNA3.1-VEGF165, and to observe the effect of vascular endothelial growth factor 165 （VEGF165） gene therapy on bone defects in rabbits. Methods Total RNA was extracted from rabbit bone tissues. VEGF165 cDNA fragment was prepared by reverse transcription and the gene was cloned by polymerase chain reaction （PCR）. Plasmid pMD18-T/VEGF165 combined with pcDNA3.1 was cloned to reconstruct pcDNA3.1-VEGF165 plasmid. Thirty New Zealand white rabbits weighing （2.50±0.13）kg were used to establish models of bone defects （1 cm in length） of the bilateral radii. The bone defects were repaired with absorbable gelatin sponge. After the operation, physiological sodium chloride solution was injected into the injured site in one of the forelegs of the rabbits as the control group, and pcDNA3.1-VEGF165 plasmid （0.2 ml, 200 ng） was injected into the opposite foreleg as the experiment groups. At weeks 1, 2, 4, 6, 8, and 12 after the treatments, the bones were examined by X-ray, and the specimens of the bone defects were collected, stained with HE, and observed under a light microscope. The expression of VEGF165 mRNA was examined by real-time quantitative polymerase chain reaction （RQ-PCR）. Results The pcDNA3.1-VEGF165 plasmid with a correct sequence was constructed successfully. Postoperative X-ray found no difference between the two groups at week 1. In the experiment group, callus and synostosis were observed after 2 weeks, and osteosis structure was normal at week 12; these phenomena occurred much later in the control group. In the experiment group, HE staining showed a large amount of newly formed blood vessels after 2 weeks, a number of bone trabeculae with osteoblasts proliferation at 4 weeks, and fresh bone cortex and reformed medullary cavity at 12 weeks; whereas in the control group these structures formed in later phases. The VEGF165 m

关键词： gene transfection vascular endothelial growth factor bone defects

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化学铣切保护涂料体系材料对化铣槽液性能影响研究

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现代涂料与涂装 2024年第4期27卷 11-13页

作者：吴明霞于建龙李清材滕志春王卫国郑翔翔徐生亮李金虎中昊北方涂料工业研究设计院有限公司

化学铣切保护涂料体系材料主要由化学铣切保护涂料、化铣保护涂料快干修补胶、化铣保护涂料线密封剂构成，本文研究了化学铣切保护涂料体系材料多批次工程化产品在经过化铣工序后产品的漆膜表面状况是否发生变化、加工零件的铣切边的平... 详细信息

化学铣切保护涂料体系材料主要由化学铣切保护涂料、化铣保护涂料快干修补胶、化铣保护涂料线密封剂构成，本文研究了化学铣切保护涂料体系材料多批次工程化产品在经过化铣工序后产品的漆膜表面状况是否发生变化、加工零件的铣切边的平直性以及浸蚀比的大小是否满足要求，判断化学铣切保护涂料体系材料经过三批次工程化产品的化铣工序验证之后是否会对化铣槽液产生影响。结果表明：化学铣切保护涂料体系材料经过批次化铣加工之后，化铣效果保持良好，不会对化铣槽液产生影响。

关键词：化铣化铣槽液浸蚀比

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New Prenylated flavonol from Hypericum japonicum

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Chinese Chemical Letters 1997年第4期8卷 317-318页

作者： qing li wu Yong Hong liAO Sheng Ping wang li wei wang yu Xiu FENG jun Shan YANG Pei Gen XIAO(Institute of Medicinal Plant Development, Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094)Shao liang HO Inst. of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100094 China Beijing Institute of Microchemistry Beijing 100091 China

One new prenylated flavonol, 7,8-(2'',2'' -dimethylpyrano)-5,3',4'-trihydroxy-3-methoxyflavone was isolated from Hypericum japonicum. The chemical structure was determined by spectroscopic methods.

关键词： ppm New Prenylated flavonol from Hypericum japonicum DMSO 亚砜

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Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals

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Chinese Journal of Integrative Medicine 2022年第6期28卷 492-500页

作者： GAO Yang XIE Yan-ming wang Gui-qian cai Ye-feng SHEN Xiao-ming ZHAO De-xi XIE Ying-zhen ZHANG Yin MENG Fan-xing yu Hai-qing JIANG jun-jie wei Rui-li Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China Department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Neurology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Neurology the Affiliated Hospital of Changchun University of Chinese MedicineChangchun130017China Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department of Neurology Taiyuan Hospital of Traditional Chinese MedicineTaiyuan140107China

Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in ***:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk ***,stroke recurrence was defined as a primary outcome ***:A total of 327(12.78%)patients endured recurrence events,1,681(65.72%)patients were men,and the average age was 63.33±9.45 *** 1,741(68.06%)patients suffered first-ever ischemic stroke,1,772(69.27%)patients reported to have hypertension,and1,640(64.11%)of them reported dyslipidemia,1,595(62.35%)patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment(TOAST)***,1,271(49.69%)patients were considered as qi-deficient constitution,and 1,227(47.97%)patients were determined as stagnant blood *** were 1,303(50.94%)patients diagnosed as blood stasis syndrome,1,280(50.04%)patients exhibited phlegm and dampness syndrome and 1,012(39.56%)patients demonstrated qi deficiency *** 1,033(40.38%)patients declared intracranial artery stenosis,and 478(18.69%)patients reported carotid artery *** plaque in 1,508(41.36%)patients were of ***,41.09%of them demonstrated abnormal levels of glycated hemoglobin(HbA1 c)***:Recurrence in minor and small-artery stroke cannot be ***,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke ***,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.(Trial registration at ***,***03174535)

关键词： noncardiogenic ischemic stroke Chinese medicine hospital onset characteristics recurrence

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Tenofovir disoproxil fumarate in Chinese chronic hepatitis B patients:Results of a multicenter,double-blind,double-dummy,clinical trial at 96 weeks

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World Journal of Clinical Cases 2021年第18期9卷 4690-4699页

作者： Xiao-Fan Chen Ya-Nan Fan Chong-Wen Si Yan-Yan yu Jia Shang Zu-Jiang yu qing Mao qing Xie wei Zhao jun li Zhi-liang Gao Shan-Ming wu Hong Tang jun Cheng Xin-yue Chen Wen-Hong Zhang Hao wang Zhong-Nan Xu ling wang jun Dai Jing-Hang Xu Department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100034China Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Infectious Diseases Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Department of Infectious Diseases The Second Affiliated Hospital of Southeast UniversityNanjing 210011Jiangsu ProvinceChina Department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Infectious Diseases The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghai 201052China Department of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Center of Hepatology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of International Medical Beijing Youan HospitalCapital Medical UniversityBeijing 10069China Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of Infectious Diseases Peking University People's HospitalBeijing 100044China Clinical Center Jiangsu Chia-tai Tianqing Pharmaceutical Co.LtdNanjing 210000Jiangsu ProvinceChina

BACKGROUND Tenofovir disoproxil fumarate(TDF)is a prodrug of a nucleotide *** an antiviral drug,TDF has been proposed in the first-line treatment of chronic hepatitis B(CHB).qingzhong,a brand name of TDF,commercialized by Jiangsu Chia-tai Tianqing Pharmaceutical Co Ltd.,and Viread,another brand name of TDF,commercialized by GlaxoSmithKline,have both been approved by the State Food and Drug Administration,*** To investigate the efficacy and safety of the two TDF agents in the treatment of Chinese CHB *** This trial was registered at *** with the identifier number of NCT02287857.A total of 330 Chinese CHB patients,among which 232 were hepatitis B e antigen(HBeAg)-positive,were included in this 5-year-long,multicenter,double-blinded,double-dummy,randomized-controlled,noninferiority phase III *** participants were initially randomized into two groups:Group A(n=161),in which the participants received 300 mg qingzhong once a day for 48 wk;and Group B,in which the participants received 300 mg Viread once a day for 48 *** from week 49,all the participants in Groups A and B received 300 mg qingzhong once a day until the 96th *** this study,the primary endpoint was the decrease in plasma level of hepatitis B virus(HBV)DNA at the 96th week,while the secondary endpoints were suppression of HBV replication,alanine aminotransferase(ALT)normalization,HBeAg loss,and HBeAg seroconversion *** For the participants with HBeAg-positive CHB,the decrease in mean HBV DNA level relative to the baseline value was comparable between Groups A and B(5.77 vs 5.73 log10 IU/mL,P>0.05)at the 96th *** addition,similar percentages of HBeAg-positive participants in the two groups exhibited undetectable levels of HBV DNA,HBeAg loss,and HBeAg seroconversion(71.05%vs 77.97%,31.00%vs 27.27%,and 20.22%vs 15.79%,respectively,in Group A vs Group B;P>0.05).For the participants with HBeAg-negative CHB,the decrease in mean HBV DNA level r

关键词： Chronic hepatitis B Hepatitis B virus infection Chronic Tenofovir disoproxil

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Target Dependence of N / Z Ratio of the Fragments Produced in 30 MeV/u ^(40)Ar Induced Reactions

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Chinese Physics Letters 1997年第6期14卷 413-416页

作者： XU Hu-shan ZHU Yong-tai wei Zhi-yong LU jun wang Qi li Song-lin ZHANG yu-hu XIE yuan-xiang wu Zhong-li ZHAO qing-zhong GOU Quan-bu Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000

An inclusive measurement was performed for 30 MeV/u ^(40)Ar+^(58,64)Ni and ^(115)*** employing the degree of freedom of N/Z,the production mechanism of the high energy component of the intermediate mass fragments(IMFs:3≤Z≤13)has been *** attention has been paid to the target dependence of N/Z ratio of the energetic *** IMFs may be produced by a projectile fragmentation process with energy dissipation.

关键词： MeV/u fragmentation inclusive

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巴戟天寡糖胶囊用于轻、中度抑郁症患者巩固期治疗的临床研究

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中国临床药理学杂志 2024年第6期40卷 815-819页

作者：周书喆韩祖成王秀珍陈燕清呼亚玲余雪芹王斌红樊国珍桑红海英贾智捷王占敏魏琰朱建国宋学勤刘志东况利王洪明田峰李玉欣张玲林海吴斌王超英刘畅孙佳凡闫少校刘君谢守付房茂胜宓为峰张鸿燕北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)国家药物临床试验机构办公室北京100191 陕西省中医医院精神科陕西西安710003 沈阳市精神卫生中心精神科辽宁沈阳110168 山西中医学院附属医院精神科山西太原030024 山西大医院中医科山西大同037046 重庆市精神卫生中心精神科重庆400036 太原市精神病医院精神科山西太原030045 吉林省神经精神病医院精神科吉林松原138001 长春市第六医院精神科吉林长春130052 辽宁中医药大学附属医院精神科辽宁沈阳110033 河北省荣军医院精神科河北石家庄050899 衡水人民医院神经科河北衡水053099 郑州大学第一附属医院精神科河北郑州450052 天津市第四中心医院精神科天津300142 重庆医科大学附属第一医院精神科重庆400042 成都市第四人民医院精神科四川成都610036 山西医科大学第二医院精神科山西太原030001 河北省精神卫生中心精神科河北保定071030 首都医科大学附属北京安定医院精神科北京100120 西安市中医医院精神科陕西西安710021 西安市精神卫生中心精神科陕西西安710061 湖南省脑科医院精神科湖南长沙410021 吉林大学第一医院精神科吉林长春130061 山西省中西医结合医院精神科山西太原030013 北京回龙观医院精神科北京102208 辽宁中医药大学附属第二医院精神科辽宁沈阳110034 大连市第七人民医院精神科辽宁大连116086 武汉市精神卫生中心精神科湖北武汉430012

目的观察巴戟天寡糖胶囊用于治疗轻、中度抑郁症患者的24周巩固期的疗效和安全性。方法本研究采用开放、单臂、多中心设计,纳入已完成巴戟天寡糖急性期治疗的成人轻、中度抑郁症患者,继续给予巴戟天寡糖胶囊24周,巩固期维持治疗剂量不变... 详细信息

目的观察巴戟天寡糖胶囊用于治疗轻、中度抑郁症患者的24周巩固期的疗效和安全性。方法本研究采用开放、单臂、多中心设计,纳入已完成巴戟天寡糖急性期治疗的成人轻、中度抑郁症患者,继续给予巴戟天寡糖胶囊24周,巩固期维持治疗剂量不变,用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表-严重度(CGI-S)和亚利桑那性体验量表(ASEX)评估治疗前后的变化,评估患者的缓解率、复燃率及复燃时间,观察患者治疗相关不良事件的发生情况。结果治疗前后患者的HAMD-17评分分别为(6.60±1.87)和(5.85±4.18)分,HAMA评分分别为(6.36±3.02)和(4.93±3.09)分,CGI-S评分分别为(1.49±0.56)和(1.29±0.81)分,ASEX评分分别为(15.92±4.72)和(15.57±5.26)分,在统计学上差异均有统计学意义(均P<0.05)。用药24周末,患者的缓解率为54.59%(202例/370例),复燃率为6.49%(24例/370例),复燃时间为(64.67±42.47)d。巴戟天寡糖胶囊药物不良反应发生率为15.35%(64例/417例)。结论巴戟天寡糖胶囊能用于轻、中度抑郁症患者的巩固期治疗,且具有良好的耐受性和安全性。

关键词：巴戟天寡糖胶囊抑郁症疗效安全性

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Detector Calibration by Monte Carlo Simulation Based on the Energy-Range Relationship of Energetic Ions

引用

Chinese Physics Letters 1999年第1期16卷 15-17页

作者： FANG De-qing FENG jun cai Xiang-zhou wang Jian-song SHEN Wen-qing MA yu-gang ZHU Yong-tai li Song-lin wu He-yu GOU Quan-bu JIN Gen-ming ZHAN Wen-long GUO Zhong-yan XIAO Guo-qing Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000

The experimental measurement of the total interaction cross sections of N,C,B,and Be isotopes on 12C target at medium energies is described.A new formula that gives a good description of the energy-range relationship of energetic ions over a wide energy range is *** energy calibration of detectors is made by a Monte Carlo simulation method based on this new formula.

关键词： formula interaction Energetic

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